Mohammad Mehdi Banoei

Publications (11)25.27 Total impact

• Article: Beta-thalassemia in iran: new insight into the role of genetic admixture and migration.

  Ali Reza Rezaee, Mohammad Mehdi Banoei, Elham Khalili, Massoud Houshmand
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  ABSTRACT: Iran with an area of 1.648 million km(2) is located between the Caspian Sea and the Persian Gulf. The Iranian population consists of multiethnic groups that have been influenced by various invasions and migration throughout history. Studies have revealed the presence of more than 47 different β-globin gene mutations responsible for β-Thalassemia in Iran. This paper is an attempt to study the origin of β-Thalassemia mutations in different parts of Iran. Distribution of β-Thalassemia mutations in Iran shows different patterns in different areas. β-Thalassemia mutations have been a reflection of people and area in correlation with migration and origin of ancestors. We compared the frequencies of β-globin mutations in different regions of Iran with those derived from neighboring countries. The analysis provided evidence of complementary information about the genetic admixture and migration of some mutations, as well as the remarkable genetic classification of the Iranian people and ethnic groups.
  TheScientificWorldJOURNAL 01/2012; 2012:635183. · 1.66 Impact Factor
• Source

  Available from: Yidong Bai

  Article: Generation and bioenergetic analysis of cybrids containing mitochondrial DNA from mouse skeletal muscle during aging.

  Youfen Li, Hong-Zhi Li, Peiqing Hu, Janice Deng, Mohammad Mehdi Banoei, Lokendra Kumar Sharma, Yidong Bai
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  ABSTRACT: Mitochondrial respiratory chain defects have been associated with various diseases and normal aging, particularly in tissues with high energy demands including skeletal muscle. Muscle-specific mitochondrial DNA (mtDNA) mutations have also been reported to accumulate with aging. Our understanding of the molecular processes mediating altered mitochondrial gene expression to dysfunction associated with mtDNA mutations in muscle would be greatly enhanced by our ability to transfer muscle mtDNA to established cell lines. Here, we report the successful generation of mouse cybrids carrying skeletal muscle mtDNA. Using this novel approach, we performed bioenergetic analysis of cells bearing mtDNA derived from young and old mouse skeletal muscles. A significant decrease in oxidative phosphorylation coupling and regulation capacity has been observed with cybrids carrying mtDNA from skeletal muscle of old mice. Our results also revealed decrease growth capacity and cell viability associated with the mtDNA derived from muscle of old mice. These findings indicate that a decline in mitochondrial function associated with compromised mtDNA quality during aging leads to a decrease in both the capacity and regulation of oxidative phosphorylation.
  Nucleic Acids Research 12/2009; 38(6):1913-21. · 8.03 Impact Factor
• Article: Vitamin D receptor homozygote mutant tt and bb are associated with susceptibility to pulmonary tuberculosis in the Iranian population.

  Mohammad Mehdi Banoei, Mehdi Seyed Mirsaeidi, Massoud Houshmand, Payam Tabarsi, Golnaz Ebrahimi, Laleh Zargari, Baharak Houshiar Kashani, Mohammad Reza Masjedi, Seyed Davood Mansouri, Julio Ramirez
  International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases 06/2009; 14(1):e84-5. · 2.17 Impact Factor
• Article: Mitochondrial tRNALeu/Lys and ATPase 6/8 gene variations in spinocerebellar ataxias.

  Sepideh Safaei, Massoud Houshmand, Mohammad Mehdi Banoei, Mehdi Shafa Shariat Panahi, Shahriar Nafisi, Kazem Parivar, Maryam Rostami, Parvin Shariati
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  ABSTRACT: The spinocerebellar ataxias (SCA) comprise a heterogeneous group of severe late-onset neurodegenerative diseases that are promoted by the expansion of a tandem-arrayed DNA sequence that modifies the primary structure of the protein. Genomic DNA of 20 patients affected with SCAs was extracted from peripheral blood and screened for deletions in mitochondrial DNA (mtDNA). Sequencing of tRNA(Leu), tRNA(Lys), cytochrome oxidase II, ATPase 6/8 and NADH dehydrogenase I (NDI) genes belonging to mtDNA from patients with SCAs was also carried out to detect the presence of variations. We identified cytosine-adenine-guanine (CAG) trinucleotide repeat expansions in 20 patients. Seven of these patients had at least one nucleotide change in mtDNA. In such cases, 5 nucleotide variations resulted in amino acid changes with two novel variations T8256G and G9010A. SCA patients showed high levels of mtDNA variations in lymphocytes. It can be proposed that the SCA gene proteins (Ataxins) are involved in the complicated intracellular mechanisms that affect cellular organelles and their components, such as the mitochondrial genome. The instability of CAG repeats in polyglutamine diseases such as SCAs and Huntington's disease might be a causative factor in mtDNA variation or possible damage.
  Neurodegenerative Diseases 02/2009; 6(1-2):16-22. · 3.06 Impact Factor
• Article: Variation of DAT1 VNTR alleles and genotypes among old ethnic groups in Mesopotamia to the Oxus region.

  Mohammad Mehdi Banoei, Morteza Hashemzadeh Chaleshtori, Mohammad Hossein Sanati, Parvin Shariati, Massoud Houshmand, Tayebeh Majidizadeh, Niloofar Jahangir Soltani, Massoud Golalipour
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  ABSTRACT: Variation of a VNTR in the DAT1 gene in seven ethnic groups of the Middle East was used to infer the history and affinities of these groups. The populations consisted of Assyrian, Jewish, Zoroastrian, Armenian, Turkmen, and Arab peoples of Iran, Iraq, and Kuwait. Three hundred forty subjects from these seven ethnic groups were screened for DAT1. DAT1 VNTR genotyping showed 3, 6, 7, 8, 9, 10, 11, and 12 alleles in the samples. Analysis of these data revealed differentiation and relationship among the populations. In this region, which covers an area of 2-2.5 million km2, the influence of geography and especially of linguistic characteristics has had potentially major effects on differentiation. Religion also has played a major role in imposing restrictions on some ethnic groups, who as a consequence have maintained their community. Overall, these ethnic groups showed greater heterogeneity compared to other populations.
  Human Biology 02/2008; 80(1):73-81. · 1.31 Impact Factor
• Article: Investigation of tRNALeu/Lys and ATPase 6 Genes Mutations in Huntington’s Disease

  Sadaf Kasraie, Massoud Houshmand, Mohammad Mehdi Banoei, Solmaz Etemad Ahari, Mehdi Shafa Shariat Panahi, Parvin Shariati, Mohammad Bahar, Mostafa Moin
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  ABSTRACT: Huntington disease (HD) is a genetically dominant condition caused by expanded CAG repeats which code for glutamine in the HD gene product, huntingtin. Huntingtin is expressed in almost all tissues, so abnormalities outside the brain can also be expected. Involvement of nuclei and mitochondria in HD pathophysiology has been suggested. In fact mitochondrial dysfunction is reported in brains of patients suffering from HD. The tRNA gene mutations are one of hot spots that can cause mitochondrial disorders. In this study, possible mitochondrial DNA (mtDNA) damage was evaluated by screening for mutations in the tRNAleu/lys and ATPase 6 genes of 20 patients with HD, using PCR and automated DNA sequencing. Mutations including an A8656G mutation in one patient were observed, which may be causal to the disease. Understanding the role of mitochondria in the pathogenesis of neurodegenerative diseases could potentially be important for the development of therapeutic strategies in HD.
  Cellular and Molecular Neurobiology 01/2008; 28(7):933-938. · 1.97 Impact Factor
• Article: An A8296G mutation in the MT-TK gene of a patient with epilepsy - a disease-causing mutation or rare polymorphism?

  Ali Mohammad Ahadi, Majid Sadeghizadeh, Massoud Houshmand, Kurosh Gharagoozli, Mohammad Mehdi Banoei, Mehdi Shafa Shariat Panahai
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  ABSTRACT: Mitochondrial DNA (mtDNA) mutations are an important cause of human diseases. mtDNA could be considered a candidate modifying factor in neurodegenerative disorders. A homoplasmic A8296G mutation was detected in a 24-year-old patient with idiopathic generalized epilepsy. The A8296G mutation in the mitochondrial DNA MT-TK gene has been associated with severe mitochondrial diseases. The pathogenicity of this mutation or its association with a specific disease is unclear. This mutation has already been reported exclusively as well as together with other mutations during trials of mtDNA. As in this case, the mutation was homoplasmic and there were no clinical findings in other family members. We suggest that this mutation is a rare polymorphism or may be a pathogenic mutation in combination with other mutations outside of the MT-TK gene.
  Neurologia i neurochirurgia polska 01/2008; 42(3):263-6. · 0.43 Impact Factor
• Article: Do mitochondrial DNA haplogroups play a role in susceptibility to tuberculosis?

  Massoud Houshmand, Mohammad Mehdi Banoei, Payam Tabarsi, Mehdi Shafa Shariat Panahi, Baharak Hooshiar Kashani, Golnaz Ebrahimi, Laleh Zargar, Parissa Farnia, Matthew W Morris, Davood Mansouri, Ali Akbar Velayati, Mehdi S Mirsaeidi
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  ABSTRACT: Mitochondrial DNA has a unique role in ATP production and subsequent mitochondrial reactive oxygen species (ROS) production in eukaryotic cells and there is a potential role for ROS and oxygen burst against Mycobacterium tuberculosis, an intracellular pathogen. This study aimed to determine whether the frequency of different mitochondrial haplogroups was significantly different in patients with tuberculosis (TB) compared with a normal population. Mitochondrial DNA haplogroups M, N, J and K were studied by PCR-restriction fragment length polymorphism and sequencing. Cases were 54 patients with confirmed smear positive pulmonary TB. Controls were 256 healthy persons. There were no statistically significant differences between those with TB and the control group. There was no statistically significant association between mtDNA haplogroups and the presence of TB infection.
  Respirology 12/2007; 12(6):823-7. · 2.42 Impact Factor
• Article: Huntington's disease and mitochondrial DNA deletions: event or regular mechanism for mutant huntingtin protein and CAG repeats expansion?!

  Mohammad Mehdi Banoei, Massoud Houshmand, Mehdi Shafa Shariat Panahi, Parvin Shariati, Maryam Rostami, Masoumeh Dehghan Manshadi, Tayebeh Majidizadeh
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  ABSTRACT: The mitochondrial DNA (mtDNA) may play an essential role in the pathogenesis of the respiratory chain complex activities in neurodegenerative disorders such as Huntington's disease (HD). Research studies were conducted to determine the possible levels of mitochondrial defect (deletion) in HD patients and consideration of interaction between the expanded Huntingtin gene as a nuclear gene and mitochondria as a cytoplasmic organelle. To determine mtDNA damage, we investigated deletions based in four areas of mitochondrial DNA, in a group of 60 Iranian patients clinically diagnosed with HD and 70 healthy controls. A total of 41 patients out of 60 had CAG expansion (group A). About 19 patients did not show expansion but had the clinical symptoms of HD (group B). MtDNA deletions were classified into four groups according to size; 9 kb, 7.5 kb, 7 kb, and 5 kb. We found one of the four-mtDNA deletions in at least 90% of samples. Multiple deletions have also been observed in 63% of HD patients. None of the normal control (group C) showed mtDNA deletions. The sizes or locations of the deletions did not show a clear correlation with expanded CAG repeat and age in our samples. The study presented evidence that HD patients had higher frequencies of mtDNA deletions in lymphocytes in comparison to the controls. It is thus proposed that CAG repeats instability and mutant Htt are causative factor in mtDNA damage.
  Cellular and Molecular Neurobiology 12/2007; 27(7):867-75. · 1.97 Impact Factor
• Article: Diversity and relationship between Iranian ethnic groups: human dopamine transporter gene (DAT1) VNTR genotyping.

  Mohammad Mehdi Banoei, Morteza Hashemzadeh Chaleshtori, Mohammah Hossein Sanati, Mehdi Shafa Sharait Panahi, Tayebeh Majidizadeh, Maryam Rostami, Massoumeh Dehghan Manshadi, Masoud Golalipour
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  ABSTRACT: The 40-bp VNTR polymorphism in the 3' untranslated region of the human DAT1 (dopamine transporter 1) was analyzed in the Iranian ethnic groups in order to examine the influence of geographical and linguistic affiliation on the genetic affinities among the Iranian population. A total of 449 subjects belonging to nine ethnic groups from the Iranian population were included in the study. The screening of 898 chromosomes showed five alleles (6, 7, 8, 9, 10, and 11), of which allele 10 revealed the highest frequency in most regions. Allele 8 was predominant in one ethnicity and occurred more frequently in the center of Iran. This study shows that the DAT1 distribution in Iran has a different pattern from those in other studies, which can contribute to an understanding of differentiation and diversity of Iranian ethnic groups. This polymorphism could represent the genetic diversity among the various ethnic groups of Iran.
  American Journal of Human Biology 08/2007; 19(6):821-6. · 2.27 Impact Factor
• Article: Variation of DAT1 VNTR Alleles and Genotypes Among Old Ethnic Groups in Mesopotamia to the Oxus Region

  Mohammad Mehdi Banoei, Morteza Hashemzadeh Chaleshtori, Mohammad Hossein Sanati, Parvin Shariati, Massoud Houshmand, Tayebeh Majidizadeh, Niloofar Jahangir Soltani, Massoud Golalipour
  [show abstract] [hide abstract]
  ABSTRACT: Variation of a VNTR in the DAT1 gene in seven ethnic groups of the Middle Eastwas used to infer the history and affinities of these groups. The populations consisted of Assyrian, Jewish, Zoroastrian, Armenian, Turkmen, and Arab peoples of Iran, Iraq, and Kuwait. Three hundred forty subjects from these seven ethnic groups were screened for DAT1. DAT1 VNTR genotyping showed 3, 6, 7, 8, 9, 10, 11, and 12 alleles in the samples. Analysis of these data revealed differentiation and relationship among the populations. In this region, which covers an area of 2–2.5 million km2, the influence of geography and especially of linguistic characteristics has had potentially major effects on differentiation. Religion also has played a major role in imposing restrictions on some ethnic groups, who as a consequence have maintained their community. Overall, these ethnic groups showed greater heterogeneity compared to other populations.
  Human Biology. 80(1):73-81.