Publications (13)36.57 Total impact
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Article: Giant basal cell carcinoma with regional lymph node and distant lung metastasis.
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ABSTRACT: The prevalence of metastatic basal cell carcinoma (MBCC) varies between 0.0028% and 0.55% of all cases. In total, more than 300 MBCC have been reported in the literature. We report the case of a 72 year old lady, who presented in September 2009 with a 10-year history of a progressively growing, giant, facial basal cell carcinoma (BCC). Clinical and imaging evaluations identified large local invasion with bone and meningeal involvement. Treatment consisted of an extensive surgery including left eye exenteration and meningeal resection followed by radiotherapy. A solitary lung metastasis was identified five months after the primary tumor resection. As the lesion remained solitary but had increased in size five months later, the patient finally accepted a surgical resection. A right upper-lobe pneumonectomy was performed and pathologic examination confirmed the metastasis as a MBCC.European journal of dermatology: EJD 09/2011; 21(6):972-5. · 2.53 Impact Factor -
Article: The neutrophilic dermatoses.
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ABSTRACT: The neutrophilic dermatoses (ND) may present with pustules, plaques, ulcerations, and general malaise. They are secondary to the invasion of the skin by normal polymorphonuclear leukocytes in the absence of infection. ND are often associated with particular systemic diseases. The management of affected patients is reviewed, with a focus on nursing care.Dermatology nursing / Dermatology Nurses' Association 09/2008; 20(4):274-6, 279-82. -
Article: [Pyoderma gangrenosum is 100 years old. From Louis Brocq to biotherapies].
La Revue du praticien 03/2008; 58(4):457-61. -
Article: Burgeoning nodule on the scalp of a 65-year-old man. Atypical fibroxanthoma (AFX).
Archives of Dermatology 06/2007; 143(5):653-8. · 3.89 Impact Factor -
Article: Topical therapy of atopic dermatitis: controversies from Hippocrates to topical immunomodulators.
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ABSTRACT: Although atopic dermatitis can be treated efficiently, there is still much controversy about the risk/benefit ratio of both topical corticosteroids and topical immunomodulators. Conflicting data may be found about the usefulness of bathing, diet regulation, and other therapeutic interventions. These controversies result in part from the persistence of Hippocratic doctrines in modern medical thinking. Humoralist and diathetic doctrines, as they pertain to eczema, are reviewed. The paradoxical worsening of oozing and the deadly hazards of hospitalization before the era of antibiotics are brought to mind. We hope that this historical review will improve the understanding of current controversies and help dermatologists to manage patients with atopic dermatitis and other chronic skin diseases.Journal of the American Academy of Dermatology 03/2007; 56(2):295-301. · 3.99 Impact Factor -
Article: From acute febrile neutrophilic dermatosis to neutrophilic disease: forty years of clinical research.
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ABSTRACT: In 1964, Sweet described an acute febrile neutrophilic dermatosis. It is now widely accepted that Sweet's syndrome belongs to a group of associated neutrophilic dermatoses. Although clinically dissimilar, Sweet's syndrome, pyoderma gangrenosum, subcorneal pustular dermatosis, erythema elevatum diutinum, and a few other conditions can be considered a part of this same pathologic spectrum of inflammatory disorders because of (1) the existence of transitional and overlap forms; (2) the similar histopathologic feature of an infiltrate by normal polymorphonuclear leukocytes; (3) the possible occurrence of extracutaneous neutrophilic infiltrates, defining the neutrophilic disease; and (4) the frequent association with systemic diseases. According to the localization of the neutrophilic infiltrate, we describe neutrophilic dermatoses en plaques (dermal), superficial (epidermal), and deep (dermal and hypodermal). Almost every organ of the body may be involved by a neutrophilic aseptic inflammation. The main systemic diseases associated with neutrophlic dermatoses are hematologic, gastrointestinal, and rheumatologic diseases. Although the pathophysiology of these conditions is still poorly understood, treatment with systemic anti-inflammatory agents is usually efficacious.Journal of the American Academy of Dermatology 01/2007; 55(6):1066-71. · 3.99 Impact Factor -
Article: Chronic recurrent lymphocytic Sweet syndrome as a predictive marker of myelodysplasia: a report of 9 cases.
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ABSTRACT: Sweet syndrome is an acute neutrophilic dermatosis that occurs with malignant diseases, mainly myeloid hemopathies, in about 20% of cases. When associated with myelodysplasia, Sweet syndrome may be clinically atypical. It can be histologically unusual. Concomitant infiltration of mature neutrophils and immature myeloid cells has been reported, and its significance is still debated. In few patients, lymphocytic infiltrates are the presenting feature of Sweet syndrome with myelodysplasia. We present 9 male adult patients with chronic Sweet syndrome, all with recurrent eruptions of erythematous and annular plaques that were associated with relapsing polychondritis in 4 of the 9 patients. Results from sequential biopsies showed that infiltrates were initially composed of lymphocytes and that neutrophilic dermal infiltration typical of Sweet syndrome occurred 24 to 96 months later, except in 2 cases. Moreover, atypical mononuclear cells were present on all initial biopsy specimens and strongly reacted to CD68 and myeloperoxidase, indicating a myeloid origin. Myelodysplastic syndrome occurred in all 9 patients, concomitantly with the neutrophilic infiltrate in 4 cases. Lymphocytic infiltrates with a clinical aspect of Sweet syndrome might represent the initial stage of a cutaneous dysgranulopoiesis syndrome and should lead to the research of atypical myeloid cells in skin infiltrate, blood, and bone marrow for the early detection of an associated myelodysplastic syndrome.Archives of Dermatology 10/2006; 142(9):1170-6. · 3.89 Impact Factor -
Article: The first images of atopic dermatitis: an attempt at retrospective diagnosis in dermatology.
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ABSTRACT: Atopic dermatitis was defined in 1933. Earlier descriptions have yet not been thoroughly studied. Our purpose was to identify the first images of atopic dermatitis among historical illustrations of skin diseases. We posted 20 selected images on an Internet site and asked experts in pediatric dermatology to decide whether or not they represented atopic dermatitis. By means of the Delphi technique, a consensus could be reached for 19 of the 20 images. The experts' accuracy was good. Thirty-one experts participated. No validated criteria were used for the selection of the images. The first representations of atopic dermatitis are engravings of skin diseases described under the names of strophulus confertus (Willan, 1796), lichen agrius (Willan, 1796), porrigo larvalis (Bateman, 1816), and eczema rubrum (Rayer, 1835). Teledermatology techniques can be reliably applied to retrospective diagnosis.Journal of the American Academy of Dermatology 11/2005; 53(4):684-9. · 3.99 Impact Factor -
Article: Neutrophilic panniculitis.
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ABSTRACT: Neutrophilic (lobular) panniculitis (NP) is a very rare condition that belongs to the group of neutrophilic dermatoses. We report the case of a patient with NP and review the relevant literature. NP appears as a subcutaneous nodular eruption. Histology shows a lobular neutrophilic infiltrate. NP must be differentiated from other types of panniculitis, and also from the subcutaneous septal involvement that may occur in some cases of Sweet's syndrome and from erythema nodosum. NP is significantly associated with myelodysplasia. It is highly sensitive to oral steroid therapy.Journal of the American Academy of Dermatology 03/2004; 50(2):280-5. · 3.99 Impact Factor -
Article: The field of cosmetic dermatology: the need for a patient-centred approach.
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ABSTRACT: Similar of knowledge and skills are required to deal with certain skin disorders and their corresponding cosmetic complaints. The field of cosmetic dermatology is growing as an overlap between the medical treatment of skin diseases and traditional cosmetology. This poses problems for dermatologists and other professionals, including regulation agencies. Dermatology should be able patients to benefit from all that is necessary for their care, whether that be surgery, drugs or cosmetics. There is no need to modify current regulations. A patient-orientated approach is advocated.Journal of Cosmetic Dermatology 11/2002; 1(3):137-41. · 0.98 Impact Factor -
Article: Diagnosis of common, benign neonatal dermatoses.
Clinics in Dermatology 21(4):264-8. · 2.33 Impact Factor -
Article: The historical basis of a misconception leading to undertreating atopic dermatitis (eczema): facts and controversies.
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ABSTRACT: The quest for clarifying the pathophysiology of atopic dermatitis (eczema) has lasted for 25 centuries. Yearning to discern the primum movens of atopic dermatitis, physicians aimed to identify the curative therapy. Recent scientific efforts has brought to the light an ever-growing amount of interplaying pathophysiologic factors, including the epidermal barrier, the digestive flora, food, early infections and antigenic stimulations, and innate and adaptive immune response; however, overfocusing on some of these factors, along with misconceptions about the benefit/risk balance of topical therapies, has sometimes led topical therapies being disregarded. Reviewing the history of pathophysiologic concepts, we aim to return topical therapies to the center of the clinical management of atopic dermatitis.Clinics in dermatology 28(1):45-51. · 3.11 Impact Factor -
Article: Infantile AcropustulosisA Clinicopathologic Study of Six Cases
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ABSTRACT: • Infantile acropustulosis is a syndrome characterized by recurrent crops of 1- to 2-mm pruritic vesiculopustules, which appear predominantly on distal extremities of infants. Nine biopsy specimens from six cases of infantile acropustulosis have been studied. We found that necrolysis of keratinocytes is the initial event leading to an inflammatory reaction and to an intraepidermal pustule, which progresses to a subcorneal pustule. These different histologic stages are correlated with clinical features. We found that the pustules may be filled with neutrophils or eosinophils, without particular significance. We have not found a correlation among blood eosinophilia, composition of cutaneous infiltrate, age of infant, and course of eruption.(Arch Dermatol 1986;122:1155-1160)Archives of Dermatology 122(10):1155-1160. · 3.89 Impact Factor
