Gleusa de Castro

Publications (3)2.4 Total impact

• Article: Episodes of Guillain-Barré syndrome associated with the acute phase of HIV-1 infection and with recurrence of viremia.

  Gleusa de Castro, Patrícia Gomes Bastos, Roberto Martinez, José Fernando de Castro Figueiredo
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  ABSTRACT: We report a severe case of Guillain-Barré syndrome (GBS) characterized by flaccid areflexive tetraplegia and signs of autonomic instability related to acute HIV-1 infection, and the occurrence of relapse episodes coinciding with the detection of HIV-1 RNA in blood during the phase of irregular treatment with antiretroviral agents. The patient has been asymptomatic for 3 years and has an HIV-1 load below the limit of detection. The recurrence of GBS in this case may be related to alterations of the immunologic response caused by disequilibrium in the host-HIV relationship due to the increase in HIV-1 viremia.
  Arquivos de Neuro-Psiquiatria 10/2006; 64(3A):606-8. · 0.72 Impact Factor
• Article: Autoimmune hemolytic anemia in HCV/HIV coinfected patients during treatment with pegylated alpha-2a interferon plus ribavirin.

  Fernando Crivelenti Vilar, Gleusa de Castro, Maria Janete Moya, Ana de Lourdes Candolo Martinelli, Gil Cunha De Santis, Ana Paula Costa Nunes da Cunha Cozac, José Fernando de Castro Figueiredo
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  ABSTRACT: Two cases of autoimmune hemolytic anemia that occurred during the treatment of chronic hepatitis C with pegylated alpha-2a interferon and ribavirin, in HIV coinfected patients, are presented and described. The late occurrence (after six months of therapy) of this severe hemolytic anemia leads to the recommendation that hemoglobin levels should be monitored throughout the treatment period, even among patients who presented stable hemoglobin levels in the preceding months.
  Revista da Sociedade Brasileira de Medicina Tropical 40(6):678-80. · 0.68 Impact Factor
• Article: Primary aspergilloma and subacute invasive aspergillosis in two AIDS patients.

  Roberto Martinez, Gleusa de Castro, Alcyone A Machado, Maria Janete Moya
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  ABSTRACT: Although uncommon, invasive aspergillosis in the setting of AIDS is important because of its peculiar clinical presentation and high lethality. This report examines two AIDS patients with a history of severe cellular immunosuppression and previous neutropenia, who developed subacute invasive aspergillosis. One female patient developed primary lung aspergilloma, with dissemination to the mediastinum, vertebrae, and spine, which was fatal despite antifungal treatment. The second patient, who had multiple cavitary brain lesions, and eye and lung involvement, recovered following voriconazole and itraconazole, and drugs for increasing neutrophil and CD4+ lymphocyte levels. These cases demonstrate the importance of Aspergillus infections following neutropenia in AIDS patients, and emphasize the need for early and effective antifungal therapy.
  Revista do Instituto de Medicina Tropical de São Paulo 51(1):49-52. · 1.00 Impact Factor