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Shahrzad Negahban,
Nasrollah Ahmadi,
Ahmad Oryan,
Habib N. Khojasteh,
Azita Aledavood, Hossein Soleimanpour,
Mohammad Mohammadianpanah,
Ilske Oschlies,
Stefan Gesk,
Reiner Siebert,
Khosrow Daneshbod,
Yahya Daneshbod
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ABSTRACT: Most foreign bodies pass through the gastrointestinal tract uneventful. We report of a case of inadvertently ingested foreign body, which by endoscopy simulated a polyp and on biopsy reported as cancer, so the patient underwent an unnecessary major operation. This report emphasizes the importance of resemblance of foreign bodies with gastrointestinal neoplasm, and endoscopists, surgeons and pathologists should consider this entity in their daily practice.
TheScientificWorldJOURNAL 01/2011; 11:2147-9. · 1.66 Impact Factor
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Shahrzad Negahban,
Inga Nagel, Hossein Soleimanpour,
Azita Aledavood,
Neda Bagheri,
Mehdi Paydar,
Khosrow Daneshbod,
Martin Hasselblatt,
Stefan Gesk,
Reiner Siebert,
Yahya Daneshbod
Journal of Clinical Oncology 11/2010; 28(33):e688-91. · 18.37 Impact Factor
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Shahrzad Negahban,
Nasrollah Ahmadi,
Ahmad Oryan,
Habib N Khojasteh,
Azita Aledavood, Hossein Soleimanpour,
Mohammad Mohammadianpanah,
Ilske Oschlies,
Stefan Gesk,
Reiner Siebert,
Khosrow Daneshbod,
Yahya Daneshbod
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ABSTRACT: Burkitt lymphoma (BL) is a highly aggressive neoplasm, which frequently affects the ileocecal region in the sporadic form and the jaw in the endemic form; however, the breast is a rare primary site of this tumor. Here we describe a case of primary bilateral breast BL presenting during lactation in a 23-year-old woman. Excisional biopsy of breast masses demonstrated a B-cell lymphoma with a characteristic 'starry sky' pattern highly suggestive of BL. The neoplastic cells strongly expressed CD20 and CD10, and showed proliferative activity as measured by Ki-67. An IGH-MYC gene fusion indicating the presence of a typical Burkitt translocation t(8;14)(q24;q32) in the tumor tissue was detected by fluorescent in situ hybridization. The present case, along with a comprehensive review of the literature, demonstrates that BL of the breast should be considered in the differential diagnosis of lesions of the breast during lactation. Whether hormonal or antigenic factors trigger Burkitt lymphomagenesis in the lactating breast warrants further investigation.
Molecular diagnosis & therapy 08/2010; 14(4):243-50. · 1.71 Impact Factor
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Shahrzad Negahban,
Nasrollah Ahmadi,
Ahmad Oryan,
Habib N Khojasteh,
Azita Aledavood, Hossein Soleimanpour,
Mohammad Mohammadianpanah,
Ilske Oschlies,
Stefan Gesk,
Reiner Siebert,
others
Molecular diagnosis & therapy 01/2010; 14(4):243-250. · 1.71 Impact Factor
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Otolaryngology Head and Neck Surgery 06/2008; 138(5):684-5. · 1.72 Impact Factor
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ABSTRACT: Visceral leishmaniasis (VL) or Kala-azar is a common parasitic infection among children in Iran. The records of 249 children with VL were evaluated retrospectively. The clinical, hematologic, and bone marrow biopsy findings were studied. In particular, we assessed whether there was an association between bone marrow biopsy findings and prognosis. Five major groups were identified: (1) hypercellular marrow with many Leishman Donovan (LD) bodies, (2) multiple noncaseating granulomas with a few LD bodies, (3) diffuse fibrosis with rare LD bodies, (4) benign lymphoid nodules with many LD bodies, and (5) marrow necrosis with many LD bodies. The patients with hypercellular marrow and benign lymphoid nodules were alive and responded well to glucantime therapy. The patients with marrow fibrosis and marrow necrosis died and were resistant to any type of therapy. Patients with granulomas did not respond to glucantime therapy but responded to amphotericin B. However, less than half of the patients died owing to malnutrition and misdiagnosis. We correlated the bone marrow biopsy findings with the treatment outcomes and prognosis. The outcome was excellent in cases of hypercellular marrow, very poor in cases of fibrosis and necrosis, and intermediate in cases of granulomas. As a result, we believe that bone marrow biopsy findings can be helpful for assessing the prognosis of VL patients.
Journal of Pediatric Hematology/Oncology 03/2007; 29(2):77-80. · 1.16 Impact Factor
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ABSTRACT: The authors describe an unusual case of a disseminated bacille Calmette-Guerin (BCG) infection in a 3-month-old girl who presented with a huge hepatosplenomegaly, fever, and pancytopenia. Clinically, an infantile kala-azar or lymphoma/leukemia was suspected. However, after thorough clinical and paraclinical investigations, the case was diagnosed as a disseminated BCG infection. The child died 2 weeks after starting antituberculosis treatment. Autopsy revealed diffuse histiocytic infiltration in the liver, spleen, and mesenteric lymph nodes, which were loaded with acid-fast bacilli. Three interesting findings were noticed in this case: circulating monocytes in the peripheral blood were loaded with ghost acid-fast bacilli; bone marrow smears revealed numerous Gaucher cell-like macrophages loaded with negative images of Mycobacterium tuberculi; and there was extensive marrow necrosis. These findings have not been previously reported in the literature.
Journal of Pediatric Hematology/Oncology 03/2005; 27(2):97-9. · 1.16 Impact Factor
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ABSTRACT: Multiple myeloma of the breast is very rare, and the fine needle aspiration (FNA) findings have not been reported before.
Two cases of multiple myeloma presented with bilateral breast nodules during treatment with chemotherapy. One case of multiple myeloma presented initially with a left breast mass. FNA smears of all 3 cases revealed numerous plasma cells, plasmablasts and multinucleated giant plasma cells. The smears were diagnosed as plasma cell tumors. Serum immunoelectrophoresis revealed IgG myeloma in 2 cases and IgA myeloma in 1. Marrow aspirates revealed > 30% plasma cells. Two patients died, and 1 was alive at this writing.
The aspiration cytology findings of myeloma can be confuse, with primary and secondary tumors of the breast. The previous clinical history and ancillary studies, such as bone marrow study and serum immunoelectrophoresis, are essential to the correct diagnosis.
Acta cytologica 49(4):445-8. · 0.49 Impact Factor
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ABSTRACT: Nonsalivary adenocarcinomas are the most interesting tumors found in the sinonasal area. They are rare tumors arising from surface epithelium. The clear cell type of this tumor is even more rare. We present cytologic findings of clear cell sinonasal adenocarcinoma and related pitfalls.
A 52-year-old woman presented with a left-cheek facial mass of 3-4 years' duration, with progressive enlargement, nasal discharge and discoloration of the lateral side of her left eye. Computed tomography was performed, revealing an expansile mass involving the nasal cavity, left maxillary sinus, ethmoid sinus with extension to sphenoid sinus, left side of oral cavity and left orbit. Fine needle aspiration performed through the upper buccogingival canine fossa showed clusters of epithelial cells with clear cytoplasm, round nuclei, inconspicuous nucleoli and slight pleomorphism. Some normal ciliated columnar epithelial cells are identified in the vicinity of neoplastic cells. The mass was reported to be a clear cell neoplasm, and excision of the whole mass was performed.
Cytologic findings of this rare tumor overlap with those of salivary gland-type tumors with clear cell change and should be added to the list of head and neck tumors with clear cell change.
Acta cytologica 53(5):597-600. · 0.49 Impact Factor
