Shigeyuki Tsurusaki

Kumamoto University, Kumamoto, Kumamoto Prefecture, Japan

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Publications (8)10.25 Total impact

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    ABSTRACT: To elucidate the molecular mechanism inducing monocyte/macrophage infiltration in the atherosclerotic lesion, we measured the monocyte chemotactic capacity in the extracts of aortic lesions. Five out of seven extracts exhibited significant chemotactic activities. Immunohistochemical examination with an anti-CD68 monoclonal antibody demonstrated that the five positive lesions possessed obvious monocyte/macrophage infiltrations at the intima, whereas the two negative lesions did so at significantly lower intensities. We subjected the chemotactic extracts to immunological analyses to identify the monocyte chemoattractant in them. The monocyte chemotactic capacities of all positive extracts were removed with anti-S19 ribosomal protein (RP S19) antibody beads and antimonocyte chemoattractant protein-1 (MCP-1) antibody beads. In three of the five extracts, the anti-RP S19 antibody beads were more effective than the anti-MCP-1 antibody beads for removal, while in the remaining two extracts, the opposite was observed. A combined immunoabsorption with these beads depleted the monocyte chemotactic capacity of a representative sample of each group. Consistently, the chemotactic capacity of an apparently RP S19 dimer-predominant extract was strongly inhibited by the presence of a C5a receptor antagonist. These results suggest that the RP S19 dimer and MCP-1 play a major role in the monocyte/macrophage infiltration of the atherosclerotic vascular lesion.
    Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin 11/2005; 447(4):747-55. DOI:10.1007/s00428-005-0012-5 · 2.56 Impact Factor
  • Hisashi Sakaguchi · Ryuji Kunitomo · Shigeyuki Tsurusaki · Michio Kawasuji
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    ABSTRACT: A 61-year-old man with angina pectoris was admitted for elective coronary artery bypass grafting. The left anterior descending artery, and the two posterolateral branches (PLA1 and PLA2) of the circumflex artery required bypass grafting. At operation, the distal portion of the left radial artery was found to bifurcate, both branches having an equal size. We decided to use the bifurcating radial artery as a conduit for bypass grafting to the branches of the left circumflex artery. One distal end of the radial artery was subsequently anastomosed to the PLA1 branch and the other distal end was anastomosed to PLA2. Postoperative coronary angiography showed both branches of the radial artery to have good patency.
    Interactive Cardiovascular and Thoracic Surgery 01/2004; 2(4):563-4. DOI:10.1016/S1569-9293(03)00139-7 · 1.11 Impact Factor
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    Journal of Thoracic and Cardiovascular Surgery 07/2003; 125(6):1535-7. DOI:10.1016/S0022-5223(03)00007-2 · 3.99 Impact Factor
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    ABSTRACT: We retrospectively searched for factors that can predict the circulating platelet count after cardiopulmonary bypass (CPB) and postoperative blood loss. Correlations between the circulating platelet count after CPB and several other perioperative variables were investigated in 42 patients who underwent cardiac surgery using the same type of oxygenator. Correlations between perioperative variables and 24 hour postoperative blood loss were also investigated. A multiple stepwise regression analysis showed that the preoperative platelet count, age, and intraoperative blood transfusion values were independent predictors of the circulating platelet count after CPB (R2 = 0.661, p < 0.0001). Gender, operation type, and priority (elective or urgent) were not associated with the platelet count after CPB or postoperative blood loss. Independent predictive factors for postoperative blood loss consisted of age and intraoperative blood loss (R2 = 0.231, p = 0.006). In addition to preoperative platelet count, age and amount of intraoperative blood transfusion are predictive factors for circulating platelet count after CPB. The association of postoperative blood loss with age and intraoperative blood loss may suggest friability of the tissues, including blood vessels, in elderly patients.
    ASAIO Journal 10/2002; 48(6):671-4. DOI:10.1097/00002480-200211000-00018 · 1.39 Impact Factor
  • 01/2002; 31(5):328-330. DOI:10.4326/jjcvs.31.328
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    ABSTRACT: We compared the operative outcomes among 14 patients who underwent the removal of left atrial myxoma with four different approaches; right lateral (n = 2), transseptal bi-atrial (Dubost, n = 4), conventional transseptal (n = 4) and superior transseptal approach (STA, n = 4). Concomitant operations were performed in 4 cases (CABG, two; aortic valvuloplasty, one; mitral valve replacement, one), and two out of 4 cases were in the STA group. The mean operation, cardiopulmonary bypass and aortic cross-clamp times were shorter in the STA group compared to the other three group. The total amount of postoperative drain discharge and the peak value of creatine kinase were also lower in the STA group compared to the other three groups. Among the patients in sinus rhythm before operation, the use of STA was associated with a greater incidence (100%) of postoperative atrial fibrillation or junctional rhythm. These rhythm disturbances were temporary, and all returned to sinus rhythms during hospital stay. We conclude that STA is an excellent approach with a nice surgical view to expose and remove the left atrial myxoma.
    Kyobu geka. The Japanese journal of thoracic surgery 04/2001; 54(3):211-4.
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    ABSTRACT: Tissue factor pathway inhibitor (TFPI) is a potent inhibitor of the extrinsic pathway of the coagulation cascade that is activated by cardiopulmonary bypass (CPB) during open-heart surgery. In the present study, we investigated whether the plasma TFPI antigen increases during CPB in 12 patients who underwent bypass procedures. The plasma levels of free and total TFPI antigens were measured using an enzyme-linked immunosorbent assay, and heparin concentrations were measured using a chromogenic substrate assay. We found that changes in the total plasma TFPI antigen level were significantly dependent on the level of free TFPI antigen (r = 0.96, P < 0.0001) which increased significantly after heparin injection (P < 0.0001), and increased further during the bypass period (P < 0.005). The increased free TFPI antigen level during CPB correlated with the duration of bypass (r = 0.65, P = 0.02). When heparin was neutralized by protamine, the free TFPI antigen level decreased immediately, but remained higher than the preoperative level (P < 0.005). These results suggest that plasma TFPI antigen levels increase during CPB.
    Surgery Today 01/2000; 30(2):122-6. DOI:10.1007/s005950050027 · 1.21 Impact Factor
  • L.-B. Sun · H. Goto · J. Utoh · S. Tsurusaki · T. Hamuro · Y. Kamikubo · N. Kitamura
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    ABSTRACT: Tissue factor pathway inhibitor (TFPI) has been reported to be a potent anticoagulant of the extrinsic coagulation cascade. This study is to investigate the antithrombogenic effects of topically applied TFPI in a rabbit traumatized arterial autograft model. The left femoral artery was traumatized, harvested, and interposed to the right femoral artery (n = 29). Before the anastomoses were completed, the lumen of the graft was irrigated with 1 ml of TFPI (20 μg/ml) (TFPI group, n = 9) or 1 ml of normal saline (Control group, n = 10). Other ten rabbits were given 300 units/kg of heparin intravenously without any irrigation (Heparin group). The patency rates of the Control group were 20% on the first postoperative day (POD 1) and 0% on POD 7. The patency rates of the Heparin group were 60% on POD 1 and 50% on POD 7. The TFPI group achieved 100% patency on both POD 1 and POD 7 (p<.001 vs. control). Compared to the Heparin group, the TFPI group had a significantly higher patency rate on POD 7 (p=.033). We conclude that topically applied TFPI has a promising effect to prevent thrombotic occlusion of traumatized arterial autografts in the early postoperative period.