A Omezzine Letaief

Centre Hôpital Universitaire Farhat Hached, Susa, Sūsah, Tunisia

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Publications (9)10.12 Total impact

  • M Khalifa, I Slim, N Kaabia, F Bahri, A Trabelsi, A Omezzine Letaief
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    ABSTRACT: We describe here in a case of a 41-year-old man, with diabetes mellitus, who presented manifestations of Kyrle's disease. Administration of metronidazole, 500 mg twice daily for 1 month, resulted in complete regression of skin lesions with no recurrence during 12 months of follow-up. This successful antibiotic treatment is to support the role of infectious agents (anaerobic bacteria) in the pathogenesis of Kyrle's disease.
    The Journal of infection 01/2008; 55(6):e139-40. · 4.13 Impact Factor
  • M Khalifa, N Kaabia, F Bahri, E Ben Jazia, E Bouajina, A Omezzine Letaief
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    ABSTRACT: Infections are common in patients with systemic lupus erythematosus (SLE) throughout the course of their disease and remain a source of mortality. The aim of this study was to determine the prevalence of infections, to describe their nature, and analyze their risk factors in adults with SLE. We performed a descriptive study, at the Farhat-Hached Hospital in Sousse, and retrospectively analyzed the charts of 75 patients with SLE seen between 1990 and 2004. The group of patients with documented infections was compared to a control group. A logistic regression analysis was performed to determine risk factors associated with infection. Our study included 64 women and 11 men (median age of 31.4 years). Forty-three patients (57.5%) had 82 infectious episodes: 23 patients had at least two infectious episodes. Most infections were community acquired, and 80% were severe. The most common infections involved the urinary tract (28%), the skin and soft tissue (26.8%), and the respiratory tract (18.3%). Documented pathogens were: 45 common bacteria, 11 Candida albicans and four Mycobacterium tuberculosis. Localized herpes zoster was noted in three cases. Factors associated with infection, found in univariate analysis, were renal involvement, serum albumin lower than 25 g/l, and corticosteroids treatment. Only corticosteroids therapy remained statistically significant after multivariate analysis.
    Médecine et Maladies Infectieuses 01/2008; 37(12):792-5. · 0.75 Impact Factor
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    A Omezzine Letaïef, N Kaabia, M Chakroun, M Khalifa, N Bouzouaia, L Jemni
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    ABSTRACT: Murine or endemic typhus, caused by Rickettsia typhi, has been reported in all continents. In the 1970s, no cases of murine typhus were diagnosed in Tunisia. The clinico-epidemiological characteristics of seven cases of murine typhus diagnosed at our hospitals since 1993 are reported. Diagnosis was confirmed by indirect fluorescence assay detecting specific R. typhi antibodies. Murine typhus occurred in all ages from 18-80 years during the hot season in rural areas. Clinical features were: sudden onset of fever and absence of eschar in all cases, with maculo-papular rash (five cases), prostration (four cases), meningism (three cases) and pneumonia (four cases). Frequent laboratory findings were moderate thrombopenia (four cases) and elevated transaminases (four cases). Before the results of serology, clinical diagnoses were Mediterranean Spotted Fever (four cases), Q fever (one case), pneumonia (one case), and lymphocytic meningitis (one case). Serology confirmed all diagnoses with cross-reactivity with Rickettsia conorii. Murine typhus exists in Tunisia and its prevalence is underestimated. Further, more specific studies are needed to evaluate the true prevalence.
    International Journal of Infectious Diseases 12/2005; 9(6):331-4. · 2.36 Impact Factor
  • A Omezzine Letaief, F Bahri, M Ernez, L Jemni
    Annales de medecine interne 01/1997; 148(4):327-8.
  • A. Omezzine Letaief, R. Battikh, F. Bahri, H. Hmouda, L. Jemni
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    ABSTRACT: Bacteremia continues to be a severe and frequent disease. Epidemiology, microbiological etiology, and prognosis of bacteremia are progressively changing, depending largely on the type of hospital and patient population. In this study, we retrospectively investigated all cases of proven bacteremia seen in our Medical unit, F. Hached Hospital, over one decade (January 1984 – December 1993) in order to define epidemiological and evolutionary characteristics of bacteremia. A total of 148 bacteremia were diagnosed among 145 patients (73 females and 72 males). The mean age was 49.5 years. Underlying diseases were present in 55.8 % of patients. Infection was community acquired in 94 % of the cases, and source of infection was frequently cutaneous or urinary. Gram-negative bacilli and Gram-positive cocci caused bacteremia in respectively 65.1 % and 34.9 % of cases. The most frequently isolated species were Escherichia coli (36.9 %), Klebsiella pneumoniae (15.8 %), Staphylococcus aureus (20.4 %). Overall mortality rate reached 18.6 %. Mortality rates associated with staphylococcal bacteremia and septic shock respectively reached 33.3 % and 79 %.
    Medecine Et Maladies Infectieuses - MED MAL INFEC. 01/1997; 27(8):778-781.
  • T Chekir, A Omezzine Letaief, F Bahri, A Jamel, S Aloui, L Jemni
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    ABSTRACT: Ten adult patients treated for pyomyositis between 1988 and 1994 in Sousse's university hospital (Tunisia) were retrospectively reviewed. Due to the non specific symptoms, the diagnosis was often delayed (mean = 17 days) and other primary diagnoses were considered, mainly including synovitis. The muscles around hip and thigh were most commonly involved (ten patients), and Staphylococcus aureus was the most common pathogen (nine patients). Ultrasonography was very helpful in the accurate diagnosis of the infection. Incision, drainage, and antibiotic therapy eradicated the infection in all patients. No residual functional limitations and no residual symptoms were noted. Our study showed that pyomyositis is present in central Tunisia and not associated with HIV infection. Clinical features and prognosis are similar to those previously described in the literature.
    La Revue de Médecine Interne 02/1996; 17(4):300-4. · 0.90 Impact Factor
  • T Chekir, A Omezzine Letaief, F Bahri, A Jamel, S Aloui, L Jemni
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    ABSTRACT: Ten adult patients treated for pyomyositis between 1988 and 1994 in Sousse's university hospital (Tunisia) were retrospectively reviewed. Due to the non specific symptoms, the diagnosis was often delayed (mean = 17 days) and other primary diagnoses were considered, mainly including synovitis. The muscles around hip and thigh were most commonly involved (ten patients), and Staphlylococcus aureus was the most commone pathogen (nine patients). Ultrasonography was very helpful in the accurate diagnosis of the infection. Incision, drainage, and antibiotic therapy eradicated the infection in all patients. No residual functional limitations and no residual symptoms were noted. Our study showed that pyomyositis is present in central Tunisia and not associated with HIV infection. Clinical features and prognosis are similar to those previously described in the literature.
    Revue De Medecine Interne - REV MED INTERNE. 01/1996; 17(4):300-304.
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    ABSTRACT: In this report we attempt to evaluate the prevalence of antibodies against Rickettsia conorii, R. typhi, Coxiella burnettii, and Ehrlichia chaffeensis in central Tunisia. Five hundred sera from blood donors, collected between March and June 1993, were tested for these 4 antibodies using an indirect immunofluorescence antibody assay (IFA). Nine percent of the sera had antibodies against R. conorii (IgG > 1:32) by IFA, and 8% by Western blotting; with IFA, 3.6% had antibodies to R. typhi, 26% to C. burnetii (> 1:50), and none to E. chaffeensis. Infection rates with R. conorii and R. typhi did not differ significantly between the sexes, but fewer young people had antibodies to R. typhi. A significantly higher prevalence of antibodies to C. burnetii was noted for males with no difference between age classes. No significant difference was detected between urban and rural areas. This study confirmed the endemicity of rickettsioses, and revealed a high seroprevalence of Q fever, in central Tunisia.
    Transactions of the Royal Society of Tropical Medicine and Hygiene 01/1995; 89(3):266-8. · 1.82 Impact Factor
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    ABSTRACT: Le syndrome d’hyperéosinophilie idiopathique (SHI) est une affection rare, qui constitue un diagnostic d’exclusion. Les manifestations cliniques les plus fréquentes sont cardiaques, pulmonaires, neurologiques et vasculaires. L’atteinte pancréatique est exceptionnelle. Nous rapportons l’observation d’une patiente, âgée de 71 ans, sans antécédents pathologiques, qui se présente pour un amaigrissement, une diarrhée liquidienne, des épigastralgies et un prurit. La biologie objectivait un syndrome inflammatoire biologique, une hyperéosinophilie persistante à 1 900 éléments/mm3, une anémie à 8,6 g/dl et une lipasémie élevée. L’examen parasitologique des selles, les sérologies parasitaires ainsi que les ANCA étaient négatifs. La tomodensitométrie abdominale avait révélé un pancréas tuméfié de rehaussement homogène associé à une densification de la graisse péripancréatique et de l’arrière cavité des épiploons. La biopsie cutanée objectivait une infiltration par des éosinophiles sans stigmates de vascularite. Le myélogramme et la biopsie ostéomédullaire montraient une infiltration par des éosinophiles avec un caryotype médullaire normal. Une polyneuropathie sensitivomotrice a été notée à l’électromyogramme. Le diagnostic du SHI était alors retenu. La patiente a été traitée par corticothérapie (prednisone: 1 mg/kg par jour) avec une bonne évolution clinique, biologique et radiologique. Idiopathic hypereosinophilic syndrome is very rare. The most common symptoms are cardiac, pulmonary, neurological, and vascular. Pancreatic involvement is exceptional. We report a 71-year-old woman without significant past medical history. She presented for weight loss, osmotic diarrhea, epigastralgia, and pruritus. Laboratory tests highlighted an inflammatory syndrome, a persistent hypereosinophilia at 1,900/mm3, an anemia at 8.6 g/dl, and increased pancreatic enzymes. Stools examination, parasite serology, and serologic testing for ANCA were all negative. The main imaging finding was pancreas hypertrophy and fat infiltration around the pancreatic gland. Skin biopsy showed an infiltration by eosinophils without vasculitis. In bone marrow aspirate and biopsy, we also noted infiltration by eosinophils and a normal karyotype. In electromyography, a motor and sensory neuropathy was found. The diagnosis of idiopathic hypereosinophilic syndrome was made and prednisone was started, with good outcomes in clinical, biological, and imaging parameters. Mots clésPancréatite aiguë–Polynucléaire éosinophile–Syndrome hyperéosinophilique idiopathique KeywordsAcute pancreatitis–Eosinophilic polymorphonuclear–Idiopathic hypereosinophilic syndrome
    Acta Endoscopica 41(1):26-28. · 0.16 Impact Factor