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ABSTRACT: A high glycemic diet may increase cardiovascular risk, yet whether the risk differs by gender or adiposity is inconclusive. Our goal was to determine the associations between dietary glycemic load (GL) and glycemic index (GI), and coronary heart disease (CHD) risk by conducting a meta-analysis of prospective studies. We searched the PubMed and Embase databases in July 2011 to identify eligible studies. The random-effects model was used to calculate pooled relative risks (RRs) comparing the highest categories of exposure to the lowest. Prespecified subgroup analyses were performed by gender and body mass index. We identified 8 prospective studies for meta-analysis, consisting of 220,050 participants and 4,826 incident CHD cases. Pooled RRs of CHD in relation to dietary GL were 1.08 (95% confidence interval [CI] 0.92 to 1.27) for men, 1.69 (95% CI 1.32 to 2.16) for women, and 1.36 (95% CI 1.13 to 1.63) for men and women combined. For dietary GI, corresponding pooled RRs were 0.99 (95% CI 0.84 to 1.16), 1.26 (95% CI 1.12 to 1.43), and 1.13 (95% CI 1.00 to 1.28), respectively. Limited evidence suggested the associations appeared more evident in the overweight and obese. There was no indication of publication bias. In conclusion, high dietary GL and GI significantly increased the risk of CHD in women but not in men, and the unfavorable effects may be more pronounced in overweight and obese patients. Further studies are needed to verify these findings and elucidate the underlying mechanisms.
The American journal of cardiology 03/2012; 109(11):1608-13. · 3.58 Impact Factor
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ABSTRACT: A history of depression may be associated with an increased risk of stroke. We aimed to determine the association between depression and risk of stroke by performing a meta-analysis of prospective studies.
Relevant studies were identified by a PubMed database search through May 2011 without restrictions and by reviewing reference lists of obtained articles. Community-based or population-based prospective studies that reported relative risk estimates with 95% confidence intervals for the association between depression and stroke were selected. Studies that enrolled participants with preexisting stroke at baseline were excluded. A random-effects model was used to compute the pooled risk estimate.
Random-effects meta-analysis of 17 prospective studies involving 206 641 participants and 6086 cases demonstrated a significant positive association between depression and subsequent risk of stroke (pooled relative risk, 1.34; 95% confidence interval, 1.17-1.54) after adjustment for potential confounding factors. The associations were similar between men and women. Potential publication bias may exist, but correction for this bias using a formal statistical method did not materially alter the combined risk estimate.
Depression significantly increased the risk of development of stroke, and this increase was probably independent of other risk factors, including hypertension and diabetes.
Stroke 01/2012; 43(1):32-7. · 5.73 Impact Factor
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ABSTRACT: Numbers of epidemiological studies assessing residential radon exposure and risk of lung cancer have yielded inconsistent results.
We therefore performed a meta-analysis of relevant published case- control studies searched in the PubMed database through July 2011 to examine the association. The combined odds ratio (OR) were calculated using fixed- or random-effects models. Subgroup and dose-response analyses were also performed.
We identified 22 case-control studies of residential radon and lung cancer risk involving 13,380 cases and 21,102 controls. The combined OR of lung cancer for the highest with the lowest exposure was 1.29 (95% CI 1.10-1.51). Dose-response analysis showed that every 100 Bq/m3 increment in residential radon exposure was associated with a significant 7% increase in lung cancer risk. Subgroup analysis displayed a more pronounced association in the studies conducted in Europe. Studies restricted to female or non-smokers demonstrated weakened associations between exposure and lung cancer.
This meta- analysis provides new evidence supporting the conclusion that residential exposure to radon can significantly increase the risk of lung cancer in a dose-response manner.
Asian Pacific journal of cancer prevention: APJCP 01/2012; 13(6):2459-65. · 0.66 Impact Factor
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ABSTRACT: Previous studies suggest that L-arginine, an amino acid and a substrate of nitric oxide synthase, may have blood pressure (BP)-lowering effect. Because some studies were performed with limited number of patients with hypertension and therefore limited statistical power with sometimes inconsistent results, we aimed to examine the effect of oral L-arginine supplementation on BP by conducting a meta-analysis of randomized, double-blind, placebo-controlled trials.
PubMed, Cochrane Central Register of Controlled Trials, and the ClinicalTrials.gov databases were searched through June 2011 to identify randomized, double-blind, placebo-controlled trials of oral L-arginine supplementation on BP in humans. We also reviewed reference lists of obtained articles. Either a fixed-effects or, in the presence of heterogeneity, a random-effects model was used to calculate the combined treatment effect.
We included 11 randomized, double-blind, placebo-controlled trials involving 387 participants with oral L-arginine intervention ranging from 4 to 24 g/d. Compared with placebo, L-arginine intervention significantly lowered systolic BP by 5.39 mm Hg (95% CI -8.54 to -2.25, P = .001) and diastolic BP by 2.66 mm Hg (95% CI -3.77 to -1.54, P < .001). Sensitivity analyses restricted to trials with a duration of 4 weeks or longer and to trials in which participants did not use antihypertensive medications yielded similar results. Meta-regression analysis suggested an inverse, though insignificant (P = .13), relation between baseline systolic BP and net change in systolic BP.
This meta-analysis provides further evidence that oral L-arginine supplementation significantly lowers both systolic and diastolic BP.
American heart journal 12/2011; 162(6):959-65. · 4.65 Impact Factor
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ABSTRACT: Epidemiological studies of dietary glycaemic index (GI) and glycaemic load (GL) in relation to diabetes risk have yielded inconsistent results. We aimed to examine the associations between dietary GI and GL and the risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. Relevant studies were identified by a PubMed database search up to February 2011. Reference lists from retrieved articles were also reviewed. We included prospective cohort studies that reported risk estimates with 95 % CI for the associations between dietary GI and GL and the risk of type 2 diabetes. Either a fixed- or random-effects model was used to compute the summary relative risk (RR). We identified thirteen prospective cohort studies of dietary GI or GL related to diabetes risk. The summary RR of type 2 diabetes for the highest category of the GI compared with the lowest was 1·16 (95 % CI 1·06, 1·26; n 12), with moderate evidence of heterogeneity (P = 0·02, I(2) = 50·8 %). For the GL, the summary RR was 1·20 (95 % CI 1·11, 1·30; n 12), with little evidence of heterogeneity (P = 0·10, I(2) = 34·8 %). No evidence of publication bias was observed. In addition, the associations persisted and remained statistically significant in the sensitivity analyses. In conclusion, the present meta-analysis provides further evidence in support of significantly positive associations between dietary GI and GL and the risk of type 2 diabetes. Reducing the intake of high-GI foods may bring benefits in diabetes prevention.
The British journal of nutrition 12/2011; 106(11):1649-54. · 3.45 Impact Factor
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ABSTRACT: Our goal was to evaluate the association between erectile dysfunction (ED) and risk of cardiovascular disease (CVD) and all-cause mortality by conducting a meta-analysis of prospective cohort studies.
Observational studies suggest an association between ED and the incidence of CVD. However, whether ED is an independent risk factor of CVD remains controversial.
The PubMed database was searched through January 2011 to identify studies that met pre-stated inclusion criteria. Reference lists of retrieved articles were also reviewed. Two authors independently extracted information on the designs of the studies, the characteristics of the study participants, exposure and outcome assessments, and control for potential confounding factors. Either a fixed- or a random-effects model was used to calculate the overall combined risk estimates.
Twelve prospective cohort studies involving 36,744 participants were included in the meta-analysis. The overall combined relative risks for men with ED compared with the reference group were 1.48 (95% confidence interval [CI]: 1.25 to 1.74) for CVD, 1.46 (95% CI: 1.31 to 1.63) for coronary heart disease, 1.35 (95% CI: 1.19 to 1.54) for stroke, and 1.19 (95% CI: 1.05 to 1.34) for all-cause mortality. Sensitivity analysis restricted to studies with control for conventional cardiovascular risk factors yielded similar results. No evidence of publication bias was observed.
This meta-analysis of prospective cohort studies suggests that ED significantly increases the risk of CVD, coronary heart disease, stroke, and all-cause mortality, and the increase is probably independent of conventional cardiovascular risk factors.
Journal of the American College of Cardiology 09/2011; 58(13):1378-85. · 14.16 Impact Factor
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ABSTRACT: Emerging epidemiological evidence suggests that higher magnesium intake may reduce diabetes incidence. We aimed to examine the association between magnesium intake and risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies.
We conducted a PubMed database search through January 2011 to identify prospective cohort studies of magnesium intake and risk of type 2 diabetes. Reference lists of retrieved articles were also reviewed. A random-effects model was used to compute the summary risk estimates.
Meta-analysis of 13 prospective cohort studies involving 536,318 participants and 24,516 cases detected a significant inverse association between magnesium intake and risk of type 2 diabetes (relative risk [RR] 0.78 [95% CI 0.73-0.84]). This association was not substantially modified by geographic region, follow-up length, sex, or family history of type 2 diabetes. A significant inverse association was observed in overweight (BMI ≥25 kg/m(2)) but not in normal-weight individuals (BMI <25 kg/m(2)), although test for interaction was not statistically significant (P(interaction) = 0.13). In the dose-response analysis, the summary RR of type 2 diabetes for every 100 mg/day increment in magnesium intake was 0.86 (95% CI 0.82-0.89). Sensitivity analyses restricted to studies with adjustment for cereal fiber intake yielded similar results. Little evidence of publication bias was observed.
This meta-analysis provides further evidence supporting that magnesium intake is significantly inversely associated with risk of type 2 diabetes in a dose-response manner.
Diabetes care 09/2011; 34(9):2116-22. · 8.09 Impact Factor
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ABSTRACT: Observational and preclinical studies suggest that dietary fiber intake may reduce the risk of breast cancer, but the results are inconclusive.
We aimed to examine the association between dietary fiber intake and risk of breast cancer by conducting a meta-analysis of prospective cohort studies.
Relevant studies were identified by a PubMed database search through January 2011. Reference lists from retrieved articles were also reviewed. We included prospective cohort studies that reported RRs with 95% CIs for the association between dietary fiber intake and breast cancer risk. Both fixed- and random-effects models were used to calculate the summary risk estimates.
We identified 10 prospective cohort studies of dietary fiber intake and risk of breast cancer involving 16,848 cases and 712,195 participants. The combined RR of breast cancer for the highest compared with the lowest dietary fiber intake was 0.89 (95% CI: 0.83, 0.96), and little evidence of heterogeneity was observed. The association between dietary fiber intake and risk of breast cancer did not significantly differ by geographic region, length of follow-up, or menopausal status of the participants. Omission of any single study had little effect on the combined risk estimate. Dose-response analysis showed that every 10-g/d increment in dietary fiber intake was associated with a significant 7% reduction in breast cancer risk. Little evidence of publication bias was found.
This meta-analysis provides evidence of a significant inverse dose-response association between dietary fiber intake and breast cancer risk.
American Journal of Clinical Nutrition 09/2011; 94(3):900-5. · 6.67 Impact Factor
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ABSTRACT: The prevalence of cardiovascular risk factors (CRFs) has been increasing in urbanization areas of China. The article aims to estimate the up-to-date prevalence and clustering of major modifiable CRFs among suburban residents in Beijing.
A cross-sectional survey in a representative sample of 16371 suburban residents aged 35 to 74 years was carried out in 2007, and results were compared with counterparts of China and the United States. Data was collected by questionnaires, blood pressure, anthropometric, and laboratory measurements.
The age-standardized prevalence of investigated major CRFs (overweight/obesity, diabetes, hypertension, dyslipidemia, and current smoking) in the study was 36.2%, 6.5%, 36.9%, 35.4%, and 36.3%, respectively. Overall, 83.5%, 47.2% and 17.5% of participants in the study had ≥1, ≥2, and ≥3 major CRFs, which were higher than total China (80.5%, 45.9%, and 17.2%) and lower than the United State (93.1%, 73.0% and 35.9%), respectively. The adjusted odds ratio (95% confidence interval) of ≥1, ≥2, and ≥3 CRFs for men compared with women was 3.4 (3.0 to 3.9), 4.3 (3.7 to 5.0), and 5.4 (4.6 to 6.5), respectively. In addition, older age groups were more likely to have ≥1, ≥2, and ≥3 of these modifiable cardiovascular risk factors compared with younger age groups, respectively.
High prevalence and clustering of major modifiable CRFs are commonly present in suburban residents in Beijing. More effective population-based interventions, such as smoking cessation, healthy diet, increased physical activity are required to reduce the prevalence of these CRFs and the increasing burden of cardiovascular diseases in China.
International journal of cardiology 08/2011; 151(1):46-9. · 7.08 Impact Factor
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ABSTRACT: Strong evidence suggests that C-reactive protein (CRP) is a novel risk factor for cardiovascular disease. We aimed to examine the effect of soy isoflavones on circulating CRP concentrations in postmenopausal women by conducting a meta-analysis of randomized controlled trials. We performed a literature search using PubMed, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases in December 2010 for randomized controlled trials conducted in postmenopausal women, using soy foods with isoflavones or isoflavone extracts as treatment, and with a report of CRP change. A meta-analysis was performed using a fixed-effects model or a random-effects model to calculate the combined effect size. In addition, subgroup and metaregression analyses were carried out to examine the influences of study designs and participant characteristics on the effect estimates. A pooled analysis of 14 trials showed a slight, but not significant, reduction of 0.17 mg/L (95% CI, -0.38 to 0.04; P = 0.12) in CRP concentrations among postmenopausal women with soy isoflavone intervention compared with controls. No substantial heterogeneity was observed. Subgroup analyses showed that soy isoflavones significantly lowered CRP by 0.70 mg/L (95% CI, -1.17 to -0.23; P = 0.003) among women with baseline CRP concentrations greater than 2.2 mg/L. No significant changes in CRP were observed in the other subgroups. Metaregression analysis further revealed that baseline CRP was a potential effect modifier of isoflavone treatment in lowering CRP. The present meta-analysis found insufficient evidence that soy isoflavones significantly reduce CRP concentrations in postmenopausal women. However, soy isoflavones may produce a significant reduction in CRP among postmenopausal women with elevated CRP.
Menopause (New York, N.Y.) 06/2011; 18(11):1256-62. · 3.08 Impact Factor
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ABSTRACT: Epidemiologic findings are inconsistent regarding risk for breast cancer related to dairy consumption. We performed a meta-analysis of prospective cohort studies to examine the association between diary product consumption and risk of breast cancer. A PubMed database search through January 2011 was performed for relevant studies. We included prospective cohort studies that reported relative risks with 95% confidence intervals for the association of dairy consumption and breast cancer risk. A random effects model was used to calculate the summary risk estimates. We identified 18 prospective cohort studies eligible for analysis, involving 24,187 cases and 1,063,471 participants. The summary relative risk of breast cancer for the highest intake of total dairy food compared with the lowest was 0.85 (95% confidence interval: 0.76-0.95), with evidence of heterogeneity (P = 0.01, I (2) = 54.5%). For milk consumption, the summary relative risk was 0.91 (95% confidence interval: 0.80-1.02), and substantial heterogeneity was observed (P = 0.003, I (2) = 59.7%). Subgroup analyses based on limited numbers of studies suggested that the associations were somewhat stronger for low-fat dairy intake than for high-fat dairy intake and for premenopausal women than for postmenopausal women. There was a significant dose-response relationship of total dairy food, but not milk, consumption with breast cancer risk. Little evidence of publication bias was observed. In conclusion, findings of the present meta-analysis indicate that increased consumption of total dairy food, but not milk, may be associated with a reduced risk of breast cancer.
Breast Cancer Research and Treatment 03/2011; 127(1):23-31. · 4.43 Impact Factor
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Journal of hypertension 02/2011; 29(2):400-1; author reply 401-2. · 4.02 Impact Factor
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ABSTRACT: Observational studies have indicated that soya food consumption is inversely associated with blood pressure (BP). Evidence from randomised controlled trials (RCT) on the BP-lowering effects of soya protein intake is inconclusive. We aimed to evaluate the effectiveness of soya protein intake in lowering BP. The PubMed database was searched for published RCT in the English language through to April 2010, which compared a soya protein diet with a control diet. We conducted a random-effects meta-analysis to examine the effects of soya protein on BP. Subgroup and meta-regression analyses were performed to explore possible explanations for heterogeneity among trials. Meta-analyses of twenty-seven RCT showed a mean decrease of 2·21 mmHg (95 % CI - 4·10, - 0·33; P = 0·021) for systolic BP (SBP) and 1·44 mmHg (95 % CI - 2·56, - 0·31; P = 0·012) for diastolic BP (DBP), comparing the participants in the soya protein group with those in the control group. Soya protein consumption significantly reduced SBP and DBP in both hypertensive and normotensive subjects, and the reductions were markedly greater in hypertensive subjects. Significant and greater BP reductions were also observed in trials using carbohydrate, but not milk products, as the control diet. Meta-regression analyses further revealed a significantly inverse association between pre-treatment BP and the level of BP reductions. In conclusion, soya protein intake, compared with a control diet, significantly reduces both SBP and DBP, but the BP reductions are related to pre-treatment BP levels of subjects and the type of control diet used as comparison.
The British journal of nutrition 02/2011; 106(3):317-26. · 3.45 Impact Factor
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ABSTRACT: Beneficial effects on body weight of supplementation with BCAA, including leucine, isoleucine, and valine, have been observed in animal and human studies. However, population-based studies on dietary BCAA intake and body weight are lacking. The objective of this study was to examine the association between dietary BCAA intake and risk of overweight status/obesity among multi-ethnic populations. The International Study of Macro-/Micronutrients and Blood Pressure is a cross-sectional epidemiological investigation in China, Japan, the UK, and the US. The study cohort included 4429 men and women ages 40-59 y who were free of diabetes. Diet was assessed by 4 multi-pass 24-h recalls; data on nutrients including BCAA were derived from country-specific food tables. Overweight status and obesity were defined as BMI ≥ 25 and BMI ≥ 30 kg/m(2), respectively. Multivariable-adjusted OR of overweight status/obesity and 95% CI by quartiles of BCAA intake were estimated by logistic regression. Mean BCAA intake was 2.6 ± 0.6% energy; intake was significantly lower among Chinese participants and similar among participants from the other 3 countries. Compared with those in the first quartile, the multivariable-adjusted OR (95% CI) of overweight status from the 2nd to 4th quartiles of BCAA intake were 0.97 (0.80-1.17), 0.91 (0.75-1.11), and 0.70 (0.57-0.86), respectively (P-trend < 0.01). BCAA intake and obesity were also inversely associated (P-trend = 0.03). In conclusion, higher dietary BCAA intake is associated with lower prevalence of overweight status/obesity among apparently healthy middle-aged adults from East Asian and Western countries.
Journal of Nutrition 02/2011; 141(2):249-54. · 3.92 Impact Factor
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ABSTRACT: Numbers of epidemiologic studies assessing soy consumption and risk of breast cancer have yielded inconsistent results. We aimed to examine the association between soy isoflavones consumption and risk of breast cancer incidence or recurrence, by conducting a meta-analysis of prospective studies. We searched for all relevant studies with a prospective design indexed in PUBMED through September 1st, 2010. Summary relative risks (RR) were calculated using fixed- or random-effects models. Pre-specified stratified analyses and dose-response analysis were also performed. We identified 4 studies of breast cancer recurrence and 14 studies of breast cancer incidence. Soy isoflavones consumption was inversely associated with risk of breast cancer incidence (RR = 0.89, 95% CI: 0.79-0.99). However, the protective effect of soy was only observed among studies conducted in Asian populations (RR = 0.76, 95% CI: 0.65-0.86) but not in Western populations (RR = 0.97, 95% CI: 0.87-1.06). Soy isoflavones intake was also inversely associated with risk of breast cancer recurrence (RR = 0.84, 95% CI: 0.70-0.99). Stratified analyses suggested that menopausal status may be an important effect modifier in these associations. We failed to identify a dose-response relationship between total isoflavones intake and risk of breast cancer incidence. Our study suggests soy isoflavones intake is associated with a significant reduced risk of breast cancer incidence in Asian populations, but not in Western populations. Further studies are warranted to confirm the finding of an inverse association of soy consumption with risk of breast cancer recurrence.
Breast Cancer Research and Treatment 01/2011; 125(2):315-23. · 4.43 Impact Factor
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ABSTRACT: Consumption diets of high glycemic index (GI) and glycemic load (GL) may increase the risk of breast cancer. We aimed to conduct a meta-analysis of prospective cohort studies to evaluate the associations between dietary GI and GL and risk of breast cancer. We searched the PubMed database for relevant studies through November 2010, with no restrictions. We included prospective cohort studies that reported relative risk (RR) with 95% confidence intervals (CIs) for the associations of dietary GI and GL with breast cancer risk. Summary RRs were calculated using both fixed- and random-effects models. We identified 10 prospective cohort studies eligible for analysis, involving 15,839 cases and 577,538 participants. The summary RR of breast cancer for the highest GI intake compared with the lowest was 1.08 (95% CI: 1.02-1.14), with no evidence of heterogeneity (P = 0.72, I (2) = 0%). For GL, the summary RR was 1.04 (95% CI: 0.95-1.15), and substantial heterogeneity was observed (P = 0.02, I (2) = 55.6%). The GI and GL and breast cancer associations did not significantly modified by geographic region, length of follow-up, number of cases, or menopausal status at baseline. Dose-response analysis was not performed due to limited number of eligible studies. There was no evidence of publication bias. In summary, the present meta-analysis of prospective cohort studies suggests that high dietary GI is associated with a significantly increased risk of breast cancer. However, there is no significant association between dietary GL and breast cancer risk.
Breast Cancer Research and Treatment 01/2011; 126(2):287-94. · 4.43 Impact Factor
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ABSTRACT: To study the effects of soybean products consumption on the risk of gastric cancer.
Literatures published in English and Chinese reporting the relationship between soybean product consumption and gastric cancer from 1988 to 2008 were searched in this study. Fifty-three relevant articles were selected and 28 of them met the criteria. Meta-analysis was applied to estimate the combined odds ratio (OR) and 95% confidence interval (95%CI) between soybean product consumption and gastric cancer.
A total of 28 independent studies were selected including 16 case-control studies, 10 cohort studies and 2 cross sectional studies. The random-effect model was used due to the heterogeneity among these studies. The overall ORs (95%CI) of Meta-analysis on subjects who consumed soybean products, tofu and miso were 0.58 (0.52 - 0.65), 0.90 (0.80 - 1.00) and 1.18 (1.09 - 1.28), respectively.
Consumption of soybean products and tofu was inversely associated with gastric cancer, while miso consumption could increase the risk to gastric cancer.
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 03/2010; 44(3):215-20.
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ABSTRACT: We calculated new prevalences of risk factors for cardiovascular disease (CVD) and examined their associations with dietary habits and physical activity in a suburban area of Beijing--one of the most urbanized cities in China.
In 2007, a cross-sectional survey of a representative sample of 19,003 suburban residents aged 18 to 76 years was conducted. Dietary and anthropometric data were collected by questionnaire, and blood pressure, fasting blood glucose, and serum lipids were measured.
The age-standardized prevalences of the CVD risk factors overweight/obesity, diabetes, hypertension, dyslipidemia, and metabolic syndrome (MS) were 31.9%, 6.1%, 33.6%, 30.3%, and 11.6%, respectively. The adjusted odd ratios (95% confidence interval [CI]) of overweight/obesity, diabetes, hypertension, dyslipidemia, and MS for participants who were physically active, as compared with those who were not physically active, were 0.67 (0.47 to 0.85), 0.87 (0.80 to 0.95), 0.92 (0.87 to 0.98), 0.89 (0.82 to 0.96), and 0.74 (0.62 to 0.89), respectively. The adjusted odds ratios (95% CI) of hypertension and MS for participants with a high intake of salt, as compared with those without a high intake of salt, were 1.72 (1.29 to 2.03) and 1.48 (1.16 to 1.77), respectively. In addition, participants who consumed a high-fat diet were more likely to be overweight/obese and dyslipidemic, whereas vegetarians had less risk of overweight/obesity, diabetes, hypertension, dyslipidemia, and MS.
In this population of adults living in suburban Beijing, there were relatively high prevalences of the CVD risk factors overweight/obesity, diabetes, hypertension, dyslipidemia, and MS. Healthy dietary habits and physical activity may reduce the risks of these conditions.
Journal of Epidemiology 01/2010; 20(3):237-43. · 1.86 Impact Factor
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ABSTRACT: Milk contains considerable quantities of estrogens and progesterone and as such may be one of the risk factors for hormone-related cancers. To determine the hormonal effects of commercial and traditional types of milk, we performed uterotrophic tests.
Forty-five rats were ovariectomized and divided into three groups of 15 animals each. The animals were kept for 7 days on powdered chow and one of three different liquids: commercial milk (C), traditional milk (T), or water. At autopsy, wet and dry uterine weights were determined. The cell heights of the uterine epithelium and endometrium were determined. The uterine 5-bromo-2-deoxyuridine (BrdU) labeling index of the epithelium and endometrium gland epithelium was also assessed.
The weights of wet and dry uterus were 142 ± 13 and 112 ± 10 mg in the C group, 114 ± 30 and 91 ± 24 mg in the T group, and 87 ± 6 and 69 ± 5 mg in the W group. Significant differences in wet and dry uterus weights were found between all pairs of groups. The ratio of the wet uterine weight to body weight was significantly higher in the C and T groups than in the W group. The heights of the uterine epithelium and endometrium were higher and BrdU labeling index was greater in the C group than in the T and W groups.
Commercially available milk and traditional milk have uterotrophic effects on young ovariectomized rats. Our findings indicate that these uterotrophic effects in the milk groups were partly due to the estrogen and progesterone in the milk.
Environmental Health and Preventive Medicine 12/2009; 15(3):162-8.
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ABSTRACT: Studies suggest that the circulating insulin-like growth factor I (IGF-I) level is positively associated with the prostate cancer risk. The association of milk consumption and circulating IGF-I level has been examined in epidemiological studies with inconsistent results. We conducted a systematic literature review to summarize and quantify the current evidence for milk or dairy product consumption and the circulating IGF-I level. We searched relevant papers published in English up to March 2009 in various databases. Fifteen cross-sectional studies and eight randomized controlled trials were finally identified. Ten cross-sectional studies showed statistically positive correlation between milk consumption and the circulating IGF-I level. Randomized controlled trials indicated that the circulating IGF-I level was significantly higher in the milk intervention group. After meta-analysis, the weighted mean difference of the circulating IGF-I level was 13.8 ng/ml (95% confidence interval: 6.1-21.5 ng/ml) comparing the intervention group with the control group. The current evidence suggests that milk consumption may increase the circulating IGF-I level.
International Journal of Food Sciences and Nutrition 10/2009; 60 Suppl 7:330-40. · 1.15 Impact Factor
