ABSTRACT: IntroductionThe sarcoma botryoides of the cervix uteri occurs very rarely in fertile women.
CaseHere is a case of a 35-year-old fertile woman, who developed a sarcoma botryoides of the cervix uteri. The diagnosis required
clinical examination, ecography, NMR, CT scan and a pathological examination of the surgical sample. Radical surgery and chemotherapy
was performed. The patients is still living after more than 1year after treatment.
DiscussionAlthough the combined modality approach has given, if not constant, acceptable outcomes, a larger investigation on all the
cases of sarcoma botryoides of the cervix uteri is expected.
Archives of Gynecology and Obstetrics 04/2012; 280(5):863-866. · 1.28 Impact Factor
ABSTRACT: The aim of this study is to investigate whether a high concentration of interleukin-6 (IL)-6 in the amniotic fluid is associated to a higher risk of preterm delivery, premature rupture of the membranes (PROM), and periventricular leucomalacia (PVL) in preterm infants; we have further investigated whether the levels of IL-6 are related to the presence of vaginal infection by mycoplasms.
One hundred eight patients were screened by vaginal swab, sonography, amniocentesis, and dosage of IL-6 in the amniotic fluid during the second trimester of pregnancy.
High levels of IL-6 and vaginal mycoplasms are related to preterm birth and PROM. We had no case of PLV.
In order to achieve a good therapeutic purpose and get to an efficient strategy, the patients have to be elected by a number of criteria, which may include anamnesis elements, vaginal swab, then cytokines dosage in selected women, thus excluding the low-risk cases. Further studies are expected in order to plan guidelines including the dosage of ILs and principally of IL-6 as a main marker of preterm birth, above all during the second trimester.
The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 11/2009; 22(11):1063-7. · 1.36 Impact Factor
ABSTRACT: Comprehensive data concerning the sexual behaviour of Italian adolescents are lacking; the planning of prevention programmes is therefore difficult.
The current study evaluates the knowledge of Italian adolescents about sexuality and their use of methods to prevent pregnancy and sexually transmitted infections. The age at first intercourse in the current sample was compared to that found in past samples to ascertain whether sex education was needed at an earlier age. The efficacy of one school-based sex education programme was analysed.
Overall 630 students in three Italian cities were surveyed. Just over half the students were sexually active. Among these, the mean age at first intercourse was 15.6 years (SD +/- 1.3). The contraception most widely used was the condom although 'coitus interruptus', 'natural family planning' and 'no method' were also mentioned. The knowledge among students from Latina, after they had received sex education, was significantly better.
Our data show a lower mean age at first intercourse than has been reported for earlier periods by other authors. School-based sexual education is effective in improving knowledge. Sexual health services for young people must be available and counselling services improved.
The European Journal of Contraception and Reproductive Health Care 05/2009; 14(4):285-9. · 1.46 Impact Factor
ABSTRACT: The sarcoma botryoides of the cervix uteri occurs very rarely in fertile women.
Here is a case of a 35-year-old fertile woman, who developed a sarcoma botryoides of the cervix uteri. The diagnosis required clinical examination, ecography, NMR, CT scan and a pathological examination of the surgical sample. Radical surgery and chemotherapy was performed. The patients is still living after more than 1 year after treatment.
Although the combined modality approach has given, if not constant, acceptable outcomes, a larger investigation on all the cases of sarcoma botryoides of the cervix uteri is expected.
Archives of Gynecology 04/2009; 280(5):863-6. · 0.91 Impact Factor
ABSTRACT: hMLH1 gene, lying on chromosome 3p21-23, is a key factor of the mismatch repair (MMR) complex, which amends DNA replication errors. MMR alterations are involved in the development of both hereditary and sporadic forms of colorectal carcinoma related to ulcerative colitis (UC). I219V Polymorphism is located on exon 8 of hMLH1 and provides an aminoacidic substitution of isoleucine to valine, on the protein codon 219. This may affect the speed and fidelity of protein synthesis because of a tRNA paucity or changes in the mRNA secondary structure. Most of the hereditary nonpolyposis colon cancer-associated missense mutations of hMLH1 cause structural changes of the amino- or carboxy-terminal regions, involving the domains that interact with ATP and hPMS2.
In this study, we analyzed the hMLH1 I219V polymorphism frequency in colectomized patients with UC. Venous blood from 100 ulcerative patients and 97 apparently healthy subjects has been collected. Out of 100 patients affected with UC, 75 noncolectomized showed an alternating course of disease, while 25 did not respond to the common drugs, and underwent colectomy. Genotyping was performed by polymerase chain reaction and following enzymatic digestion by BccI.
No significant differences were found between patients with UC and controls both for genotype and allele frequencies. However, our data show a significant association when colectomized and noncolectomized patients are compared. The frequencies of G homozygosity were 28% in colectomized and 10.7% in noncolectomized patients (p < 0.05, chi(2) = 4.4, Odds ratio = 3.3). The allele frequencies of allele A were 52% in colectomized and 68% in noncolectomized patients; while those of allele G were 48% and 32%, respectively.
I219V polymorphism in hMLH1 could influence the clinical course of the disease and lead to resistance to therapy.
Genetic Testing and Molecular Biomarkers 04/2009; 13(2):193-7. · 1.11 Impact Factor
ABSTRACT: To investigate whether CYP17 T>C polymorphism and polymorphisms C1558T and Val80 of CYP19 are related to endometriosis.
Women affected with endometriosis (n = 104) and control group (n = 86). The diagnosis of endometriosis was confirmed by the histologic examination of the endometriotic lesions.
In patients affected with endometriosis, we observed that AA and CC genotypes were significantly represented in Val80 and C1558T polymorphisms of CYP19.
The molecular mechanisms that underlie the development of endometriosis are unclear. Both environmental and genetic factors are involved in the pathogenesis of the disease. The inheritable susceptibility to endometriosis justifies the growing interest in identifying genes and/or genetic polymorphisms that predispose women to an increased risk of developing endometriosis. The identification of single-nucleotide polymorphism (SNP), probably linked to endometriosis, could help to explain its pathogenesis.
Fertility and sterility 10/2008; 92(5):1532-5. · 3.97 Impact Factor