-
[show abstract]
[hide abstract]
ABSTRACT: Six new cardenolides, periforosides D-E (1-2), periforgenin C (3) and periforosides F-H (4-6), as well as 10 previously identified cardenolides (7-16) were isolated from the ethanol extract of the stems of Periploca forrestii. The structures of the new compounds were determined using extensive spectroscopic analyses including HRESI-MS, 1D and 2D NMR data. Evaluation of the cytotoxic activity of all the isolated compounds in five different human cancer cell lines indicated that compounds 2-6, 8, 9 and 12-16 have potent activity.
Steroids 12/2011; 77(5):375-81. · 2.83 Impact Factor
-
Shuang-Gang Ma,
Wen-Zhao Tang,
Yu-Xi Liu, You-Cai Hu,
Shi-Shan Yu,
Yi Zhang,
Xiao-Guang Chen,
Jing Qu,
Jin-Hong Ren,
Yun-Bao Liu,
Song Xu,
Jing Liu,
Yuan-Yan Liu,
Yong Li,
Hai-Ning Lü,
Xian-Fu Wu
[show abstract]
[hide abstract]
ABSTRACT: Eleven prenylated C(6)-C(3) compounds, illioliganpyranone A (1), illioliganfunone A-D (2-5), and illioliganone D-I (6-11), together with five known prenylated C(6)-C(3) compounds (12-16), were isolated from roots of Illicium oligandrum. The structures of 1-11 were elucidated by spectroscopic methods including 1D and 2D NMR, HRESIMS, and CD experiments. Possible biosynthetic pathways to compounds 1-16 derived from a common precursor of 5-allylbenzene-1,2,4-triol were postulated. All compounds were evaluated for cytotoxic activities against five human cancer cell lines (HCT-8, Bel-7402, BGC-823, A549 and A2780). Compound 15 exhibited significant cytotoxicity against HCT-8, BGC-823, A549, and A2780 cell lines with IC(50) values of 0.30-2.57 μM. Compound 16 showed moderate selective cytotoxicity against sensitive A2780 cells with IC(50) value of 1.38 μM.
Phytochemistry 01/2011; 72(1):115-25. · 3.35 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Two new compounds, lysidiside S (1) and 7-O-(+)-peltogynol-beta-d-glucopyranoside (2), together with six known phenolic glycosides (3-8) were isolated from the bark of Lysidice brevicalyx Wei. The structures of these compounds were characterized by chemical and spectroscopic methods. The antioxidant activities of compounds 1-8 were evaluated, and compound 3 exhibited remarkable antioxidant activity at concentrations of 10(-4), 10(-5), and 10(-6) mol/l.
Journal of Asian natural products research 06/2010; 12(6):516-21. · 0.61 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Three new phloroglucinols, named lysidicins F-H (1-3), were isolated from the roots of Lysidice rhodostegia. These compounds have a unprecedented benzyl benzo[b]furo[3,2-d]furan skeleton, and lysidicin F (1) is the first example of natural product with trans-fused furan rings. Their structures were established on the basis of extensive spectroscopic analysis, and the absolute configurations of them were determined by computational methods. A possible biosynthetic pathway for 1-3 was also postulated.
Organic Letters 05/2010; 12(10):2390-3. · 5.86 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: A combination of electrospray ionization tandem mass spectrometry with high-performance liquid chromatography (HPLC/ESI-MSn), and hyphenation of liquid chromatography to nuclear magnetic resonance spectroscopy (HPLC/NMR), have been extensively utilized for on-line analysis of natural products, analyzing metabolite and drug impurity. In our last paper, we reported an on-line analytical method for structural identification of trace alkaloids in the same class. However, the structural types of the constituents in plants were various, such as flavanoids, terpenoids and steroids. It is important to establish an effective analytical method for on-line structural identification of constituents with molecular diversity in extracts of plants. So, in the present study, the fragmentation patterns of some isolated stilbenes, phloroglucinols and flavanoids from Lysidice rhodostegia were investigated by ESI-MSn. Their fragmentation rules and UV characteristics are summarized, and the relationship between the spectral characteristics, rules and the structures is described. According to the fragmentation rules, NMR and UV spectral characteristics, 24 constituents of different types in the fractions from L. brevicalyx of the same genus were structurally characterized on the basis of HPLC/HRMS, HPLC-UV/ESI-MSn, HPLC/1H NMR and HPLC/1H-1H COSY rapidly. Of these, six (10, 13, 14, 16, 17 and 23) are new compounds and all of them are reported from L. brevicalyx for the first time. The aim is to develop an effective analytical method for on-line structural identification of natural products with molecular diversity in plants, and to guide the rapid and direct isolation of novel compounds by chemical screening.
Rapid Communications in Mass Spectrometry 02/2008; 22(6):755-65. · 2.79 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Three new oleanane-type triterpene saponins, named pithelucosides A-C (1-3), together with two known saponins (4, 5) were isolated from the roots of Pithecellobium lucidum. The structures of the new saponins were established on the basis of extensive 1D and 2D NMR experiments and mass spectrometry and confirmed by acid and alkaline hydrolysis. Compounds 1-5 and 7 (pro-sapogenin obtained from the mild alkaline hydrolysate of 1) were evaluated for cytotoxic activity on five human tumoral cell lines (HCT-8, Bel-7402, BGC-823, A549, and A2780) and for hemolytic property against rabbit erythrocytes. Compounds 2-5 showed significant cytotoxic activities with IC50 values of 0.61-7.56 microM. All tested compounds did not exhibit any hemolytic activity in the concentration range 0.01-100 microM.
Journal of Natural Products 02/2008; 71(1):41-6. · 3.13 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Two new lignan glucosides, compounds 2 and 3, two new 1H-indole-alkaloid glucosides, 5 and 6, as well as two new phenolic glucosides, 7 and 10, were isolated from the roots of Capparis tenera, together with five known compounds. Their structures were characterized by chemical and spectroscopic methods. Most of these isolates were obtained for the first time from Capparidaceae. The antioxidant and anti-inflammatory activities of the new compounds were investigated.
Chemistry & Biodiversity 01/2008; 4(12):2852-62. · 1.80 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: A new triterpenoid, 11-O-trans-p-coumaroyltaraxerol (1), along with 11 known triterpenoids, taraxerone (2), taraxerol (3), 2,3β,23,24-tetrahydroxyolean-12-en-28-oic acid (4), oleanolic acid (5), β-amyrin (6), 3β,23-dihydroxylursan-12-en-28-oic acid (7), 2,3β-dihydroxyursan-12-en-28-oic acid (8), 2,3β,23-trihydroxyursan-12-en-28-oic acid (9), 2,3β,24-trihydroxyursan-12-en-28-oic acid (10), ursolic acid (11), and 3-O-acetylursolic acid (12), was isolated from Craibiodendron henryi W. W. Smith (Ericaceae). The structures of these compounds were elucidated on the basis of spectral evidence. Antioxidant activity and vasodilator effect of compound 1 were assessed.
Journal of Integrative Plant Biology 10/2007; 49(11):1615 - 1618. · 2.53 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: To study the chemical constituents from the roots of Craibiodendron henryi.
Various chromatographic techniques were used to isolate and purify the constituents. The structures were elucidated by chemical evidence and spectral methods.
Twelve compounds were isolated from the ethyl acetate soluble fraction of the 95% ethanolic extract and their struc- tures were elucidated as quercetin (1), quercetin-3-O-rhamnicoside (2), quercetin-3-O-arabinofuranoside (3), (-)-epicatechin (4), proanthocyanidin A-2 (5), procyanidin B-2 (6), (-)-isolariciresinol-2a-O-beta-D-xylopyranoside (7), lyoniside (8), sitoster-yl-3beta-glucoside-6'-O-palmitate (9), beta-sitosterol (10), daucosterol (11) and octacosanoic acid (12).
Compounds 1-12 were isolated from this plant for the first time.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 05/2007; 32(7):599-603.
-
[show abstract]
[hide abstract]
ABSTRACT: To study the chemical constituents of Cynanchum forrestii.
Chromatographic techniques were applied to isolated chemical constituents. The structures were identified on the basis of physico-chemical constants and spectroscopic data.
Eight compounds were isolated from the 95% ethanol extract of the roots of C. forrestii and elucidated as ( + ) -5'-methoxyisolariciresinol 3a-O-beta-D-glucopyranoside (1), hexahydroxycholest-7-en-6-one (2), tylophorinidine (3), sucrose (4), palmitic acid (5), beta-sitosterol (6), daucosterol (7), nonanedioic acid (8).
Compounds 1-3 from this genus, and compounds 4-8 from the plant were obtained for the first time.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 04/2007; 32(6):500-3.
-
[show abstract]
[hide abstract]
ABSTRACT: Seven new steroidal glycosides, cynaforrosides K (1), L (2), M (3), N (4), and Q (7), based on a 13,14:14,15-disecopregnane-type aglycone, and cynaforrosides O (5) and P (6) with a 14,15-secopregnane-type aglycone, were isolated from the 95% ethanol extract of the roots of Cynanchum forrestii Schlechter. The structures of new compounds were determined on the basis of spectroscopic and chemical evidence. The sugar units of cynaforrosides K-P contained two moieties of glucoses with the mode of 1-->4 linkage and those of cynaforrosides K-O contained six moieties of sugars.
Steroids 04/2007; 72(4):313-22. · 2.83 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Two new phloroglucinol glycosides, lysidisides C (1) and D (2), together with two new resveratrol glycosides, lysidisides E (3) and F (4), were isolated from the n-BuOH extract of the roots of Lysidice rhodostegia. The structures were elucidated on the basis of spectroscopic and chemical evidence. The antioxidant activity of the isolates was also investigated
Planta Medica 03/2007; 73(2):163-6. · 2.15 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: [structure: see text] Three novel phloroglucinol derivatives of lysidicins A-C (1-3) have been isolated from the roots of Lysidice rhodostegia and structures were elucidated by comprehensive NMR and MS spectroscopic analysis. 1 and 2 possess spirocyclic benzodihydrofuran skeleton. Their relative stereochemistries were assigned by NOE or NOESY experiment. A plausible pathway for the biosynthesis of 1-3 from 4 and a ketose derivative was postulated.
Organic Letters 06/2006; 8(11):2269-72. · 5.86 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: A phytochemical investigation of the bark of Erythrophleum fordii led to six new cassaine diterpenoid amides (2, 4-8), together with two known compounds of the same skeleton, nor-cassamide ( 1) and nor-erythrosuamide (3). The structures were mainly established on the basis of 1D, 2D NMR and HR-MS analysis. The compounds 1, 2, 4, 6-8 exhibited selective cytotoxic activities (IC50 values < 10 microM) against A2780, KB, Bel-7402, BGC-823, MCF-7, HCT-8, Hela, PC-3M, A549 and Ketr3 human cancer cell lines in the MTT test.
Planta Medica 04/2006; 72(5):442-9. · 2.15 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Four new iridoid glycosides, 10-O-trans-p-coumaroylscandoside (1), 10-O-cis-p-coumaroylscandoside (2), 10-O-trans-p-coumaroyldesacetyl asperulosidic acid (3), and 10-O-cis-p-coumaroyldesacetyl asperulosidic acid (4), and two new grayanane diterpenoids, 14beta-O-(2S,3S-nilyl)-2alpha,3beta,5beta,6beta,16alpha-pentahydroxygrayanane (5) and 14beta-O-(2S,3S-nilyl)-2alpha,3beta,5beta,6beta,16alpha-pentahydroxygrayan-10(20)-ene (6), have been isolated from Craibiodendron henryi. The structures of these compounds were determined by chemical and spectroscopic methods including 1H-1H COSY, HMQC, HMBC, and NOESY experiments. Antioxidant activities and vasodilator effects of these compounds were assessed.
Journal of Natural Products 12/2005; 68(11):1646-50. · 3.13 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Two new compounds, lysidicin D (1) and lysidicin E (2), were isolated from the roots of Lysidice rhodostegia. Their structures were elucidated by means of spectroscopic methods. Among them compound 1 showed potent anti-oxidant activity on in vitro.
Journal of Asian Natural Products Research 9(3-5):471-7. · 0.94 Impact Factor
