E I Adamskaya

Russian Academy of Sciences, Moscow, Moscow, Russia

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Publications (19)3.67 Total impact

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    ABSTRACT: The role of endogenous luteinizing hormone-releasing hormone (LHRH) in the development of concanavalin A (ConA)-induced proliferative responses was studied in rat fetuses. Preliminary treatment of fetuses in utero with either the LHRH receptor antagonist or anti-LHRH antibodies resulted in the suppression of ConA-induced proliferative responses of thymocytes. LHRH and LHRH-immunopositive cells, morphologically similar to thymocytes, were detected in intact fetal thymus. A significant content of LHRH was also found in the peripheral blood of fetuses. The LHRH content in thymus and plasma was similar in males and females. Surgical ablation of the hypothalamus resulted in 2-fold decreases in thymus and plasma levels of LHRH in 21-day-old fetuses compared to sham-operated fetuses. It was concluded that LHRH regulates mitogen-induced proliferative responses of thymocytes during prenatal ontogenesis in the rat. The main source of plasma LHRH at that period is the hypothalamus. Moreover, LHRH is synthesized in the fetal thymus. Thus, LHRH is suggested to have not only a central effect but also to be involved in autocrine or paracrine regulation of proliferative immune responses.
    NeuroImmunoModulation 02/2005; 12(2):85-91. · 1.84 Impact Factor
  • Doklady Biological Sciences 01/2003; 389:111-3.
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    ABSTRACT: Role of sex hormones in the development of pituitary adenomas was investigated by analyzing the content of nuclear estradiol and testosterone receptors in different tumors of the anterior pituitary: prolactinomas, meningiomas, growth hormone-producing adenomas, astrocytomas, neurinomas, and ependymomas. The concentration of nuclear estrogen and androgen receptors in prolactin-secreting pituitary adenomas was much higher than in growth hormone-producing adenomas and other pituitary tumors.
    Bulletin of Experimental Biology and Medicine 05/2001; 131(4):309-11. · 0.34 Impact Factor
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    ABSTRACT: The effect of endogenous luteinizing hormone-releasing hormone (LHRH) on the proliferation induced by concanavalin A (Con A) in rat fetal thymocytes was studied. A selective antagonist (2 microg per fetus) or antibodies to LHRH (20 microl per fetus) were injected in utero into 20-day-old rat fetuses, and this resulted in a two- or fivefold decrease in the Con A-induced proliferation of thymocytes, respectively. In combined culture of the antagonist (10-5-10-6 M) with fetal thymocytes, the proliferative response was not decreased. The concentration of LHRH was determined by radioimmunoassay in tissues of immunocompetent organs and in blood serum of 18- and 21-day-old fetuses, and the hormone was found in the hypothalamus, thymus, and peripheral blood. The initially low level of LHRH in the thymus increased by 65 and 40%, respectively, on the first day after birth and became similar to the level in the hypothalamus. In the fetal blood serum, the LHRH level was significantly higher than in the thymus and hypothalamus of fetuses of the same age. The hormone concentration was greatest in the 18-day-old fetuses, and it decreased twofold by the 21st day. The findings indicate that LHRH is involved in regulation of T-cell immunity even during prenatal ontogenesis.
    Biochemistry (Moscow) 11/2000; 65(10):1135-9. · 1.15 Impact Factor
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    ABSTRACT: The stability of the function of the reproductive system depends on a multitude of factors of the internal and external milieux. Serious disturbances in its function, with alterations in carbohydrate homeostasis, underlie such diseases as diabetes mellitus. Disturbances to the functional activity of the reproductive system in laboratory animals with diabetes are known to be associated not only with destructive changes in the gonads, but also with dysfunction of the hypothalamo-hypophyseal complex [9, 11]. Published data show that these lesions have different severities in male and female individuals [7, 8]. The question of the extent to which lesions due to the diabetic state depend on the level of sex steroids and insulin in the body thus far remains unanswered. Unlike the situation in males, females are characterized by cyclic changes in the activity of the reproductive system. Thus, it is possible that differences in the regulation of gonadotropic function in male and female rats, observed in normal animals, could explain their different sensitivities to diabetes. Thus, we elected to carry out various studies of the functional activity of the hypothalamo-hypophyseal-gonadal system in male and female rats with experimental diabetes induced by administration of streptozotocin (STZ).
    Neuroscience and Behavioral Physiology 01/1998; 28(1):1-7.
  • V N Babichev, E I Adamskaya, T A Peryshkova
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    ABSTRACT: It is known that the disturbance in the functional activity of the reproductive system of the organism in diabetic laboratory animals is associated not only with destructive changes in the gonads, but with dysfunction of the hypothalamo-hypophyseal complex as well [11, 12]. It has been demonstrated that the decrease in the basal secretion of gonadotropins and sex hormones and the absence of its cyclical changes in female rats with experimental diabetes may be determined by disturbances in the central hypothalamic regulation of the reproductive system [6, 14]. The possibility of changes in the secretion of gonadotropins that are associated with a disturbance in the sensitivity of gonadotrops of the hypophysis to the action of luliberin (LH-RH) has not been excluded. Also, it is known from the literature that these disturbances are manifested to different degrees in male and female individuals [3]. The question as to the degree to which the disturbances arising in diabetes depend on the level of sex steroids and insulin in the organism remains controversial [4, 19]. Considering the fact that insulin may participate directly in the regulation of the function of the gonadotrops [2], we investigated under in vitro conditions its influence on the sensitivity of the hypophysis to LH-RH in a model of ovariectomized female rats with streptozotocin-induced diabetes which received estradiol as compensatory hormone therapy.
    Neuroscience and Behavioral Physiology 01/1995; 25(1):42-5.
  • V N Babichev, E I Adamskaya, T A Peryshkova
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    ABSTRACT: Investigations to assess the state of the reproductive system in female rats in experimental streptozotocin (STZ)-induced diabetes have been a logical continuation of studies we have carried out previously [4, 5] to analyze the interrelationship of disturbances of the reproductive system and sexual behavior in male rats in diabetes. It is known that by contrast with males, cyclical changes in the activity of the reproductive system are characteristic for females. Consequently, it is not excluded that the differences observed in the norm in the regulation of the gonadotropic function of the hypophysis in male and female rats may explain the fact that males are in the main more sensitive to the hyperglycemic action of STZ than females [13]. In addition, some data point to nonidentical changes in the organism of males and females in the presence of an insulin deficit [10]. Bestetti et al. [7] have concluded, on the basis of the results of morphological and physiological investigations, that changes in the hypophysis are less clearly manifested in the females than the males. The interpretation of the results obtained by various investigators when studying the reproductive system in diabetic females has been complicated by the presence of cyclical changes. The disturbances in cyclicity in the severe forms of diabetes may be caused by the numerous disturbances of the hypothalamohypophyseogonadal axis, which includes both CNS structures and the ovarian level. A comprehensive investigation was carried out in this study of the of the functional activity of the hypothalamo-hypophyseogonadal system in female rats with streptozotocin-induced diabetes. The concentration of nuclear receptors of the sex hormones in the adenohypophysis and regions of the hypothalamus which participate in the regulation of the secretion of the gonadotropins through the feedback mechanism was determined for this purpose. In addition, the sensitivity of the hypophysis to luliberin (LH-RH) in ovariectomized female rats with compensatory administration of estradiol (E2) and progesterone was determined to exclude a possible disturbance in the secretion of steroids at the ovarian level in diabetes.
    Neuroscience and Behavioral Physiology 01/1995; 25(1):46-51.
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    ABSTRACT: Luteinizing hormone-releasing hormone drops in the hypothalamus of male but not female rat fetuses in serotonin (5-HT) deficiency. This drop is coincident with an increase of the luteinizing hormone (LH) level in blood plasma of males. An influence of testosterone on LH-RH or LH secretion should be ruled out, because the level of testosterone is not changed in the testes and blood plasma.
    Bulletin of Experimental Biology and Medicine 05/1994; 117(6):619-621. · 0.34 Impact Factor
  • V N Babichev, T A Peryshkova, E I Adamskaya
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    ABSTRACT: Conclusions 1. The level of LH and FSH in the blood of male rats did not change during the development of experimental diabetes; the concentration of T decreased. 2. The sensitivity of the hypophysis to LH-RH in rats that have received STZ declined sharply when it was incubated for more than 1 h. 3. A decrease in the concentration of the nuclear T receptors in the adenohypophysis was observed during the development of experimental diabetes. 4. The alterations in the concentration of hormones in the blood and in the level of androgen receptors in the hypophysis of rats receiving STZ were restored through insulin replacement therapy.
    Neuroscience and Behavioral Physiology 03/1994; 24(2):159-62.
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    ABSTRACT: Sexual behavior is a constituent of the reproductive function of the organism. In sexually mature individuals the synchronization of the level of sexual activity with the reaction of the hypothalamo-hypophyseo-gonadal system to the relevant environmental stimuli is a necessary condition for the preservation of the species. In this context, the study of the neuroendocrine mechanisms shaping a specific level of activity of sexual behavior is an important problem for investigators. The dependence of the level of sexual activity on the integrity of certain CNS structures (first of all, the olfactory bulbs, amygdala, hypothalamus, and hypophysis) has been established. It has been demonstrated that label sex steroids accumulate selectively, and the regulation of the function of the gonads on the negative feedback principle is also accomplished in these regions precisely. In addition to the participation of the sex steroids in the formation of a specific level of sexual activity, an important role has been established at the present time for luliberin (LHRH) producing system and the neurotransmitters. The stability of the functioning of the reproductive system depends on a multiplicity of factors of the internal and external milieu. Serious disturbances in its function are associated with the alteration in carbohydrate homeostasis underlying a disease such as diabetes mellitus. This is manifested in a reduction in the weight of the accessory sex glands, steroidogenic activity and spermatogenesis, in a change in the secretion of gonadotropins, as well as in a diminution of fertility and sexual behavior.(ABSTRACT TRUNCATED AT 250 WORDS)
    Neuroscience and Behavioral Physiology 01/1993; 23(6):538-44.
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    ABSTRACT: Conclusions 1.The noradrenergic and serotoninergic innervation of the OB and the noradrenergic innervation of the POA participate in the interaction of these structures of the limbic system through the LHRH-synthesizing neurons.2.The secretion of LHRH from the nerve terminals of the OB and the POA is under the inhibitory influence of serotonin, and the secretion of the peptide from the nerve terminals of the MBH is activated by norepinephrine.3.LHRH exerts a varied influence on sexual behavior of the male rat when it is liberated in different structures of the limbic system: at the level of the OB the peptide influences the length of the post-ejaculatory refractory period, and at the level of the POA, it affects the latent interval of ejaculation.
    Neuroscience and Behavioral Physiology 01/1991; 21(4):330-4.
  • V N Babichev, T A Peryshkova, E I Adamskaya
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    ABSTRACT: Conclusions 1.The administration of a blocker of a-adrenoreceptors does not influence the blood content of LH and FSH in the early hours of the E stage.2.The administration of a blocker of DA (haloperidol) decreased, while a stimulator of the action (parlodel) increased the concentration of FSH in the blood at the 1 and 3 h stages of E without changes in the blood of LH.3.An interconnection between the decrease in the secretion of FSH and the level of nuclear E2 receptors in the adenohypophysis in the early hours of the E stage.
    Neuroscience and Behavioral Physiology 01/1991; 21(3):255-9.
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    ABSTRACT: We have studied the level of LH-RH in the synaptosomal fraction of the olfactory bulbs, preoptic area, and mediobasal hypothalamus, and the blood level of HL in adult male rats with sexual activity after noradrenergic denervation of the preoptic area using 6-oxydopamine. A neurotoxic effect of a 0.1% solution of ascorbic acid, preventing 6-oxydopamine disintegration was observed. Both sexual activity and level of LH-RH in synaptosomes of the preoptic area were reduced in male rats with noradrenergic denervation of the preoptic area. The maximum blood level of LH was observed during exposure to a recipient female rat, the LH-RH concentration in the synaptosomal fraction of the olfactory bulbs being raised, and that in the mediobasal hypothalamus being decreased. The results showed that LH-RH synthesizing cerebral neurons with terminals in the olfactory bulbs, preoptic area, and mediobasal hypothalamus are involved in the regulation of sexual behavior and the interaction of LH-RH-containing terminals with noradrenergic nerve endings at the level of the preoptic area.
    Neuroscience and Behavioral Physiology 01/1989; 19(3):212-6.
  • V N Babichev, N G Bukiya, E I Adamskaya
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    ABSTRACT: Conclusions 1.Administration of phentolamine (a-adrenoblocker) decreases the LH level in the blood of male rats. Administration against this background of mezatone (a-adrenostimulator) or apomorphine (DA stimulator) reverses the effect of phentolamine.2.On administration into the PA or ARC, NA stimulates the release of gonadotropins from the adenohypophysis, by acting on the neurons of the hypothalamus producing LH-RH. The steroiddependent effect of NA is expressed only at the level of the rostral hypothalamus.3.Administration of DA into the PA and ARC changes the concentration of LH-RH in the rostral and mediobasal sections of the hypothalamus, and increases the level of gonadotropins in the blood of intact males. However, the DA effect was steroid-dependent only at the level of the mediobasal hypothalamus.
    Neuroscience and Behavioral Physiology 11/1988; 18(6):522-5.
  • E I Adamskaya, V N Babichev
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    ABSTRACT: Conclusions 1.The amplitude of the circadian fluctuations of the level of NE, DA, and 5-HT in the hypothalamus of female rats depends on the phase of the estrous cycle: the most pronounced deviations from the circadian rhythm were observed in the preovulatory period in the anterior and mediobasal divisions of the hypothalamus.2.All three investigated monoamines participate in the regulation of cyclic LH secretion. The stimulatory effects of NE and the inhibitory effects of 5-HT at the level of the cyclic center of the hypothalamus in the control of the gonadotropic function of the pituitary are manifested in the presence of an increased content of estrogens in the circulating blood. At the level of the tonic center of the hypothalamus, the stimulating effect of DA is also estrogen-dependent.
    Neuroscience and Behavioral Physiology 01/1986; 16(2):146-51.
  • V N Babichev, E I Adamskaya
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    ABSTRACT: Injection of serotonin into the mediobasal hypothalamus inhibits LH secretion in phase P. An analogous effect with serotonin injection into the PO region is seen only in the initial period of this stage. Injection of serotonin into the PO region of OE rats does not alter blood concentration of LH, while injection into the mediobasal region results in a decrease in blood LH. Pretreatment of the OE animals with estradiol leads to a recovery of the inhibitory effects of serotonin injected into the rostral hypothalamus and blocks its effects on the release of LH when it is injected into the mediobasal hypothalamus.
    Neuroscience and Behavioral Physiology 03/1983; 13(2):130-4.
  • E I Adamskaya, V N Babichev
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    ABSTRACT: Conclusion 1.DA is involved in the control of the ovulatory release of LH and acts in the ARC-ME.2.The effects of DA on the gonadotropic function are determined by the levels of circulating estrogens in the blood. The maximum response is recorded in the second half of the diestrus-2 stage.
    Neuroscience and Behavioral Physiology 09/1982; 12(5):397-401.
  • E. I. Adamskaya, V. N. Babichev
    Bulletin of Experimental Biology and Medicine - BULL EXP BIOL MED-ENGL TR. 01/1981; 91(6):813-816.
  • V N Babichev, E I Adamskaya
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    ABSTRACT: Conclusions 1.The monoamine content in the various parts of the hypothalamus changes during the estrous cycle.2.In the course of the estrous cycle the DA concentration in the arcuate region reaches a maximum at 6 p.m. of stage D2 and falls to a minimum at 10 a.m. of stage P.3.The NA level in the preoptic region is raised at 6 p.m. of stage D2 and lowered at 10 a.m. of stage P.
    Neuroscience and Behavioral Physiology 07/1976; 7(3):206-11.

Publication Stats

35 Citations
3.67 Total Impact Points

Institutions

  • 2005
    • Russian Academy of Sciences
      • Institute of Developmental Biology
      Moscow, Moscow, Russia
  • 1976–2003
    • Russian Academy of Medical Sciences
      Moskva, Moscow, Russia