-
Zhi-Gong Wang, Xiaoying Lu,
Yang Xia,
Weyuan Li,
Zonghao Huang,
Yuxuan Zhou,
Xiaoyan Shen,
Xintai Zhao,
Jingdong Yang,
Suyang Wang,
Ming Ma,
Bilei Wang
[show abstract]
[hide abstract]
ABSTRACT: In this paper, we report our novel idea on the function rebuilding for hemiplegic limbs and the primary experiments. The main concept is to connect the control-lost nerves or neuromuscular junctions by using a multi-channel micro- electronic neural bridge (MENB), regenerate the nervous signal, and rebuild the motor functions of the related limb. Since the injured nervous system in stroke-related hemiplegia is located in the brain and difficult to be identified and operate on, we use another nervous system functioning as a new signal source to supply similar neural signals. In these cases, that means, two independent nervous systems are connected by a MENB. As preclinical experiments, we have made a series of tests on bodies of animals and healthy human. The principle, the system construction and the experimental results will be given.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 08/2012; 2012:843-6.
-
[show abstract]
[hide abstract]
ABSTRACT: The combination of the neural science and the microelectronics science offers a new way to restore the function of central nervous system. A neural regeneration module is used to be implanted into body to bridge the damaged nerve. A microelectronics neural bridge IC designed in CSMC 0.5□m CMOS process which can detect the neural signal and stimulate the nerve is presented. The neural regeneration module is composed of the microelectronics neural bridge IC and some discrete devices. An animal experiment has been done to check whether the neural signal can be transmitted with the chip normally or not. The animal experiment results suggest that the neural regeneration module can make the neural signal transmit normally.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 08/2012; 2012:823-6.
-
[show abstract]
[hide abstract]
ABSTRACT: The presence of neural signals is the most important feature of animals' life. Monitoring, analysis and regeneration of neural signals are important for the rehabilitation of paralyzed patients. In this paper, the neural signal regeneration between the proximal and the distal end of an injured nerve is introduced. In the experiment a microelectronic module is used as a channel bridge. The regeneration of nerve signals is realized from one toad's sciatic nerve to another's. Corresponding neural signals and EMG were recorded and analyzed. It will be a reference to further study on the neural signals and the relationship between a neural signal and the muscle locomotion.
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE; 10/2009
-
[show abstract]
[hide abstract]
ABSTRACT: A six-channel neural signal regeneration integrated circuit (IC) was designed and fabricated in CSMC's 0.5-mum CMOS technology. The circuit consists of a low-noise and high common mode rejection ratio (CMRR) instrument amplifier, an inverted operational amplifier (OPA) and a buffer. The six-channel IC occupies a die area of 1.9 mm x 1.6 mm. The testing result shows that the consumption of a single channel is less than 5 mW, and the output voltage swing reaches 5 V under plusmn 2.5 V power supply, the gain can be adjusted from 60 dB to 110 dB. The circuit has been used for in-vivo experiments on toad's nerve with electrodes to regenerate neural signals. Different neural signals have been successfully regenerated on toad's nerve and corresponding actions have been observed.
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE; 10/2009
-
[show abstract]
[hide abstract]
ABSTRACT: Find an optimal function model of spikes of high signal-to-noise ratio (SNR) spontaneous signals in the spinal cord of a rat, and use it to recognize the patterns of spikes of low SNR signals in the sciatic nerve of the rat. Method: Firstly, several function models of spikes of high SNR spontaneous signals in the spinal cord of a rat are calculated under the rule of least square. By choosing an optimal function model based on minimum standard deviation (SD) of error of fitting, it is contrasted with the waveform of classical action potential (AP). Then, this model is used as a pattern to recognize spikes of low SNR signals in the sciatic nerve of the rat. Result: The optimal function model of spikes of high SNR spontaneous signals in the spinal cord of a rat is a proportional model whose numerator is a 5-order polynomial while the denominator is a 4-order polynomial. The waveform of a typical AP can be obtained from this model. It can also achieve good performance by recognizing the pattern of spikes of signals whose SNR is lower than 8 dB in sciatic nerve of the rat.
Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE; 10/2009
-
[show abstract]
[hide abstract]
ABSTRACT: A six-channel neural signal regeneration integrated circuit (IC) was designed and fabricated in CSMC's 0.5-microm CMOS technology. The circuit consists of a low-noise and high common mode rejection ratio (CMRR) instrument amplifier, an inverted operational amplifier (OPA) and a buffer. The six-channel IC occupies a die area of 1.9mmx1.6mm. The testing result shows that the consumption of a single channel is less than 5 mW, and the output voltage swing reaches 5 V under +/-2.5V power supply, the gain can be adjusted from 60dB to 110dB. The circuit has been used for in-vivo experiments on toad's nerve with electrodes to regenerate neural signals. Different neural signals have been successfully regenerated on toad's nerve and corresponding actions have been observed.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 01/2009; 2009:1627-30.
-
[show abstract]
[hide abstract]
ABSTRACT: Find an optimal function model of spikes of high signal-to-noise ratio (SNR) spontaneous signals in the spinal cord of a rat, and use it to recognize the patterns of spikes of low SNR signals in the sciatic nerve of the rat. Method: Firstly, several function models of spikes of high SNR spontaneous signals in the spinal cord of a rat are calculated under the rule of least square. By choosing an optimal function model based on minimum standard deviation (SD) of error of fitting, it is contrasted with the waveform of classical action potential (AP). Then, this model is used as a pattern to recognize spikes of low SNR signals in the sciatic nerve of the rat. Result: The optimal function model of spikes of high SNR spontaneous signals in the spinal cord of a rat is a proportional model whose numerator is a 5-order polynomial while the denominator is a 4-order polynomial. The waveform of a typical AP can be obtained from this model. It can also achieve good performance by recognizing the pattern of spikes of signals whose SNR is lower than 8 dB in sciatic nerve of the rat.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 01/2009; 2009:1537-40.
-
[show abstract]
[hide abstract]
ABSTRACT: The presence of neural signals is the most important feature of animals' life. Monitoring, analysis and regeneration of neural signals are important for the rehabilitation of paralyzed patients. In this paper, the neural signal regeneration between the proximal and the distal end of an injured nerve is introduced. In the experiment a microelectronic module is used as a channel bridge. The regeneration of nerve signals is realized from one toad's sciatic nerve to another's. Corresponding neural signals and EMG were recorded and analyzed. It will be a reference to further study on the neural signals and the relationship between a neural signal and the muscle locomotion.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 01/2009; 2009:5953-6.
-
[show abstract]
[hide abstract]
ABSTRACT: This paper presents a fully integrated and low power CMOS amplifier for neural signal recording. It consists of a band-filtering preamp and a current-mode instrumentation amplifier. The design approach and the noise optimization are briefly discussed. A 0.6 mum CMOS technology is used for the design of the amplifier IC. The simulation shows that it has a pass band from 59 Hz to 12.8 kHz and a mid-band gain of 80 dB. The supply voltage is plusmn1.25V and the power consumption is 180 muW
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the; 02/2006
-
[show abstract]
[hide abstract]
ABSTRACT: This paper presents a fully integrated and low power CMOS amplifier for neural signal recording. It consists of a band-filtering preamp and a current-mode instrumentation amplifier. The design approach and the noise optimizing are briefly discussed. A 0.6 μm CMOS technology is used for the design of the amplifier IC. The simulation shows that it has a pass band from 59Hz to 12.8 kHz and a mid-band gain of 80 dB. The supply voltage is ±1.25V and the power consumption is 180µW.
Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 01/2005; 5:5250-3.
