Rodolfo Bonamini

Publications (9)54.51 Total impact

• Article: Left ventricular noncompaction in patients with β-thalassemia: Uncovering a previously unrecognized abnormality.

  Antonio Piga, Filomena Longo, Khaled M Musallam, Andrea Veltri, Francesca Ferroni, Amedeo Chiribiri, Rodolfo Bonamini
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  ABSTRACT: Left ventricular noncompaction (LVNC) is a rare cardiomyopathy with potentially serious outcomes. It results in multiple and excessive trabeculations, deep intertrabecular recesses, and a thickened ventricular myocardium with two distinct layers, compacted and noncompacted. The condition is most commonly congenital; however, acquired forms have also been described. A recent report of LVNC detected in a β-thalassemia twin suggested an association with cardiac siderosis. In a cross-sectional study of 135 transfusion-dependent patients with β-thalassemia (130 major and 5 intermedia, mean age 29.6 ± 7.7 years, 49.6% males) presenting for cardiac iron assessment by magnetic resonance imaging (MRI), we evaluated the prevalence and risk factors for LVNC. None of the patients had neuromuscular or congenital heart disease. Eighteen patients (13.3%; 95% confidence interval [CI] = 8.6-20.1) fulfilled the preassigned strict criteria for LVNC on cardiac MRI. There were no statistically significant differences between patients with and without LVNC with respect to demographics; hemoglobin levels; splenectomy status; systemic, hepatic, and cardiac iron overload indices; hepatic disease and infection studies; or iron chelator type. Patients with LVNC were more likely to have heart failure (adjusted odds ratio = 1.77; 95% CI = 0.29-10.89); although with high uncertainty. Patients with β-thalassemia have a higher prevalence of LVNC than normal individuals. As this finding could not be explained by conventional risk factors in this patient population, further investigation of the underlying mechanisms of LVNC is warranted. This remains crucial for an entity with adverse cardiac outcomes, especially in patients with β-thalassemia where cardiac disease remains a primary cause of mortality. Am. J. Hematol., 2012. © 2012 Wiley Periodicals, Inc.
  American Journal of Hematology 09/2012; · 4.67 Impact Factor
• Article: 1054 Noninvasive Qp/Qs ratio measurement with phase-contrast cine MRI in patients with atrial septal defect: comparison with heart catheterization

  Amedeo Chiribiri, Laura Rizzo, Maria Cristina Marocco, Marco Allasia, Rodolfo Bonamini, Fulvio Orzan, Cesare Fava, Gian Paolo Trevi
  Journal of Cardiovascular Magnetic Resonance 04/2012; 10:1-2. · 3.72 Impact Factor
• Article: Late gadolinium enhancement on cardiac magnetic resonance and phenotypic expression in hypertrophic cardiomyopathy.

  Maria Rosa Conte, Sergio Bongioanni, Amedeo Chiribiri, Stefano Leuzzi, Elisabetta Lardone, Paolo Di Donna, Alfredo Pizzuti, Stefania Luceri, Federico Cesarani, Barbara Mabritto, Giuseppe Biondi Zoccai, Rodolfo Bonamini, Fiorenzo Gaita
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  ABSTRACT: Cardiac magnetic resonance (CMR) imaging with late gadolinium enhancement (LGE) can identify areas of myocardial fibrosis in vivo in patients with hypertrophic cardiomyopathy (HCM). The aim of this study was to examine the association between clinical-morphological variables, risk factor for sudden death, and LGE findings in a consecutive, unselected population of HCM patients. From January 2005 to August 2009, 124 HCM patients (53 ± 17 years, 86 men) were prospectively evaluated with CMR examination, assessing left ventricular (LV) hypertrophy, function, and LGE. In univariate analysis, patients were divided into tertiles according to the number of segments positive for LGE (first tertile, 0.3 ± 0.4; second tertile, 2.2 ± 0.4; third tertile, 5.2 ± 1.9 segments). Male gender (P = .05), maximum LV wall thickness (P = .002), nonsustained ventricular tachycardia (P = .001), ejection fraction <50% (P = .02), LV mass (P = .02), left atrium dilation (P = .04), perfusion defects (P ≤ .001), and telesystolic volume (P = .04) were all positively related with the number of segments of LGE. In multivariable analysis, male gender (P = .007), maximum LV wall thickness (P = .006), LV mass (P = .031), and perfusion alterations (P = .017) were independent predictors of LGE extent. Our study shows an independent association, even at multivariate analysis, between the entity of LGE and maximum LV wall thickness, mass, and perfusion defects in patients with HCM. Whether the presence and the extent of LGE translates into clinical events later on awaits further long-term follow-up studies.
  American heart journal 06/2011; 161(6):1073-7. · 4.65 Impact Factor
• Article: Late gadolinium enhancement and sudden cardiac death in hypertrophic cardiomyopathy.

  Amedeo Chiribiri, Maria Rosa Conte, Rodolfo Bonamini, Fiorenzo Gaita, Eike Nagel
  Journal of the American College of Cardiology 03/2011; 57(12):1402; author reply 1402-3. · 14.16 Impact Factor
• Article: First pass perfusion MRI identifies microvascular anatomical damage in patients with hypertrophic cardiomyopathy

  Amedeo Chiribiri, Sergio Bongioanni, Stefano Leuzzi, Di Bella Paolo, Simone Cacherano, Christian Jansen, Andreas Schuster, Rodolfo Bonamini, Federico Cesarani, Fiorenzo Gaita, Maria Conte, Eike Nagel
  Journal of Cardiovascular Magnetic Resonance. 01/2010;
• Article: Extensive myocardial fibrosis in a patient with hypertrophic cardiomyopathy and ventricular tachycardia without traditional high-risk features.

  Sergio Bongioanni, Paolo Spirito, Andrea Sibona Masi, Amedeo Chiribiri, Rodolfo Bonamini, Maria Rosa Conte
  Circulation Cardiovascular Imaging 07/2009; 2(4):349-50. · 5.94 Impact Factor
• Article: Magnetic resonance cardiac vein imaging: relation to mitral valve annulus and left circumflex coronary artery.

  Amedeo Chiribiri, Sebastian Kelle, Uwe Köhler, Laurens F Tops, Bernhard Schnackenburg, Rodolfo Bonamini, Jeroen J Bax, Eckart Fleck, Eike Nagel
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  ABSTRACT: To evaluate in vivo anatomical relationships between the coronary sinus-great cardiac vein (CS-GCV), the mitral valve annulus (MVA), and left circumflex coronary artery (LCX) with cardiovascular magnetic resonance. The CS-GCV has become an anatomical structure of interest because it provides a way of access to the heart for a number of interventional procedures. Previous reports demonstrate that the postulated close anatomical proximity of the CS-GCV to the MVA does not always hold true in patients, both in autopsy specimens and in vivo by computed tomography. In 31 participants (24 volunteers and 7 patients; 15 men; 42 +/- 19 years), cardiovascular magnetic resonance was performed for noninvasive evaluation of the coronary sinus and of the coronary arteries using whole-heart imaging and intravascular contrast agents. Three-dimensional reconstructions, standard orthogonal planes, and unprocessed raw data were used to assess CS-GCV anatomy and its relation to the MVA and the LCX along their entire course. The CS-GCV was located behind the left atrium in all examined participants, at a minimum distance of 8.6 +/- 3.9 mm from the MVA. In 80% of the participants, the LCX crossed the CS-GCV inferiorly, between the CS-GCV and the MVA. The CS-GCV and the LCX had a parallel course for 26.2 +/- 23.0 mm, with great variability of location and length. In several participants, the CS-GCV had a long parallel course, but in other participants, the LCX crossed below the CS-GCV at a discrete point. In all participants, the CS-GCV coursed behind the left atrium rather than behind the MVA. In the majority of the participants, the LCX coursed between the CS-GCV and the MVA. These anatomical relationships should be kept in mind when referring a patient for interventional procedures requiring the access to the CS-GCV, and cardiovascular magnetic resonance might provide important information for the selection of candidates for these procedures.
  JACC. Cardiovascular imaging 12/2008; 1(6):729-38. · 14.29 Impact Factor
• Article: Isolated noncompaction of the right ventricular myocardium in the adulthood?

  Amedeo Chiribiri, Stefano Leuzzi, Ilaria Salvetti, Salvatore Patané, Rodolfo Bonamini, Gian Paolo Trevi, Fiorenzo Gaita, Federico Cesarani
  International journal of cardiology 04/2008; 134(1):e17-9. · 7.08 Impact Factor
• Article: 1054 Noninvasive Qp/Qs ratio measurement with phase-contrast cine MRI in patients with atrial septal defect: comparison with heart catheterization

  Amedeo Chiribiri, Laura Rizzo, Maria Marocco, Marco Allasia, Rodolfo Bonamini, Fulvio Orzan, Cesare Fava, Gian Trevi
  Journal of Cardiovascular Magnetic Resonance. 01/2008;