Peter Elsner

Universitätsklinikum Jena, Jena, Thuringia, Germany

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Publications (630)1290.3 Total impact

  • Peter Elsner · Sibylle Schliemann
    Journal der Deutschen Dermatologischen Gesellschaft 10/2015; 13(10). DOI:10.1111/ddg.100_12664 · 2.05 Impact Factor
  • Claudia Schummer · Jörg Tittelbach · Peter Elsner
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    ABSTRACT: History and clinical findings: A 44-year-old man presented at a dermatologist with a 2 months history of a blue-brown reticular macule on the right thigh that had appeared spontaneously. It was neither painful nor itching and showed no growth or further colour change. Investigations: Punch biopsy, antinuclear antibodies, CrP, immune electrophoresis, hepatitis serology, urine diagnostics showed normal results. Diagnosis: On specific inquiry the patient, a long-distance truck driver, reported to rest his laptop during driving breaks always on the right thigh. We diagnosed a "laptop dermatitis". Conclusion: Consider external mechanical or thermal triggers if skin changes are unilateral. Thermal isolation from permanent heat exposure prevents an erythema ab igne reliably.
    DMW - Deutsche Medizinische Wochenschrift 09/2015; 140(18):1376-1377. DOI:10.1055/s-0041-103615 · 0.54 Impact Factor
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    ABSTRACT: Background Contact allergy to fragrances is mostly assessed in clinical populations of patients. Studies in the general population are scarce and vary in their methodology across countries.Objectives To determine the prevalence of fragrance contact allergy in the European general population and to assess the clinical relevance of positive patch test reactions to different fragrances.Methods In five European countries (Germany, Italy, The Netherlands, Portugal and Sweden) a random sample from the general population aged 18 to 74 years was drawn. In total 12,377 subjects were interviewed in this cross-sectional study and a random sample (n=3,119) was patch tested using True test and Finn chamber technique. Patch test procedures were harmonized by a mandatory training in advance of and a monitoring during the study.ResultsThe highest prevalence for contact allergy of 2.6% (95% CI 2.1-3.2) was found for FM I in petrolatum with a high content of atranol and chloratranol, and 1.9% (95% CI 1.5-2.4) for FM II in petrolatum. The conservatively estimated prevalence of fragrance contact allergy (defined by the existence of a positive patch test to Fragrance Mix I (FM I) or Fragrance Mix II (FM II) or any of the individual materials in either FM I or FM II or Myroxylon pereirae or sesquiterpene lactones or 3 and 4-hydroxyisohexyl 3-cyclohexene carboxaldehyde) that show clinical relevance, defined conservatively as lifetime avoidance of scented products and an itchy skin rash lasting more than 3 days in a lifetime, was 1.9% (95% CI 1.5-2.5). If we use the reported lifetime prevalence of any contact dermatitis instead of the lifetime prevalence of any itchy skin rash, the prevalence is 0.8% (95% CI 0.5-1.2).The prevalence rates of contact allergy to fragrances in females are about two times higher than in males.Conclusions The study helps identifying targets for prevention of fragrance allergy.This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 09/2015; DOI:10.1111/bjd.14151 · 4.28 Impact Factor
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    ABSTRACT: Background Population-based studies about contact allergy are scarce.Objectives: To obtain reliable estimates of prevalence of contact allergy in the general population in Europe.Methods Cross-sectional study of a random sample from the general population, aged 18 to 74 years, in 5 different European countries (Sweden, The Netherlands, Germany, Italy, Portugal). In total 12,377 subjects were interviewed and a random sample (n=3,119) patch tested to TRUE-test panel 1, 2 and 3 plus fragrance mix II, HICC, and sesquiterpene lactone mix. A positive patch test reaction is considered as contact allergy.ResultsIn total, 27.0% (95% CI 25.5-28.5) had at least one positive reaction to an allergen of the European baseline series with a significant higher prevalence in females compared to males. The highest age-standardized prevalences (≥ 1%) were found for nickel (14.5%; 95% CI 13.2-15.8), thimerosal (5.0%; 95% CI 4.2-5.8), cobalt (2.2%; 95% CI 1.7-2.7), fragrance mix II (1.9%, 95% CI 1.5-2.5), fragrance mix I (1.8% 95% CI 1.4-2.3), hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC)(1.4%, 95% CI 1.0-1.9), p-tert-butylphenol- formaldehyde-resin (1.3%; 95% CI 0.9-1.7), and p-phenylenediamine (1.0%; 95% CI 0.6-1.3). Only Nickel and Thimerosal showed a statistically significant different prevalence for contact allergy amongst the different European populations. Subjects that reported contact dermatitis in lifetime (age-standardized prevalence 15.1%, 95%CI 13.8-16.3) had an increased risk for contact allergy (OR 1.9, 95% CI 1.5-2.5) the risk of having a contact allergy was not increase in those with atopic dermatitis (prevalence 7.6%, 95% CI 6.7-8.6; OR 1.0, 95% CI 0.7-1.4).Conclusions Contact allergy to at least one allergen of the European baseline series was diagnosed in more than one quarter of the general European population. Therefore measures to improve the primary prevention of contact allergy have to be enforced.This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 09/2015; DOI:10.1111/bjd.14167 · 4.28 Impact Factor
  • Der Hautarzt 08/2015; 66(9). DOI:10.1007/s00105-015-3667-0 · 0.56 Impact Factor
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    ABSTRACT: Considering the scarcity of dermatologic resources in many parts of the world, self-testing by patients is not only of interest for internal medicine but also for dermatology. In this open, nonrandomized, multicenter diagnostic trial involving subjects with suspected contact sensitization to nickel and/or a fragrance mix, we assessed the agreement of self-testing by subjects with readings made by dermatologists. The self-test product (Nixema(TM)) is based on Thin-Layer Rapid Use Epicutaneous Test (TRUE Test®) technology. One hundred and sixty-five subjects self-tested the ready-made patch-test product. The test was applied for 48 h and then read after 3 or 4 days. It was also evaluated independently by experienced dermatologists after 3 or 4 days. In the 162 evaluable subjects, the proportion of agreement for both allergens together was 89.5% [95% confidence interval (CI) 83.7-93.8], the sensitivity was 97.5 % (95% CI 86.8-99.9) and the specificity was 86.9% (95% CI 79.6-92.3). Cohen's kappa was also high at 0.749 (95% CI 0.637-0.862). Discrepancies between the subjects' readings and the dermatologists' readings were mainly due to the subjects interpreting reactions of 'irritant' or 'doubtful' as 'positive'. Apart from itching and burning sensations and tape irritation, no side effects were observed. In conclusion, this study showed a high rate of agreement between the self-reading of the upper arm and the readings made by the dermatologists. The upper arm proved to be an appropriate area for self-testing. Self-testing may improve the screening for contact sensitization for patients, particularly where dermatologic health resources are scarce. © 2015 S. Karger AG, Basel.
    Skin pharmacology and physiology 07/2015; 28(5):257-263. DOI:10.1159/000437017 · 2.37 Impact Factor
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    Allergo Journal International 07/2015; 23(4):126-138. DOI:10.1007/s40629-014-0013-5
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    ABSTRACT: Hemocompatibility of aqueous solutions of antimicrobial 6-deoxy-6-aminoethyleneamino (AEA) cellulose with different degree of substitution (DS, 0.54 - 0.92) was investigated in vitro. The AEA cellulose derivatives were synthesized by tosylation of cellulose and subsequent nucleophilic substitution with 1,2-diaminoethane. The structure was confirmed by elemental analysis as well as by FTIR- and NMR spectroscopy. Markers for coagulation (thrombin generation, aPTT, PT, blood clotting, thrombocyte activation) and membrane integrity (hemolysis) were measured in human whole blood, human platelet rich plasma, human pooled plasma, and erythrocytes suspension. AEA cellulose with a low DS of 0.54 showed the highest hemocompatibility in vitro, suggesting the possibility of biomedical applications.
    Journal of Biomaterials Science Polymer Edition 07/2015; 26(14):1-26. DOI:10.1080/09205063.2015.1068546 · 1.65 Impact Factor
  • Peter Elsner · Sibylle Schliemann
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 07/2015; DOI:10.1111/ddg.12664 · 2.05 Impact Factor
  • Sibylle Schliemann · Peter Elsner
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 07/2015; 13(7):698-9. DOI:10.1111/ddg.12739 · 2.05 Impact Factor
  • 06/2015; DOI:10.2147/CWCMR.S60315
  • Peter Elsner · Sibylle Schliemann
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 06/2015; 13(6). DOI:10.1111/ddg.12554_suppl · 2.05 Impact Factor
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    ABSTRACT: ZusammenfassungBeruflich bedingte Handekzeme stehen an der Spitze der angezeigten Berufskrankheiten. Zur Primär-und Sekundärprävention von beruflich bedingten Handekzemen werden sog. berufliche Hautmittel – worunter Hautschutz, Hautpflege- und Hautreinigungsmittel verstanden werden – eingesetzt. Im Sinne einer evidenzbasierten Medizin sollten nur solche Präventivmaßnahmen bzw. nur solche beruflichen Hautmittel Verwendung finden, deren Einsatzmöglichkeiten und Wirksamkeit wissenschaftlich untermauert werden kann. Zu diesem Zwecke hat die Arbeitsgemeinschaft für Berufs- und Umweltmedizin e.V. (ABD) der DDG und die Deutsche Gesellschaft für Arbeits- und Umweltmedizin (DGAUM) den wissenschaftlichen Kenntnisstand und Empfehlungen dazu, in der aktualisierten Leitlinie dargelegt. Im Rahmen von rezenten klinisch-epidemiologischen Studien konnte der Benefit der kombinierten Anwendung von Hautschutz- und Hautpflegeprodukte in der Primär- und Sekundärprävention beruflich bedingter Kontaktekzeme weitgehend bestätigt werden. Die Leitlinie legt ferner dezidiert die Notwendigkeit der Darlegung des Wirksamkeitsnachweises von Hautschutz und Hautreinigungsmitteln durch in-vivo – Methoden im Sinne repetitiver Applikationen dar. Hierzu wurden zwischenzeitlich durch Multicenterstudien sowohl für Hautschutzpräparate als auch für die Hautreinigung transferfähige und standardisiertes Testverfahren für die Untersuchung des Irritationspotentials und damit der Hautverträglichkeit beruflicher Hautreinigungsmittel und der Reduktion der Irritation durch Hautschutzmittel entwickelt und multizentrisch validiert. Außerdem wird der Stand der aktuellen Sicherheitsbewertung der beruflichen Hautmittel dargelegt.
    Journal der Deutschen Dermatologischen Gesellschaft 06/2015; 13(6). DOI:10.1111/ddg.12617_suppl · 2.05 Impact Factor
  • Judit Lukács · Sibylle Schliemann · Peter Elsner
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    ABSTRACT: Lichen planus (LP) is a chronic disease that involves the skin, scalp, mucous membranes, and nails. The etiology of LP is still unknown; however, some external and internal factors (eg. drugs, stress, hepatitis C virus) have been suggested to trigger the disease. Many studies have investigated an immunologic pathogenesis that is probably related to T-cell autoimmunity with the keratinocyte as the target cell. Altered self-antigens on the surface of basal keratinocytes modified by viruses or by drugs are believed to be the targets of the T-cell response. Various drugs and contact allergens like amalgam may cause lichenoid reactions, which are the main differential diagnoses of LP. Clinically and histologically, LP and lichenoid reactions cannot be distinguished with certainty in many cases. Treatment is mainly symptomatic and can be difficult. The first-line therapies for LP are topical or systemic corticosteroids; however, some studies have mentioned acitretin leading to similar improvement. Medical treatment, together with patient education and psychosocial support, can significantly benefit patients' quality of life. Copyright © 2015 Elsevier Inc. All rights reserved.
    Clinics in Dermatology 05/2015; 33(5). DOI:10.1016/j.clindermatol.2015.05.001 · 2.47 Impact Factor
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    05/2015; 2015(05). DOI:10.17147/ASUI.2015-05.05-02
  • Christian Hiernickel · Susanne Metz · Peter Elsner
    Journal der Deutschen Dermatologischen Gesellschaft 05/2015; 13(5). DOI:10.1111/ddg.12597 · 2.05 Impact Factor
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    ABSTRACT: Job-related hand dermatitis heads up the list of reported occupational diseases. So-called skin products - understood to mean protective creams, skin cleansers and skin care products - are used for the primary and secondary prevention of job-related hand dermatitis. In the interests of evidence-based medicine, the only preventive measures and/or occupational skin products that should be used are those whose potential uses and efficacy are underpinned by scientific research. To this end, the Arbeitsgemeinschaft für Berufs- und Umweltdermatologie e.V. (Working Group for Occupational and Environmental Dermatology, ABD) of the DDG (German Dermatological Society) and the Deutsche Gesellschaft für Arbeits- und Umweltmedizin (German Society for Occupational and Environmental Medicine, DGAUM) have summed up the latest scientific findings and recommendations in the updated guideline.The benefit of the combined application of protective creams and skin care products in the primary and secondary prevention of work-related contact dermatitis has been widely confirmed by recent clinical-epidemiological studies. The guideline clearly explains the necessity of demonstrating the efficacy of protective creams and cleansing products by means of in vivo methods in the sense of repetitive applications. Transferable standardised testing systems designed to examine the irritation potential and thus the compatibility of occupational skin cleansers and the reduction of irritation by protective skin creams have now been developed and validated by multicentre studies for skin protection creams and cleansers. The status of the current assessment of the safety of occupational skin products is also summarised. © 2015 The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.
    Journal der Deutschen Dermatologischen Gesellschaft 05/2015; 13(6). DOI:10.1111/ddg.12617 · 2.05 Impact Factor
  • Christian Hiernickel · Susanne Metz · Peter Elsner
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    ABSTRACT: No abstract is available for this article.
    Journal der Deutschen Dermatologischen Gesellschaft 05/2015; 13(5). DOI:10.1111/ddg.12597_suppl · 2.05 Impact Factor
  • Dimitar Antonov · Sibylle Schliemann · Peter Elsner
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    ABSTRACT: Hand dermatitis is a socially significant health problem. This review provides a discussion on the clinical features and patterns as well as the differential diagnosis of hand dermatitis, because these are essential for proper diagnosis in clinical practice. The morphology, however, is poorly related to the etiology in chronic cases. In all cases of chronic hand dermatitis, a full diagnostic examination should be undertaken and the etiology should be clarified and addressed in the treatment concept, instead of just moving directly from a morphological diagnosis to therapy. Preventive measures should be included in the treatment concept according to etiology. A stepwise approach for escalating therapy is advised, including basic topical therapy, topical corticosteroids, calcineurin inhibitors, as well as phototherapy and systemic therapy with corticosteroids, alitretinoin, cyclosporine, methotrexate, azathioprine, and others.
    American Journal of Clinical Dermatology 04/2015; 16(4). DOI:10.1007/s40257-015-0130-z · 2.73 Impact Factor
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    P Elsner · M Glitsch · H F Merk
    Der Hautarzt 04/2015; 66(5). DOI:10.1007/s00105-015-3638-5 · 0.56 Impact Factor

Publication Stats

7k Citations
1,290.30 Total Impact Points


  • 2002–2015
    • Universitätsklinikum Jena
      • Klinik für Hautkrankheiten
      Jena, Thuringia, Germany
  • 1998–2014
    • Friedrich-Schiller-University Jena
      • • Clinic of Dermatology
      • • Institute of Medical Statistics, Computer Sciences and Documentation
      Jena, Thuringia, Germany
  • 2013
    • Universität Heidelberg
      Heidelburg, Baden-Württemberg, Germany
  • 2010
    • Technische Universität Dresden
      Dresden, Saxony, Germany
  • 2008
    • Procter & Gamble
      Cincinnati, Ohio, United States
  • 2007
    • Universität zu Lübeck
      Lübeck Hansestadt, Schleswig-Holstein, Germany
  • 2004
    • Universität Ulm
      Ulm, Baden-Württemberg, Germany
    • Northwestern University
      • Division of Dermatology
      Evanston, Illinois, United States
  • 2003
    • University of Freiburg
      • Department of Pneumology
      Freiburg, Lower Saxony, Germany
  • 1993–1999
    • University of Zurich
      • Dermatologische Klinik und Poliklinik
      Zürich, Zurich, Switzerland
  • 1996–1998
    • University Hospital Zürich
      Zürich, Zurich, Switzerland
  • 1993–1998
    • Schulthess Klinik, Zürich
      Zürich, Zurich, Switzerland
  • 1989–1991
    • University of California, San Francisco
      • • Department of Dermatology
      • • Division of Hospital Medicine
      San Francisco, CA, United States
  • 1988–1991
    • University of Wuerzburg
      • Department of Dermatology, Venereology and Allergology
      Würzburg, Bavaria, Germany