A Boibieux

Publications (65)205.81 Total impact

• Article: Microbiological markers suggesting high inoculum size at time of surgery are risk factors for relapse in patients with Staphylococcus aureus prosthetic joint infection.

  Anissa Bouaziz, Ilker Uçkay, Sébastien Lustig, André Boibieux, Frédéric Laurent, Daniel Lew, Pierre Hoffmeyer, Philippe Neyret, Christian Chidiac, Tristan Ferry
  The Journal of infection 09/2012; · 4.13 Impact Factor
• Article: [Influenza A H1N1 in neonatal intensive care unit: analysis and lessons].

  C Leick-Courtois, S Haÿs, T Perpoint, E Basson, M Valette, B Lina, A Boibieux, J-C Picaud
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  ABSTRACT: Since WHO announced the flu-like pandemic H1N1v in autumn 2009, data on clinical presentation and treatment of H1N1v infection in preterm infants with oseltamivir remain scarce. We cared for four infected preterm infants and ordered prophylactic treatment with oseltamivir in 13 additional contact preterm infants. A number of lessons can be drawn from this experience. The first two cases in twins were revealed by an increase in the number of apnea and one infant required mechanical ventilation. Cough was the major symptom in the two other infected infants. No digestive intolerance was observed among the 17 preterm infants during oseltamivir treatment. Polymerase chain reaction (PCR) quickly determined whether an infant was infected, making it helpful in deciding on initial containment. PCR remained positive, whereas culture became negative. Therefore, culture appeared to be more relevant in deciding on the end of containment. Follow-up of the four infected infants showed their ability to develop immunity against H1N1v.
  Archives de Pédiatrie 09/2011; 18(10):1069-75. · 0.30 Impact Factor
• Article: Clostridium sordellii brain abscess diagnosed by 16S rRNA gene sequencing.

  F Valour, S Boisset, L Lebras, B Martha, A Boibieux, T Perpoint, C Chidiac, T Ferry, D Peyramond
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  ABSTRACT: Clostridium sordellii is usually associated with skin and soft tissue infections. We describe the first case to our knowledge of a Clostridium sordellii-associated brain abscess, diagnosed by 16S rRNA gene sequencing, expanding the microbiological spectrum of brain abscesses, with emphasis on the role of 16S rRNA gene PCR in their etiologic diagnosis.
  Journal of clinical microbiology 09/2010; 48(9):3443-4. · 4.16 Impact Factor
• Article: Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients.

  P Miailhes, P Pradat, M Chevallier, K Lacombe, F Bailly, L Cotte, M-A Trabaud, A Boibieux, J Bottero, C Trepo, F Zoulim
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  ABSTRACT: Transient elastography (TE) is a noninvasive technique to evaluate liver fibrosis. We compared the performance of TE with liver biopsy (LB) in patients with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) coinfection. Patients prospectively underwent TE and LB. The diagnosis accuracy of TE was calculated using receiver operating characteristic (ROC) curves for different stages of fibrosis, and optimal cut-off values were defined. A sequential algorithm combining TE with biochemical score (Fibrotest) is proposed. Fifty-seven patients had both TE and LB (median time: 3 days) and two with proven cirrhosis, only TE. Forty-six (78%) were under antiretroviral therapy with anti-HBV drugs in 98%, and 19 (32%) had elevated alanine aminotransferase (ALT). A significant correlation was observed between liver stiffness measurement (LSM) and METAVIR fibrosis stages (P < 0.0001). Patients with elevated ALT tended to have higher LSM than those with normal ALT. The areas under the ROC curves were 0.85 for significant fibrosis (≥ F2), 0.92 for advanced fibrosis (≥ F3) and 0.96 for cirrhosis. Using a cut-off of 5.9 kPa for F ≥ 2 and 7.6 kPa for F ≥ 3, the diagnosis accuracy was 83% and 86%, respectively. With an algorithm combining TE and Fibrotest, 97% of patients were well classified for significant fibrosis. Using this algorithm, the need for LB can be reduced by 67%. In HIV/HBV-coinfected patients, most of them with normal ALT under antiretroviral treatment including HBV active drugs, TE was proficient in discriminating moderate to severe fibrosis from minimal liver disease.
  Journal of Viral Hepatitis 02/2010; 18(1):61-9. · 4.09 Impact Factor
• Article: Disseminated nontuberculous infections with Mycobacterium genavense during sarcoidosis.

  H Dumouchel-Champagne, C Charlier-Woerther, A Boibieux, M Ffrench, G Carret, C Chidiac, D Peyramond, F Ader
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  ABSTRACT: Sarcoidosis is a chronic disease characterised by the development and accumulation of granulomas in multiple organs. We report two observations of disseminated Mycobacterium genavense infection in patients with proven sarcoidosis. High fever and abdominal pain appeared at 8 and 18&emsp14;months following the initiation of immunosuppressive therapy. Abdominal computed tomography scans of the patients showed diffuse mesenteric lymphadenitis and splenomegaly. The diagnosis was obtained on bone marrow specimens for both patients with numerous acid-fast bacteria at direct examination and positive specific mycobacterial identification by nucleic acid amplification test. Despite prompt antimycobacterial therapy, occurrence of complications (peritonitis post-splenectomy surgery and lung carcinoma) resulted in a fatal outcome for both patients. These cases highlight that opportunistic infections like M. genavense or other nontuberculous mycobacterial infections should be considered for long-standing immunocompromised patients with sarcoidosis.
  European Respiratory Review 12/2009; 18(114):299-301.
• Article: [Spinal cord toxoplasmosis in HIV infection].

  Y Pittner, J-F Dufour, G David, A Boibieux, D Peyramond
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  ABSTRACT: We report the case of an atypical localization of a spinal cord "toxoplasmic abscess". The 46-year-old patient, HIV-1 positive, was admitted for acute urine retention and gait disorders. MRI revealed a T12-L1 medullary lesion suggesting a tumoral, inflammatory and infectious pathology. The radiological aspect and immunosuppression lead to the initiation of a treatment against Toxoplasma gondii, following the same treatment principles as for cerebral toxoplasmosis. The diagnosis can only be proved by data from autopsy or surgical biopsy, but toxoplasmosis PCR on CSF seems to be an interesting alternative to confirm the diagnosis. According to the literature, PCR is not sensitive enough as a diagnostic tool. Improvement after treatment supported the diagnosis confirmed by PCR.
  Médecine et Maladies Infectieuses 04/2009; 39(6):401-5. · 0.72 Impact Factor
• Article: Follicular borreliosis: an atypical presentation of erythema chronicum migrans.

  E Ducroux, S Debarbieux, A Boibieux, S Boisset, C Roure, S Dalle, B Balme, L Thomas
  Dermatology 04/2009; 219(1):84-5. · 2.05 Impact Factor
• Article: [Vaccination against influenza: results of a study on vaccination coverage among health care workers in the Croix-Rousse Hospital (Hospitals of Lyon)].

  F Valour, L Maulin, F Ader, T Perpoint, H Champagne, G David, A Boibieux, F Biron, D Peyramond, C Chidiac
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  ABSTRACT: The aim of this study was to evaluate the vaccinal status among Croix-Rousse Hospital workers, attitude towards this vaccination, and the information delivered in order to promote this vaccination. Questionnaires were delivered by electronic mailing. Six hundred (and) twenty-nine questionnaires were analyzed (26.7% of hospital workers); 30.7% of responders were vaccinated against influenza, 89.2% of responders were aware of influenza and vaccine. Vaccine coverage was lower in younger workers, non health-care workers, non physician health-care workers, and surgeons who responded. Motivation and reserve varied according to the status, position, and age, with some discrepancies. These results suggest implementing a better targeted vaccination campaign, according to the various categories of personnel.
  Médecine et Maladies Infectieuses 02/2007; 37(1):51-60. · 0.72 Impact Factor
• Article: [Lemierre syndrome variant: Hepatic abscesses and hepatic venous thrombosis due to Fusobacterium nucleatum septicemia].

  K Le Roux, P Sève, E Gomard, A Boibieux, C Beziat, K Stankovic, C Broussolle
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  ABSTRACT: Like Fusobacterium necrophorum, Fusobacterium nucleatum is capable causing Lemierre's syndrome. Various locations of venous thrombosis have been described associated with Fusobacterium sp. septicemia. We describe a 43-year old alcoholic patient with F.nucleatum septicemia complicated with hepatic abscesses, middle hepatic venous thrombosis, osteomyelitis and infiltrative pneumonia. A pancreatic prosthesis was the only potentially identified infectious entrance. Our patient showed an alternative presentation of Lemierre's syndrome, a "digestive variant". To the best of our knowledge, this is the first report of Fusobacterium septicemia associated with hepatic venous thrombosis. This report is close to the cases of portal thrombosis and opens the clinical sphere of the lemierre's syndrome, whose incidence is increasing.
  La Revue de Médecine Interne 07/2006; 27(6):482-6. · 0.61 Impact Factor
• Article: [Treatment interruption in HIV infected patients: clinical and biological evolution].

  M Giard, A Boibieux, B Ponceau, F Biron, E Braun, B Issartel, C Lalain, J Lippmann, F Daoud, C Delbrassine, C Delorme, C Chidiac, D Peyramond
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  ABSTRACT: The authors had for aim to evaluate the clinical and biological evolution in HIV-infected patients with viraemia lower than 30,000 copies/mL having decided to interrupt their treatment. Patients with highly active antiretroviral therapy (HAART) for more than 3 months followed by treatment interruption longer than 1 month were included in a retrospective analysis. Forty-six patients having stopped treatment between November 1999 and July 2003 were included. The median duration of treatment interruption was 9.5 months. During the study, no clinical event occurred for 21 patients, and at least 1 clinical event occurred for the 25 others. The median CD4(+) cell counts (CD4) before and at the end of treatment interruption were 597/mm(3) and 437/mm(3), respectively (P<0.001). The median values of viral load before and at the end of treatment interruption were <50 and 23749 copies/mL, respectively (P<0.001). Among the 26 patients having started a new HAART, pre-treatment interruption and post-new HAART median CD4 (with a median delay after HAART of 9.7 months) were 548 and 432.5/mm(3) (P=0.02). Pre-treatment interruption and post-new HAART median viral load were 131.5 and 94.5 copies/mL (NS). Treatment interruption must be used with caution in spite of the absence of virological impact, because CD4 cell count after new HAART is lower than CD4 preceding treatment interruption. Treatment interruption is contraindicated for patients with AIDS. Physicians must carefully follow other patients who decide on a treatment interruption.
  Médecine et Maladies Infectieuses 11/2005; 35(11):525-9. · 0.72 Impact Factor
• Article: Possibly linezolid-induced peripheral and central neurotoxicity: report of four cases.

  T Ferry, B Ponceau, M Simon, B Issartel, P Petiot, A Boibieux, F Biron, C Chidiac, D Peyramond
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  ABSTRACT: Linezolid is the first member of the new synthetic class of antibacterial agents that prevent the formation of the 70S ribosomal subunit. It represents an attractive choice in the therapeutic arsenal because it is effective against methicillin-resistant strains of Staphylococcus spp. Adverse hematological events have been reported. They are rapidly reversible after discontinuation of treatment and usually occur during treatment courses of more than 2 weeks. The advised duration of linezolid use is 28 days and the consequences of prolonged use are unknown. In addition, this drug has some dopaminergic properties that can induce the serotonin syndrome if a monoamine oxidase inhibitor is used simultaneously. Since linezolid became available for use in 2002, four cases of probable central and peripheral linezolid-induced neurotoxicity have been recorded in our unit. Two de novo peripheral neuropathies and one worsening of a preexisting toxic neuropathy have been observed. In each case, linezolid therapy was used during a prolonged duration of 8, 23, and 24 weeks, respectively. First neurological signs appeared in one case during the 2nd week of treatment and beyond the 1st month in the other cases. To date, all cases of peripheral neuropathy resulted in persistent neurological damage after discontinuation of linezolid. Assessments did not reveal any other explanation for these neurological impairments. Another case concerned a patient who developed transient encephalopathy attributed to linezolid during a coadministration with hydroxyzine. Linezolid may induce persistent peripheral neuropathy after prolonged use and may cause a transient central neurotoxicity in combination with an anticholinergic agent, such as an antihistamine. Close neurological monitoring should be recommended in prolonged linezolid therapy and coadministration of a serotonin reuptake inhibitor or antihistamine should be avoided to limit neurological adverse events.
  Infection 07/2005; 33(3):151-4. · 2.66 Impact Factor
• Article: [Tuberculoma and tuberculous meningeal-radiculitis with paradoxical progression during treatment].

  D Rabar, B Issartel, P Petiot, A Boibieux, C Chidiac, D Peyramond
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  ABSTRACT: Neuromeningeal tuberculosis of deleterious, paradoxical, progression despite appropriate antibiotic therapy is rare. An immunocompetent woman exhibited an immediately disseminated form of tuberculosis with progressive neurological involvement associating expanding intracranial tuberculomas and meningeal-radiculitis despite adapted anti-tuberculosis quadritherapy. During anti-tuberculosis therapy clinical worsening is rare, particularly when 2 different manifestations are associated and the worsening occurs in an immunocompetent patient. This possibility should be systematically evoked in such cases. The explanation of this phenomenon is still unclear.
  La Presse Médicale 02/2005; 34(1):32-4. · 0.67 Impact Factor
• Article: [Factitious disorder revealed by polymicrobial septic arthritis of a lumbar facet joint diagnosed by percutaneous biopsy].

  T Euvrard, F Biron, N Blineau, A Boibieux, Y Berthezène, B Marchand
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  ABSTRACT: Septic arthritis of a lumbar facet joint is rare with few reports in the literature. Clinically, septic arthritis of a lumbar facet joint can mimic spondylodiscitis. Imaging is usually required for diagnosis. Bacteriological diagnosis is needed to optimize treatment with antibiotics. Most of the previously reported cases were due to staphylococcus aureus. We report one case due to rare bacteria which lead to a diagnosis of factitious disorder. Precise bacteriological diagnosis was obtained by CT-guided percutaneous biopsy.
  Journal de Radiologie 02/2004; 85(1):43-6. · 0.42 Impact Factor
• Article: [Imaging of osteoarticular tuberculosis].

  L Boussel, B Marchand, N Blineau, C Pariset, M Hermier, G Picaud, M Emin, A Coulon, P Pagnon, A Rode, J Pin-Leveugle, A Boibieux, Y Berthezène
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  ABSTRACT: and methods. To perform an illustrated and educational review of musculoskeletal tuberculosis. As the incidence of musculoskeletal tuberculosis still increases, a review appears justified. The following four main presentations are detailed and illustrated, by emphasizing the value of both CT and MR imaging: a) spine tuberculosis (~ 50%) commonly involves two adjacent vertebral bodies with usual large paravertebral abscesses. The following lesions are highly suggestive of tuberculosis: solitary vertebral involvement, solitary epidural abscess with or without erosive spondylitis; b) osteo-arthritis: peripherally located erosions at synovial insertions with gradual narrowing of the joint space are highly suggestive; c) osteomyelitis: unusual, may involve any bones; d) tenosynovitis and bursitis. Imaging studies are essential for diagnosis and to assess the extent of musculo-skeletal tuberculosis.
  Journal de Radiologie 10/2002; 83(9 Pt 1):1025-34. · 0.42 Impact Factor
• Article: Successful treatment of prosthetic knee infection due to Campylobacter upsaliensis.

  B Issartel, C Pariset, C Roure, A Boibieux, D Peyramond
  European Journal of Clinical Microbiology 04/2002; 21(3):234-5. · 2.86 Impact Factor
• Article: [Pubic osteomyelitis in athletes].

  P Sève, A Boibieux, C Pariset, P L Clouet, D Bouhour, S Tigaud, F Biron, C Chidiac, D Peyramond
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  ABSTRACT: Pubic osteomyelitis has been described in three situations: children in whom Staphylococcus aureus is the preeminent pathogen; elderly patients who have undergone genitourinary procedures, and parenteral drug abusers. In contrast, pubic osteomyelitis in athletes has been described less often. We report three cases of acute staphylococcal pubic osteomyelitis in young athletic men and present a review of the literature. The clinical presentation in each case was acute groin, hip, or perineal pain; fever; inability to bear weight; and pubic symphysis tenderness. The diagnosis was established by blood culture and radiologic changes. Staphylococcus aureus pubic osteomyelitis should be suspected in athletes who have febrile hip or groin pain. The pathogenesis of this disease is thought to involve preexisting trauma or athletic injury and subsequent seeding of this area during transient bacteremia. Prolonged antimicrobial therapy is required for the cure, and debridement with curettage may be necessary if patients have persistent infection or sequestra.
  La Revue de Médecine Interne 07/2001; 22(6):576-81. · 0.61 Impact Factor
• Article: Long-term safety and antiretroviral activity of hydroxyurea and didanosine in HIV-infected patients.

  F Biron, B Ponceau, D Bouhour, A Boibieux, B Verrier, D Peyramond
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  ABSTRACT: Long-term safety, immunologic effects, and antiretroviral activity of hydroxyurea and didanosine were evaluated in this retrospective study. Some 65 HIV-1-infected patients (39 of whom were antiretroviral naive) were studied (mean baseline CD4 count, 362 cells/mm3; mean plasma HIV-1 RNA viral load, 4.8 log10 copies/ml). The mean treatment duration was 20 months. Overall tolerance was good: 15 patients interrupted treatment because of clinical or biologic side effects. Four patients experienced a category B event. Patients had a mean increase of 27 CD4 cell counts after 12 months, of 112 after 24 months and of 59 after 36 months. They had a mean 1. 03 log10 fall in HIV-1 RNA after 12 months, 1.59 log10 after 24 months, and 1.27 log10 after 36 months. After 12 months, 35% developed an HIV-1 RNA viral load <200 copies/ml, 53% after 24 months, and 36% after 36 months. Those whose viral load became undetectable after 12 months have significantly lower baseline RNA values (p =.03). Fourteen patients had a viral load <3.4 log10 copies/ml after 24 months of the double therapy. A prolonged viral load suppression can be achieved using a simple combination of two drugs that are inexpensive and well tolerated.
  JAIDS Journal of Acquired Immune Deficiency Syndromes 12/2000; 25(4):329-36. · 4.43 Impact Factor
• Article: Diagnosis and surveillance of herpes simplex virus infection of the central nervous system.

  F Najioullah, S Bosshard, D Thouvenot, A Boibieux, B Menager, F Biron, M Aymard, B Lina
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  ABSTRACT: Herpes simplex viruses (HSV) are responsible for neurological disorders that require rapid diagnostic methods and specific antiviral therapy. During 1997, 1431 cerebrospinal fluid samples (CSF) collected from 1339 patients with neurological disorder presentations were processed for HSV detection. Eleven patients were positive for HSV, seven presenting with encephalitis (6/7 due to HSV1) and 4 with aseptic meningitis (4/4 due to HSV2). The incidence of HSV encephalitis was 2.33 cases / 10(6) inhabitants/year. Among encephalitis (HSV encephalitis) cases, 1 patient died due to the late implementation of antiviral therapy, and sequelae were observed in 4 cases. No sequelae were observed in aseptic meningitis cases. Four HSV encephalitis cases were monitored by PCR detection in CSF. Despite acyclovir therapy, PCR remained positive in CSF up to 20 days in 2 cases. This result suggest that the antiviral treatment for HSV encephalitis should be monitored by PCR detection of HSV in CSF.
  Journal of Medical Virology 09/2000; 61(4):468-73. · 2.82 Impact Factor
• Article: [Acquired ocular toxoplasmosis (panuveitis) after liver transplantation].

  C Chiquet, J Fleury, M Blanc-Jouvan, M Wallon, A Boibieux
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  ABSTRACT: We present one case of acquired Toxoplasma gondii retinochoroiditis after livrer transplantation. Three weeks after receiving liver transplant from a seropositive donor for Toxoplasma gondii, the fundus examination showed a vitreal haze and an edematous retinal lesion with retinal hemorrhages. Routine screening tests for uveitis were performed. The serum toxoplasmosis titers revealed a seroconversion for toxoplasmosis (pre-transplantation tests were negative). The PCR assay on aqueous humor resulted in an amplified product identical to toxoplasmosis. This immunocompromised patient likely received an infected hepatic transplant. The patient's ocular inflammation cleared on 1-month pyrimethamine-sulfadiazine medication. Four months later, the patient developed a retinal detachment with massive proliferative vitreoretinopathy.
  Journal Français d Ophtalmologie 05/2000; 23(4):375-9. · 0.51 Impact Factor
• Article: Decreased production of local immunoglobulin A to Pneumocystis carinii in bronchoalveolar lavage fluid from human immunodeficiency virus-positive patients.

  A Jalil, P Moja, C Lambert, M Perol, L Cotte, J M Livrozet, A Boibieux, J M Vergnon, F Lucht, R Tran, C Contini, C Genin
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  ABSTRACT: An enzyme-linked immunosorbent assay and a Western blot analysis were developed to study the antibody response to Pneumocystis carinii in serum and bronchoalveolar lavage fluid from 27 human immunodeficiency virus 27 (HIV)-infected patients with P. carinii pneumonia (Pcp), 32 patients without Pcp, and 51 HIV-negative controls. Urea was used for the correct dilution of epithelial lining fluid, and albumin was used to evaluate transudation from plasma for the assessment of local production of antibodies to P. carinii. By contrast with those of immunoglobulin G (IgG), IgA responses to P. carinii were increased in serum from HIV-positive patients compared to negative controls. Local production of antibodies to P. carinii, especially IgA, was decreased in patients with Pcp. In a study of 10 patients of each group, IgG and IgA responses to gp116 from P. carinii were lower in patients with Pcp than in other groups. These results suggest that, in addition to alveolar macrophages, local antibodies may play a role in host defense against P. carinii.
  Infection and Immunity 04/2000; 68(3):1054-60. · 4.16 Impact Factor