R Aller

Universidad de Valladolid, Valladolid, Castille and León, Spain

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Publications (336)645.66 Total impact

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    ABSTRACT: Background: Studies of the glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) have been directed at identifying polymorphisms in the GLP-1R gene that may be a contributing factor in the pathogenesis of obesity. Objective: We decided to investigate the role of the rs6923761 GLP-1R polymorphism on outcomes after biliopancreatic diversion. Design: A sample of 137 morbidly obese patients was operated. Weight, blood pressure, basal glucose and lipid profile were measured at the basal visit and at each following visit (basal, 3, 9, 12 and 18 months). Results: Body mass index, weight and waist circumference were lower in non-A allele carriers than A allele carriers 12 and 18 months after surgery. The initial weight percent loss at 12 months (45.6 vs. 39.8%; p < 0.05) or 18 months (49.6 vs. 41.3%; p < 0.05) was higher in patients with GG genotype than A allele carriers. Conclusion: Our study showed a higher weight loss 12 and 18 months after bariatric surgery in GG variant than A allele carriers. The biochemical parameters and cardiovascular comorbidity rates improved similarly in both genotypes. © 2014 S. Karger AG, Basel.
    Annals of Nutrition and Metabolism 10/2014; 65(4):259-263. · 2.75 Impact Factor
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    ABSTRACT: Background: The role of glucagon-like peptide 1 (GLP-1) variants in metabolic syndrome (MS) and its components remains unclear in obese subjects. Objective: The aim of our study was to evaluate the relationship of rs6923761 with MS and its components in obese subjects. Design: A population of 1,122 obese subjects was analyzed in a cross-sectional survey. To estimate the prevalence of MS, we considered the definitions of the Adult Treatment Panel III. Results: Five hundred and forty-eight patients (48.8%) had the GG genotype (wild-type group), whereas 487 patients (43.4%) had the GA genotype and 87 patients (7.8%) the AA genotype. The mean age was 48.9 ± 12.8 years. The prevalence of MS was 47.4% (532 patients), and 52.6% of patients had no MS (n = 590). The odds ratio of MS for the wild-type versus the mutant genotype was 1.02, with a 95% confidence interval of 0.88-1.12. Body mass index, weight, fat mass, waist circumference, and waist to hip ratio were lower in the mutant than in the wild-type group in patients with and without MS. Conclusion: The GLP-1 receptor variant rs6923761 was found to be associated with decreased weight and anthropometric parameters in A allele carriers with and without MS. MS or its components were not associated with this polymorphism in obese adults. © 2014 S. Karger AG, Basel.
    Annals of Nutrition and Metabolism 10/2014; 65(4):253-258. · 2.75 Impact Factor
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    ABSTRACT: Role of GLP-1 variants on basal GLP-1 levels, body weight and cardiovascular risk factors remains unclear in patients with diabetes mellitus type 2.
    Journal of endocrinological investigation 09/2014; · 1.65 Impact Factor
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    ABSTRACT: Background Human obesity is characterized by high levels of leptin, and leptin levels may change with weight loss and dietary restriction. The aim of our study was to investigate the influence of Lys656Asn polymorphism in the leptin receptor gene on cardiovascular risk factors, weight loss, and serum leptin levels to a high polyunsaturated fatty acid (PUFA) hypocaloric diet in obese patients.DesignA sample of 132 obese patients was analyzed in a prospective way with a dietary intervention. The enriched PUFAs hypocaloric intervention consisted in a diet of 1,459 kcal, 45.7% of carbohydrates, 34.4% of lipids, and 19.9% of proteins.ResultsIn wild-type group, BMI (−1.9 ± 1.4 kg/m2), weight (−4.4 ± 3.2 kg), fat mass (−4.2 ± 3.8 kg), waist circumference (−4.1 ± 3.1 cm), systolic blood pressure (−7.0 ± 12.1 mmHg), diastolic blood pressure (−3.9 ± 6.8 mmHg), insulin (−1.8 ± 5.6 MUI/l) and HOMA-IR (−0.5 ± 1.5 Units) decreased. In mutant genotype group, BMI (−2.0 ± 2.1 kg/m2), weight (−3.6 ± 4.1 kg), waist circumference (−3.1 ± 4.1 cm), total cholesterol (−25.2 ± 19.6 mg/dl), LDL cholesterol (−16.6 ± 25.6 mg/dl), and tryglicerides (−26.6 ± 39.1 mg/dl) decreased. Only leptin levels have a significant decrease in wild genotype group (−6.6 ± 10.2 ng/ml) (25.1%).Conclusion Carriers of ASn656 allele have a different response than wild-type obese, with a lack of decrease in insulin levels, leptin levels, and HOMA-IR. However, obese patients with this mutant allele have a better lipid profile after weight loss.
    Journal of Clinical Laboratory Analysis 08/2014; · 1.14 Impact Factor
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    ABSTRACT: The correction of hepatopulmonary syndrome (HPS) after liver transplantation (LT) remains controversial. The aims of our study were to: 1) analyze whether LT reverses HPS; 2) note any relationship between HPS and the systemic hemodynamic disturbance; and 3) note changes in circulating sex hormones and the possible association with pulmonary and systemic hemodynamic changes. Systemic hemodynamic parameters, cardiac output and systemic vascular resistance (SVR), sex hormones, and intrapulmonary vasodilatation assessed by contrast transesophageal echocardiography, and gas exchange abnormalities were investigated in 19 patients with advanced cirrhosis prior to and 6 months (176.8+/-30 days) after LT. LT was followed by a marked reduction in cardiac output (6.6+/-1.7 vs 3.5+/-0.5 l/min; p<0.001) and SVR (1039+/-460 vs 1978+/-294 dyn x sec x cm(-5); p<0.005). Before LT, circulating estradiol and progesterone levels were invariably elevated (66+/-22 pg/ml and 1.8+/-1.1 ng/ml, respectively, normal values <31 pg/ml and 0.35 ng/ml, respectively), and dropped after LT (28+/-12 pg/ml p<0.001 and 0.38+/-0.2 ng/ml; p<0.001, respectively). Seventeen of 19 patients had intrapulmonary vasodilatation and increased alveolar-arterial oxygen difference, thereby fulfilling diagnostic criteria for HPS. Patients with HPS presented higher cardiac output (p<0.05), lower SVR (p<0.01), and higher progesterone and estradiol levels than patients without HPS (p<0.05). LT produced normalization of intrapulmonary vasodilatation in all patients. LT normalized hyperdynamic circulation and is a useful therapeutic option in patients with HPS. Normalization of sex hormone levels after LT suggests that they could play a pathogenic role in the development of HPS.
    Journal of endocrinological investigation 07/2014; 24(7):503-9. · 1.55 Impact Factor
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    ABSTRACT: Studies of the GLP-1 receptor (GLP-1 R) have been directed at identifying polymorphisms in the GLP-1 R gene that may be a contributing factor in the pathogenesis of obesity and cardiovascular risk factors. Nevertheless, the role of GLP-1 R variants on body weight response after dietary intervention has not been evaluated.
    Journal of endocrinological investigation 06/2014; · 1.65 Impact Factor
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    ABSTRACT: The role of GLP-1 R variants on body weight response after dietary intervention is unclear.
    Journal of endocrinological investigation 06/2014; · 1.65 Impact Factor
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    ABSTRACT: Hyperaminotransferasemia is an important problem in obese patients. We decide to examine the changes in hyperaminotransferasemia after weight reduction in obese patients with and without NAFLD secondary to a high monounsaturated fat vs. a high polyunsaturated fat hypocaloric diets. A population of 306 obese patients was randomly allocated to two groups: Diet M (high monounsaturated fat hypocaloric diet) and Diet P (high polyunsaturated fat hypocaloric diet). Patients were classified as group I (obese subjects; n=262) when serum ALT activity was normal or group II (NAFLD patients; n=44) when serum ALT activity was (≥ 43 UI/L). In NAFLD group with diet M, BMI, weight, fat mass, waist circumference, systolic blood pressure, total cholesterol, LDL cholesterol), insulin and HOMA-R decreased. In NAFLD group with diet P, BMI, weight, fat mass, waist circumference, systolic blood pressure, total cholesterol, LDL cholesterol), insulin and HOMA-R decreased, too. In NAFLD group, alanine aminotransferase [(diet M) -20.3±19.2 UI/L vs. (diet P) -14.2±20.1 UI/L], aspartate aminotransferase [(diet M) -11.3±12.2 UI/L vs. (diet P) -11.1±10.1 UI/L], and gammaglutamyl transferase [(diet M) -18.1±12.2 UI/L vs. (diet P) -10.9±20.1 UI/L] improved with both diets. We showed that weight reduction secondary to two hypocaloric diets was associated with improvement in hypertransaminasemia and insulin resistance in NAFLD patients.
    European review for medical and pharmacological sciences 04/2014; 18(7):1041-7. · 0.99 Impact Factor
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    ABSTRACT: Studies of the glucagon-like peptide 1 (GLP-1) receptor have been directed at identifying polymorphisms in the GLP-1 receptor gene that may be a contributing factor in the pathogenesis of diabetes mellitus and cardiovascular risk factors. Nevertheless, the role of GLP-1 variants on body weight, cardiovascular risk factors, and adipokines remains unclear in obese patients. Our aim was to analyze the effects of rs6923761 GLP-1 receptor polymorphism on body weight, cardiovascular risk factors, and serum adipokine levels in nondiabetic obese females. A sample of 645 obese nondiabetic Caucasian females was enrolled in a prospective way. Basal fasting glucose, c-reactive protein (CRP), insulin, insulin resistance (homeostasis model assessment (HOMA)), total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides concentration, and adipokines were measured. Weights, body mass index (BMI), waist circumference, fat mass by bioimpedance, and blood pressure measures were measured. Three hundred and twenty-seven participants (50.7%) had the genotype GG and 318 (49.3%) study subjects had the next genotypes; GA (270 study subjects, 41.9%) or AA (48 study subjects, 7.4%) (second group). In wild group (GG genotype), BMI (1.8 ± 2.3 kg/m(2) ; P < 0.05), weight (3.1 ± 1.3 kg; P < 0.05), fat mass (2.4 ± 1.1 kg; P < 0.05), waist circumference (2.7 ± 1.9 cm; P < 0.05), triglyceride levels (10.4 ± 5.3 mg/dl; P < 0.05), interleukin 6 (IL-6) (1.5 ± 0.9 ng/dl; P < 0.05), resistin (1.1 ± 0.3 ng/dl; P < 0.05), and leptin (30.1 ± 10.3 ng/dl; P < 0.05) levels were higher than mutant group (GA + AA). Data from our study revealed an association with decreased metabolic and cardiovascular markers in obese females. BMI weight, fat mass, waist circumference, triglycerides, leptin, resistin, and IL-6 serum levels were lower in subjects with A allele than non-A allele subjects.
    Journal of Clinical Laboratory Analysis 03/2014; · 1.14 Impact Factor
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    ABSTRACT: In the nutritional management of patients with dys - phagia and/or elderly must make a multidisciplinary approach and a main tool is changing the texture of food. Patients with dysphagia, who need a texture modified diet, generally do not have a calorie and nutrient requirements different from those exhibited by people of the same age and sex, unless a condition or disease coexist. In these patients, Texture of foods should be individualized according to the patient and the time course of their disease. The use of texture modified diets without specifying produces a clear decrease in caloric and protein intakes and nutritional disorders. These patients may have other characteristics associated diseases, which would require special modification, as in the case of diabetes mellitus, hypertension, osteoporosis and constipation. Sometimes it is ne - cessary to use artificial products to achieve different desired textures and precooked dishes, too.
    Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral 01/2014; 29(n04):751-759. · 1.25 Impact Factor
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    ABSTRACT: Introduction: Previous studies have found that L-arginine induced beneficial effects over insulin resistance both in type 2 diabetes mellitus patients and healthy individuals. The aim of our study was to investigate whether an L-arginine enteral supplementation (20 g per day) in head and neck cancer patients could modify insulin resistance, leptin and adiponectin levels after surgery. Material and Methods: At surgery 82 patients were randomly allocated to two groups: group I received an enteral diet supplements with a high dose of arginine (20g per day) and group II received an enteral formula without arginine. At basal time and on postoperative day 10, the following parameters were recorded: glucose, c-reactive protein, insulin, HOMA (homeostasis model assessment), leptin and adiponectin. Results: Values of weight, body mass index, fat mass and fat free mass remained unchaged during the acute nutritional intervention in both groups. Insulin levels UI/L (-0.21+/-0.18) and HOMA units (-0.07+/-0.13) decreased in the arginine group. Adiponectin levels (+1.8+/-2.3ng/ml) increased in the arginine group. Conclusion: Short-term enteral L-arginine therapy addeded to usual enteral nutrition of patients affected by head and neck cancer and surgery without diabetes mellitus type 2 is able to improve insulin resistance and adiponectin levels.
    Nutricion hospitalaria. 01/2014; 30(n04):870-875.
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    ABSTRACT: Background: Studies of the GLP-1 receptor have been directed at identifying polymorphisms in the GLP-1 receptor gene that may be a contributing factor in the pathogenesis of diabetes mellitus and cardiovascular risk factors. Nevertheless, the role of GLP-1 variants on body weight, cardiovascular risk factors and adipokines remains unclear in obese patients. Objective: Our aim was to analyze the effects of rs6923761 GLP-1 receptor polymorphism on body weight, cardiovascular risk factors and serum adipokine levels in morbid obese patients. Design: A sample of 175 morbid obese patients was enrolled in a prospective way. Basal fasting glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides concentration and adipokines were measured. Weights, body mass index, waist circumference, fat mass by bioimpedance and blood pressure measures were measured. Results: 87 patients (49,7%) had genotype GG and 88 (50,3%) had; GA (71 patients, 40,6%) or AA (17 patients, 9,7%) (second group). In the group with GG genotype, levels of glucose (4,4 ± 2,3 mg/dl, p < 0,05), tryglicerides (6,8 ± 4,3 mg/dl , p < 0,05), insulin (4,5 ± 2,3 UI/l , p < 0,05) and HOMA (1,5 ± 0,9 units, p < 0,05) were higher than mutant group. No differences were detected in other parameters. Conclusion: Data from our study revealed an association with metabolic parameters and rs6923761. Levels of triglycerides, insulin and HOMA were higher in subjects with A alelle than non A allele subjects.
    Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral 01/2014; 29(n04):889-893. · 1.25 Impact Factor
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    ABSTRACT: Malnutrition in surgical patients is associated with delayed recovery, higher rates of morbidity and mortality, prolonged hospital stay, increased healthcare costs and a higher early re-admission rate.
    Nutricion hospitalaria. 01/2014; 30(n03):509-513.
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    ABSTRACT: Background: The role of glucagon-like peptide-1 receptor (GLP-1R) variants on body weight response after dietary intervention has not been evaluated so far. Objective: Our aim was to evaluate weight loss and adipocytokine levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs6923761. Design: A sample of 280 obese subjects was randomized to two hypocaloric diets. Results: 124 patients (44.3%) had the genotype GG (wild-type) and 156 (55.7%) had another genotype (mutant), i.e. GA (n = 132, 47.1%) or AA (n = 24, 8.6%). With the type I diet (low in carbohydrates) in the wild-type and mutant groups, BMI, weight, fat mass, waist circumference, insulin levels, insulin resistance and triglycerides decreased. Anthropometric parameters were higher in non-A-allele carriers than A-allele carriers. With the type II diet (low in fats) in all genotypes, BMI, weight, fat mass, waist circumference, insulin levels, total cholesterol and LDL cholesterol decreased. Conclusion: Our data showed better anthropometric parameters in obese subjects with the mutant allele (A) of the rs6923761 GLP-1R polymorphism. A lack of association of this polymorphism with weight loss or biochemical parameters after two different hypocaloric diets was observed. © 2013 S. Karger AG, Basel.
    Annals of Nutrition and Metabolism 12/2013; 63(4):277-282. · 1.66 Impact Factor
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    ABSTRACT: The C385A polymorphism of FAAH gene (rs324420C>A) has been associated with obesity. We investigate the role of this polymorphism on anthropometric and insulin resistance responses to a high polyunsaturated fat hypocaloric diet. Obese individuals (no.=99) were assessed at baseline and after 3 months of a high polyunsaturated fat hypocaloric diet. Seventy-one patients (71.7%) had the genotype C385C and 28 (28.3%) patients had the C385A (26 patients, 26.3%) or A358A (2 patients, 2.0%) (A allele carriers group) genotype. In A allele carriers and after dietary intervention, total cholesterol (-16.3±37.4 mg/dl) and LDL-cholesterol (-12.9±6.5 mg/dl) levels decreased. In subjects with C385C genotype, the decreases were significant in total cholesterol (-12.3±27.4 mg/dl), LDL-cholesterol (-7.5±20.5 mg/dl), insulin (-2.2±6.2 mUI/l), and homeostasis model assessment of insulin resistance (HOMA-R) (-0.79±1.15 units) levels. The weight loss was similar in both genotype groups (-4.1±3.8 kg vs -4.2±3.2 kg). Only leptin levels had a significant similar decrease in both genotypes. Subjects with C385C genotype of the FAAH showed an improvement on insulin and HOMA-R levels with a high polyunsaturated fat hypocaloric diet after weight loss during 3 months.
    Journal of endocrinological investigation 12/2013; 36(11):965-9. · 1.65 Impact Factor
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    ABSTRACT: One of the genetic variants (rs9939609) of FTO gene is related with obesity and type 2 diabetes mellitus. The aim of the present study was to analyze the relationship of the rs9939609 FTO gene polymorphism to body weight, insulin resistance, cardiovascular risk factors and serum adipokine levels in patients with diabetes. 123 naïve patients with diabetes mellitus type 2 were analyzed in a cross sectional design. Body weight, blood pressure, fast blood glucose, c-reactive protein (CRP), insulin, HbA1c, insulin resistance (homeostasis model assessment, HOMA-R), total cholesterol, HDL-cholesterol, HDL-cholesterol, triglycerides blood and adipocytokines levels were measured. Forty one patients (14 males/27 females) (33.3 %) had the genotype TT (wild type group), 51 (11 males/40 females) (41.5 %) TA and 31 (9 males/22 females) (25.2 %) AA (mutant type group). No association between the FTO variant and anthropometric parameters or blood pressure was found. Wild type group had higher HOMA-R (1.3 units:CI95% 0.51–5.8), insulin (3.3 mUI/L:CI95% 0.31–13.4) and triglyceride (12.6 mg/dl: CI95% 3.90–46.1) levels than mutant allelic group (TA and AA). Adipocytokines levels were similar in both genotype groups. The FTO gene polymorphism, rs9939609, was found to be associated with HOMA-R, insulin and triglyceride levels in naïve diabetic patients with TT variant.
    International Journal of Diabetes in Developing Countries 12/2013; 33(4). · 0.37 Impact Factor
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    ABSTRACT: The aim of our study was to study the association of insulin resistance expressed by HOMA and adipokines in obese type 2 diabetic patients with or without hyper-transaminasemia. A population of 72 obese patients with type 2 diabetes mellitus was analyzed. HOMA-IR was calculated as indicator of insulin-resistance. Adipocytokines blood levels were measured. Patients were classified as group I (n=37) when serum ALT activity was normal or group II (NAFLD patients: n=35) when serum ALT activity was greater than the median value of the group (≥ 28 UI/L). In NAFLD group, BMI, weight, fat mass, waist to hip ratio, waist circumference, triglycerides, HOMA and insulin levels were higher than control group. In the logistic regression analysis with a dependent variable (ALT) and the statistical univariant variables as independent variables, the HOMA-IR remained in the model, with an Odd's ratio of 1.21 (CI:95%: 1.11-1.35) to have a high ALT level with each 1 unit of HOMA-IR adjusted by age, sex, weight, and dietary intake. Some metabolic parameters are associated with elevated ALT in female obese patients. However, adjusted by other variables, only insulin resistance remained associated.
    European review for medical and pharmacological sciences 08/2013; 17(15):2059-64. · 0.99 Impact Factor
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    ABSTRACT: It has been found that the expression of fatty acid binding protein 2 (FABP2) mRNA is under dietary control. This polymorphism was associated with high insulin resistance, and fasting insulin concentrations. The aim of our study was to investigate the influence of Thr54 polymorphism in the FABP2 gene on metabolic response, weight loss and serum adipokine levels secondary to a high monounsaturated fat hypocaloric diet. A sample of 122 obese patients was analyzed in a prospective way. The hypocaloric diet had 1342 kcal, 46.6% of carbohydrates, 34.1% of lipids and 19.2% of proteins, with a 67.5% of monounsaturated fats, and lasted 3 months. Fifty-five patients (45.1%) had the genotype Ala54/Ala54 (wild group) and 67 (64.9%) patients a mutant genotype, Ala54/Thr54 (54 patients, 44.3%) or Thr54/Thr54 (13 patients, 10.7%). In wild group, body mass index (-1.5±1.2 kg/m2), weight (-4.1±3.6 kg), fat mass (-3.6±3.3 kg), waist circumference (-4.9±2.9 cm), insulin (-1.7±3.6 mUI/l), homeostasis model assessment of insulin resistance (HOMA-IR) (-0.6±1.8 units) and leptin levels decreased (-7.6±7.1 ng/ml). In mutant group, anthropometric parameters improved, without changes in biochemical parameters. Carriers of Thr54 allele have a different response than wild type obese, with a lack of decrease of insulin levels, leptin levels and HOMA-IR.
    Journal of endocrinological investigation 06/2013; 36(6):402-6. · 1.65 Impact Factor
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    ABSTRACT: Objective: The aim of our study was to investigate the role of Trp64Arg polymorphism of the beta 3-adrenergic receptor (beta 3-AR) gene on metabolic changes and weight loss secondary to a high monounsaturated fat versus a high polyunsaturated fat hypocaloric diet in obese subjects. Material and Methods: A population of 260 obese subjects was analyzed. In the basal visit, patients were randomly allocated for 3 months to either diet M (high monounsaturated fat hypocaloric diet) or diet P (high polyunsaturated fat hypocaloric diet). Results: There were no significant differences between the positive effects (on weight, body mass index, waist circumference, fat mass) in either genotype group with both diets. With diet P and in genotype Trp64Trp, glucose levels (-6.7 ± 12.1 vs. -1.2 ± 2.2 mg/dl; p < 0.05), total cholesterol (-11.2 ± 8.1 vs. -1.0 ± 7.1 mg/dl; p < 0.05), low-density lipoprotein (LDL) cholesterol (-9.7 ± 10.1 vs. -2.2 ± 8.1 mg/dl; p < 0.05), triglycerides (-11.7 ± 13.1 vs. +1.7 ± 10.3 mg/dl; p < 0.05), homeostasis model assessment for insulin resistance (HOMA-R; -0.7 ± 1.1 vs. -0.3 ± 2.1 units; p < 0.05) and insulin levels (-1.8 ± 4.6 vs. -1.0 ± 9.1 mIU/l; p < 0.05) decreased. Conclusion: The metabolic effect of weight reduction by the two hypocaloric diets is greatest in subjects with the normal homozygous beta 3-AR gene. Improvements in total cholesterol, LDL cholesterol, triglyceride, glucose, insulin and HOMA-R levels were better than in the heterozygous group.
    Annals of Nutrition and Metabolism 05/2013; 62(4):303-309. · 1.66 Impact Factor
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    ABSTRACT: BACKGROUND: Serum visfatin are associated with cardiovascular risk factors and obesity. Relation of this adipokine with nmetabolic syndrome is unclear. We decide to investigate the association between metabolic syndrome and resistin levels in female obese subjects. SUBJECTS: A sample of 826 female obese subjects was analyzed. A complete nutritional and biochemical evaluation was performed. Serum visfatin levels were measured and to estimate the prevalence of Metabolic Syndrome, the definitions of the ATPIII was considered RESULTS: Mean age was 48.1 + 12.6 years. Patients were divided in three groups by tertiles of visfatin value, group I (< 7.94 ng/ml), group II (7.95 ng/ml- 11.78 ng/ml) and group 3 (> 11.79 ng/ml). A total of 350 females had metabolic syndrome (42.4%). Values of body mass index (BMI), weight, fat mass and waist circumference were lower in patients in the highest tertile group of visfatin than the lowest and middle tertiles of visfatin. Values of C reactive protein were higher in patients in the highest tertile group of visfatin than the lowest and middle tertiles of visfatin. Correlation analysis showed a significant correlation among serum visfatin levels and the independent variables; total cholesterol (r = 0.14;p < 0.05) and C reactive protein (r = 0.12;p < 0.05). In the multivariate analysis, only visfatin concentration increase 0.123 ng/ml (CI95%:0.033-0.445) for each mg/dl of C reactive protein. CONCLUSION: Only C reactive protein remained associated, in an independent way. Serum visfatin was not associated with the accumulation of metabolic syndrome factors or the diagnosis of metabolic syndrome in obese female subjects. This article is protected by copyright. All rights reserved.
    Diabetes/Metabolism Research and Reviews 05/2013; · 3.59 Impact Factor

Publication Stats

2k Citations
645.66 Total Impact Points

Institutions

  • 2000–2014
    • Universidad de Valladolid
      • Facultad de Medicina
      Valladolid, Castille and León, Spain
  • 1999–2014
    • Hospital Universitario Fundacion Alcorcon
      Madrid, Madrid, Spain
  • 2001–2012
    • Hospital Universitario "Rio Hortega"
      • Department of Internal Medicine
      Valladolid, Castille and León, Spain
  • 2005–2009
    • Hospital Clínico Universitario de Valladolid
      Valladolid, Castille and León, Spain
  • 2001–2009
    • Facultad de Medicina
      Madrid, Madrid, Spain
  • 2007
    • Hospital Universitario de La Princesa
      Madrid, Madrid, Spain
  • 1996–2002
    • Hospital Universitario Ramón y Cajal
      • Departamento de Medicina Interna
      Madrid, Madrid, Spain
  • 1998
    • University of Alcalá
      Cómpluto, Madrid, Spain