D Bouchier-Hayes

Beaumont Hospital, Dublin, Leinster, Ireland

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Publications (198)592.72 Total impact

  • J P O'Neill · D Power · C Condron · D Bouchier-Hayes · M Walsh ·
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    ABSTRACT: Anaplastic thyroid cancer (ATC) is a fatal endocrine malignancy. Current therapy fails to significantly improve survival. Recent insights into thyroid tumorigenesis, post-malignant dedifferentiation and mode of metastatic activity offer new therapeutic strategies. An extensive literature search of Medline and Pubmed was conducted to include all published reports on ATC. Secondary articles were identified from key paper reference listings. Significant progress, in the last 5 years, has been made outlining thyroid tumorigenesis and the progression to anaplasia. Continued identification and development of drug therapies is required to counter specific molecular targets responsible for the post-malignant dedifferentiation process and ultimately the fatal neoplastic phenotype.
    Irish Journal of Medical Science 09/2009; 179(1):9-15. DOI:10.1007/s11845-009-0364-y · 0.83 Impact Factor
  • A. Qureshi · A. Darzi · P. Grace · E. Kay · A. L. Leahy · D. Bouchier-hayes ·
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    ABSTRACT: Summary Carbon dioxide (CO2) laser may selectively destroy peripheral nerves and preserve the accompanying blood vessels within the same neurovascular bundle. In this study we examined the effects on acid secretion of CO2 laser irradiation on the vagal distribution of the anterior wall of the stomach with posterior truncal vagotomy. Posterior truncal vagotomy and CO2 laser anterior seromyotomy (LV) was carried out on 10 mongrel dogs. Furthermore, five dogs received posterior truncal vagotomy and anterior highly selective vagotomy as controls (HSV). Basal acid pH (BpH) and maximal acid pH (MpH) in response to pentagastrin (7.5μg/kg) were measured pre- and post-vagotomy. The mean BpH in the carbon dioxide laser vagotomy group pre-operatively was 4.01 ± 0.8 compared to 4.96 ± 1.3 post-operatively (ns). The mean MpH pre-operatively was 1.55 ± 0.6 compared to 4.17 ± 1.0 postoperatively (P < 0.05), showing a significant reduction in pentagastrinstimulated acid output following carbon dioxide laser vagotomy. In the surgical vagotomy group, the mean BpH pre-operatively was 4.17 ± 0.8 compared to 4.57 ± 1.4 post-operatively (ns). The mean MpH pre-operatively was 1.07 ± 0.2 compared to 3.92 ± 0.8 post-operatively (P < 0.05). The pre- and post-operative BpH was the same in both treatment groups, although there was no significant difference in the MApH post-vagotomy in either group. There was a greater than 50% increase in the MpH post-vagotomy in LV and HSV. The application of CO2 laser vagotomy through an operating laparoscope should be investigated.
    Minimally Invasive Therapy & Allied Technologies 07/2009; 3(6):357-360. DOI:10.3109/13645709409153038 · 1.27 Impact Factor
  • D. Kelly · A. Darzi · P. Grace · D. Bouchier-hayes ·
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    ABSTRACT: Summary Gall-stone fragmentation is mainly a function of the physical characteristics of both the administered shock waves and the gall-stones. Geometrical irregularities, such as holes and cracks, have previously been shown to reduce the local stress required to break solid structures. We therefore tested the hypothesis that contact lithotripsy would fragment fractured gall-stone sooner than intact gall-stones. Fifty-four gall-stones harvested from 18 consecutive cholecystectomy patients were randomized into three groups. Group A included gall-stones which were drilled by a diamond-tipped knife creating a small crater in the stone surface. Group B were sister stones from the same gall bladder used as controls. A third stone from the same patient was used for chemical analysis. All stones were fragmented by ultrasonic contact lithotripsy using a Wolf Lithotrite at 100% power and at a frequency of 10 shock waves per s. Fragmentation time for drilled stones was 27 ± 6 s compared to 71 ± 13 s for nondrilled stones (P lt; 0.001). There was no correlation between chemical analysis and time to stone fragmentation. We conclude that fracturing of stones prior to lithotripsy reduces fragmentation time, and may thus increase the efficacy and safety of contact lithotripsy of both gall-stones and common bile duct stones.
    Minimally Invasive Therapy & Allied Technologies 07/2009; 5(4):339-341. DOI:10.3109/13645709609153058 · 1.27 Impact Factor
  • B. J. Manning · G. McGreal · J. Harmey · N. Relihan · E. Kay · D. Bouchier-Hayes · H. P. Redmond ·

    British Journal of Surgery 01/2009; 89:73-73. · 5.54 Impact Factor
  • J McGuinness · D Bouchier-Hayes · J.M. Redmond ·
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    ABSTRACT: The systemic inflammatory response to cardiac surgery is common, and resultant impairment of multiple organ function is generally mild or subclinical due to physiological reserve within organ systems. Unfortunately, the changing profile of patients referred for surgery suggests that the systemic inflammatory response may prominently influence surgical outcome in the future. Older, co-morbid patients with more limited physiological reserve are being referred for complex lengthy procedures, and paediatric surgery has witnessed a shift to earlier complex primary correction or palliation involving long cardiopulmonary bypass times or a period of suboptimal organ perfusion using circulatory arrest or low flow cardiopulmonary bypass. Unique to cardiac surgery is the predictability of the inflammatory response, but prophylactic therapies have not translated into clinical benefit, which the preconditioning phenomenon may address.
    The surgeon: journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 07/2008; 6(3):162-71. DOI:10.1016/S1479-666X(08)80113-8 · 2.18 Impact Factor
  • C Healy · K J Mulhall · D. Fitz Patrick · E W Kay · D Bouchier-Hayes ·
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    ABSTRACT: Thermal preconditioning reduces inflammation by inducing cytoprotective heat shock proteins. We evaluated the role of limb thermal preconditioning in a rabbit model of flexor tendon repair. The treatment groups underwent limb preconditioning by elevating the limb temperature to 41.5 degrees C for 20 minutes. The animals were sacrificed three and six weeks after flexor tendon repair. Heat shock protein72 expression of the treated limb was measured at 18 hours. Macroscopic analysis demonstrated a significant decrease in adhesion formation in the three week treatment group. The inflammatory infiltrate was significantly reduced for both treatment groups. The difference in ultimate tensile strength was not significant. We conclude that thermal preconditioning of the limb before flexor tendon repair decreases inflammation and adhesion formation in a rabbit model and has the potential to improve clinical outcome of flexor tendon surgery.
    Journal of Hand Surgery (European Volume) 07/2007; 32(3):289-95. DOI:10.1016/j.jhsb.2007.01.004 · 2.04 Impact Factor
  • J Caird · C Napoli · C Taggart · M Farrell · D Bouchier-Hayes ·
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    ABSTRACT: Matrix metalloproteinases 2 and 9 (MMP 2 and -9) have been implicated in the pathogenesis of atherosclerosis and aneurysm formation. The goal of the study was to establish the role of these metalloproteinases in both human atherosclerotic and non-atherosclerotic cerebral aneurysms. Eleven cerebral aneurysms (four atherosclerotic, seven non-atherosclerotic) were immunohistochemically stained for MMP 2 and -9. As controls, atherosclerotic and normal Circle of Willis arteries were similarly immunostained. All specimens were retrieved at autopsy and were paraffin-embedded. In order to evaluate the real MMP 2 and -9 activities, gelatin zymography was also performed in only two available specimens of non-atherosclerotic intracranial aneurysms, because of the relative unavailability of fresh intracranial aneurysm tissue (i.e. reluctance to excise the aneurysm fundus at surgery). Our data establish that MMP 2 and -9 were expressed minimally or not at all in normal Circle of Willis arteries but were strongly expressed in medial smooth muscle cells of atherosclerotic Circle of Willis arteries. In the aneurysm group, both MMP 2 and -9 were strongly expressed in the atherosclerotic aneurysms, but MMP 2 alone was detected in the non-atherosclerotic aneurysms. Zymography revealed a weak enzyme activity correlating to MMP 9 standard recombinant protein. MMP 2 activity was not demonstrated in either specimen. This study shows that the expression of MMP 2 and -9 is associated with atherosclerosis, be it in aneurysmal or non-aneurysmal cerebral vessels but MMP 2 appears to be specifically expressed in aneurysms devoid of atherosclerosis perhaps suggesting a pathogenic role for MMP 2 in the alteration of the extracellular matrix of cerebral arteries during aneurysm formation.
    European Journal of Neurology 11/2006; 13(10):1098-105. DOI:10.1111/j.1468-1331.2006.01469.x · 4.06 Impact Factor
  • J McGuinness · T.G. Neilan · A Sharkasi · D Bouchier-Hayes · J.M. Redmond ·
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    ABSTRACT: Omega-3 fatty acids exhibit anti-inflammatory, antithrombotic, and antiarrhythmic properties. We investigated the extent and underlying mechanism of protection conferred by a pre-emptive omega-3 infusion in a model of regional cardiac ischemia-reperfusion injury. New-Zealand White rabbits received either the omega-3 infusion or a control infusion of 0.9% saline (n = 14 in each group). The large marginal branch of the left coronary artery was occluded for 30 minutes, cardiac function was assessed during 3 hours of reperfusion, and infarct size was measured. Pretreatment-induced alterations in myocardial membrane fatty acid composition and intramyocardial heat shock protein 72 were additionally assessed (n = 5 in each group). Serum markers of myocardial membrane oxidative stress, malonaldehyde and 8-isoprostane, were also determined. Results are expressed as means +/- standard error of the mean and significance was tested with analysis of variance. Pretreatment increased myocardial membrane omega-3 fatty acid content 5-fold, from 0.94% +/- 0.07% in controls to 5.38% +/- 0.44% in the omega-3 group (P < .01), and it produced a 225% elevation of levels of heat shock protein 72 (P = .019) before ischemia-reperfusion. This was associated with a 40% reduction in infarct size (P < .01). Whereas the reperfusion-induced rise in malonaldehyde levels was higher with omega-3 pretreatment, 10.2 +/-1.5 micromol/L versus 6.1 +/- 0.7 micromol/L in controls (P = .04), 8-isoprostanes showed a 9-fold reduction, 679 +/- 190 pg/mL in controls vs 74 +/- 45 pg/mL in the omega-3 group (P = .0077). A pre-emptive omega-3 infusion significantly reduces infarct size through the dual mechanisms of upregulation of heat shock protein 72, a key preconditioning protein, and a dramatic increase in the omega-3 content of myocardial membranes, which appears to facilitate a shift in oxidant ischemia-reperfusion injury. Further study to optimally shorten the pretreatment regimen for this potentially acceptable infusion will now be pursued.
    The Journal of thoracic and cardiovascular surgery 08/2006; 132(1):72-9. DOI:10.1016/j.jtcvs.2005.10.061 · 4.17 Impact Factor
  • J C Coffey · M J F Smith · J H Wang · D Bouchier-Hayes · T G Cotter · H P Redmond ·
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    ABSTRACT: In the recent past, several papers have pointed to the possibility that tumour removal generates a permissive environment in which tumour growth is potentiated. This phenomenon has been coined "perioperative tumour growth" and whilst it represents a departure in terms of our attitude to the surgical process, this concept was first hinted at by Paget(1) himself. Despite this, the time interval immediately before and after cancer surgery (i.e. the perioperative period) remains an underutilised interval during which chemotherapeutic regimens are rarely implemented. Herein, we present a summarised review of the literature that supports the concept that tumour removal may potentiate the growth of residual neoplastic disease. We also outline current knowledge regarding underlying mechanisms and in this manner highlight potential therapeutic entry points. Finally, we emphasise the urgent need for trials of agents that could protect patients against the harmful host-tumour interactions that may occur during the perioperative period.
    BioEssays 04/2006; 28(4):433-7. DOI:10.1002/bies.20381 · 4.73 Impact Factor
  • S. Brophy · E. Kaye · D. McNamara · D. Bouchier-Hayes ·

    Journal of Surgical Research 02/2006; 130(2):193-193. DOI:10.1016/j.jss.2005.11.089 · 1.94 Impact Factor
  • J P O'Neill · B O'Neill · C Condron · M Walsh · D Bouchier-Hayes ·
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    ABSTRACT: BACKGROUND: This review article discusses the clinical and diagnostic implications of anaplastic thyroid cancer, recognizing the aggressive nature of the disease and extensive disease progression upon diagnosis. Standard treatment strategies (surgical, chemotherapy, radiation) are discussed, comparing adjuvant and neo-adjuvant regimens and the emergence of tumour resistance with expression of multidrug resistance pumps. We question the pathological evolution of anaplasia as a 'de novo' disease or a post malignant transformation or dedifferentiation and the therapeutic implications of p53 mutation. Future treatment options are reviewed with an emphasis on specific molecular targets responsible for the neoplastic phenotype. METHOD: An electronic search on Medline and Pubmed was performed under 'anaplastic thyroid carcinoma', 'anaplastic thyroid carcinogenesis', 'anaplastic thyroid carcinoma treatment reviews'. Relevant papers were systematically reviewed from 1965 to present.
    The Journal of Laryngology & Otology 09/2005; 119(8):585-91. DOI:10.1258/0022215054516197 · 0.67 Impact Factor
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    J V Lunn · P M Gallagher · S Hegarty · M Kaliszer · J Crowe · P Murray · D Bouchier-Hayes ·
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    ABSTRACT: Hereditary hemochromatosis (HH) results in increased iron absorption and subsequent deposition in tissue. This condition occurs predominantly in individuals of Northern European and Celtic origin with Ireland having one of the highest allele frequencies in the world. This study examines the hypothesis that homozygosity for either the C282Y or H63D mutations in the HFE gene may be associated with aseptic loosening following total hip arthroplasty (THA). Two groups of individuals were screened for the C282Y and H63D mutations associated with HH. Group 1 were individuals who had undergone primary hip arthroplasty and group 2 were individuals who had undergone revision hip arthroplasty for aseptic loosening. Exclusion criteria included rheumatoid or other inflammatory arthropathies and revision due to causes other than aseptic loosening. Significantly more patients in the revision THA group were homozygous for the C282Y genotype (P = 0.014). Aseptic loosening occurred earlier in these patients (P = 0.009), in particular in the patients who had clinical signs of hemochromatosis. No association was seen with the H63D mutation and revision THA. The incidence of HH in the group of primary THA patients was no higher than the background incidence. Patients who require primary THA and who are homozygous for the C282Y mutation have an increased risk of developing aseptic loosening, leading to revision THA. Moreover C282Y homozygosity appears to be associated with earlier aseptic loosening than in individuals without the C282Y mutation.
    Journal of Orthopaedic Research 06/2005; 23(3):542-8. DOI:10.1016/j.orthres.2004.11.004 · 2.99 Impact Factor
  • R.G. Casey · M Joyce · G Roche-Nagle · G Chen · D Bouchier-Hayes ·
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    ABSTRACT: Development of diabetes causes early functional (endothelial dysfunction) and morphological abnormalities in the kidney. If left untreated, these will ultimately progress to renal failure. Apart from strategies aimed at maintaining very tight glycemic control, attention has turned to the development of adjuvant therapy to maintain endothelial function in these patients. The agents receiving the most critical appraisal due to their endothelial protective effects are the 3-hydrox 3-methylglutaryl (HMG)-Co-enzyme A (CoA) reductase inhibitors. The aim of the study was to investigate: (1) the early alterations in the renal diabetic injury; and (2) to examine the protective role of Pravastatin in this end-organ diabetic model. Sprague Dawley rats (n = 21) were randomized into three groups: (1) control; (2) diabetic; and (3) diabetic treated with Pravastatin. Diabetic nephropathy was investigated with serum biochemical parameters (urea, creatinine), functional parameters (total urinary protein loss, glomerular filtration rate, renal cortical blood flow), and structural assessment (hemotoxylin and eosin staining). We demonstrated impairment in functional, biochemical, and structural parameters in the diabetic nephropathy group, which was diminished by treatment with Pravastatin. This was attributed to an up-regulation in endothelial constitutive nitric oxide synthase (ecNOS) expression in the treated diabetic group. We have shown that Pravastatin, in an experimental model of early diabetes nephropathy preserves microvascular endothelial function in the presence of hyperglycemia, thus inhibiting the early stage of diabetic microangiopathy.
    Journal of Surgical Research 03/2005; 123(2):176-81. DOI:10.1016/j.jss.2004.08.001 · 1.94 Impact Factor
  • R G Casey · D Galvin · D Bouchier-Hayes · G Lennon ·
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    ABSTRACT: A 'fracture' of the penis refers to a tear in the deep layer of the tunica albuginea (Buck's fascia) and may be associated with a urethral injury. To describe a classical case of a 'fractured' penis and discuss the management options. A case report of a 30-year-old man presented with a 'fractured' penis and who underwent surgical intervention. This rare occurrence represents a urological emergency and necessitates imaging and repair of the cavernosal defect in order to prevent poor functional outcome.
    Irish Journal of Medical Science 03/2005; 174(1):55-7. DOI:10.1007/BF03168520 · 0.83 Impact Factor
  • W. B. Robb · P. Naughton · J. J. Kelly · C. Condron · T. N. Walsh · D. Bouchier-Hayes ·
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    ABSTRACT: Introduction.Evidence continues to grow that the bone marrow is a reservoir for mesenchymal stem cells that may be mobilized and differentiated into numerous tissues and participate in a reparative response to injury. We previously reported that the amino acid taurine increases the mobilization of bone marrow stem cells. We hypothesize that tissue injury in Barrett’s esophagitis increases the mobilization of epithelial stem cells which can be further augmented with supplemental taurine. Methods. Bone marrow derived epithelial progenitor cells (EPPCs, CD45−, CD34+, Pancytokeratin+) and endothelial progenitor cells (EPCs, CD45−, CD133+, CD146+) were identified in peripheral blood samples from 16 patients with Barrett’s esophagus and 12 age- and sex-matched controls. Samples were analyzed by flow cytometry before and after 7 days of oral taurine supplementation (500 mg tds). Statistical comparison utilized ANOVA with LSD post-hoc correction. Results are expressed as mean ± standard error of the mean (SEM). Data were taken as statistically significant where P < 0.05. Results. Patients with Barrett’s esophagus were found to have significantly increased levels of baseline EPPCs and this was further significantly increased by the period of taurine supplementation. No significant difference in the levels of EPCs was found between any group before or after treatment. Conclusion. Oral taurine supplementation significantly increases the number of circulating epithelial progenitor cells without inducing a pro-angiogenic state in patients with Barrett’s esophagus. Studies to demonstrate engrafting of peripheral epithelial stem cells are now warranted.
    Journal of Surgical Research 10/2004; 121(2):310-310. DOI:10.1016/j.jss.2004.07.141 · 1.94 Impact Factor
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    S.R. Kearns · A.F. Daly · K Sheehan · P Murray · C Kelly · D Bouchier-Hayes ·
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    ABSTRACT: Compartment syndrome is a unique form of ischaemia of skeletal muscle which occurs despite patency of the large vessels. Decompression allows the influx of activated leucocytes which cause further injury. Vitamin C is a powerful antioxidant which concentrates preferentially in leucocytes and attenuates reperfusion-induced muscle injury. We have evaluated the use of pretreatment with oral vitamin C in the prevention of injury caused by compartment syndrome in a rat cremasteric muscle model. Acute and delayed effects of pretreatment with vitamin C were assessed at one and 24 hours after decompression of compartment syndrome. Muscle function was assessed electrophysiologically. Vascular, cellular and tissue inflammation was assessed by staining of intercellular adhesion molecule-1 (ICAM-1) and by determination of the activity of myeloperoxidase (MPO) in neutrophils and tissue oedema. Compartment syndrome impaired skeletal muscle function and increased the expression of ICAM-1, activity of MPO and muscle weight increased significantly. Pretreatment with vitamin C preserved muscle function and reduced the expression of ICAM-1, infiltration of the neutrophils and oedema.
    The Bone & Joint Journal 09/2004; 86(6):906-11. DOI:10.1302/0301-620X.86B6.14177 · 3.31 Impact Factor
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    P Ó Ceallaigh · N Hogan · R McLaughlin · D Bouchier-Hayes ·

    EJVES Extra 02/2004; 7(2):33-35. DOI:10.1016/j.ejvsextra.2004.01.001
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    J C Coffey · J H Wang · M J F Smith · D Bouchier-Hayes · T G Cotter · H P Redmond ·
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    ABSTRACT: Excisional surgery is one of the primary treatment modalities for cancer. Minimal residual disease (MRD) is the occult neoplastic disease that remains in situ after curative surgery. There is increasing evidence that tumour removal alters the growth of MRD, leading to perioperative tumour growth. Because neoplasia is a systemic disease, this phenomenon may be relevant to all patients undergoing surgery for cancer. In this review we discuss the published work that addresses the effects of tumour removal on subsequent tumour growth and the mechanisms by which tumour excision may alter residual tumour growth. In addition, we describe therapeutic approaches that may protect patients against any oncologically adverse effects of tumour removal. On the basis of the evidence presented, we propose a novel therapeutic paradigm; that the postoperative period represents a window of opportunity during which the patient may be further protected against the oncological effects of tumour removal.
    The Lancet Oncology 01/2004; 4(12):760-8. DOI:10.1016/S1470-2045(03)01282-8 · 24.69 Impact Factor
  • C Condron · D Toomey · R G Casey · M Shaffii · T Creagh · D Bouchier-Hayes ·
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    ABSTRACT: Urinary tract infection (UTI), most frequently caused by Escherichia coli, is one of the most common bacterial infections in humans. It is a host inflammatory response to bacterial invasion in which large numbers of neutrophils are recruited into the bladder in response to cytokines secreted by the infected bladder epithelium. We hypothesise that an impaired host neutrophil response leads to susceptibility to recurrent UTI (rUTI). Therefore, the neutrophil inflammatory response of patients with a history of rUTI was compared to healthy controls. No difference in neutrophil adhesion receptor expression or complement receptor expression following bacterial stimulus was detected between the two groups. However, the expression of the IgG receptor CD16, bacterial phagocytosis and reactive oxygen intermediate (ROI) production were significantly reduced in UTI patient neutrophils compared to controls. Neutrophils from rUTI patients have a significantly reduced bactericidal function when compared to healthy controls, with the former showing a reduced capacity for activation. This reduced neutrophil function may result in defective bacterial clearance and lead to susceptibility to recurrent infection.
    Urological Research 11/2003; 31(5):329-34. DOI:10.1007/s00240-003-0344-z · 1.39 Impact Factor
  • G Roche-Nagle · F Chambers · J Nanra · D Bouchier-Hayes · S Young ·
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    ABSTRACT: Warfarin sodium [Coumadin] is widely used since its introduction in 1954. The dosage varies from individual to individual and is subject to adjustment due to interactions with other medications and alcohol. It is therefore important for the patient to be educated fully regarding warfarin therapy as outside the narrow therapeutic range either failure to prevent thromboembolism or serious bleeding with potential fatal complications may occur. Patient comprehension of the risks of anticoagulation, tablet recognition skills and knowledge of complications of warfarin therapy were evaluated in 150 patients attending the anticoagulation clinic in a Dublin teaching hospital. The majority, 125 (83%) perceived that they had received education about the therapy. Concomitant aspirin was avoided by 125 (83%) patients, but 25 (17%), thought it safe in combination with warfarin; 33 (22%) believed that alcohol was safe in combination with warfarin. When asked about the colours and strengths of warfarin tablets, 125 (83%) patients identified the 1 mg tablet correctly. Only 105 (70%) identified the 3 mg tablet and 98 (65%) the 5 mg tablet correctly. In 42 (28%), patients could not describe their current therapy. Potential complications from over- and under-dosage with warfarin were unknown to 89 (59%) and 90 (60%) patients respectively. This study suggests that patient knowledge regarding anticoagulation therapy is not optimal. A significant group may be at risk from serious complications because of inadequate knowledge. We suggest improving patient knowledge may improve control, reduce complication and therefore reduce the burden on the health service.
    Irish medical journal 07/2003; 96(7):211-3. · 0.51 Impact Factor

Publication Stats

3k Citations
592.72 Total Impact Points


  • 1989-2009
    • Beaumont Hospital
      Dublin, Leinster, Ireland
  • 1978-2009
    • Royal College of Surgeons in Ireland
      • • Department of Surgery
      • • Department of Biochemistry
      Dublin, Leinster, Ireland
  • 2005
    • St Vincent's University Hospital
      Dublin, Leinster, Ireland
  • 1992
    • Wistar Institute
      Philadelphia, Pennsylvania, United States
    • Royal Australasian College of Surgeons
      Beaumont, South Australia, Australia
  • 1985
    • Dublin Dental University Hospital
      Dublin, Leinster, Ireland
  • 1977
    • University College Dublin
      Dublin, Leinster, Ireland