Peter Elsner

Universitätsklinikum Jena, Jena, Thuringia, Germany

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Publications (643)1301.85 Total impact

  • Melanie Peckruhn · Peter Elsner ·
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 12/2015; 13(12):1285-1286. DOI:10.1111/ddg.120_12818 · 2.05 Impact Factor
  • Steven Goetze · Peter Elsner ·
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    ABSTRACT: Solar urticaria is a rare IgE-mediated and chromophore-dependent photodermatosis. In some cases, these chromophores, designated as “serum factor”, may be detected in serum or plasma. To date, the exact pathogenesis of solar urticaria has, however, not been elucidated. Typical clinical features include the onset of urticarial lesions within a few minutes after light exposure, which already raises diagnostic suspicion. The most common triggers are UVA and visible light. Determination of the action spectrum as well as the minimal urticarial dose (MDU) is diagnostically crucial. Other photodermatoses such as polymorphic light eruption or porphyrias (especially erythropoietic protoporphyria) have to be ruled out. Apart from sunlight avoidance, which is always required, further therapeutic options used include nonsedating antihistamines as well as light hardening. Newer treatment modalities such as plasmapheresis or the anti-IgE antibody omalizumab are reserved for severe, recalcitrant forms of solar urticaria.
    Journal der Deutschen Dermatologischen Gesellschaft 12/2015; 13(12):1250-1253. DOI:10.1111/ddg.12809 · 2.05 Impact Factor
  • Steven Goetze · Peter Elsner ·
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    ABSTRACT: Die Lichturtikaria ist eine seltene, IgE-vermittelte und von Chromophoren abhängige Photodermatose. In manchen Fällen können diese Chromophore im Serum oder Plasma der Patienten als sogenannter „Serumfaktor“ nachgewiesen werden. Die genaue Pathogenese der Lichturtikaria ist jedoch bislang ungeklärt. Typisch ist die Quaddelbildung innerhalb weniger Minuten nach Lichtexposition, welche anamnestisch schon zur Verdachtsdiagnose führt. Die häufigsten Auslöser sind UV-A oder sichtbares Licht. Diagnostisch von Bedeutung ist die Feststellung des Aktionsspektrums und der minimalen urtikariellen Dosis (MUD). Differenzialdiagnostisch müssen andere Lichtdermatosen (wie polymorphe Lichtdermatose) oder Porphyrien (insbesondere erythropoetische Protoporphyrie) ausgeschlossen werden. Außer dem stets notwendigen Lichtschutz werden moderne Antihistaminika sowie Lichtabhärtung (hardening) therapeutisch eingesetzt. Neuere Therapieverfahren wie die Plasmapherese oder der Anti-IgE-Antikörper Omalizumab bleiben schweren, therapieresistenten Formen vorbehalten.
    Journal der Deutschen Dermatologischen Gesellschaft 12/2015; 13(12):1250-1254. DOI:10.1111/ddg.100_12809 · 2.05 Impact Factor
  • Melanie Peckruhn · Peter Elsner ·
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 12/2015; 13(12):1285-1286. DOI:10.1111/ddg.12818 · 2.05 Impact Factor
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    ABSTRACT: Colophony is not used as a fragrance ingredient. However, colophony is a well-established marker of fragrance contact allergy(2-4) . Colophony was therefore included as a fragrance allergy marker in our recent paper in BJD on contact allergy in the general population (prevalence 1.0%; 95%-CI 0.6%-1.3%)(5) . When including colophony as a fragrance marker in the article on fragrance contact allergy(1) together with fragrance mix I (FM I) in the True test containing an evernia prunastri (oak moss) with a high content of atranol and chloratranol or fragrance mix II (FM II) or any of the individual materials in either FM I or FM II or Myroxylon pereirae (MP) or sesquiterpene lactones, some information in table 5 of this article(1) change slightly according to the numbers given here: This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 11/2015; DOI:10.1111/bjd.14297 · 4.28 Impact Factor
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    ABSTRACT: History and clinical findings: In a 58-year-old man progressive yellowing of all nails was associated with the diagnosis of chronic rhinosinusitis and COPD, later the COPD exacerbated with pneumonias. Investigations: Repeated fungal cultures and polymerase chain reactions to detect fungal DNA in order to exclude Onychomycosis, chest X-ray, computed tomography of the lung, extended pulmonary function tests, ECG, echocardiography and abdominal ultrasonography were performed and had normal results. Treatment and course: Normal fingernails regrew after a 6 month-course of vitamin E intake, most of the toenails remained coloured and thickened. After the initial presentation at the dermatological outpatient department the pulmonary situation remained stable, there was no need for additional pulmonary interventions. Conclusion: Yellowing of all nails is a diagnostic sign of the Yellow-nail-Syndrome, which is associated with respiratory diseases, the treatment is often difficult and also an interdisciplinary approach is needed.
    DMW - Deutsche Medizinische Wochenschrift 11/2015; 140(22):1696-1698. DOI:10.1055/s-0041-105774 · 0.54 Impact Factor
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    ABSTRACT: Background Antihistamines (AH) are often used to treat chronic skin diseases related to allergy and/or pruritus. Data on the use of AH in patients with chronic hand eczema (CHE) is scarce.Objective The objective of this study was to investigate prevalence and determinants of AH use in patients with CHE.Methods Data were drawn from the German CARPE registry. The relationship of clinical, demographic and treatment-related variables with AH use in the past 12 months was analysed by means of logistic regression. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were computed.ResultsA total of 1255 patients with CHE were eligible for analysis (54.1% female; mean age: 47.1 years, standard deviation (SD) 13.6 years). Mean subjective disease severity was 5.0 (SD 2.5). 25% of the sample reported to have used AH in the past 12 months. Significant positive associations with AH use were identified for moderate (OR = 3.05, 95% CI 1.81–5.15) or severe (OR = 4.27, 95% CI 2.40–7.59) pruritus, a history of systemic treatment (e.g. alitretinoin) (OR = 2.85, 95% CI: 2.06–3.96), UV phototherapy (OR = 1.78, 95% CI 1.28–2.46), flexural eczema (OR = 1.89, 95% CI 1.32–2.71), allergic rhinitis/conjunctivitis (OR = 2.41, 95% CI 1.71–3.39) and female gender (OR = 1.58, 95% CI 1.16–2.14) in multivariate analyses (N = 1184). Significant inverse associations were found for an eczema localization besides the hands (OR = 0.66, 95% CI 0.46–0.94) and for patients being recruited in hospital (vs. dermatological practice; OR = 0.47, 95% CI 0.33–0.67).Conclusions This study suggests that AH use is frequent in patients with CHE and mainly related to female gender, disease severity, pruritus, comorbid atopic disease and treatment centre.
    Journal of the European Academy of Dermatology and Venereology 10/2015; DOI:10.1111/jdv.13398 · 2.83 Impact Factor
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  • Peter Elsner · Sibylle Schliemann ·
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 10/2015; 13(10). DOI:10.1111/ddg.100_12664 · 2.05 Impact Factor
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    ABSTRACT: Background: Contact allergy to phenol-formaldehyde resins (PFRs) based on phenol and formaldehyde is not detected by a p-tertiary-butylphenol-formaldehyde resin included in most baseline patch test series. Objective: The aims of this study were to investigate the contact allergy rate to PFR-2 in an international population and to investigate associated simultaneous allergic reactions. Methods: Thirteen centers representing the International Contact Dermatitis Research Group included PFR-2 into their patch test baseline series during a period of 6 months in 2012. Results: Of 2259 patients tested, 28 (1.2%) reacted to PFR-2. Of those 28 individuals, one had a positive reaction to formaldehyde and 2 to p-tertiary-butylphenol-formaldehyde resin. Simultaneous allergic reactions were noted to colophonium in 3, to Myroxylon pereirae in 5, and to fragrance mix I in 8. Conclusions: The contact allergy frequency in the tested population (1.2%) merits its inclusion into the international baseline series and possibly also into other baseline series after appropriate investigations. Significantly, overrepresented simultaneous allergic reactions were noted for M. pereirae and fragrance mix I.
    Dermatitis 09/2015; 26(5):230-4. DOI:10.1097/DER.0000000000000137 · 1.63 Impact Factor
  • Claudia Schummer · Jörg Tittelbach · Peter Elsner ·
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    ABSTRACT: History and clinical findings: A 44-year-old man presented at a dermatologist with a 2 months history of a blue-brown reticular macule on the right thigh that had appeared spontaneously. It was neither painful nor itching and showed no growth or further colour change. Investigations: Punch biopsy, antinuclear antibodies, CrP, immune electrophoresis, hepatitis serology, urine diagnostics showed normal results. Diagnosis: On specific inquiry the patient, a long-distance truck driver, reported to rest his laptop during driving breaks always on the right thigh. We diagnosed a "laptop dermatitis". Conclusion: Consider external mechanical or thermal triggers if skin changes are unilateral. Thermal isolation from permanent heat exposure prevents an erythema ab igne reliably.
    DMW - Deutsche Medizinische Wochenschrift 09/2015; 140(18):1376-1377. DOI:10.1055/s-0041-103615 · 0.54 Impact Factor
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    ABSTRACT: Background Contact allergy to fragrances is mostly assessed in clinical populations of patients. Studies in the general population are scarce and vary in their methodology across countries.Objectives To determine the prevalence of fragrance contact allergy in the European general population and to assess the clinical relevance of positive patch test reactions to different fragrances.Methods In five European countries (Germany, Italy, The Netherlands, Portugal and Sweden) a random sample from the general population aged 18 to 74 years was drawn. In total 12,377 subjects were interviewed in this cross-sectional study and a random sample (n=3,119) was patch tested using True test and Finn chamber technique. Patch test procedures were harmonized by a mandatory training in advance of and a monitoring during the study.ResultsThe highest prevalence for contact allergy of 2.6% (95% CI 2.1-3.2) was found for FM I in petrolatum with a high content of atranol and chloratranol, and 1.9% (95% CI 1.5-2.4) for FM II in petrolatum. The conservatively estimated prevalence of fragrance contact allergy (defined by the existence of a positive patch test to Fragrance Mix I (FM I) or Fragrance Mix II (FM II) or any of the individual materials in either FM I or FM II or Myroxylon pereirae or sesquiterpene lactones or 3 and 4-hydroxyisohexyl 3-cyclohexene carboxaldehyde) that show clinical relevance, defined conservatively as lifetime avoidance of scented products and an itchy skin rash lasting more than 3 days in a lifetime, was 1.9% (95% CI 1.5-2.5). If we use the reported lifetime prevalence of any contact dermatitis instead of the lifetime prevalence of any itchy skin rash, the prevalence is 0.8% (95% CI 0.5-1.2).The prevalence rates of contact allergy to fragrances in females are about two times higher than in males.Conclusions The study helps identifying targets for prevention of fragrance allergy.This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 09/2015; DOI:10.1111/bjd.14151 · 4.28 Impact Factor
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    ABSTRACT: Background Population-based studies about contact allergy are scarce.Objectives: To obtain reliable estimates of prevalence of contact allergy in the general population in Europe.Methods Cross-sectional study of a random sample from the general population, aged 18 to 74 years, in 5 different European countries (Sweden, The Netherlands, Germany, Italy, Portugal). In total 12,377 subjects were interviewed and a random sample (n=3,119) patch tested to TRUE-test panel 1, 2 and 3 plus fragrance mix II, HICC, and sesquiterpene lactone mix. A positive patch test reaction is considered as contact allergy.ResultsIn total, 27.0% (95% CI 25.5-28.5) had at least one positive reaction to an allergen of the European baseline series with a significant higher prevalence in females compared to males. The highest age-standardized prevalences (≥ 1%) were found for nickel (14.5%; 95% CI 13.2-15.8), thimerosal (5.0%; 95% CI 4.2-5.8), cobalt (2.2%; 95% CI 1.7-2.7), fragrance mix II (1.9%, 95% CI 1.5-2.5), fragrance mix I (1.8% 95% CI 1.4-2.3), hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC)(1.4%, 95% CI 1.0-1.9), p-tert-butylphenol- formaldehyde-resin (1.3%; 95% CI 0.9-1.7), and p-phenylenediamine (1.0%; 95% CI 0.6-1.3). Only Nickel and Thimerosal showed a statistically significant different prevalence for contact allergy amongst the different European populations. Subjects that reported contact dermatitis in lifetime (age-standardized prevalence 15.1%, 95%CI 13.8-16.3) had an increased risk for contact allergy (OR 1.9, 95% CI 1.5-2.5) the risk of having a contact allergy was not increase in those with atopic dermatitis (prevalence 7.6%, 95% CI 6.7-8.6; OR 1.0, 95% CI 0.7-1.4).Conclusions Contact allergy to at least one allergen of the European baseline series was diagnosed in more than one quarter of the general European population. Therefore measures to improve the primary prevention of contact allergy have to be enforced.This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 09/2015; DOI:10.1111/bjd.14167 · 4.28 Impact Factor
  • C Hiernickel · S Goetze · S Schliemann · I Bischoff · P Elsner ·

    Der Hautarzt 08/2015; 66(9). DOI:10.1007/s00105-015-3667-0 · 0.56 Impact Factor
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    ABSTRACT: Considering the scarcity of dermatologic resources in many parts of the world, self-testing by patients is not only of interest for internal medicine but also for dermatology. In this open, nonrandomized, multicenter diagnostic trial involving subjects with suspected contact sensitization to nickel and/or a fragrance mix, we assessed the agreement of self-testing by subjects with readings made by dermatologists. The self-test product (Nixema(TM)) is based on Thin-Layer Rapid Use Epicutaneous Test (TRUE Test®) technology. One hundred and sixty-five subjects self-tested the ready-made patch-test product. The test was applied for 48 h and then read after 3 or 4 days. It was also evaluated independently by experienced dermatologists after 3 or 4 days. In the 162 evaluable subjects, the proportion of agreement for both allergens together was 89.5% [95% confidence interval (CI) 83.7-93.8], the sensitivity was 97.5 % (95% CI 86.8-99.9) and the specificity was 86.9% (95% CI 79.6-92.3). Cohen's kappa was also high at 0.749 (95% CI 0.637-0.862). Discrepancies between the subjects' readings and the dermatologists' readings were mainly due to the subjects interpreting reactions of 'irritant' or 'doubtful' as 'positive'. Apart from itching and burning sensations and tape irritation, no side effects were observed. In conclusion, this study showed a high rate of agreement between the self-reading of the upper arm and the readings made by the dermatologists. The upper arm proved to be an appropriate area for self-testing. Self-testing may improve the screening for contact sensitization for patients, particularly where dermatologic health resources are scarce. © 2015 S. Karger AG, Basel.
    Skin pharmacology and physiology 07/2015; 28(5):257-263. DOI:10.1159/000437017 · 2.37 Impact Factor
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    Allergo Journal International 07/2015; 23(4):126-138. DOI:10.1007/s40629-014-0013-5
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    ABSTRACT: Hemocompatibility of aqueous solutions of antimicrobial 6-deoxy-6-aminoethyleneamino (AEA) cellulose with different degree of substitution (DS, 0.54 - 0.92) was investigated in vitro. The AEA cellulose derivatives were synthesized by tosylation of cellulose and subsequent nucleophilic substitution with 1,2-diaminoethane. The structure was confirmed by elemental analysis as well as by FTIR- and NMR spectroscopy. Markers for coagulation (thrombin generation, aPTT, PT, blood clotting, thrombocyte activation) and membrane integrity (hemolysis) were measured in human whole blood, human platelet rich plasma, human pooled plasma, and erythrocytes suspension. AEA cellulose with a low DS of 0.54 showed the highest hemocompatibility in vitro, suggesting the possibility of biomedical applications.
    Journal of Biomaterials Science Polymer Edition 07/2015; 26(14):1-26. DOI:10.1080/09205063.2015.1068546 · 1.65 Impact Factor
  • Peter Elsner · Sibylle Schliemann ·
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 07/2015; 13(10). DOI:10.1111/ddg.12664 · 2.05 Impact Factor
  • Sibylle Schliemann · Peter Elsner ·
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 07/2015; 13(7):698-9. DOI:10.1111/ddg.12739 · 2.05 Impact Factor
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    06/2015; DOI:10.2147/CWCMR.S60315

Publication Stats

8k Citations
1,301.85 Total Impact Points


  • 2000-2015
    • Universitätsklinikum Jena
      • Klinik für Hautkrankheiten
      Jena, Thuringia, Germany
  • 1998-2014
    • Friedrich-Schiller-University Jena
      • • Clinic of Dermatology
      • • Institute of Medical Statistics, Computer Sciences and Documentation
      Jena, Thuringia, Germany
  • 2013
    • Universität Heidelberg
      Heidelburg, Baden-Württemberg, Germany
  • 2010
    • Technische Universität Dresden
      Dresden, Saxony, Germany
  • 2008
    • Procter & Gamble
      Cincinnati, Ohio, United States
  • 2007
    • Universität zu Lübeck
      Lübeck Hansestadt, Schleswig-Holstein, Germany
  • 2004
    • Universität Ulm
      Ulm, Baden-Württemberg, Germany
    • Northwestern University
      • Division of Dermatology
      Evanston, Illinois, United States
  • 2003
    • University of Freiburg
      • Department of Pneumology
      Freiburg, Lower Saxony, Germany
  • 1993-1999
    • University of Zurich
      • Dermatologische Klinik und Poliklinik
      Zürich, Zurich, Switzerland
  • 1996-1998
    • University Hospital Zürich
      Zürich, Zurich, Switzerland
  • 1993-1998
    • Schulthess Klinik, Zürich
      Zürich, Zurich, Switzerland
  • 1989-1991
    • University of California, San Francisco
      • • Department of Dermatology
      • • Division of Hospital Medicine
      San Francisco, CA, United States
  • 1988-1991
    • University of Wuerzburg
      • Department of Dermatology, Venereology and Allergology
      Würzburg, Bavaria, Germany