Patravoot Vatanasapt

Khon Kaen University, Kawn Ken, Khon Kaen, Thailand

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Publications (29)38.29 Total impact

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    ABSTRACT: Background Besides the well-known risk factors, Epstein-Barr virus (EBV) might play a significant role in oral squamous cell carcinoma (OSCC). To explore the role of EBV in OSCC, the prevalence of EBV infection in oral exfoliated cells of OSCC cases and controls in northeastern Thailand was investigated, and the association of EBV in tumor lesion cells was further confirmed.Methods Oral exfoliated cells were collected from OSCC cases and non-cancer controls. Cells from tumor lesions were taken from OSCC patients for further strong confirmation of the association of EBV with OSCC. EBV DNA was detected by polymerase chain reaction (PCR) using primers specific for EBV DNA polymerase. The EBV DNA positive samples were confirmed further by nested PCR.ResultsEpstein-Barr virus was detected in the oral exfoliated cells of 45.05% of OSCC patients and 18.08% of the non-cancer control (P < 0.001). Similarly, EBV was detected in 32.5% of the tumor lesions. Betel quid chewing was statistically significantly associated with EBV prevalence (OR = 2.08), whereas no association with tobacco smoking and alcohol consumption. Alcohol consumption and betel quid chewing were significantly associated with OSCC (OR = 3.05 and OR = 5.05, respectively), but tobacco smoking was not associated. Interestingly, EBV was significantly associated with OSCC (OR = 3.76).Conclusions Epstein-Barr virus prevalence is associated with OSCC and seems to be enhanced by betel quid chewing, suggesting that EBV may, together with betel quid chewing, act as an important etiological risk factor of OSCC.
    Journal of Oral Pathology and Medicine 08/2014; 44(4). DOI:10.1111/jop.12231 · 1.87 Impact Factor
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    ABSTRACT: Background: Because of the gender disparity in the incidence of thyroid cancer, this study aimed to determine the association between reproductive factors and thyroid cancer. Methods: A total of 10,767 eligible women from the Khon Kaen Cohort, recruited and interviewed between 1990 and 2001, were followed up until 2011. The data were linked to the Khon Kaen Population-Based Cancer Registry to detect thyroid cancer cases. Results: There was 17 thyroid cancer cases detected, an incidence of 11.2 per 100,000 person-years, of which 70.6 % were papillary tumors. The incidence was apparently greater among those with an early age of menarche, nulligravida women, and oral contraceptive users. Conlusions: There was a trend for thyroid cancer to develop in relation to longer estrogen exposure. This evidence is inconclusive but warrants further investigation.
    Asian Pacific journal of cancer prevention: APJCP 09/2013; 14(9):5153-5. DOI:10.7314/APJCP.2013.14.9.5153 · 1.50 Impact Factor
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    ABSTRACT: Background: This study aimed to determine the association between betel quid chewing and the occurrence of upper aerodigestive tract (UADT) cancers. Methods: A cohort of 17,388 subjects, recruited and interviewed over the 1990-2001 period, in Khon Kaen, Thailand, was followed up until 2011. The data were linked to the Khon Kaen Population-Based Cancer Registry. Results: The prevalence of betel quid chewing was 15.9%, with a female predominance (97.7%); the mean age of chewers was 57.7 years (SD 6.6). The overall incidence of UADT cancers from the cohort was 14.7 per 100,000 person-years, whereas the incidence among the chewers was 45.7. Betel nut chewing was the only major risk factor for UADT cancers in this population (HR=5.26, 95%CI=2.51- 11.0), while weak associations were found for tobacco smoking and alcohol (HR=1.16, 95%CI=0.45-3.01 and 1.47, 95%CI=0.72-3.03 respectively). Conclusions: We found betel quid chewing to be a main risk factor for UADT cancers, resulting in a higher incidence in females. However, further study is required to explore the potential risk factors among non-chewers, non-smokers, and non-drinkers.
    Asian Pacific journal of cancer prevention: APJCP 07/2013; 14(7):4335-8. DOI:10.7314/APJCP.2013.14.7.4335 · 1.50 Impact Factor
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    ABSTRACT: Ethmoid arteries, branches of the ophthalmic artery, are crucial structures supplying ethmoid mucosa. Its locations are important during ethmoid sinus surgery. There has been no study in Thais before. To determine the number and locations of ethmoid arteries in relation to important surrounding structures. A prospective, descriptive study in 42 Thai cadaveric adult half-heads was conducted at departments of Otorhinolaryngology and Anatomy, Faculty of Medicine, Khon Kaen University, Thailand. Meticulous dissections were performed to identify number of ethmoid arteries branching from ophthalmic artery and site of entrance of the arteries into ethmoid sinus. Relationships of these arteries with anterior ethmoid crest, optic foramen, bulla lamella and middle third of basal lamella of middle turbinate were studied. Outcomes:Types of ethmoid arteries, distances between ethmoid arteries and their relations to important surrounding structures: anterior lacrimal crest, optic foramen, superior aspects of bulla lamella, middle third of basal lamella of middle turbinate and the superior aspect of anterior wall of sphenoid sinus. All specimens had anterior and posterior ethmoid arteries. The prevalence of tertiary ethmoid artery was 36% (95% CI22-52%). The mean distance between the anterior ethmoid artery and anterior lacrimal crest, anterior ethmoid artery and posterior ethmoid artery and the distance between posterior ethmoid artery and optic foramen were 24.3, 13.5 and 6.4 millimeters respectively. Most of the entry of anterior ethmoid artery into the ethmoid sinus was in the posterior half of the distance between the bulla lamella and middle third of basal lamella of middle turbinate, 85.7%. This is the first study of location of ethmoid arteries in Thai adult cadavers. The information of the present study may be useful for sinus surgeon.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet 11/2012; 95 Suppl 11:S153-6.
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    ABSTRACT: To study the pattern of the nasofrontal drainage in relation to the neighboring anatomical structures in adult Thai cadavers. The anterior aspect of the frontal bone of the embalmed half-head was drilled to identify the presence of the frontal sinus i.e. 40 from only one side of each cadaver were chosen. A silicone base and catalyst were combined then injected into the frontal sinus, which flowed into the nasal cavity through its natural ostium, thereby creating a cast of the nasofrontal connection(s). After allowing five minutes for the silicone to set, the total vertical lamella of the middle turbinate was removed, so the cast could be measured, the connections meticulously dissected and the surrounding structures observed The investigation revealed five patterns of nasofrontal drainage. The most (60%) common pathway was directly through the frontal recess, while the other pathways 12.5, 10, 10 and 7.5 percent were drained directly into the ethmoid infundibulum, through the agger nasi cell and then into the ethmoid infundibulum, into both the agger nasi cell, the ethmoid infundibulum and the suprabullar recess, respectively. The average sizes of the anteroposterior and mediolateral diameters of the frontal sinus ostium were 6.5 and 5.5 mm, respectively. The agger nasi cell was present in every cadaver with a frontal sinus and was always superior to the ventral attachment of the middle turbinate. The agger nasi cell is the key structure vis-a-vis planning and performing frontal sinus surgery. In preparation for endoscopic intranasal frontal sinus surgery, it is practical to extend the infundibulotomy superiorly into the agger nasi cell, then remove its medial, posterior and superior wall.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet 11/2012; 95 Suppl 11:S130-4.
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    ABSTRACT: This qualitative research within the project entitled "Multiprofessional Intervention and training for Ongoing Volunteer-based Community Health Programs in the Northeast of Thailand (MITV-NET) " was aimed at explaining changes of health behavior of community people in the Northeast after the intervention. The participants comprised 15 community volunteers and 27 villagers. Data were collected by indepth interview, focus group discussion, participation and non-participation observation, and note taking. Analyses were conducted in parallel with data collection, through content and comparative analysis. It was found that the health behavior fell into 2 categories: easy-to-change and difficult-to-change. The former involved fun activities joined by community people that improved their health or made them recover from illnesses after a short period without becoming addicted. These activities could be done by themselves, for example, exercising and cooking. The difficult-to- change health behavior is habitual, for example, chewing betel nuts or eating uncooked food. The following factors were found affecting behavioral changes: 1) underlying disease; 2) enjoyment in doing activities; 3) habitual behaviour; 4) improved health in a short period; 5) ability of community leaders and volunteers; and 6) community health-supporting resources. It is suggested that improving people's health requires cooperation of community people through fun activities and some initial external support. People who persist in bad habits should be encouraged to stop by showing them health deteriorating effects.
    Asian Pacific journal of cancer prevention: APJCP 09/2012; 13(9):4801-5. DOI:10.7314/APJCP.2012.13.9.4801 · 1.50 Impact Factor
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    ABSTRACT: To determine the overall burden of disease vis-a-vis head and neck cancers in Thailand, as indicated by visits to healthcare units, admissions for treatment and expenditures at all levels of the healthcare delivery system. A descriptive study was conducted by retrieving and analysing data for the fiscal year 2010 from the National Health Security Office (NHSO) and the Social Security Office, Thailand and from in-patient data of the Civil Servants Benefit System from the Comptroller General's Department. In 2010, there were 167,199 visits to outpatient departments (OPDs) and 26,012 admissions to hospital (IPD) for diagnosis and treatment of head and neck cancers. The most common diagnosis for visits to OPD and admission to IPD was oral cancer (28.2% and 25%, respectively). The mean length of hospital stay was 9 days. About half of admissions took place in the central region. The hospital charges totalled 691 million Baht (US$ 21.8 million), or an average of 26,556 Baht (USS 838) per admission. Since a relatively high volume of hospital visits was found, there is an urgent need to train sufficient numbers of specialists in the field of head and neck cancer treatments to provide efficient healthcare.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet 07/2012; 95 Suppl 7:S182-9.
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    International Journal of Infectious Diseases 06/2012; 16. DOI:10.1016/j.ijid.2012.05.234 · 2.33 Impact Factor
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    ABSTRACT: This was a survey research conducted in Northestern Thailand during 2009-2010 and designed to evaluate the success of a health education program by comparing levels of health knowledge in the community before and after the launching of a Multi-professional Intervention and Training for Ongoing Volunteer-based Community Health Programme. The survey questionnaire included items about demographic characteristics and health knowledge. The participants were 1,015 members of various communities, who were randomly selected to be included in the survey before launching the intervention, and 1,030 members of the same communities randomly selected to be included in the survey after the intervention was completed. The demographic characteristics of both groups were similar. Overall knowledge and knowledge of all the diseases, except lung and cervical cancer, were significantly higher after the intervention. In conclusion, a Volunteer-based Community Health Programme has advantages for areas where the numbers of health personnel are limited. The use of trained community health volunteers may be one of the best sustainable alternative means for the transfer of health knowledge.
    Asian Pacific journal of cancer prevention: APJCP 05/2012; 13(5):1753-5. DOI:10.7314/APJCP.2012.13.5.1753 · 1.50 Impact Factor
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    ABSTRACT: Oral cancer is a common site of head and neck cancer, and is relatively frequent in Northeast Thailand. The objective of this hospital-based, case-control study was to determine associations with risk factors. A total of 104 oral cancer cases diagnosed between July 2010 and April 2011 in 3 hospitals were matched with control subjects by age, sex and hospital. Data were collected by personal interview. There were significant associations between oral cancer and tobacco smoking (OR=4.47; 95%CI=2.00 to 9.99), alcohol use among women (OR=4.16; 95%CI=1.70 to 10.69), and betel chewing (OR=9.01; 95%CI=3.83 to 21.22), and all three showed dose-response effects. Smoking is rare among Thai women (none of the control women were smokers), but betel chewing, especially among older women, is relatively common. We did not find any association between practicing oral sex and oral cancer.
    Asian Pacific journal of cancer prevention: APJCP 01/2012; 13(10):5087-90. DOI:10.7314/APJCP.2012.13.10.5087 · 1.50 Impact Factor
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    ABSTRACT: To evaluate the effectiveness of the Pap smear screening programme in Thailand in the prevention of invasive cervical cancer. Four tertiary hospitals, in two provinces of north-east Thailand. A hospital-based case-control study of women aged 30-64, who were resident in north-east Thailand. A total of 130 women with a diagnosis of invasive cervical cancer were compared with two groups of controls: a) hospital controls, b) hospital patient companions. Information on risk factors for cervical cancer and history of screening by cytology (Pap smear) were collected using a structured interview. Eighty percent of control subjects reported having had a Pap test in the past, and some two-thirds within the three years before interview. There was a significant protective effect for multiple (6+) previous screening tests as reported by 20% of controls. When women who had tests less than six months prior to the study were excluded, there was a strong, significant protective effect of the number of tests (for 1-5 tests: OR = 0.45 95% CI = 0.25 to 0.84, and for 6+ tests: OR = 0.29 95% CI = 0.11 to 0.82). Tests carried out 1-2 years and 3+ years before diagnosis were associated with an OR of 0.27 (95% CI = 0.13-0.56) and 0.42 (95% CI = 0.20-0.88), respectively. The cervical screening programme in north-east Thailand has achieved excellent coverage and is preventing cervical cancer. Women who have been screened multiple times are at substantially lower risk than those only screened a few times suggesting that the quality of the screening could be improved.
    Journal of Medical Screening 11/2011; 18(3):147-53. DOI:10.1258/jms.2011.011075 · 2.72 Impact Factor
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    ABSTRACT: This study was aimed to describe incidence, trends, and survival of oral and pharyngeal cancers in Khon Kaen, the province situated in the northeast of Thai-land. Data on oral and pharyngeal cancer cases diagnosed during 1985 - 2001 were retrieved from the population-based cancer registry of Khon Kaen. The final status of the patients was verified by database linkage and follow-up using postcards. Of 1,038 cases, 62.6% were female and 37.4% were male, with a mean age of 63 years. The age-standardized incidence rate (ASR) in females (6.2 per 100 000; 95%CI 5.7-6.7) was significantly higher than in males (3.9 per 100 000; 95%CI 3.5-4.4). Annual percent changes in ASR were 1.7 in females (p<0.05), but 1.2 in males. Lip and buccal cancers were the most common sites respectively; however, the incidence of tongue cancer was increasing in the last period. Eighty five percent of all cases were diagnosed in advanced stage (stage III and IV). The overall five-year relative survival was 43.1%. We found stage distribution and survival did not change during the study period. The considerably high incidence in female suggests a need for research on specific risk factors. Moreover, attempts should be made to detect oral cancers earlier in order to improve the outcomes of cancer control.
    Asian Pacific journal of cancer prevention: APJCP 01/2011; 12(10):2505-8. · 1.50 Impact Factor
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    ABSTRACT: A descriptive cross-sectional study was carried out in Khon Kaen Province during January 1 to June 30, 2008. The aims were to assess: (1) the prevalence of risk factors for chronic diseases such as cancer, diabetes, blood pressure; and (2) health behaviour and health education needs. There were 338 sample subjects aged between 20-60 years, from urban, semi-urban and rural areas. Some 20.4 % of the sample subjects reported that they were unhealthy (10.4% diagnosed with hypertension, 9.8% with diabetes, and 0.9% with cancer). For history of illness in the family, the most common were diabetes (42%), high blood pressure (16.5 %) and cancer (14.8 %), and 66.9% reported stress within the last 6 months. In terms of risk behavior, 82.3% of males smoked cigarettes but only 1.9% of females. The respective figures for alcohol were 68.4% and 26.6%. The majority (61.2) had low physical activity (sitting or standing, little movement). Almost one third (32%) reported testing positive for Opisthorchis viverrini eggs in stool. For health education needs, 64.2%, 54.7% and 42.6% wanted to learn more about cancer, diabetes and hypertension, respectively. For means of health education delivery, 31.7% want to learn from medical doctors, 20.4% from TV, 16.3% from village's broadcasting and 13.6% from health volunteers. Suitable means to delivery health education are needed to convey knowledge to the population. Community health volunteers may be one of the best sustainable alternative methods to transfer knowledge.
    Asian Pacific journal of cancer prevention: APJCP 01/2011; 12(5):1337-40. · 1.50 Impact Factor
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    ABSTRACT: The Khon Kaen cancer registry was established in 1984 as a hospital-based cancer registry, and population-based cancer registration started in 1988 with retrospective data collection from 1985. Cancer registration is done by passive and active methods. Data on survival for 13 cancer sites or types registered during 1993-1997 were reported. Follow-up was done by active methods, with median follow-up ranging between 8-32 months for different cancers. The proportion with histologically verified diagnosis for various cancers ranged between 54-100%; death certificates only (DCOs) comprised 0-5%; 85-97% of total registered cases were included for survival analysis. Five-year follow-up ranged from 40-83%. Five-year age-standardized relative survival rates for common cancers were cervix (58%), breast (61%), colon (39%), ovary (43%), non-Hodgkin lymphoma (42%) and rectum (43%). Five-year relative survival by age group portrayed an inverse relationship or was fluctuating. Five-year survival was the highest for localized disease, followed by the regional and distant metastasis categories. Trends in 5-year relative survival in 1993-1997 compared to 1985-1992 showed a marked increase for cancers of the rectum, breast, ovary, Hodgkin and non-Hodgkin lymphomas and decrease for cancers of the lip and larynx.
    IARC scientific publications 01/2011;
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    ABSTRACT: Tracheostomy is a common airway procedure for life support. The fracture of the tracheostomy tube is a rare complication. We report a case of a 14-year-old boy whose fractured stainless steel tracheostomy tube dislodged into the tracheobronchial tree. We include a literature review and proposed recommendations for tracheostomy care. A 14-year-old Thai boy who had a stainless steel tracheostomy tube presented with a complaint of intermittent cough for 2 months. During tracheostomy tube cleaning, his parents found that the inner tube was missing. A chest X-ray revealed a metallic density foreign body in his right main bronchus. He underwent bronchoscopic removal of the inner tracheostomy tube and was discharged without further complications. A fractured tracheostomy tube is a rare complication. Appropriate cleaning and scheduled replacement of the tracheostomy tube may prevent this complication.
    Journal of Medical Case Reports 08/2010; 4:234. DOI:10.1186/1752-1947-4-234
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    ABSTRACT: To evaluate the outcome of mobile ear surgery, in terms of tympanic membrane perforation closure, absence of otorrhoea and hearing threshold improvement. Descriptive study. The study enrolled patients with chronic ear disorders requiring surgery who presented to the mobile ear surgery unit at Sakaeo Hospital, Thailand, from 1 to 4 July 2008. The following data were recorded: pre-operative audiogram, post-operative middle-ear and mastoid infection, wound infection, graft condition, any complications, and post-operative audiogram. Patients were followed up at one week, two weeks, four weeks and 24 weeks post-operatively. For the 31 cases of tympanic membrane perforation, the closure rate was 90.3 per cent. For the 32 patients with otorrhoea, the rate of ear dryness was 87.5 per cent. All 35 patients had impaired hearing initially; the rate of hearing improvement was 74.3 per cent (95 per cent confidence intervals = 56.7-87.5 per cent). Patients' mean hearing improvement was 22.9 dB. The assessed ear surgery procedures had good results.
    The Journal of Laryngology & Otology 11/2009; 124(4):382-6. DOI:10.1017/S0022215109991836 · 0.70 Impact Factor
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    ABSTRACT: Evidence on the benefits of music during caesarean section under regional anaesthesia to improve clinical and psychological outcomes for mothers and infants has not been established. To evaluate the effectiveness of music during caesarean section under regional anaesthesia for improving clinical and psychological outcomes for mothers and infants. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2008). We included randomised controlled trials comparing music added to standard care during caesarean section under regional anaesthesia to standard care alone. Two review authors, Malinee Laopaiboon and Ruth Martis, independently assessed eligibility, risk of bias in included trials and extracted data. We analysed continuous outcomes using a mean difference (MD) with a 95% confidence interval (CI). One trial involving 76 women who planned to have their babies delivered by caesarean section met the inclusion criteria, but data were available for only 64 women. This trial was of low quality with unclear allocation concealment and only a few main clinical outcomes reported for the women. The trial did not report any infant outcomes. It appears that music added to standard care during caesarean section under regional anaesthesia had some impact on pulse rate at the end of maternal contact with the neonate in the intra-operative period (MD -7.50 fewer beats per minute, 95% CI -14.08 to -0.92) and after completion of skin suture for the caesarean section (MD -7.37 fewer beats per minute, 95% CI -13.37 to -1.37). There was also an improvement in the birth satisfaction score (maximum possible score of 35) (MD of 3.38, 95%CI 1.59 to 5.17). Effects on other outcomes were either not significant or not reported in the one included trial. The findings indicate that music during planned caesarean section under regional anaesthesia may improve pulse rate and birth satisfaction score. However, the magnitude of these benefits is small and the methodological quality of the one included trial is questionable. Therefore, the clinical significance of music is unclear. More research is needed to investigate the effects of music during caesarean section under regional anaesthesia on both maternal and infant outcomes, in various ethnic pregnant women, and with adequate sample sizes.
    Cochrane database of systematic reviews (Online) 02/2009; DOI:10.1002/14651858.CD006914.pub2 · 5.94 Impact Factor
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    ABSTRACT: Cancer pain remains an invisible problem in cancer care and our study aimed to document its prevalence, characteristics, and patterns of management at a tertiary care teaching hospital. Descriptive, prospective, cohort study. We recruited 335 consecutive adult patients diagnosed with cancers, admitted to Srinagarind Hospital, between February and April 2004. All of the participants were interviewed, and their pain evaluated by direct assessment using a numeric rating scale. The overall prevalence of cancer pain prior to admission was 56.5%, and within the first 24 hours of admission 41.5%. Three-quarters (74%) of patients with pain reported improvement; however one-third of those with pain never received any pain control intervention. Moreover; about half of those with persistent pain only received treatment by requesting it and then only received simple analgesics. Cancer pain remains under-detected and under-treated in many patients. Pain monitoring on a regular basis as well as a training program on pain management should be considered as first-line tools for improving pain control among cancer patients.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet 01/2009; 91(12):1873-7.
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    ABSTRACT: Acute otitis media (AOM) is a common problem in children, for which the antibiotic amoxicillin, with or without clavulanate, is frequently prescribed. To compare the effectiveness of one or two daily doses with three or four daily doses of amoxicillin, with or without clavulanate, for the treatment of AOM in children. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, issue 1), which contains the Acute Respiratory Infections (ARI) Group's Specialized Register; MEDLINE (January 1950 to March 2008); EMBASE (1974 to March 2008); the Science Citation Index (2001 to March 2008); and NLM Gateway (HSRProj) (March 2008). We included studies if they met the following criteria: randomized controlled trials (RCTs) of children aged 12 years or younger with AOM, diagnosed by the following explicit criteria: acute ear pain (otalgia) and inflamed ear drum (confirmed by positive tympanocentesis or tympanogram of type B or C). We extracted data on treatment outcomes from individual trials. We assessed quality based on selection bias, performance bias, attrition bias and sample size calculation. The quality grading was defined as low risk of bias, moderate risk of bias or high risk of bias. The results were summarized as risk ratio (RR) and 95% confidence intervals (CI). We included six studies with 1601 children in the review. Although the clinical cure rates at the end of therapy and at the follow-up periods of each study were shown to be comparable between the two groups, we did not perform pooled data analysis because of moderate to high risk of biases in the included studies. Most of the children were aged 2 months to 12 years. None of the studies had any consistently significant results either for benefit or harm. The outcomes were assessed at the end of therapy (often 10 days) and this may have been too late to measure any differences. This review showed insufficient evidence to judge whether once or twice daily doses of amoxicillin, with or without clavulanate, were comparable with three or four daily doses for the treatment of AOM. The evidence appears to be biased and therefore no firm conclusions can be drawn.
    Cochrane database of systematic reviews (Online) 02/2008; DOI:10.1002/14651858.CD004975.pub2 · 5.94 Impact Factor
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    ABSTRACT: An acute complication of thyroidectomy is fatal hematoma, which can produce an upper airway obstruction needing immediate intubation or tracheostomy. After neck surgery, we usually apply a pressure dressing with a non-woven, adhesive fabric to reduce bleeding and fluid collection at the operative bed. We conducted a prospective, randomized, controlled study to evaluate a pressure vs. a non-pressure dressing after thyroid surgery by monitoring blood and serum in the operative bed. We studied 108 patients who underwent 116 thyroid surgeries at Srinagarind Hospital, Khon Kaen University, between December 2006 and September 2007. The patients were randomized to either the pressure dressing or non-pressure dressing group. Ultrasound of the neck was performed 24 +/- 3 hours after surgery. The volume of fluid collection in the operative bed was calculated. All patients were observed for any post-operative respiratory distress, wound complications, tingling sensation or tetany. The distributions of age, sex, surgical indications and approaches were similar between the two groups. There was no statistically significant difference in the volume of fluid collection in the operative bed (p = 0.150) and the collected drained content (p = 0.798). The average time a drain was retained was 3 days. One patient in the pressure dressing group suffered cutaneous bruising while one patient in the non-pressure dressing group developed immediate hemorrhage after the skin sutures. Pressure dressing after thyroidectomy does not have any significant impact on decreasing fluid collection at the operative bed. The use of pressure dressing after thyroidectomy may not therefore be justified. NCT00400465, ISRCTN52660978.
    BMC Ear Nose and Throat Disorders 02/2008; 8:1. DOI:10.1186/1472-6815-8-1