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ABSTRACT: The events leading to preterm birth are still not completely understood. A quantitative systematic review was performed to estimate the effects of periodontal care during pregnancy on preventing preterm birth and low birth weight. The meta-analysis included randomized trials with pregnant women with a diagnosis of periodontal disease before 20 weeks of gestation. Relative risk (RR) with 95% confidence intervals (95%CI) was calculated. We evaluated the reduction in preterm and low birth weight. Thirteen trials were included, comparing 3,576 women in intervention groups with 3,412 women receiving usual care. The meta-analysis of the effects of periodontal disease treatment during pregnancy indicated a non-significant reduction in preterm births (RR = 0.90; 95%CI: 0.68-1.19) and low birth weights (RR = 0.92; 95%CI: 0.71-1.20). The creation and examination of a funnel plot revealed clear evidence of publication bias. In summary, primary periodontal care during pregnancy cannot be considered an efficient way of reducing the incidence of preterm birth.
Cadernos de saúde pública / Ministério da Saúde, Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública 10/2012; 28(10):1823-33. · 0.83 Impact Factor
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ABSTRACT: Obesity is currently one of the major epidemics, representing an important public health problem that is associated with an increase in chronic disease. The scope of this study is to investigate the prevalence of excess weight and obesity and associated factors in 20 to 59-year-old women attended at First Aid Units of the Unified Health System. Standardized interviews and anthropometric measurements were conducted with 440 women. Factors associated with the presence of excess weight/obesity were investigated using the Poisson model with robust variance. The prevalence of excess weight and obesity (64.3%) as well as central obesity (44.1%) in women attended at First Aid Units is higher than that in the population in general and is associated with an increased incidence of health problems. Insufficient physical activity (PR=1.44; 95% CI 1.24-1.66), a history of three pregnancies or more (PR=1.45; 95% CI 1.05-2.00), age above 50 (PR=1.34; 95% CI 1.00-1.82) and central obesity (PR=1.92; 95% CI 1.64-2.25) are associated with a higher prevalence of obesity. The implementation of public health polices focused on the prevention of obesity would undoubtedly have a major impact on primary prevention of chronic diseases in the female population.
Ciencia & saude coletiva 05/2011; 16(5):2559-66.
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ABSTRACT: A quantitative systematic review was performed to estimate the accuracy ultrasonography with color Doppler in the diagnosis of ovarian tumors. Studies that compared color Doppler ultrasonography with paraffin-embedded sections parameters for the diagnosis of ovarian tumors were included. Twelve studies were analyzed, which included 2398 women. The pooled sensitivity was 0.87 (95% confidence interval [CI] 0.84-0.90); and the specificity was 0.92 (95%CI, 0.87-0.90). The diagnostic odds ratio for ovarian cancer and borderline lesions versus benign lesions was 125 (95%CI, 55-283). Summary receiver operating characteristic curves were constructed because of heterogeneity in the diagnostic odds ratio. For malignant ovarian cancer and borderline versus benign lesions the area under the curve was 0.9577. In conclusion, ultrasonography with color Doppler is a useful preoperative test for predicting the diagnosis of pelvic masses.
International Journal of Gynecological Cancer 10/2009; 19(7):1214-20. · 1.65 Impact Factor
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ABSTRACT: Human papillomavirus (HPV) types cause approximately 70% of cervical cancer worldwide. Two vaccines have been recently evaluated in randomized controlled trials: the bivalent vaccine for HPV 16 and 18 (Cervarix, GlaxoSmithKline Biologicals, Rixensart, Belgium) and the quadrivalent vaccine for HPV 6, 11, 16, and 18 (Gardasil, Merck and Co, Inc, Whitehouse Station, NJ). We have performed a systematic review of all randomized controlled trials in which vaccines against HPV were compared with placebo regarding efficacy, safety, and immunogenicity. Six studies met the inclusion criteria, which included 47,236 women. The first objective in this systematic review was to assess vaccine efficacy in the prevention of cytologically and/or histologically proven lesions. And the secondary objective was the evaluation of safety and vaccine immunogenicity. Bivalent and quadrivalent HPV vaccines significantly reduced the rate of lesions in the cervix, vulva, vagina, and anogenital region, with efficacy of 93% (95% confidence interval [CI], 87-96) and 62% (95% CI, 27-70), respectively, when compared with the control groups according to intention to treat. Regarding safety, we found more symptoms in the bivalent vaccine group (35%; 95% CI, 5-73) when compared with the control groups. In regard to vaccine immunogenicity, there was seroconversion in the group that received the vaccine when compared with the placebo group in the bivalent and quadrivalent vaccines. Prophylactic vaccination can prevent HPV infection in women aged 9 to 26 years not previously infected with the HPV subtypes covered by the vaccines. To evaluate cervical cancer incidence and mortality, a longer follow-up is necessary.
International Journal of Gynecological Cancer 10/2009; 19(7):1166-76. · 1.65 Impact Factor
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ABSTRACT: This article focuses on the frequency of condom use and associated factors in university students, based on a cross-sectional study of 633 students in 2006. Associations were investigated using a logistic regression model with 5% significance. Condom use prevalence was 60%. Having candidiasis was a protective factor for condom use in both sexual initiation (OR = 0.49; 95%CI: 0.31-0.79) and the most recent sexual intercourse (OR = 0.39; 95%CI: 0.24-0.65). Condom use was associated with single marital status (OR = 2.89; 95%CI: 1.60-5.23) and having a sex partner from the health field (OR = 0.50; 95%CI: 0.34-0.75). Condom use was high in all sexual relations in this sample of university students. Single marital status and having a sex partner from a health-related course were positively associated with condom use in the most recent intercourse. Self-reported genital candidiasis was protective for condom use during early sexual activity and in the most recent sexual relation. Belonging to the health field did not show a significant impact on the use of male condoms.
Cadernos de saúde pública / Ministério da Saúde, Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública 07/2009; 25(6):1245-50. · 0.83 Impact Factor
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ABSTRACT: Human papillomavirus (HPV) has been established as an important etiological factor for the development of cervical cancer. This DNA virus primarily infects the epithelium and can induce benign and malignant lesions of the mucous membranes and skin. Some HPVs are considered high risk due to their role in malignant progression of cervical tumors. Genital HPV infections are common and usually transient among young sexually active women. Only a small fraction of infected women develop cervical cancer, implying the involvement of environmental and genetic cofactors in cervical carcinogenesis. Classification, virology, pathology, natural history, epidemiological features of genital HPV infection, and future prospects for cervical cancer prevention with HPV vaccines will be reviewed here.
Cadernos de saúde pública / Ministério da Saúde, Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública 06/2009; 25(5):953-64. · 0.83 Impact Factor
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ABSTRACT: A quantitative systematic review was performed to estimate the accuracy of CA 125 assay in the diagnosis of ovarian tumors. Studies that evaluated CA 125 levels for the diagnosis of ovarian tumors and compared them with paraffin-embedded sections as the diagnostic standard were included. Seventeen studies were analyzed, which included 2374 women. The pooled sensitivity for the diagnosis of borderline tumors or ovarian cancer was 0.80 (I.C. 95% 0.76-0.82) and the specificity was 0.75 (I.C. 95% 0.73-0.77). The diagnostic odds ratio for ovarian cancer and borderline lesions vs. benign lesions was 21.2 (95% C.I., 12-37). Summary receiver operating characteristic curves were constructed due to heterogeneity in the diagnostic odds ratio. For malignant and borderline ovarian tumors vs. benign lesions the area under the curve was 0.8877. A CA 125 level of >or= 35 U/ml is a useful preoperative test for predicting the benign or malignant nature of pelvic masses. The accuracy of CA 125 in the diagnosis of ovarian tumors is high and very important in helping the surgeon to decide what kind of surgery should be performed.
European journal of obstetrics, gynecology, and reproductive biology 11/2008; 142(2):99-105. · 1.97 Impact Factor
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ABSTRACT: Determining malnutrition and associated variables in the elderly.
A cross-sectional study was conducted among elderly people vaccinated against influenza in order to evaluate their nutritional status. Nutritional assessment was performed with the Mini Nutritional Assessment. To verify association of studied variables with the outcome, odds ratios was estimated using multiple logistic regression.
A total of 236 elderly patients were recruited. The Mini Nutritional Assessment identified three patients (1.3%) with malnutrition and 59 (25%) at risk of malnutrition. Factors with a positive association to the outcome were psychological stress or acute disease in the past three months, weight loss (< 3 kg) during the last three months and sores or skin ulcers. On the other hand, consuming two or more servings of fruits or vegetables daily, eating meat, fish or poultry every day and drinking more than three cups of fluids per day were negatively associated to malnutrition and risk of malnutrition.
The low prevalence of malnutrition found in this study may be due to the study sample of elderly individuals in good health. Some factors related to a recent health problem (psychological stress or acute disease) seem to be positively associated while regular consumption of fluids and certain foods seem to be negatively associated with malnutrition.
Revista da Associação Médica Brasileira 57(1):56-61. · 0.77 Impact Factor
