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[show abstract]
[hide abstract]
ABSTRACT: A sensitive, specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established for the quantitative determination of amlodipine and bisoprolol, using clenbuterol as the internal standard (IS). The analytes and IS were isolated from 100μL plasma samples by a simple liquid-liquid extraction (LLE). Reverse-phase high performance liquid chromatography (RP-HPLC) separation was accomplished on a Diamonsil C(18) column (50mm×4.6mm, 5μm) with a mobile phase composed of methanol-water-formic acid (75:25:0.01, v/v/v) at a flow rate of 0.3mL/min. The method had a chromatographic total run time of 3min. Multiple reacting monitoring (MRM) transitions of m/z [M+H](+) 409.1→237.9 (amlodipine), m/z [M+H](+) 326.2→116.0 (bisoprolol) and m/z [M+H](+) 277.0→203.0 (clenbuterol, IS) were used to quantify amlodipine, bisoprolol and IS, respectively. The method was sensitive with a lower limit of quantitation (LLOQ) of 0.2ng/mL for both amlodipine and bisoprolol, and the linear range was 0.2-50ng/mL for both amlodipine and bisoprolol (r(2)>0.9961). All the validation data, such as accuracy, precision and inter-day repeatability, were within the required limits. The method was successfully applied to pharmacokinetic studies of amlodipine and bisoprolol in Sprague-Dawley (SD) rats.
Journal of pharmaceutical and biomedical analysis 08/2012; 71:104-10. · 2.45 Impact Factor
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M Battaglieri,
R De Vita,
A P Szczepaniak,
K P Adhikari,
M Aghasyan,
M J Amaryan,
P Ambrozewicz,
M Anghinolfi,
G Asryan,
H Avakian, [......],
D P Weygand,
M Williams,
E Wolin,
M H Wood,
A Yegneswaran,
M Yurov,
L Zana,
J Zhang,
B Zhao,
Z W Zhao
[show abstract]
[hide abstract]
ABSTRACT: We report on the results of the first measurement of exclusive f_{0}(980) meson photoproduction on protons for E_{gamma}=3.0-3.8 GeV and -t=0.4-1.0 GeV2. Data were collected with the CLAS detector at the Thomas Jefferson National Accelerator Facility. The resonance was detected via its decay in the pi;{+}pi;{-} channel by performing a partial wave analysis of the reaction gammap-->ppi;{+}pi;{-}. Clear evidence of the f_{0}(980) meson was found in the interference between P and S waves at M_{pi;{+}pi;{-}} approximately 1 GeV. The S-wave differential cross section integrated in the mass range of the f_{0}(980) was found to be a factor of about 50 smaller than the cross section for the rho meson. This is the first time the f_{0}(980) meson has been measured in a photoproduction experiment.
Physical Review Letters 04/2009; 102(10):102001. · 7.37 Impact Factor
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M Nozar,
C Salgado,
D P Weygand,
L Guo,
G Adams, Ji Li,
P Eugenio,
M J Amaryan,
M Anghinolfi,
G Asryan, [......],
D P Watts,
L B Weinstein,
M Williams,
E Wolin,
M H Wood,
A Yegneswaran,
L Zana,
J Zhang,
B Zhao,
Z W Zhao
[show abstract]
[hide abstract]
ABSTRACT: A search for exotic mesons in the pi;{+}pi;{+}pi;{-} system photoproduced by the charge exchange reaction gammap-->pi;{+}pi;{+}pi;{-}(n) was carried out by the CLAS Collaboration at Jefferson Lab. A tagged-photon beam with energies in the 4.8 to 5.4 GeV range, produced through bremsstrahlung from a 5.744 GeV electron beam, was incident on a liquid-hydrogen target. A partial wave analysis was performed on a sample of 83 000 events, the highest such statistics to date in this reaction at these energies. The main objective of this study was to look for the photoproduction of an exotic J;{PC}=1;{-+} resonant state in the 1 to 2 GeV mass range. Our partial wave analysis shows production of the a_{2}(1320) and the pi_{2}(1670) mesons, but no evidence for the a_{1}(1260), nor the pi_{1}(1600) exotic state at the expected levels. An upper limit of 13.5 nb is determined for the exotic pi_{1}(1600) cross section, less than 2% of the a_{2}(1320) production.
Physical Review Letters 04/2009; 102(10):102002. · 7.37 Impact Factor
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The CLAS Collaboration,
S. A. Morrow,
M. Guidal,
M. Garçon,
J. M. Laget,
E. S. Smith,
G. Adams,
K. P. Adhikari,
M. Aghasyan,
M. J. Amaryan, [......],
D. P. Weygand,
M. Williams,
E. Wolin,
M. H. Wood,
A. Yegneswaran,
M. Yurov,
L. Zana,
J. Zhang,
B. Zhao,
Z. W. Zhao
[show abstract]
[hide abstract]
ABSTRACT: The ep → e
′
pρ0 reaction has been measured using the 5.754GeV electron beam of Jefferson Lab and the CLAS detector. This represents the largest
ever set of data for this reaction in the valence region. Integrated and differential cross-sections are presented. The W , Q2 and t dependences of the cross-section are compared to theoretical calculations based on the t -channel meson-exchange Regge theory, on the one hand, and on quark handbag diagrams related to Generalized Parton Distributions
(GPDs) on the other hand. The Regge approach can describe at the » \approx 30% level most of the features of the present data while the two GPD calculations that are presented in this article which
succesfully reproduce the high-energy data strongly underestimate the present data. The question is then raised whether this
discrepancy originates from an incomplete or inexact way of modelling the GPDs or the associated hard scattering amplitude
or whether the GPD formalism is simply inapplicable in this region due to higher-twists contributions, incalculable at present.
European Physical Journal A 12/2008; 39(1):5-31. · 2.19 Impact Factor
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K. Park,
V. D. Burkert,
W. Kim,
I. G. Aznauryan,
R. Minehart,
L. C. Smith,
K. Joo,
L. Elouadrhiri,
G. Adams,
M. J. Amaryan, [......],
E. Wolin,
M. H. Wood,
A. Yegneswaran,
J. Yun,
M. Yurov,
L. Zana,
B. Zhang,
J. Zhang,
B. Zhao,
Z. W. Zhao
[show abstract]
[hide abstract]
ABSTRACT: The exclusive electroproduction process e⃗p→e'nπ+ was measured in the range of the photon virtuality Q2=1.7-4.5 GeV2, and the invariant mass range for the nπ+ system of W=1.15-1.7 GeV using the CEBAF Large Acceptance Spectrometer. For the first time, these kinematics are probed in exclusive π+ production from protons with nearly full coverage in the azimuthal and polar angles of the nπ+ center-of-mass system. The nπ+ channel has particular sensitivity to the isospin ½ excited nucleon states, and together with the pπ0 final state will serve to determine the transition form factors of a large number of resonances. The largest discrepancy between these results and present modes was seen in the σLT' structure function. In this experiment, 31,295 cross section and 4,184 asymmetry data points were measured. Because of the large volume of data, only a reduced set of structure functions and Legendre polynomial moments can be presented that are obtained in model-independent fits to the differential cross sections.
Phys. Rev. C. 01/2008; 77(1).
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R Nasseripour,
M H Wood,
C Djalali,
D P Weygand,
C Tur,
U Mosel,
P Muehlich,
G Adams,
M J Amaryan,
P Ambrozewicz, [......],
D P Watts,
L B Weinstein,
M Williams,
E Wolin,
A Yegneswaran,
L Zana,
B Zhang,
J Zhang,
B Zhao,
Z W Zhao
[show abstract]
[hide abstract]
ABSTRACT: The photoproduction of vector mesons on various nuclei has been studied using the CLAS detector at Jefferson Laboratory. The vector mesons, rho, omega, and varphi, are observed via their decay to e;{+}e;{-}, in order to reduce the effects of final-state interactions in the nucleus. Of particular interest are possible in-medium effects on the properties of the rho meson. The rho mass spectrum is extracted from the data on various nuclei, 2H, C, Fe, and Ti. We observe no significant mass shift and some broadening consistent with expected collisional broadening for the rho meson.
Physical Review Letters 01/2008; 99(26):262302. · 7.37 Impact Factor
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K S Egiyan,
G Asryan,
N Gevorgyan,
K A Griffioen,
J M Laget,
S E Kuhn,
G Adams,
M J Amaryan,
P Ambrozewicz,
M Anghinolfi, [......],
L B Weinstein,
D P Weygand,
M Williams,
E Wolin,
M H Wood,
A Yegneswaran,
L Zana,
J Zhang,
B Zhao,
Z W Zhao
[show abstract]
[hide abstract]
ABSTRACT: The reaction 2H(e,e'p)n has been studied with full kinematic coverage for photon virtuality 1.75<Q2<5.5 GeV2. Comparisons of experimental data with theory indicate that for very low values of neutron recoil momentum (p(n)<100 MeV/c) the neutron is primarily a spectator and the reaction can be described by the plane-wave impulse approximation. For 100<p(n)<750 MeV/c, proton-neutron rescattering dominates the cross section, while Delta production followed by the NDelta-->NN transition is the primary contribution at higher momenta.
Physical Review Letters 06/2007; 98(26):262502. · 7.37 Impact Factor
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P. E. Bosted,
K. V. Dharmawardane,
G. E. Dodge,
T. A. Forest,
S. E. Kuhn,
Y. Prok,
G. Adams,
M. Amarian,
P. Ambrozewicz,
M. Anghinolfi, [......],
D. P. Weygand,
M. Williams,
E. Wolin,
M. H. Wood,
A. Yegneswaran,
J. Yun,
L. Zana,
J. Zhang,
B. Zhao,
Z. Zhao
[show abstract]
[hide abstract]
ABSTRACT: New measurements of the spin structure functions of the proton and deuteron g1p(x,Q2) and g1d(x,Q2) in the nucleon resonance region are compared with extrapolations of target-mass-corrected next-to-leading-order (NLO) QCD fits to higher energy data. Averaged over the entire resonance region (W<2 GeV), the data and QCD fits are in good agreement in both magnitude and Q2 dependence for Q2>1.7 GeV2/c2. This “global” duality appears to result from cancellations among the prominent “local” resonance regions: in particular strong σ3/2 contributions in the Δ(1232) region appear to be compensated by strong σ1/2 contributions in the resonance region centered on 1.5 GeV. These results are encouraging for the extension of NLO QCD fits to lower W and Q2 than have been used previously.
Phys. Rev. C. 03/2007; 75(3).
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M Ungaro,
P Stoler,
I Aznauryan,
V D Burkert,
K Joo,
L C Smith,
G Adams,
M Amarian,
P Ambrozewicz,
M Anghinolfi, [......],
L B Weinstein,
D P Weygand,
M Williams,
E Wolin,
M H Wood,
A Yegneswaran,
L Zana,
B Zhang,
J Zhang,
B Zhao
[show abstract]
[hide abstract]
ABSTRACT: We report a new measurement of the exclusive electroproduction reaction gamma(*)p-->pi(0)p to explore the evolution from soft nonperturbative physics to hard processes via the Q(2) dependence of the magnetic (M(1+)), electric (E(1+)), and scalar (S(1+)) multipoles in the N-->Delta transition. 9000 differential cross section data points cover W from threshold to 1.4 GeV/c(2), 4pi center-of-mass solid angle, and Q(2) from 3 to 6 GeV(2)/c(2), the highest yet achieved. It is found that the magnetic form factor G(M)(*) decreases with Q(2) more steeply than the proton magnetic form factor, the ratio E(1+)/M(1+) is small and negative, indicating strong helicity nonconservation, and the ratio S(1+)/M(1+) is negative, while its magnitude increases with Q(2).
Physical Review Letters 09/2006; 97(11):112003. · 7.37 Impact Factor
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V Kubarovsky,
M Battaglieri,
R De Vita,
J Goett,
L Guo,
G S Mutchler,
P Stoler,
D P Weygand,
P Ambrozewicz,
M Anghinolfi, [......],
M F Vineyard,
A V Vlassov,
L B Weinstein,
M Williams,
E Wolin,
M H Wood,
A Yegneswaran,
L Zana,
J Zhang,
B Zhao
[show abstract]
[hide abstract]
ABSTRACT: The reaction gammap --> pK+K- was studied at Jefferson Lab with photon energies from 1.8 to 3.8 GeV using a tagged photon beam. The goal was to search for a Theta++ pentaquark, a narrow, doubly charged baryon state having strangeness S=+1 and isospin I=1, in the pK+ invariant mass spectrum. No statistically significant evidence of a Theta++ was found. Upper limits on the total and differential cross section for the reaction gammap --> K-Theta++ were obtained in the mass range from 1.5 to 2.0 GeV/c2, with an upper limit for a narrow resonance with a mass M(Theta++) = 1.54 GeV/c2 of about 0.15 nb, 95% C.L.. This result places a stringent upper limit on the Theta++ width Gamma(Theta++) <0.1 MeV/c2.
Physical Review Letters 09/2006; 97(10):102001. · 7.37 Impact Factor
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S Chen,
H Avakian,
V D Burkert,
P Eugenio,
G Adams,
M Amarian,
P Ambrozewicz,
M Anghinolfi,
G Asryan,
H Bagdasaryan, [......],
D P Weygand,
M Williams,
E Wolin,
M H Wood,
A Yegneswaran,
J Yun,
L Zana,
J Zhang,
B Zhao,
Z Zhao
[show abstract]
[hide abstract]
ABSTRACT: The longitudinal target-spin asymmetry AUL for the exclusive electroproduction of high-energy photons was measured for the first time in ep-->e;'pgamma. The data have been accumulated at JLab with the CLAS spectrometer using 5.7 GeV electrons and a longitudinally polarized NH3 target. A significant azimuthal angular dependence was observed, resulting from the interference of the deeply virtual Compton scattering and Bethe-Heitler processes. The amplitude of the sinvarphi moment is 0.252+/-0.042stat+/-0.020sys. Theoretical calculations are in good agreement with the magnitude and the kinematic dependence of the target-spin asymmetry, which is sensitive to the generalized parton distributions H and H.
Physical Review Letters 08/2006; 97(7):072002. · 7.37 Impact Factor
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S Niccolai,
M Mirazita,
P Rossi,
N A Baltzell,
D S Carman,
K Hicks,
B McKinnon,
T Mibe,
S Stepanyan,
D J Tedeschi, [......],
L B Weinstein,
D P Weygand,
M Williams,
E Wolin,
M H Wood,
A Yegneswaran,
L Zana,
J Zhang,
B Zhao,
Z Zhao
[show abstract]
[hide abstract]
ABSTRACT: For the first time, the reaction gammad-->DeltanK+ has been analyzed in order to search for the exotic pentaquark baryon Theta+(1540). The data were taken at Jefferson Laboratory, using the Hall-B tagged-photon beam of energy between 0.8 and 3.6 GeV and the CEBAF Large Acceptance Spectrometer (CLAS). No statistically significant structures were observed in the nK+ invariant-mass distribution. The upper limit on the gammad-->DeltaTheta+ integrated cross section has been calculated and found to be between 5 and 25 nb, depending on the production model assumed. The upper limit on the differential cross section is also reported.
Physical Review Letters 08/2006; 97(3):032001. · 7.37 Impact Factor
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R. De Vita,
M. Battaglieri,
V. Kubarovsky,
N. A. Baltzell,
M. Bellis,
J. Goett,
L. Guo,
G. S. Mutchler,
P. Stoler,
M. Ungaro, [......],
D. P. Watts,
L. B. Weinstein,
M. Williams,
E. Wolin,
M. H. Wood,
A. Yegneswaran,
L. Zana,
J. Zhang,
B. Zhao,
Z. Zhao
[show abstract]
[hide abstract]
ABSTRACT: The exclusive reactions γp→K̅ 0K+n and γp→K̅ 0K0p have been studied in the photon energy range 1.6–3.8 GeV, searching for evidence of the exotic baryon Θ+(1540) in the decays Θ+→nK+ and Θ+→pK0. Data were collected with the CLAS detector at the Thomas Jefferson National Accelerator Facility. The integrated luminosity was about 70 pb-1. The reactions have been isolated by detecting the K+ and proton directly, the neutral kaon via its decay to KS→π+π- and the neutron or neutral kaon via the missing mass technique. The mass and width of known hyperons such as Σ+, Σ- and Λ(1116) were used as a check of the mass determination accuracy and experimental resolution. Approximately 100 000 Λ*(1520)’s and 150 000 ϕ’s were observed in the K̅ 0K+n and K̅ 0K0p final state, respectively. No evidence for the Θ+ pentaquark was found in the nK+ or pKS invariant mass spectra. Upper limits were set on the production cross section of the reaction γp→K̅ 0Θ+ as functions of center-of-mass angle, nK+ and pKS masses. Combining the results of the two reactions, the 95% C.L. upper limit on the total cross section for a resonance peaked at 1540 MeV was found to be 0.7 nb. Within most of the available theoretical models, this corresponds to an upper limit on the Θ+ width, ΓΘ+, ranging between 0.01 and 7 MeV.
Phys. Rev. D. 07/2006; 74(3).
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M. Osipenko,
G. Ricco,
S. Simula,
M. Battaglieri,
M. Ripani,
G. Adams,
P. Ambrozewicz,
M. Anghinolfi,
B. Asavapibhop,
G. Asryan, [......],
A. V. Vlassov,
L. B. Weinstein,
D. P. Weygand,
M. Williams,
E. Wolin,
M. H. Wood,
A. Yegneswaran,
J. Yun,
L. Zana,
J. Zhang
[show abstract]
[hide abstract]
ABSTRACT: Inclusive electron scattering off the deuteron has been measured to extract the deuteron structure function F2 with the CEBAF Large Acceptance Spectrometer (CLAS) at the Thomas Jefferson National Accelerator Facility. The measurement covers the entire resonance region from the quasielastic peak up to the invariant mass of the final-state hadronic system W≃2.7 GeV with four-momentum transfers Q2 from 0.4 to 6 (GeV/c)2. These data are complementary to previous measurements of the proton structure function F2 and cover a similar two-dimensional region of Q2 and Bjorken variable x. Determination of the deuteron F2 over a large x interval including the quasielastic peak as a function of Q2, together with the other world data, permit a direct evaluation of the structure function moments for the first time. By fitting the Q2 evolution of these moments with an OPE-based twist expansion we have obtained a separation of the leading twist and higher twist terms. The observed Q2 behavior of the higher twist contribution suggests a partial cancelation of different higher twists entering into the expansion with opposite signs. This cancelation, found also in the proton moments, is a manifestation of the “duality” phenomenon in the F2 structure function.
Phys. Rev. C. 04/2006; 73(4).
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H. Egiyan,
I. G. Aznauryan,
V. D. Burkert,
K. A. Griffioen,
K. Joo,
R. Minehart,
L. C. Smith,
G. Adams,
P. Ambrozewicz,
E. Anciant, [......],
H. Weller,
D. P. Weygand,
C. S. Whisnant,
E. Wolin,
M. H. Wood,
A. Yegneswaran,
J. Yun,
J. Zhang,
J. Zhao,
Z. Zhou
[show abstract]
[hide abstract]
ABSTRACT: The ep→e'π+n reaction was studied in the first and second nucleon resonance regions in the 0.25 GeV2<Q2<0.65 GeV2 range by use of the CLAS detector at Thomas Jefferson National Accelerator Facility. For the first time, to our knowledge, the absolute cross sections were measured, covering nearly the full angular range in the hadronic center-of-mass frame. We extracted the structure functions σTL,σTT, and the linear combination σT+εσL by fitting the ϕ dependence of the measured cross sections and compared them with the MAID and Sato-Lee models.
Phys. Rev. C. 02/2006; 73(2).
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H. Egiyan,
I. G. Aznauryan,
V. D. Burkert,
K. A. Griffioen,
K. Joo,
R. Minehart,
L. C. Smith,
G. Adams,
P. Ambrozewicz,
E. Anciant, [......],
H. Weller,
D. P. Weygand,
C. S. Whisnant,
E. Wolin,
M. H. Wood,
A. Yegneswaran,
J. Yun,
J. Zhang,
J. Zhao,
Z. Zhou
[show abstract]
[hide abstract]
ABSTRACT: The ep→e'π+n reaction was studied in the first and second nucleon resonance regions in the 0.25 GeV2<Q2<0.65 GeV2 range by use of the CLAS detector at Thomas Jefferson National Accelerator Facility. For the first time, to our knowledge, the absolute cross sections were measured, covering nearly the full angular range in the hadronic center-of-mass frame. We extracted the structure functions σTL,σTT, and the linear combination σT+εσL by fitting the ϕ dependence of the measured cross sections and compared them with the MAID and Sato-Lee models.
Phys. Rev. C. 02/2006; 73(2).
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M Battaglieri,
R De Vita,
V Kubarovsky,
L Guo,
G S Mutchler,
P Stoler,
D P Weygand,
P Ambrozewicz,
M Anghinolfi,
G Asryan, [......],
M F Vineyard,
A V Vlassov,
L B Weinstein,
M Williams,
E Wolin,
M H Wood,
A Yegneswaran,
L Zana,
J Zhang,
B Zhao
[show abstract]
[hide abstract]
ABSTRACT: The exclusive reaction gammap-->K0K+n was studied in the photon energy range between 1.6 and 3.8 GeV searching for evidence of the exotic baryon Theta+ (1540)-->nK+. The decay to nK+requires the assignment of strangeness S=+1 to any observed resonance. Data were collected with the CLAS detector at the Thomas Jefferson National Accelerator Facility corresponding to an integrated luminosity of 70 pb-1. No evidence for the Theta+ pentaquark was found. Upper limits were set on the production cross section as function of center-of-mass angle and nK+ mass. The 95% C.L. upper limit on the total cross section for a narrow resonance at 1540 MeV was found to be 0.8 nb.
Physical Review Letters 02/2006; 96(4):042001. · 7.37 Impact Factor
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S. Taylor,
G. S. Mutchler,
G. Adams,
P. Ambrozewicz,
E. Anciant,
M. Anghinolfi,
B. Asavapibhop,
G. Asryan,
G. Audit,
H. Avakian, [......],
L. B. Weinstein,
H. Weller,
D. P. Weygand,
C. S. Whisnant,
M. Williams,
E. Wolin,
M. H. Wood,
A. Yegneswaran,
J. Yun,
L. Zana
Physical Review C 08/2005; 72(3):39902. · 3.31 Impact Factor
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P Rossi,
M Mirazita,
F Ronchetti,
E De Sanctis,
G Adams,
P Ambrozewicz,
E Anciant,
M Anghinolfi,
B Asavapibhop,
G Audit, [......],
L B Weinstein,
H Weller,
D P Weygand,
C S Whisnant,
E Wolin,
M H Wood,
A Yegneswaran,
J Yun,
B Zhang,
Z Zhou
[show abstract]
[hide abstract]
ABSTRACT: We investigate the transition from the nucleon-meson to the quark-gluon description of the strong interaction using the photon energy dependence of the d(gamma,p)n differential cross section for photon energies above 0.5 GeV and center-of-mass proton angles between 30 degrees and 150 degrees. A possible signature for this transition is the onset of cross-section s(-11) scaling with the total energy squared, s, at some proton transverse momentum P(T). The results show that the scaling has been reached for proton transverse momentum above about 1.1 GeV/c. This may indicate that the quark-gluon regime is reached above this momentum.
Physical Review Letters 02/2005; 94(1):012301. · 7.37 Impact Factor
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L. Morand,
D. Doré,
M. Garçon,
M. Guidal,
J. -M. Laget,
S. Morrow,
F. Sabatié,
E. Smith,
G. Adams,
P. Ambrozewicz, [......],
M. Ungaro,
M. F. Vineyard,
A. V. Vlassov,
L. B. Weinstein,
D. P. Weygand,
M. Williams,
E. Wolin,
M. H. Wood,
A. Yegneswaran,
L. Zana
[show abstract]
[hide abstract]
ABSTRACT: The exclusive ω electroproduction off the proton was studied in a large kinematical domain above the nucleon resonance region and for the highest possible photon virtuality (Q2) with the 5.75 GeV beam at CEBAF and the CLAS spectrometer. Cross-sections were measured up to large values of the four-momentum transfer (- t < 2.7="">2) to the proton. The contributions of the interference terms σ{TT} and σ{TL} to the cross-sections, as well as an analysis of the ω spin density matrix, indicate that helicity is not conserved in this process. The t-channel π0 exchange, or more generally the exchange of the associated Regge trajectory, seems to dominate the reaction γ*p↦ωp, even for Q2 as large as 5 GeV2. Contributions of handbag diagrams, related to Generalized Parton Distributions in the nucleon, are therefore difficult to extract for this process. Remarkably, the high-t behaviour of the cross-sections is nearly Q2-independent, which may be interpreted as a coupling of the photon to a point-like object in this kinematical limit.
European Physical Journal A 01/2005; 24(3):445-458. · 2.19 Impact Factor
