P Elsner

Universitätsklinikum Jena, Jena, Thuringia, Germany

Are you P Elsner?

Claim your profile

Publications (480)877.53 Total impact

  • Journal der Deutschen Dermatologischen Gesellschaft 04/2014; 12(4). · 1.40 Impact Factor
  • Peter Elsner, Sibylle Schliemann
    Journal der Deutschen Dermatologischen Gesellschaft 03/2014; · 1.40 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: Health-related quality of life (HRQOL) has become an important patient reported outcome in health service research. The dermatology life quality index (DLQI) is the most commonly used instrument in dermatology. In recent years, the psychometric properties of the DLQI have been a subject of debate as principles of modern test theory seem to be violated. The aim of this study was to test whether those violations also occur in patients with hand eczema. We collected data of 602 hand eczema patients who participated in an inpatient dermatology rehabilitation program in Germany. In order to report meaningful scores of the DLQI, data were analysed according to the principles of modern test theory. We calibrated the DLQI using the Rasch model, resulting in a 6 item version with a range between 0-15 points. This version showed no significant misfit to the Rasch model (p > 0.14). The results were evaluated in a second sample of hand eczema patients and confirmed (n = 511, p > 0.21). In conclusion, we recommend to use an alternative scoring procedure as presented in this article if the DLQI is used in hand eczema patients.
    Acta Dermato-Venereologica 03/2014;
  • Anja Putz, Susanne Metz, Peter Elsner
    Journal der Deutschen Dermatologischen Gesellschaft 03/2014; · 1.40 Impact Factor
  • Journal der Deutschen Dermatologischen Gesellschaft 03/2014; 12(3). · 1.40 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: Frequent skin cleaning fulfils the definition of occupational 'wet work'. Standardized methods are required to assess the irritation potential of workplace cleansers. To develop a standardized procedure for testing the irritation potential of occupational skin cleansers. In this single-blind, single-centre trial in 25 healthy volunteers, the irritation potential of five generic reference cleansers was tested by three-times-daily washing with an automated skin cleaning device for 4 days, and quantification of cumulative skin barrier damage was performed by visual scoring, chromametry, transepidermal water loss TEWL, and corneometry. For two cleansers, reproducibility of the irritancy assessment was assessed. Furthermore, the irritation induced by four commercial workplace skin cleansers was studied. Whereas no significant changes were observed for any of the tested cleansers by either visual scoring or chromametry, significant increases in TEWL and significant decreases in stratum corneum hydration were found for all cleansers. Cleansers differed significantly in their irritation potential. On retesting of two cleansers, the first results were confirmed. Among the four commercial cleansers, one that was claimed to be mild was found to be disproportionally irritant. The presented model for testing cleansing preparations allows a highly controlled, practically relevant and reproducible irritancy assessment of occupational skin cleansers.
    Contact Dermatitis 03/2014; 70(3):151-7. · 2.93 Impact Factor
  • Journal of the European Academy of Dermatology and Venereology 01/2014; · 2.69 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: The objective of our study was to investigate the tandem irritation potential of two organic solvents with concurrent exposure to the hydrophilic detergent irritant sodium lauryl sulphate (SLS). A tandem repeated irritation test was performed with two undiluted organic solvents, cumene (C) and octane (O), with either alternating application with SLS 0.5% or twice daily application of each irritant alone in 27 volunteers on the skin of the back. The cumulative irritation induced over 4 days was quantified using visual scoring and non-invasive bioengineering measurements (skin colour reflectance, skin hydration and transepidermal water loss). Repeated application of C/SLS and O/SLS induced more decline of stratum corneum hydration and higher degrees of clinical irritation and erythema compared to each irritant alone. Our results demonstrate a further example of additive harmful skin effects induced by particular skin irritants and indicate that exposure to organic solvents together with detergents may increase the risk of acquiring occupational contact dermatitis. © 2014 S. Karger AG, Basel.
    Skin pharmacology and physiology 01/2014; 27(3):158-163. · 2.89 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: History and clinical findings: A 49-year-old patient with malignant germ cell tumor within the first cycle PEB (platinum [P], etoposid [E] and bleomycin [B]) presented with an itchy linear papular erythema with discrete vesicles. The rash had appeared three days ago i. e. four days after the second application of bleomycin. Investigations: Visual diagnosis of a flagellate dermatitis. Treatment and clinical course: Primary treatment consisted of systemic antihistamines, local and systemic application of steroids. Bleomycin treatment was stopped and substituted by ifosfamide. Conclusion: Flagellate dermatitis occurs with an incidence up to 66 % after bleomycin treatment. There is no association between bleomycin dose and incidence or severity of the lesions. Flagellate dermatitis is a self-limiting condition but hyperpigmentation may persist. Similar lesions may occur with bendamustine and docetaxel, the intake of insufficiently cooked shiitake mushrooms as well as in dermatomyositis and Still's syndrome.
    DMW - Deutsche Medizinische Wochenschrift 01/2014; 139(3):84-6. · 0.65 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: Latex allergy can be diagnosed by different test methods such as IgE quantification, Western blot, cellular antigen stimulation test (CAST), and in vivo methods [e.g. skin prick test (SPT)]. Phadia provides two modern methods using recombinant latex allergens: ImmunoCAP(®) and the Immuno Solid-phase Allergen Chip (ISAC(®)), which enables simultaneous determination of specific IgE against five latex allergens. We compared the diagnostic sensitivity of the ISAC(®) test kit and the conventional Hev b 5-spiked ImmunoCAP(®) latex extract. Forty sera were sampled from subjects with suspected natural rubber latex (NRL) allergy. These patients had positive SPT to NRL extract, positive NRL Western blots, and positive results in the CAST. All sera were analysed using the ISAC(®) and recombinant NRL ImmunoCAP(®) allergens and compared to the results of 20 negative control sera. Only 22 of the 40 subjects (55 %) showed positivity to at least one latex allergen on the ISAC(®) (sensitivity ISAC(®) 55 %). The sensitivity of the ImmunoCAP(®) latex extract was 70 %. The most frequently detected sensitization was against Hev b 6.01 (n = 12). When the serum samples were tested with all recombinant ImmunoCAP(®) allergens, three additional sensitizations against latex could be detected compared to the ISAC(®). Microarrays do offer many potential benefits such as elegant simultaneous determination of sensitizations against different NRL allergens with minimal amounts of serum. However, a negative NRL test result should be regarded with caution and at least be confirmed by other in vitro methods.
    International Archives of Occupational and Environmental Health 12/2013; · 2.10 Impact Factor
  • Journal der Deutschen Dermatologischen Gesellschaft 11/2013; · 1.40 Impact Factor
  • Journal der Deutschen Dermatologischen Gesellschaft 11/2013; 11(11):1083-1086. · 1.40 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: To date, there are no legally binding requirements concerning product testing in cosmetics. This leads to various manufacturer-specific test methods and absent transparent information on skin cleansing products. A standardized in vivo test procedure for assessment of cleansing efficacy and corresponding barrier impairment by the cleaning process is needed, especially in the occupational context where repeated hand washing procedures may be performed at short intervals. For the standardization of the cleansing procedure, an Automated Cleansing Device (ACiD) was designed and evaluated. Different smooth washing surfaces of the equipment for ACiD (incl. goat hair, felt, felt covered with nitrile caps) were evaluated regarding their skin compatibility. ACiD allows an automated, fully standardized skin washing procedure. Felt covered with nitrile as washing surface of the rotating washing units leads to a homogenous cleansing result and does not cause detectable skin irritation, neither clinically nor as assessed by skin bioengineering methods (transepidermal water loss, chromametry). Automated Cleansing Device may be useful for standardized evaluation of the cleansing effectiveness and parallel assessment of the corresponding irritancy potential of industrial skin cleansers. This will allow objectifying efficacy and safety of industrial skin cleansers, thus enabling market transparency and facilitating rational choice of products.
    Skin Research and Technology 10/2013; · 1.41 Impact Factor
  • Journal der Deutschen Dermatologischen Gesellschaft 10/2013; · 1.40 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: Occupational skin cleansing is a risk factor for cumulative irritant dermatitis. Standardized methods are required to assess the cleaning efficacy of occupational skin cleansers, allowing us to choose the optimal cleanser with minimal irritation for specific workplaces. To develop a standardized procedure for testing the cleaning efficacy of occupational skin cleansers. In this single-blind, randomized, monocentric clinical trial in 24 healthy volunteers, the cleaning efficacy of generic reference cleansers was assessed against standardized test dirts. The test procedure included standardized dirt application, standardized washing with an automated skin cleaning device, and quantification of the cleaning efficacy by chromametry. For two cleansers, reproducibility of the cleaning efficacy assessment was studied. Furthermore, the performance of two cleansers was compared with that of commercial skin cleansers. Cleaning factors ranged from 12% up to 97% for the respective model dirts. A high reproducibility of the washing and the assessment procedure could be shown. The comparison of the washing efficacies for two reference cleansers with those of commercial cleansers showed partly similar performances, but also a higher cleaning efficacy for some dirts of the reference cleansers. The testing procedure proved to be applicable to a wide spectrum of cleansers and model dirts.
    Contact Dermatitis 09/2013; · 2.93 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: Skin cleansers for occupational use are manufactured for different types and degrees of soiling without common, legally binding requirements for product testing. This leads to different, manufacturer-specific test methods and a lack of comparable information on skin cleansing products. The aim of this investigation was to validate a newly developed standardized automated cleansing device (ACiD) for in vivo evaluation of industrial skin cleansers. Two ACiD were tested regarding the intra- and inter-device specific reproducibility of test results. Skin cleansing process carried out by the three independent washing modules which constitute an ACiD-unit and two separate ACiD-units led to highly comparable results. There was no significant difference between the washing modules or between the two separate ACiD-units detected. Only different parameter settings resulted in significantly different detergency. Intra- and inter-device specific test results of an in vivo model of skin cleansing using the automated cleansing device (ACiD) were reproducible. The long-term aim is a standardized classification of occupational skin cleansing products comparing their skin cleansing effectiveness in relation to their skin irritancy. This might then provide the basis for a rational specific product selection by consumers and may be used as a tool for future product development by manufacturers.
    Skin Research and Technology 09/2013; · 1.41 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: Phlebologic diseases have become extremely common and have major socio-economic impact. However, the percentage of dermatologists working in phlebology appears to be decreasing according to the data of the German Society of Phlebology (DGP). To investigate the reasons for this development, we-on behalf of the DGP-sent a questionnaire to 120 German Departments of Dermatology in autumn 2012. In 76 returned questionnaires, the number of physicians with additional fellowship training in phlebology averaged 1.5; the average number of those who fulfill the criteria for training fellows in phlebology was 0.9. In 71.1 % of the departments there was a phlebologist. A special phlebologic outpatient clinic existed in 73.7 % of the departments. Sonography with Doppler (89.5 %) and duplex (86.8 %) was used as the most frequent diagnostic tool. For therapy, compression (94.7 %), sclerotherapy (liquid 78.9 %, foam 63.2 %, catheter 18.4 %), endoluminal thermic procedures (radio wave 28.9 %, laser 17.1 %) and surgery (especially crossectomy and stripping 67.1 %, phlebectomy of tributaries 75 %) were used. The average number of treatments was very heterogenous in the different departments. Phlebology definitely plays an important role in dermatology. Most departments fulfill the formal criteria for the license to conduct advanced training in phlebology. A wide spectrum of phlebological diagnostic and therapeutic procedures is available.
    Der Hautarzt 09/2013; 64(9):685-94. · 0.50 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: The aim of the CARPE registry is to investigate characteristics and medical care in patients affected by chronic hand eczema. Patients are assessed by dermatological examination and patient questionnaire. Socio-economic and clinical data are collected, and quality of life is measured using the Dermatology Life Quality Index (DLQI). A total of 1,163 patients with chronic hand eczema were eligible for analysis (mean age 47.0 years; 54.6% female; mean disease duration 7.6 years). At inclusion, chronic hand eczema was very severe in 23.4%, severe in 47.0%, moderate in 20.1%, and clear or almost clear in 9.6% of patients. Median DLQI was 8.0. In all, 93.8% of patients reported use of topical corticosteroids, 25.6% systemic antihistamines, 28.3% topical calcineurin-inhibitors, 38.0% ultraviolet phototherapy, and 35.3% systemic treatment (19.7% alitretinoin) prior to inclusion in the registry. A significant proportion of patients may not receive adequate treatment according to the guideline on management of hand eczema.
    Acta Dermato-Venereologica 08/2013;
  • Journal der Deutschen Dermatologischen Gesellschaft 07/2013; · 1.40 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: Skin protection creams (PC)s are used in the occupational setting to prevent irritant hand dermatitis. The actual amounts of PC applied and the resulting dose per unit area on hands at work are lower than recommended. To assess the influence of the applied dose on the efficacy of PCs in the prevention of irritant contact dermatitis. Experimental cumulative irritant contact dermatitis was induced by twice daily application of 0.5% NaOH or sodium lauryl sulfate (SLS) for 4 days on the backs of 20 healthy volunteers. Test areas were left unprotected or were pretreated with three different PCs applied at a low dose (2 mg/cm(2) ) or a high dose (20 mg/cm(2) ) before irritation. Irritant responses were assessed by visual scoring and measurement of transepidermal water loss, chromametry, and corneometry. Although cumulative irritant dermatitis developed in all unprotected test sites, irritation was significantly reduced in a dose-dependent manner on PC-protected sites. The higher doses of all PCs provided significant protection against irritation. However, the lower dose of one product did not significantly protect against SLS-induced irritation. The protective efficacy of PCs depends on the amount of product applied per unit skin surface area. Some products may show no protective efficacy when used at doses close to those practically applied at workplaces. Future efficacy studies of PCs should be performed with doses not higher than 2 mg/cm(2) , to avoid overestimation of their protective efficacy.
    Contact Dermatitis 07/2013; · 2.93 Impact Factor

Publication Stats

4k Citations
877.53 Total Impact Points

Institutions

  • 2002–2014
    • Universitätsklinikum Jena
      • Klinik für Hautkrankheiten
      Jena, Thuringia, Germany
  • 1998–2014
    • Friedrich-Schiller-University Jena
      • Clinic of Dermatology
      Jena, Thuringia, Germany
    • AVACO AG, Switzerland
      Basel-Landschaft, Switzerland
  • 2010–2013
    • University of Leipzig
      • Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
      Leipzig, Saxony, Germany
    • Innovaderm Research Inc.
      Montréal, Quebec, Canada
  • 2012
    • Universität zu Lübeck
      Lübeck Hansestadt, Schleswig-Holstein, Germany
  • 2011–2012
    • Charité Universitätsmedizin Berlin
      • Institute of Microbiology and Hygiene
      Berlín, Berlin, Germany
  • 2009–2011
    • Universität Heidelberg
      • Department Section Clinical Tropical Medicine
      Heidelburg, Baden-Württemberg, Germany
    • Universität des Saarlandes
      Saarbrücken, Saarland, Germany
    • Unfallkrankenhaus Hamburg
      Hamburg, Hamburg, Germany
  • 2008–2011
    • Universität Osnabrück
      Osnabrück, Lower Saxony, Germany
  • 2005–2008
    • Procter & Gamble
      Cincinnati, Ohio, United States
  • 2006
    • Medical University of Sofia
      • Department of Dermatology and Venereology
      Ulpia Serdica, Sofia-Capital, Bulgaria
  • 2004
    • University of Liège
      Luik, Walloon Region, Belgium
    • Universität Ulm
      Ulm, Baden-Württemberg, Germany
    • Northwestern University
      Evanston, Illinois, United States
  • 2003–2004
    • University of Freiburg
      • Department of Pneumology
      Freiburg, Lower Saxony, Germany
    • University of Geneva
      • Division of Dermatology
      Genève, GE, Switzerland
  • 1992–1999
    • University of Zurich
      Zürich, Zurich, Switzerland
  • 1993–1998
    • Schulthess Klinik, Zürich
      Zürich, Zurich, Switzerland
  • 1990–1991
    • University of California, San Francisco
      • • Department of Dermatology
      • • Division of Hospital Medicine
      San Francisco, CA, United States
  • 1987–1991
    • University of Wuerzburg
      • Department of Dermatology, Venereology and Allergology
      Würzburg, Bavaria, Germany