Ji Young Choi

Seoul National University of Science and Technology, Sŏul, Seoul, South Korea

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Publications (82)261.62 Total impact

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    ABSTRACT: Objective: Ghrelin is mainly secreted by the gastric oxyntic mucosa and its production is impaired in chronic atrophic gastritis. This study aimed at evaluating how serum total ghrelin correlates with the extent of atrophy, and to compare its performance as a serologic marker with that of pepsinogen (PG). Material and methods: Data were collected from 154 patients with atrophic gastritis. The histological extent of atrophy was assessed by three paired biopsies from the antrum, corpus lesser curvature (CLC), and corpus greater curvature (CGC). Fasting serum concentrations of total ghrelin, pepsinogen I and II were measured. Regression analysis was performed to evaluate the factors associated with serum total ghrelin. The serologic performance was compared with that of pepsinogen using receiver-operating characteristic (ROC) curves. Results: The Helicobacter pylori infection rate was 85%, and extensive atrophic gastritis involving CGC was found in 24%. Serum total ghrelin was significantly decreased in patients with extensive CGC atrophy (median: 170.4 pg/mL, vs 201.1 pg/mL in patients without atrophy; p < 0.001), and its levels correlated with those of pepsinogen I and I/II ratio. The decrease of serum total ghrelin was independent of age, gender, body mass index (BMI), and H. pylori infection status. The sensitivity and specificity of serum total ghrelin in predicting extensive atrophy were 57% and 79%, respectively. The discriminatory ability was similar to that of pepsinogen I/II ratio (p = 0.612), and lower than that of pepsinogen I (p = 0.040). Conclusions: Serum total ghrelin is decreased during extensive atrophy involving CGC. The serologic performance is lower than that of pepsinogen I.
    Scandinavian Journal of Gastroenterology 10/2015; 51(2):137-144. DOI:10.3109/00365521.2015.1083049 · 2.36 Impact Factor

  • 06/2015; 30(2):40-44. DOI:10.7852/ijie.2015.30.2.40
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    ABSTRACT: The present study examined the role of posttraumatic stress symptoms in the relationship between childhood abuse and self-reported psychotic symptoms in severe mental illness. A total of 126 patients diagnosed with major psychiatric conditions with comorbid symptoms of psychosis participated in the present study. The representative psychiatric diagnoses included schizophrenia, bipolar disorder with psychotic features, major depressive disorder with psychotic features, schizoaffective disorder, schizophreniform disorder, and delusional disorder. The Korean Child Trauma Questionnaire measured the type and degree of childhood abuse including emotional, physical, and sexual abuse. Korean version of the Impact of Event Scale-Revised assessed posttraumatic stress symptoms, and PSYC subscale of the PSY-5 Factor Scale of the MMPI-2 was used as a measure of self-reported psychotic symptoms. There was a significant relationship between childhood physical, emotional, sexual abuse and psychotic symptoms. Posttraumatic stress symptoms partially mediated the relationship between childhood abuse and psychotic symptoms. This implies that childhood abuse is significantly associated with the experience of chronic posttraumatic stress symptoms, and that such symptoms in turn increases the likelihood of experiencing psychotic symptoms. The results highlight the need for appropriate assessment and intervention concerning childhood abuse and posttraumatic stress symptoms in severe mental illness. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    06/2015; 229(1-2). DOI:10.1016/j.psychres.2015.05.112
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    ABSTRACT: The synthesis, Zn2+ binding, crystal structure, and cell imaging studies of a new pyrazole amine quinoline receptor with a flexible binding pocket are described. Upon coordination to Zn2+, the absorption of the receptor increases at 364 nm and it fluoresces at 500 nm. The fluorescence response to Zn2+ is selective for Zn2+ and does not occur with other metal ions, not even Cd2+. In solution, the receptor forms 1:1 complexes with Zn2+, but in the solid-state two Zn2+ ions coordinate to the receptor. The aqueous solubility of the receptor allows for imaging of Zn2+ in living cells. Cells exposed to receptor and Zn2+ fluoresce when excited with visible light.
    Dyes and Pigments 02/2015; 113:723-729. DOI:10.1016/j.dyepig.2014.10.006 · 3.97 Impact Factor
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    Young-Nam Kim · Ji Young Choi · Youn-Ok Cho ·
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    ABSTRACT: Physical exercise promotes energy producing pathways requiring thiamin and riboflavin as a coenzyme. Therefore, this study investigated the effects of regular exercise training on urinary excretion of thiamin and riboflavin. Fifty rats were randomly assigned to one of two groups: non-exercise training (NT, n = 25) and regular exercise training (ET, n = 25) for 5 weeks. The rats performed moderate exercise on a treadmill (0.5-0.8 km/hour) for 30 min/day, 5 days/week. Twenty-four hour urine samples were collected at the end of the 0 week, 3(rd) week, and 5(th) week of training and thiamin and riboflavin were analyzed. No significant differences in thiamin and riboflavin intakes for each week were observed between the NT and ET groups. Urinary thiamin excretion of each group was the highest at the 5(th) week compared to the levels at 0 and 3(rd) week. Urinary thiamin at the 5(th) week was significantly lower in the ET group than in the NT group. Urinary riboflavin excretion was increased by training duration, however, no difference was observed between NT and ET for each week. At 0 and 3(rd) week, no significant relationships were observed between dietary intake and urinary excretion of thiamin and riboflavin, however, at the 5(th) week, urinary excretion was significantly increased by dietary intake only in the NT group (P < 0.05). Thiamin excretion of both NT and ET groups was significantly increased with riboflavin excretion at the 5(th) week (P < 0.01). Regular moderate exercise training increased urinary excretion of thiamin. Dietary intakes and urinary excretions of thiamin and riboflavin showed positive correlation in both the exercise training and non-exercise training groups as the exercise training period went by, while the correlations in the exercise training group were weaker than those in the non-exercise training group. Therefore, regular exercise training can alter the urinary excretion of thiamin and riboflavin in rats.
    Nutrition research and practice 02/2015; 9(1):43-8. DOI:10.4162/nrp.2015.9.1.43 · 1.44 Impact Factor
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    Ji Young Choi · Young-Nam Kim · Youn-Ok Cho ·
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    ABSTRACT: A recent Korea National Health and Nutrition Survey indicated inadequate riboflavin intake in Koreans, but there is limited research regarding riboflavin status in South Korea. The purpose of this study was to determine riboflavin intake and status of Korean adults. Three consecutive 24-h food recalls were collected from 412 (145 men and 267 women) healthy adults, aged 20-64 years, living in South Korea and urine samples were collected from 149 subjects of all subjects. The dietary and total (dietary plus supplemental) riboflavin intake was 1.33 ± 0.34 and 2.87 ± 6.29 mg/day, respectively. Approximately 28% of the subjects consumed total riboflavin less than the Estimated Average Requirement. Urinary riboflavin excretion was 205.1 ± 190.1 μg/g creatinine. Total riboflavin intake was significantly positively correlated to the urinary riboflavin excretion. (r = 0.17171, p = 0.0363). About 11% of the Korean adults had urinary riboflavin <27 μg/g creatinine indicating a riboflavin deficiency and 21% had low status of riboflavin (27 μg/g creatinine ≤ urinary riboflavin < 80 μg/g creatinine). Thus, one-third of Korean adults in this study had inadequate riboflavin status. In some adults in Korea, consumption of riboflavin-rich food sources should be encouraged.
    Nutrients 12/2014; 7(1):253-64. DOI:10.3390/nu7010253 · 3.27 Impact Factor
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    ABSTRACT: Endoscopic resection (ER) of superficial esophageal neoplasm (SEN) is a technically difficult procedure. We investigated the clinical outcomes of ER for SEN to determine its feasibility and effectiveness. Subjects who underwent ER for SEN at Asan Medical Center between December 1996 and December 2010 were eligible. The clinical features of patients and tumors, histopathological characteristics, adverse events, ER results and survival were investigated. A total of 129 patients underwent ER for 147 SENs. En bloc resection (EnR) was performed in 118 lesions (80.3%). Complete resection (CR) was accomplished in 128 lesions (86.5%), and curative resection (CuR) was performed in 118 lesions (79.7%). The EnR, CR, and CuR rates were significantly greater in the endoscopic submucosal dissection group when compared to those in the endoscopic resection group. Adverse events occurred in 22 patients (17.1%), including bleeding (n=2, 1.6%), perforation (n=12, 9.3%), and stricture (n=8, 6.2%). Local tumor recurrence occurred in 2.0% of patients during a median follow-up of 34.8 months. The 5-year overall and disease-specific survival rates were 94.0% and 97.5%, respectively. ER is a feasible and effective method for the treatment of SEN as indicated by favorable clinical outcomes. (Gut Liver, Published online December 5, 2014).
    Gut and liver 12/2014; 81(5). DOI:10.5009/gnl13263 · 1.81 Impact Factor
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    ABSTRACT: Background: The use of endoscopic submucosal dissection (ESD) for the treatment of minute submucosal (SM) invasive cancer that fulfills the current expanded criteria remains controversial. This study investigated the clinicopathological parameters of patients with sm1 gastric cancers to predict lymph node metastasis (LNM) and evaluate the feasibility of ESD as a curative treatment. Methods: Data from 278 patients who underwent surgical resection of sm1 gastric cancer between 2006 and 2010 were retrospectively collected, and their clinicopathological parameters were analyzed to identify predictive factors of LNM. Results: Of 278 patients, 28 patients (10.1 %) had LNM. Multivariate analysis identified multiple lesions (p = 0.018), lymphovascular invasion (LVI) (p < 0.001), SM invasion depth >500 µm (p = 0.007), undifferentiated histology (p = 0.012), and ulceration (p = 0.024) as factors significantly associated with LNM in patients with sm1 gastric cancer. Additionally, SM invasion width/superficial tumor size ratio >0.04 (p = 0.036) demonstrated a significant association with LNM in patients with sm1 gastric cancer falling within the current expanded criteria for ESD. LNM was not identified among 35 patients who met the absence of ulceration, SM invasion depth ≤ 500 µm, and SM invasion width/superficial tumor size ratio ≤ 0.04 besides the current expanded indications. Conclusions: Endoscopic resection can be performed on patients with minute SM invasive, differentiated cancers of ≤ 3 cm without LNM on pretreatment examination. In addition, if histological assessment shows the absence of LVI and ulceration, SM invasion depth ≤ 500 µm, and SM invasion width/superficial tumor size ratio ≤ 0.04, the patient can be carefully observed without additional treatment.
    Surgical Endoscopy 09/2014; 29(6). DOI:10.1007/s00464-014-3828-8 · 3.26 Impact Factor

  • The American Journal of Gastroenterology 07/2014; 109(7):1081. DOI:10.1038/ajg.2014.128 · 10.76 Impact Factor
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    ABSTRACT: Little is known about the effects of periodic endoscopic screening before detection of primary gastric cancer. We compared clinical outcomes in patients who did and did not undergo endoscopy before diagnosis. Between January 2009 and November 2011, 769 patients were referred to Asan Medical Center after diagnosis of gastric cancer. Clinical outcomes were compared in patients who had (n=512) and had not (n=257) undergone endoscopic screening before diagnosis of gastric cancer. Factors about resectability and possibility of endoscopic resection were analyzed. In the nonexamined group, 225 patients (87.5%) had resectable gastric cancers and were treated surgically (n=151, 67.1%) or by endoscopic resection (n=74, 32.9%). In the examined group, 493 (96.3%) had resectability and were resected surgically (n=243, 49.3%) or endoscopically (n=250, 50.7%). Multivariate analysis showed that symptoms, no endoscopic screening, and lower serum albumin were associated with unresectability. Of the 718 resectable tumors, 394 underwent surgery and 324 underwent endoscopic resection. Multivariate analysis showed that older age, no symptoms, ≤1 year interval endoscopy, and higher serum albumin were associated with endoscopic resection. Previous endoscopy can increase gastric cancer resectability. Moreover, a ≤1 year interval from endoscopic examination can increase the possibility of endoscopic resection.
    Hepato-gastroenterology 07/2014; 61(133):1465-71. DOI:10.5754/hge13450 · 0.93 Impact Factor
  • Ji Young Choi · In Hee Cho · Young-Suk Kim · Hyong Joo Lee ·
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    ABSTRACT: This study revealed that monoterpene and sesquiterpene hydrocarbons, and their oxygenated derivatives were the major volatile compounds in Korean mugwort extracted by both simultaneous steam distillation and solvent extraction and headspace solid-phase microextraction. In particular, β-caryophyllene was the most predominant compound. Furthermore, 1,8-cineol, described as camphoraceous and minty notes, was found to be the most potent aroma-active compound of Korean mugwort, followed by (Z)-3-hexenal (described as green and apple-like notes), γ-terpinene (described as grassy note), and (E,Z)-2,6-nonadienal (described as cucumber-like and green notes). Moreover, ethyl 2-methylpropanoate, methyl 3-methylbutanoate, and ethyl 2-methylbutanoate could contribute to sweet and fruity notes of Korean mugwort with their characteristic odor properties.
    Journal of the Korean Society for Applied Biological Chemistry 06/2014; 57(3). DOI:10.1007/s13765-014-4082-4 · 0.69 Impact Factor
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    ABSTRACT: The purpose of the present study was to first examine whether childhood abuse predicts symptom complexity, as indicated by the number of clinically elevated scales on the MMPI-2 in an adult clinical sample. Secondly, we investigated whether emotion regulation difficulties mediated the relationship between childhood abuse and symptom complexity. A total of 162 adult outpatients not presenting with psychotic symptoms completed the Korean Childhood Trauma Questionnaire (K-CTQ), Life Events Checklist (LEC), Difficulties in Emotion Regulation Scale (DERS), and Korean Minnesota Multiphasic Personality Inventory-2 (MMPI-2). Partial correlation analysis results indicated that after controlling for the presence of adulthood trauma, childhood abuse was associated with more symptom complexity, or more clinically elevated scales on the MMPI-2. Furthermore, structural equation modeling results showed that emotion regulation difficulties partially mediated the relationship between childhood abuse and symptom complexity. These findings indicate that individuals who had experienced childhood abuse evidence simultaneous presentation of diverse clinical symptoms.
    Child Abuse & Neglect 05/2014; 38(8). DOI:10.1016/j.chiabu.2014.04.016 · 2.47 Impact Factor
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    ABSTRACT: Objectives: Although many epidemiologic studies have shown that Helicobacter pylori (H. pylori) eradication has prophylactic effects on gastric cancer, their results are less clear in high-risk populations. We conducted this study to examine whether H. pylori eradication would affect the occurrence of metachronous gastric cancer after endoscopic resection in patients with early gastric cancer. Methods: We retrospectively analyzed 2,089 adults who underwent endoscopic resection of gastric low-grade neoplasia, high-grade neoplasia, or differentiated invasive neoplasia from 2004 to 2008 at Asan Medical Center. Of these, a total of 1,007 patients with early gastric cancer were enrolled in this study. We evaluated the demographic data, the pathology, and the incidence of metachronous recurrence by dividing them into three groups: those without active H. pylori infection (Hp negative group, n=340), those who successfully underwent H. pylori eradication (eradicated group, n=485), and those who failed or did not undergo H. pylori eradication (noneradicated group, n=182). Results: Metachronous recurrence was diagnosed in 75 patients, including 17 in the Hp, 34 in the eradicated, and 24 in the noneradicated groups. Median time to metachronous recurrence was 18 months (range, 7-75 months). The incidence of metachronous gastric cancer was 10.9 cases per 1,000 person-years in the Hp negative group, 14.7 cases per 1,000 person-years in the eradicated group, and 29.7 cases per 1,000 person-years in the noneradicated group. The hazard ratios in the noneradicated group compared with the Hp negative and eradicated groups were 2.5 (P<0.01) and 1.9 (P=0.02), respectively. H. pylori eradication reduced metachronous recurrence of gastric neoplasm, which was also shown in the secondary analysis of 1,487 patients with low-grade neoplasia and early gastric cancer. Conclusions: Successful H. pylori eradication may reduce the occurrence of metachronous gastric cancer after endoscopic resection in patients with early gastric cancer.
    The American Journal of Gastroenterology 12/2013; 109(1). DOI:10.1038/ajg.2013.404 · 10.76 Impact Factor
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    ABSTRACT: Endoscopic forceps biopsy (EFB) is a major diagnostic procedure for gastric epithelial neoplasia (GEN). However, discrepancy between the result of EFB and endoscopic resection (ER) is not uncommon. Thus, there is controversy over whether specimens obtained by EFB are optimal for diagnosis of GEN. We investigated the discrepancy between EFB and ER in the diagnosis of GEN. A total of 1,850 GEN cases were histologically diagnosed with EFB, including 954 low-grade dysplasias (LGDs), 315 high-grade dysplasias (HGDs), and 581 carcinomas. Following diagnosis with EFB, all patients were treated with ER. We retrospectively reviewed the pathologic findings and patient characteristics and analyzed predictors for the discrepancy between the two procedures (largest diameter, number of biopsy fragments, number of biopsy fragments/largest diameter, location, macroscopic type, color, surface unevenness, and erosion). The overall discrepancy rate between EFB and ER was 31.7 % (587/1,850). Among the discordant group, 440 (23.9 %) cases showed a higher grade of disease after ER; 229 of the 954 LGDs (24.0 %) were diagnosed as HGD or carcinoma, 166 of the 315 HGDs (52.7 %) as carcinoma, and 45 of the 581 differentiated carcinomas (7.7 %) as undifferentiated carcinoma. In the LGD group with EFB, the largest diameter (≥1.8 cm; P < 0.001), surface unevenness (P = 0.014), and depressed macroscopic type (P < 0.001) were factors associated with discrepancy. In the carcinoma group with EFB, flat macroscopic type (P = 0.043) was the only significant factor. In the HGD group with EFB, there were no significant factors for discrepancy. EFB can be insufficient for diagnosing GENs, and ER can be considered not only as treatment but also as a diagnostic modality in GEN. It is especially pertinent to all cases of HGD regardless of their endoscopic features and to cases of LGDs with the largest lesion diameter ≥1.8 cm, surface unevenness, or a depressed macroscopic type.
    Surgical Endoscopy 12/2013; 28(4). DOI:10.1007/s00464-013-3316-6 · 3.26 Impact Factor
  • Ji Young Choi · Kyung Ja Oh ·
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    ABSTRACT: The purpose of the present study was to identify the mediating effects of emotion regulation on the association between cumulative childhood trauma and behavior problems in sexually abused children in Korea, using structural equation modeling (SEM). Data were collected on 171 children (ages 6-13 years) referred to a public counseling center for sexual abuse in Seoul, Korea. Cumulative childhood traumas were defined on the basis of number of traumas (physical abuse, witnessing domestic violence, neglect, traumatic separation from parent, and sexual abuse) and the severity and duration of traumas. Children were evaluated by their parents on emotion regulation using the Emotion Regulation Checklist and internalizing and externalizing behavior problems using the Korean-Child Behavior Checklist. SEM analyses confirmed the complete mediation model, in which emotion dysregulation fully mediates the relationship between cumulative childhood traumas and internalizing/externalizing behavior problems. These findings indicate that emotion regulation is an important mechanism that can explain the negative effects of cumulative childhood traumas and that there is a need to focus on emotion regulation in sexually abused children exposed to cumulative trauma.
    Child abuse & neglect 10/2013; 38(2). DOI:10.1016/j.chiabu.2013.09.009 · 2.34 Impact Factor
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    ABSTRACT: Six gram-negative, non-fermentative bacteria, which were designated as strains 11-0202T, 11-0607, LUH13522, LUH8638, LUH10268, and LUH10288 were isolated from soil in South Korea, from soil of a beetfield in Germany, soil in the Netherlands, and sediment of integrated fish in Malaysia and Thailand, respectively. Based on 16S rRNA, rpoB, and gyrB gene sequences, they represented a novel species of Acinetobacter. Their 16S rRNA gene sequences showed the greatest pairwise similarity to A. beijerinckii (97.9 to 98.4%). A. johnsonii and A. bouvetii were the species showing the greatest similarities with the six strains in rpoB and gyrB gene sequences, but they showed sequence divergences (85.4-87.6 and 78.1-82.7%, respectively). A strains 11-0202T displayed low DNA-DNA reassociation values less than 40% with the closely related Acinetobacter species. The strains utilized 2,3-butanediol, ethanol, and DL-lactate as sole carbon sources. Cellular fatty acid (CFA) analyses showed similarities to those of related Acinetobacter species: summed feature 3 (C16:1 ω7c, C16:1 ω6c)' (26.0-27.0%), C18:1 ω9c (22.1-23.4%), C16:0 (17.3%-22.0%), and C12:0 (9.2-12.4%). On the basis of current findings, it is concluded that the six strains represent a novel species, for which the name Acinetobacter kookii sp. nov. is proposed. The type strain is strain 11-0202T (= KCTC 32033T = JCM 18512T).
    International Journal of Systematic and Evolutionary Microbiology 08/2013; 63(Pt 12). DOI:10.1099/ijs.0.047969-0 · 2.51 Impact Factor
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    ABSTRACT: Recent analysis of prokaryotic N(ε) -lysine-acetylated proteins highlights the post-translational regulation of a broad spectrum of cellular proteins. However, the exact role of acetylation remains unclear due to a lack of acetylated proteome data in prokaryotes. Here, we present the N(ε) -lysine-acetylated proteome of gram-positive thermophilic Geobacillus kaustophilus. Affinity enrichment using acetyl-lysine-specific antibodies followed by LC-MS/MS analysis revealed 253 acetylated peptides representing 114 proteins. These acetylated proteins include not only common orthologs from mesophilic Bacillus counterparts, but also unique G. kaustophilus proteins, indicating that lysine acetylation is pronounced in thermophilic bacteria. These data complement current knowledge of the bacterial acetylproteome and provide an expanded platform for better understanding of the function of acetylation in cellular metabolism. This article is protected by copyright. All rights reserved.
    Proteomics 08/2013; 13(15). DOI:10.1002/pmic.201200072 · 3.81 Impact Factor
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    ABSTRACT: The 4-propargylamino-1,8-naphthalimide based fluorescent probe 1 has been explored as a sensor for selective detection of Au(3+). 4-Amino-1,8-naphthalimides, that possess typical intramolecular charge transfer (ICT) electronic characteristics, have been widely used as versatile platforms for fluorescent probes. The newly designed probe 1 contains a propargylamine moiety at C-4 of the naphthalimide chromophore that reacts with Au(3+) to generate a product that has distinctly different electronic properties from 1. Specifically, the probe undergoes a remarkable change in its absorption spectrum upon addition of Au(3+) that is associated with a distinct color change from yellow to light pink. In addition, a blue shift of ca. 56nm also takes place in the emission spectra of the probe. Consequently, 1 serves as a reaction-based sensor or so called chemodosimeter for Au(3+). Importantly, surfactants enhance the rate of reaction of 1 with Au(3+), thus, enhancing its use as a real time sensor. Finally, the results of studies probing its application to bioimaging of Au(3+) in live cells show that the probe 1 has a unique ability to sense Au(3+) in cells and, in particular, in lipid droplets within cells.
    Biosensors & Bioelectronics 06/2013; 49C:438-441. DOI:10.1016/j.bios.2013.05.033 · 6.41 Impact Factor
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    ABSTRACT: Background: There are insufficient reports on the outcomes and local recurrence rates for gastric neoplasms treated using argon plasma coagulation (APC). The purpose of this study was to analyze the clinical outcomes in early gastric cancer or gastric adenoma patients following APC treatment. Methods: Seventy-one patients were enrolled and all underwent APC at the Asan Medical Center between July 2007 and August 2011. Clinical and oncological outcomes were analyzed. Results: The median follow-up period was 20 months (interquartile range 13-29 months). Among the 71 patients we evaluated, nonlifting after submucosal saline injection was found in 35 patients and 15 patients (21.2%) experienced local recurrence with a median period of 10 months (IQR 5-13 months). The rate of local recurrence was higher in the nonlifting group and the 40-W group than in the lifting group and the 60- or 80-W groups (31.4 vs. 11.1%, p = 0.045 and 31.7 vs. 6.7%, p = 0.017, respectively). Multivariate analysis showed that the power setting with the 40-W and nonlifting groups after submucosal injection was associated with local recurrence. Conclusions: APC therapy after submucosal saline injection using high power (60 or 80 W) appears to be an effective alternative in the management of gastric neoplasm.
    Surgical Endoscopy 02/2013; 27(9). DOI:10.1007/s00464-013-2868-9 · 3.26 Impact Factor
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    ABSTRACT: One hundred and twenty-one isolates of S. maltophilia complex were collected from seven Korean hospitals. Species and groups were identified using partial gyrB gene sequences and antimicrobial susceptibility testing was performed using a broth microdilution method. Based on partial gyrB gene sequences, 118 isolates were identified to belong to S. maltophilia complex including S. maltophilia, S. pavanii, Pseudomonas beteli, P. geniculata, and P. hibisciola. S. maltophilia were further divided into three groups, I to III. While S. maltophilia groups II and III were clustered into Clade A with S. pavanii and P. beteli, S. maltophilia group I was clustered into Clade B with P. geniculata and P. hibisciola. For all S. maltophilia complex isolates, resistance rate to trimethoprim/sulfamethoxazole (TMP/SMX) was very high (30.5%). Antimicrobial resistance rates were varied by species or groups of S. maltophilia complex. Isolates of Clade A showed significantly lower antimicrobial resistance rates than those of Clade B; while 25.0% of Clade A isolates were multidrug-resistant, 46.0% of Clade B isolates were multidrug-resistant (P 0.001). In this study, high antimicrobial resistance rates, particularly to TMP/SMX, were identified among S. maltophilia complex isolates from Korea. Distinct groups among S. maltophilia complex isolates were revealed and antimicrobial resistance rates differed among those groups. These data suggest consideration of alternative agents to TMP/SMX to treat S. maltophilia infections and warrant importance of accurate identification of appropriate selection of treatment option.
    Journal of Medical Microbiology 02/2013; 62(Pt_5). DOI:10.1099/jmm.0.053355-0 · 2.25 Impact Factor

Publication Stats

733 Citations
261.62 Total Impact Points


  • 2015
    • Seoul National University of Science and Technology
      Sŏul, Seoul, South Korea
  • 2014-2015
    • Duksung Women's University
      • Department of Food and Nutrition
      Sŏul, Seoul, South Korea
    • Seoul National University
      • Department of Agricultural Biotechnology
      Sŏul, Seoul, South Korea
  • 2013-2015
    • Inje University
      Kŭmhae, Gyeongsangnam-do, South Korea
    • Korea Research Institute of Bioscience and Biotechnology KRIBB
      • BioMedical Proteomics Research Center
      안산시, Gyeonggi-do, South Korea
  • 2011-2014
    • University of Ulsan
      • • College of Medicine
      • • Department of Internal Medicine
      Ulsan, Ulsan, South Korea
    • Asan Medical Center
      • Department of Gastroenterology
      Sŏul, Seoul, South Korea
    • MEDIPOST Biomedical Research Institute
      Sŏul, Seoul, South Korea
  • 2012-2013
    • Ewha Womans University
      • • Department of Chemistry Nano Science
      • • Department of Bioinspired Science
      Sŏul, Seoul, South Korea
  • 2010-2013
    • Ulsan University Hospital
      Urusan, Ulsan, South Korea
    • Catholic Kwandong University
      Gangneung, Gangwon-do, South Korea
  • 2009-2013
    • Sungkyunkwan University
      • Department of Molecular and Cell Biology
      Sŏul, Seoul, South Korea
    • Korea Polar Research Institute
      Sŏul, Seoul, South Korea
  • 2010-2011
    • Jeju National University
      • Department of Chemistry
      Tse-tsiu, Jeju, South Korea
  • 2009-2011
    • Catholic University of Daegu
      Kayō, North Gyeongsang, South Korea
  • 2007-2011
    • Sahmyook University
      Sŏul, Seoul, South Korea
  • 2006-2010
    • National Cancer Center Korea
      • • Lung Cancer Branch
      • • Colorectal Cancer Branch
      Kōyō, Gyeonggi Province, South Korea
  • 2008-2009
    • Yeungnam University
      • College of Pharmacy
      Gyeongsan, Gyeongsangbuk-do, South Korea