T Tsachalis

Publications (17)20.29 Total impact

• Article: Colonic lipomas: our experience in diagnosis and treatment.

  I Mantzoros, D Raptis, M G Pramateftakis, D Kanellos, S Psomas, A Makrantonakis, T Tsachalis, S Angelopoulos
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  ABSTRACT: The aim of this study is to present our experience in colonic lipomas. We present 4 patients (1 male, 3 females) of mean age 65.5 years (range, 61-72 years) treated for single colonic lipomas. The diameters of the lesions were 4.5, 4, 3.5 and 2.5 cm, respectively. In 3 cases, colonic lipomas were located within the cecum, while in one patient within the descending colon, proximally to the splenic flexure. Lipomas of diameter greater than 3 cm caused nonspecific symptoms. Lipomas of higher diameter were removed laparoscopically with colotomy; in two cases, the patients underwent open hemicolectomy, because of the suspicion of malignancy, while the smallest lesion was resected endoscopically, using a bipolar snare. All patients recovered without complications and remain healthy with no signs of recurrence. In cases of ulcerated lipomas, greater than 3 cm of diameter, surgical resection is recommended.
  Techniques in Coloproctology 09/2011; 15 Suppl 1:S71-3. · 1.29 Impact Factor
• Article: The handsewn anastomosis after colon resection due to colonic cancer.

  M G Pramateftakis, G Vrakas, P Hatzigianni, T Tsachalis, I Matzoros, E Christoforidis, D Raptis, G Roidos, C Lazaridis
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  ABSTRACT: The purpose of our study is to present the results of the handsewn single-layer interrupted extramucosal anastomosis following colon cancer. In the period between 1989 and 2009, 276 intestinal anastomoses were fashioned following colon resection using single-layer interrupted extramucosal 3/0 Vicryl. The mean hospital stay was 8.2 days. Twenty-three patients had postoperative complications, and the total morbidity was 8.3%. Seven anastomotic leakages occurred (2.5%). The mortality rate was 2.5%. The single-layer anastomosis with interrupted extramucosal sutures after colon resection is safe and effective.
  Techniques in Coloproctology 11/2010; 14 Suppl 1:S57-9. · 1.29 Impact Factor
• Article: Laparoscopic sigmoidectomy for colon cancer.

  D Kanellos, M G Pramateftakis, G Vrakas, I Mantzoros, T Tsachalis, P Hatzigianni, I Kanellos
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  ABSTRACT: The aim of this study is to report our experience with laparoscopic sigmoidectomy due to cancer. Between 2007 and 2009, laparoscopic sigmoidectomy for cancer was performed in 3 patients. The average operative time was 176 min. The average hospital stay was 10.2 days. There was one anastomotic leak. The patient was subjected to laparotomy and a Hartmann's procedure and drainage of the peritoneal cavity was performed. In conclusion, laparoscopic sigmoidectomy for cancer is a safe and efficient procedure.
  Techniques in Coloproctology 11/2010; 14 Suppl 1:S73-4. · 1.29 Impact Factor
• Article: Laparoscopic right hemicolectomy due to colon cancer.

  D Kanellos, M G Pramateftakis, G Vrakas, P Hatzigianni, S Agelopoulos, T Tsachalis, Z Koukouritaki, D Raptis, I Kanellos
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  ABSTRACT: The aim of this study is to present our patients with laparoscopic right hemicolectomy due to cancer. Between 2005 and 2009, laparoscopic right hemicolectomy for cancer was performed in 9 patients. The average operative time was 168 min. The average hospital stay was 5.3 days. There was one conversion (11.1%) to an open procedure. There were no postoperative complications. All the patients remain so far with no signs of tumor recurrence. Laparoscopic right hemicolectomy for cancer in the hands of an experienced laparoscopic surgeon is a safe and efficient procedure.
  Techniques in Coloproctology 11/2010; 14 Suppl 1:S71-2. · 1.29 Impact Factor
• Article: Abstracts colorectal games, rethymnom, crete, Greece, may 2008.

  S H Suleiman, O E H Salim, D O Yousif, M A Eltahir, K Elzaki, S Z Ibrahim, K M Ahmed, H M Mudawi, L Vini, A Silyvridou, [......], S Angelopoulos, K Despoudi, H Lazarides, T Tsachalis, N Sapidis, N Gouvas, J Tsiaoussis, G Pechlivanides, N Zervakis, E Xynos
  Techniques in Coloproctology 10/2008; 12(3):267-71. · 1.29 Impact Factor
• Article: Influence of the stable prostacyclin analog iloprost on the healing of colonic anastomosis in rats.

  K Vasiliadis, I Kanellos, T Tsachalis, K Blouhos, T Zaraboukas, G Koliakos, D Betsis
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  ABSTRACT: The aim of this study was to investigate whether iloprost injected intraperitoneally immediately after colon resection can improve anastomotic healing on the fifth and eighth postoperative days. Forty Wistar rats were randomised into 2 equal groups. After the resection of a 1 cm segment of transverse colon, an end to end sutured anastomosis was generated. From the day of the operation, group 1 (control) received intraperitoneal 3 cc saline solution once daily until sacrifice, while group 2 (iloprost) received iloprost in a dose of 2 mg/kg body weight intraperitoneally once daily until sacrifice. Each group was further randomly divided into 2 equal subgroups and animals were sacrificed on the fifth (subgroup A), and eighth (subgroup B) postoperative days. After sacrifice, anastomoses were examined macroscopically and were measured for bursting pressures and tissue hydroxyproline levels while anastomotic healing process was evaluated histopathologically. None of the rats exhibited any clinical evidence of leakage and there were no instances of peri-anastomotic abscess or peritonitis. Bursting pressure on the fifth postoperative day was significantly higher in the iloprost group than in the control group (P<0.001), while on the eighth postoperative day, bursting pressure was higher in the iloprost group but not significantly different (P=0.165). On both the fifth and eighth postoperative days rats in the iloprost group developed significantly more marked neo-angiogenesis and, in parallel with this, there was a trend showing a higher inflammatory cell infiltration. The intraperitoneal administration of iloprost promoted neo-angiogenesis and enhanced colonic healing on the fifth postoperative day.
  Minerva chirurgica 09/2007; 62(4):241-8. · 0.77 Impact Factor
• Source

  Available from: Manousos-Georgios Pramateftakis

  Article: Long-term results after stapled haemorrhoidopexy for third-degree haemorrhoids.

  I Kanellos, E Zacharakis, D Kanellos, M G Pramateftakis, T Tsachalis, D Betsis
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  ABSTRACT: Stapled haemorrhoidopexy (SH) is associated with low postoperative pain but, when performed for advanced piles, carries high recurrence rates. The aim of our study was to assess our long-term results after SH for third-degree haemorrhoids. A total of 126 consecutive patients (67 men and 59 women) with third-degree haemorrhoids underwent SH in our unit between 1998 and 2002. Of these, 120 (95.2%) were followed up in the outpatient department after a median interval of 61.5 months (range, 38-84 months). During the postoperative period, 7 patients (5.8%) experienced pain for 5-12 days, which was treated with oral analgesia. Seven patients (5.8%) experienced gas incontinence and one of them also reported soiling; the incontinence subsided within 2-8 weeks. Recurrence of the haemorrhoidal disease occurred in 8 patients (6.6%). SH is a safe, low-pain and, in the long-term, effective technique for the treatment of third-degree haemorrhoids.
  Techniques in Coloproctology 04/2006; 10(1):47-9. · 1.29 Impact Factor
• Article: Recurrent arterial thromboses in a woman with heparin induced thrombocytopenia, successfully managed with iloprost followed by clopidogrel. An alternative therapeutic option for heparin induced thrombocytopenia type II syndrome.

  A Megalopoulos, K Vasiliadis, T Tsachalis, K Tsalis, K Blouhos, S Alexandridou, D Betsis
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  ABSTRACT: In its more severe form heparin induced thrombocytopenia (HIT) is a rare immune mediated complication of heparin administration that potentially has catastrophic results, and significant mortality. In view of the severity of this condition it is important for the clinician to maintain a high index of suspicion and get alerted to the HIT syndrome by the precocity of platelet count decrease in any patient group, and especially in those previously exposed to heparin. We report on a 72-year-old woman who developed HIT syndrome that was complicated by recurrent arterial thromboses after receiving postoperative antithrombotic prophylaxis with tinzaparin, a low molecular weight heparin. The patient was successfully treated with iloprost (Ilomedin, iloprost tromethamine, Schering) a stable prostacyclin analogue, at the acute phase of the syndrome, followed by long-term treatment with clopidogrel (Plavix, clopidogrel bisulfate, Sanofi) an inhibitor of adenosine diphosphate (ADP) receptor. Although direct thrombin inhibitors have been proven to be effective for the treatment of HIT thrombosis, they do not completely eliminate the morbidity and mortality of this disorder. Our case report suggests that antithrombotic treatment by targeting of the activated platelets with a potent platelet inhibitor during the acute phase of type II HIT syndrome followed by long-term administration of oral anticoagulation may be an additional, safe and effective therapeutic alternative that merits to be systematically studied.
  International angiology: a journal of the International Union of Angiology 04/2006; 25(1):84-9. · 1.65 Impact Factor
• Source

  Available from: Konstantinos Tsalis

  Article: Sebaceous gland tumors and internal malignancy in the context of Muir-Torre syndrome. A case report and review of the literature.

  K Tsalis, K Blouhos, K Vasiliadis, T Tsachalis, S Angelopoulos, D Betsis
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  ABSTRACT: The Muir-Torre syndrome is a rare autosomal dominant condition and is currently considered a subtype of the more common hereditary nonpolyposis colorectal cancer syndrome, in which multiple primary malignancies occur together with sebaceous gland tumors. We describe a case of a 62-year-old woman with three primary colorectal tumors, genital tumor, and sebaceous adenomas and present her family history of three generations. Our case represents the first case reported from Greece in the international literature. Recognition of the syndrome in patients with sebaceous gland tumors should facilitate early detection of subsequent malignancies if the patient is entered into appropriate screening programs.
  World Journal of Surgical Oncology 02/2006; 4:8. · 1.12 Impact Factor
• Article: ENDOSCOPIC DRAINAGE OF PANCREATIC PSEUDOCYSTS (case report and technique review): Christoforidis E., K. Blouhos, T. Tsachalis, K. Tsalis, D. Betsis Annals of Gastroenterology. 2005; 18 (4): 445-450

  Christoforidis E, K. Blouhos, T. Tsachalis, K. Tsalis, D. Betsis
  Annals of Gastroenterology 01/2005; 18(4):445-450.
• Article: Radio-frequency ablation of hepatic metastases from colorectal cancer.

  I Kanellos, H Demetriades, K Blouhos, T Tsachalis, M G Pramateftakis, D Betsis
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  ABSTRACT: The aim of our study is to present the preliminary results of an ongoing radio-frequency (RF) ablation study in patients with hepatic metastases from colorectal cancer. From November 2003, two patients affected with metachronous liver metastases from colorectal cancer were treated with RF ablation. The mean age of the patients was 66 years (58 and 74 years). Tumours were unifocal right-lobe lesions in one patient and bifocal in the second patient. Under general anaesthesia, a Radionics 200-W RF generator was used to ablate lesions with H2O-cooled electrodes via laparotomy. Patients' follow-up ranged from two to five months including evaluation of salient clinical, radiological and laboratory parameters. The patients experienced moderate-to-severe pain in the right abdomen lasting for 2-3 days and mild fever for 3-6 days after treatment. During the follow-up period no local recurrence was observed. RF ablation emerges to be a promising method for the treatment of hepatic metastases from colorectal cancer.
  Techniques in Coloproctology 12/2004; 8 Suppl 1:s119-22. · 1.29 Impact Factor
• Article: Is TNM classification related to early postoperative morbidity and mortality after colorectal cancer resections?

  E Christoforidis, I Kanellos, T Tsachalis, S Angelopoulos, K Blouhos, D Betsis
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  ABSTRACT: To examine the role of TNM staging system as a predictive factor for postoperative morbidity and mortality, after colorectal cancer resections. During the last ten years, 368 patients with colorectal cancer were referred to our institution. All patients, who underwent primary treatment elsewhere or defunctioning colostomy only, or who did not undergo surgical therapy were excluded from the analysis. The early postoperative outcomes registration of the remaining 351 patients (197 men, median age 66.2 years) was retrospectively linked to TNM stage. TNM stage had a poor prognostic value for the early postoperative morbidity rate. In addition, according to the statistical analysis, the proportion of early postoperative mortality proved to be higher in patients with TNM stage III or IV colorectal cancer. TNM classification could be considered as a reliable predictor of early postoperative mortality, but has no role in the prediction of early postoperative morbidity after colorectal resections.
  Techniques in Coloproctology 12/2004; 8 Suppl 1:s89-92. · 1.29 Impact Factor
• Article: Five-year survival after curative resection for adenocarcinoma of the colon.

  S Angelopoulos, I Kanellos, E Christophoridis, T Tsachalis, A Kanellou, D Betsis
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  ABSTRACT: The purpose of this study was to evaluate the 5-year survival of patients with colon adenocarcinoma that underwent elective or emergency curative surgical treatment. Between 1993 and 1998, 80 patients underwent a potentially curative colonic resection based on mobilisation along anatomic planes. Among the patients, 26 underwent right colectomy, 3 transverse colectomy, 13 left colectomy and 38 sigmoidectomy. All patients classified as TNM stage III underwent adjuvant chemotherapy. The Kaplan-Meier method was used to analyse survival. Overall 5-year survival was 69.5%. Patient's sex and age, mucinous characteristics of the tumour and tumour location did not significantly affect survival. Patients with higher Duke's classification and TNM stage had significantly worse 5-year survival (p=0.025 and p=0.007, respectively). Although patients with good tumour differentiation had the highest 5-year survival, this difference was not statistically significant (p=0.211). The treatment of colon adenocarcinoma with curative resection by the end of the 20th century is accompanied with acceptable rates of overall 5-year survival.
  Techniques in Coloproctology 12/2004; 8 Suppl 1:s152-4. · 1.29 Impact Factor
• Article: Locally recurrent rectal cancer after curative resection.

  E Christoforidis, I Kanellos, T Tsachalis, K Blouhos, I Lamprou, D Betsis
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  ABSTRACT: To determine the incidence of local recurrence, after curative resection for rectal cancer, with the application of total mesorectal excision (TME). During the last ten years, 120 patients underwent curative resection for rectal cancer. As a rule, except for the cases that underwent high anterior resection, TME was applied. In terms of local relapse, routine TME, preoperative radiotherapy, tumour's stage, differentiation grade and number of positive nodes were taken into account. Eight patients (6.7%) presented with local relapse. At 5 years, 91.9% of patients were free of local recurrence and the actuarial disease-free survival was 81%. A significant association between routine TME, tumour's stage, differentiation grade, lymph node invasion and local recurrence was observed. Conversely, preoperative radiotherapy appeared to play no protective role. The curative resection of rectal cancer, with the application of TME, has led to a very low incidence of local relapse during the last few years.
  Techniques in Coloproctology 12/2004; 8 Suppl 1:s132-4. · 1.29 Impact Factor
• Article: Synchronous polyps in patients with colorectal cancer.

  H Demetriades, I Kanellos, K Blouhos, T Tsachalis, K Vasiliadis, M G Pramateftakis, D Betsis
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  ABSTRACT: The aim of this study is to underscore the incidence of synchronous polyps in patients with colorectal cancer and to emphasise the importance of their perioperative detection and management. Three hundred and seven patients underwent a potentially curative resection for colorectal cancer during the last ten years. A total of 129 synchronous polyps were detected in 72 of the patients (23.5%). Complete preoperative colonoscopy was performed in 62 of the patients. Forty-three polyps (33.4%) in 37 patients were removed preoperatively, while 69 polyps (53.4%) in 25 patients were included in the surgical specimen. In 10 patients the colon was evaluated postoperatively and 17 polyps (13.1%) were removed via endoscopy. A total of 81 polyps were detected in different surgical segments than the index cancer. Furthermore, 15 polyps were detected in the right colon of 55 patients with left colon cancer. Synchronous polyps in patients with colorectal cancer are a frequent event. Thus, all patients should undergo a perioperative colonoscopy and endoscopic polypectomy, if feasible. The planned surgical procedure may alter as a consequence of the colonoscopic findings in some of the patients.
  Techniques in Coloproctology 12/2004; 8 Suppl 1:s72-5. · 1.29 Impact Factor
• Article: Anastomotic leakage following anterior resection for rectal cancer.

  I Kanellos, K Vasiliadis, S Angelopoulos, T Tsachalis, M G Pramateftakis, I Mantzoros, D Betsis
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  ABSTRACT: The aim of this study is to present the incidence of anastomotic leakage after anterior resection for rectal cancer and to demonstrate the therapeutic approach for the treatment of this complication. During the last ten years, 93 patients underwent anterior resection of the rectum for rectal cancer. Low anterior resection with total mesorectal excision (TME) was performed in 72, and high anterior resection in 21 patients. The definition of the anastomotic leakage was based on clinical features, peripheral blood investigations and abdominal CT scan. Clinically apparent anastomotic leakage developed in 9 patients (9.7%). Four patients were managed conservatively and five operatively. Postoperative mortality among the patients with anastomotic leakage was not recorded. The incidence of anastomotic leakage after anterior resection of the rectum for rectal cancer is relatively low. It remains however the most serious complication following rectal resection for cancer.
  Techniques in Coloproctology 12/2004; 8 Suppl 1:s79-81. · 1.29 Impact Factor
• Article: FIVE-YEAR SURVIVAL AFTER CURATIVE RESECTION FOR ADENO-CARCINOMA OF THE COLON: S. Angelopoulos, I. Kanellos, E. Christophoridis, T. Tsachalis, D. Betsis. Tech Coloproctol suppl.2004, 8: 152-4

  Angelopoulos, I. Kanellos, E. Christophoridis, T. Tsachalis, D. Betsis
  Techniques in Coloproctology 01/2004; · 1.29 Impact Factor