Peter Elsner

Universitätsklinikum Jena, Jena, Thuringia, Germany

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Publications (624)1171.76 Total impact

  • Der Hautarzt 08/2015; DOI:10.1007/s00105-015-3667-0 · 0.54 Impact Factor
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    ABSTRACT: Hemocompatibility of aqueous solutions of antimicrobial 6-deoxy-6-aminoethyleneamino (AEA) cellulose with different degree of substitution (DS, 0.54 - 0.92) was investigated in vitro. The AEA cellulose derivatives were synthesized by tosylation of cellulose and subsequent nucleophilic substitution with 1,2-diaminoethane. The structure was confirmed by elemental analysis as well as by FTIR- and NMR spectroscopy. Markers for coagulation (thrombin generation, aPTT, PT, blood clotting, thrombocyte activation) and membrane integrity (hemolysis) were measured in human whole blood, human platelet rich plasma, human pooled plasma, and erythrocytes suspension. AEA cellulose with a low DS of 0.54 showed the highest hemocompatibility in vitro, suggesting the possibility of biomedical applications.
    Journal of Biomaterials Science Polymer Edition 07/2015; 26(14):1-26. DOI:10.1080/09205063.2015.1068546 · 1.36 Impact Factor
  • Peter Elsner · Sibylle Schliemann
    Journal der Deutschen Dermatologischen Gesellschaft 07/2015; DOI:10.1111/ddg.12664 · 1.40 Impact Factor
  • Sibylle Schliemann · Peter Elsner
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 07/2015; 13(7):698-9. DOI:10.1111/ddg.12739 · 1.40 Impact Factor
  • 06/2015; DOI:10.2147/CWCMR.S60315
  • Peter Elsner · Sibylle Schliemann
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 06/2015; 13(6). DOI:10.1111/ddg.12554_suppl · 1.40 Impact Factor
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    ABSTRACT: ZusammenfassungBeruflich bedingte Handekzeme stehen an der Spitze der angezeigten Berufskrankheiten. Zur Primär-und Sekundärprävention von beruflich bedingten Handekzemen werden sog. berufliche Hautmittel – worunter Hautschutz, Hautpflege- und Hautreinigungsmittel verstanden werden – eingesetzt. Im Sinne einer evidenzbasierten Medizin sollten nur solche Präventivmaßnahmen bzw. nur solche beruflichen Hautmittel Verwendung finden, deren Einsatzmöglichkeiten und Wirksamkeit wissenschaftlich untermauert werden kann. Zu diesem Zwecke hat die Arbeitsgemeinschaft für Berufs- und Umweltmedizin e.V. (ABD) der DDG und die Deutsche Gesellschaft für Arbeits- und Umweltmedizin (DGAUM) den wissenschaftlichen Kenntnisstand und Empfehlungen dazu, in der aktualisierten Leitlinie dargelegt. Im Rahmen von rezenten klinisch-epidemiologischen Studien konnte der Benefit der kombinierten Anwendung von Hautschutz- und Hautpflegeprodukte in der Primär- und Sekundärprävention beruflich bedingter Kontaktekzeme weitgehend bestätigt werden. Die Leitlinie legt ferner dezidiert die Notwendigkeit der Darlegung des Wirksamkeitsnachweises von Hautschutz und Hautreinigungsmitteln durch in-vivo – Methoden im Sinne repetitiver Applikationen dar. Hierzu wurden zwischenzeitlich durch Multicenterstudien sowohl für Hautschutzpräparate als auch für die Hautreinigung transferfähige und standardisiertes Testverfahren für die Untersuchung des Irritationspotentials und damit der Hautverträglichkeit beruflicher Hautreinigungsmittel und der Reduktion der Irritation durch Hautschutzmittel entwickelt und multizentrisch validiert. Außerdem wird der Stand der aktuellen Sicherheitsbewertung der beruflichen Hautmittel dargelegt.
    Journal der Deutschen Dermatologischen Gesellschaft 06/2015; 13(6). DOI:10.1111/ddg.12617_suppl · 1.40 Impact Factor
  • Judit Lukács · Sibylle Schliemann · Peter Elsner
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    ABSTRACT: Lichen planus (LP) is a chronic disease that involves the skin, scalp, mucous membranes, and nails. The etiology of LP is still unknown; however, some external and internal factors (e.g. drugs, stress, hepatitis C virus) have been suggested to trigger the disease. Many studies have investigated an immunologic pathogenesis that is probably related to T-cell auto-immunity with the keratinocyte as the target cell. Altered self-antigens on the surface of basal keratinocytes modified by viruses or by drugs are believed to be the targets of the T-cell response. Various drugs and contact allergens like amalgam may cause lichenoid reactions, which are the main differential diagnosis of LP. Clinically and histologically, LP and lichenoid reactions cannot be distinguished with certainty in many cases. Treatment is mainly symptomatic and can be difficult. The first-line therapies for LP are topical or systemic corticosteroids; however, some studies have mentioned acitretin leading to similar improvement. Medical treatment together with patient education and psychosocial support can significantly ameliorate the patients’ quality of life.
    Clinics in Dermatology 05/2015; DOI:10.1016/j.clindermatol.2015.05.001 · 1.93 Impact Factor
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    05/2015; 2015(05). DOI:10.17147/ASUI.2015-05.05-02
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    ABSTRACT: Job-related hand dermatitis heads up the list of reported occupational diseases. So-called skin products - understood to mean protective creams, skin cleansers and skin care products - are used for the primary and secondary prevention of job-related hand dermatitis. In the interests of evidence-based medicine, the only preventive measures and/or occupational skin products that should be used are those whose potential uses and efficacy are underpinned by scientific research. To this end, the Arbeitsgemeinschaft für Berufs- und Umweltdermatologie e.V. (Working Group for Occupational and Environmental Dermatology, ABD) of the DDG (German Dermatological Society) and the Deutsche Gesellschaft für Arbeits- und Umweltmedizin (German Society for Occupational and Environmental Medicine, DGAUM) have summed up the latest scientific findings and recommendations in the updated guideline.The benefit of the combined application of protective creams and skin care products in the primary and secondary prevention of work-related contact dermatitis has been widely confirmed by recent clinical-epidemiological studies. The guideline clearly explains the necessity of demonstrating the efficacy of protective creams and cleansing products by means of in vivo methods in the sense of repetitive applications. Transferable standardised testing systems designed to examine the irritation potential and thus the compatibility of occupational skin cleansers and the reduction of irritation by protective skin creams have now been developed and validated by multicentre studies for skin protection creams and cleansers. The status of the current assessment of the safety of occupational skin products is also summarised. © 2015 The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.
    Journal der Deutschen Dermatologischen Gesellschaft 05/2015; 13(6). DOI:10.1111/ddg.12617 · 1.40 Impact Factor
  • Christian Hiernickel · Susanne Metz · Peter Elsner
    Journal der Deutschen Dermatologischen Gesellschaft 05/2015; 13(5). DOI:10.1111/ddg.12597 · 1.40 Impact Factor
  • Christian Hiernickel · Susanne Metz · Peter Elsner
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 05/2015; 13(5). DOI:10.1111/ddg.12597_suppl · 1.40 Impact Factor
  • Dimitar Antonov · Sibylle Schliemann · Peter Elsner
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    ABSTRACT: Hand dermatitis is a socially significant health problem. This review provides a discussion on the clinical features and patterns as well as the differential diagnosis of hand dermatitis, because these are essential for proper diagnosis in clinical practice. The morphology, however, is poorly related to the etiology in chronic cases. In all cases of chronic hand dermatitis, a full diagnostic examination should be undertaken and the etiology should be clarified and addressed in the treatment concept, instead of just moving directly from a morphological diagnosis to therapy. Preventive measures should be included in the treatment concept according to etiology. A stepwise approach for escalating therapy is advised, including basic topical therapy, topical corticosteroids, calcineurin inhibitors, as well as phototherapy and systemic therapy with corticosteroids, alitretinoin, cyclosporine, methotrexate, azathioprine, and others.
    American Journal of Clinical Dermatology 04/2015; DOI:10.1007/s40257-015-0130-z · 2.52 Impact Factor
  • P Elsner · M Glitsch · H F Merk
    Der Hautarzt 04/2015; 66(5). DOI:10.1007/s00105-015-3638-5 · 0.54 Impact Factor
  • P Elsner
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    ABSTRACT: Dermatologists from Germany are increasingly involved in international missions under tropical conditions. While civilian operations take place primarily in the context of international development cooperation, non-governmental organizations and private initiatives, dermatologists of the German Armed Forces have been engaged in numerous military missions and international disaster relief missions abroad. The specific requirements of these missions require a specialist qualification; however, the specialist training in "Skin and Venereal Diseases" under the medical care situation in Germany is generally insufficient. To be optimally prepared for dermatological missions in tropical regions, additional qualification in tropical medicine is recommended. Since this additional training is time consuming and can often not be put into practice, especially in the civilian sector, the acquisition of the certificate Tropical and Travel Dermatology (DDA) of the International Society for Dermatology in the Tropics in cooperation with the German Dermatological Academy (DDA)is recommended. In the future, training in tropical dermatology should be incorporated into the main curriculum of dermatology for those specialists planning to work on dermatological missions in the tropics.
    Der Hautarzt 04/2015; 66(5). DOI:10.1007/s00105-015-3637-6 · 0.54 Impact Factor
  • Peter Elsner · Sibylle Schliemann
    Journal der Deutschen Dermatologischen Gesellschaft 04/2015; 13(6). DOI:10.1111/ddg.12554 · 1.40 Impact Factor
  • T L Diepgen · H Drexler · P Elsner · J Schmitt
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    ABSTRACT: With the revision of the German Ordinance on Occupational Diseases, skin cancer due to UV irradiation was amended as a new occupational disease to the list of occupational diseases in Germany. The new occupational disease BK 5103 has the following wording: "Squamous cell carcinoma or multiple actinic keratosis of the skin caused by natural UV irradiation". Actinic keratoses are to be considered as multiple according to this new occupational diseases if they occur as single lesions of more than five annually, or are confluent in an area > 4 cm(2) (field cancerization). It is estimated that more than 2.5 million employees are exposed to natural UV irradiation due to their work (outdoor workers) in Germany and therefore have an increased risk of skin cancer. In this article the medical and technical prerequisites which have to be fulfilled for this new occupational disease in Germany are introduced.
    Der Hautarzt 03/2015; 66(3). DOI:10.1007/s00105-015-3587-z · 0.54 Impact Factor
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    P. Elsner · S.M. John · Ch. Skudlik
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    ABSTRACT: Am 09.11.2014 wurde feierlich des Falls der Mauer in Berlin vor 25 Jahren gedacht. Nach dem Mauerfall überstürzten sich damals die Ereignisse, und zum 03.10.1990 wurde die deutsche Einheit vollzogen.Auch im deutschen Berufskrankheitenrecht vollzieht sich in diesen Tagen - mit Verspätung - die deutsche Einheit.In der ehemaligen DDR (und für einen Übergangszeitraum bis 01.01.1992 im Gebiet der neuen Bundesländer) galt die „Liste der Berufskrankheiten gemäß Anlage zur BK-Verordnung der ehemaligen DDR vom 6. Mai 1981“. Diese sah unter Nr. 90 die Anerkennung von „Bösartigen Neubildungen der Haut und zur Krebsbildung neigenden Hautveränderungen“ vor, wobei unter dieser Ziffer nicht nur Hautkrebserkrankungen „durch Ruß, Rohparaffin, Teer, Anthrazen, Pech oder ähnliche Stoffe“ (entsprechend der in der Bundesrepublik geltenden Ziffer 5102 der Anlage 1 der Berufskrankheitenverordnung) anerkannt wurden, sondern auch Fälle von Hautkrebs durch berufliche Exposition mit UV-Licht.Im „Vertrag zwischen ...
    Der Hautarzt 03/2015; 66(3):152-153. DOI:10.1007/s00105-015-3588-y · 0.54 Impact Factor
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    ABSTRACT: (18) F-fluorodeoxyglucose positron emission tomography (FDG-PET)/CT is commonly used to assess tumour recurrence in high-risk patients with malignant melanoma (MM). However, results can be ambiguous either because of the CT's insufficient soft-tissue contrast or non-specific FDG accumulation caused by inflammation. Ultrasound (US) can provide additional morphologic information that is superior to CT. For precisely combining PET and US findings, we used a real-time fusion technique based on navigated US (PET/US fusion). Here, we describe our results from patients where PET/US fusion proved helpful in differentiating unclear PET/CT findings. This fusion technique is likely to be helpful for decision making in MM patients and biopsy guidance. © 2015 The Royal Australian and New Zealand College of Radiologists.
    Journal of Medical Imaging and Radiation Oncology 03/2015; 59(3). DOI:10.1111/1754-9485.12280 · 0.95 Impact Factor
  • P Elsner · S Schliemann
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    ABSTRACT: The different definitions of skin disease in medicine and in law are frequently confusing for dermatologists. While a skin disease may be defined medically referring to the definition of health by the WHO as a pathological condition of the skin leading to a disruption of the physical, mental and social well-being of the individual, legal definitions vary depending on the field of insurance law that is referred to. In the law of private health insurance, a skin disease is defined as an anomalous condition of the skin requiring medical treatment that exists independently of the subjective judgement of the insured person and needs to be objectively confirmed by a medical evaluation. In contrast, in the law of the social health insurance, the Federal Court of Social Justice defines disease as irregular physical or mental condition, deviating from the perception of a healthy human being that requires medical treatment or leads to inability to work. Substantial bodily disfigurement may be regarded as an irregular physical condition. In the law of the statutory accident insurance, occupational skin diseases are defined under clause 5101 of the occupational disease regulation as serious or repeatedly relapsing skin diseases that have forced a person to refrain from any work activities causal for the development, the aggravation or the recurrence of the disease. The Federal Court of Social Justice interprets the term "skin disease" from the protective purpose of the law, i.e. the protection against the economic and health consequences of the exposure to harmful agents and a thereby forced change of profession. This broad interpretation of the term "skin disease" leads to the recognition of diseases of the conjunctiva of the eye or diseases of the blood vessels of the skin due to cold damage as skin diseases according to clause 5101. For the correct treatment and possibly notification of occupational skin diseases in collaboration with various insurance carriers, dermatologists should be familiar not only with the medical definition, but also with these different legal definitions of skin disease.

Publication Stats

7k Citations
1,171.76 Total Impact Points


  • 2002–2015
    • Universitätsklinikum Jena
      • Klinik für Hautkrankheiten
      Jena, Thuringia, Germany
  • 1999–2014
    • Friedrich-Schiller-University Jena
      • • Clinic of Dermatology
      • • Institute of Medical Statistics, Computer Sciences and Documentation
      Jena, Thuringia, Germany
  • 2013
    • Universität Heidelberg
      Heidelburg, Baden-Württemberg, Germany
  • 2010
    • Technische Universität Dresden
      Dresden, Saxony, Germany
  • 2005–2008
    • Procter & Gamble
      Cincinnati, Ohio, United States
  • 2007
    • Universität zu Lübeck
      Lübeck Hansestadt, Schleswig-Holstein, Germany
  • 2004
    • Universität Ulm
      Ulm, Baden-Württemberg, Germany
    • Northwestern University
      • Division of Dermatology
      Evanston, Illinois, United States
  • 2003–2004
    • University of Freiburg
      • Department of Pneumology
      Freiburg, Lower Saxony, Germany
  • 1993–1998
    • University of Zurich
      • Dermatologische Klinik und Poliklinik
      Zürich, Zurich, Switzerland
    • Schulthess Klinik, Zürich
      Zürich, Zurich, Switzerland
  • 1996–1997
    • University Hospital Zürich
      Zürich, Zurich, Switzerland
  • 1989–1991
    • University of California, San Francisco
      • • Department of Dermatology
      • • Division of Hospital Medicine
      San Francisco, CA, United States
  • 1988–1991
    • University of Wuerzburg
      • Department of Dermatology, Venereology and Allergology
      Würzburg, Bavaria, Germany