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Central European neurosurgery 11/2011; 72(4):215-8. · 0.84 Impact Factor
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Y Levet,
J Eichhorn-Sens,
W Gubisch,
N Antohi,
V Stan,
S Tatulescu,
I De Benito,
L Nelson,
K Stewart,
Y Ullmann, [......],
A Cardoso,
G Coelho,
H Costa,
G Smirnov,
H Zenha,
I Szemerey,
J Fedeles,
D Palencar,
P Ziak,
Norbert Pallua
Aesthetic Plastic Surgery 08/2010; · 1.41 Impact Factor
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Aesthetic Plastic Surgery 06/2008; 32(3):571-2. · 1.41 Impact Factor
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ABSTRACT: Poor neovascularization in free-flap transfers is considered to be a consequence of insufficient hypoxic stimulus in a transferred flap with good axial-pattern circulation and a short warm ischemia time. The purpose of the study was to investigate the effect of warm ischemia time on neovascularization of axial-pattern flaps. Oblique adipomusculocutaneous groin island flaps based on the superficial epigastric vessels were raised on the right side of 21 Wistar rats, evaluated in three groups. In Group 1 (n=7), flaps were resutured without creating ischemia; in Groups 2 (n=7) and 3 (n=7), flaps were resutured after 90-min and 180-min warm ischemic periods, respectively. At 5 days postoperatively, an intravenous fluorescein test was performed following pedicle ligation, and survival was assessed by planimetric technique 7 days after pedicle ligation. Histopathologic scoring was performed according to capillary formation, inflammation, and necrosis. The intravenous fluorescein test revealed significantly higher uptake in the group with the longest ischemic period, while the mean surviving area was greater in the groups with ischemic insult, comparing to the non-ischemic group. Similarly, histopathologic scoring showed significantly higher values in the ischemic groups. The authors demonstrated that neovascularization was enhanced after 90- and 180-min warm ischemia times. The authors concluded that short ischemia time in free flaps may be an attributable factor in late flap failures, due to pedicle obstruction.
Journal of Reconstructive Microsurgery 12/2001; 17(8):643-9; discussion 650-1. · 1.43 Impact Factor
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Annals of Plastic Surgery 10/2001; 47(3):354-5. · 1.32 Impact Factor
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ABSTRACT: In vivo preservation of tissues may exist as a problem in experimental and clinical research. Adipose tissue, nerves, and vessels are the tissues that are usually preserved in vivo for future use or for the evaluation of results in experimental research. Limited volume and difficult conditions in such areas in animal models usually create disappointing results, because of the difficulty in distinguishing the experimental from the surrounding tissues; the insufficiency of the volume of space; and the lack of compliance in animals. A new rat model for in vivo preservation studies is described. A muscular pocket designed between the external and internal oblique muscles is a good choice as an animal model for tissue preservation in plastic surgery research.
Journal of Reconstructive Microsurgery 09/2001; 17(6):439-43. · 1.43 Impact Factor
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ABSTRACT: Although, one out of every eight women has a risk of developing breast cancer, the reported incidence of breast carcinoma detection in reduction mammaplasty materials is rather low. To our knowledge, specimen radiography, which is used for breast biopsies has not been used for the assessment of breast reduction materials. We investigated the applicability of specimen radiography and its potential benefits in detection of the breast pathologies, especially malignancies in reduction mammaplasty materials. Forty patients scheduled for reduction mammaplasty operation were included. In all cases an inferior pedicle reduction technique was preferred and the radiographs of the resected breast tissues were taken immediately. The radiographs were evaluated for any possible pathologic appearance and all abnormal findings were marked. For the histopathologic evaluation, in addition to the random sampling of the pathologist, any marked areas were also microscopically examined. In two cases fibrocystic changes were found in radiographs and the same results were obtained in the histological examination. No false negative mammogram was seen. Specimen radiography, which is applicable for breast reduction materials is an easy and cheap method and does not cause any patient discomfort. It seems that the radiographs of reduction mammaplasty materials are useful to provide guidance to the pathologist during tissue sampling for microscopic examination especially when large amounts of breast tissue is excised.
Aesthetic Plastic Surgery 01/2001; 25(6):432-5. · 1.41 Impact Factor
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Annals of Plastic Surgery 07/2000; 44(6):682-3. · 1.32 Impact Factor
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ABSTRACT: Autologous nerve grafting is the conventional technique for bridging nerve gaps, despite its various disadvantages. In this study, the authors investigated the effects of the turnover epineurial sheath tube (TEST) as an alternative to nerve grafting for the repair of nerve gaps, using a rat sciatic nerve model in four groups: Group 1 (n = 5): sham control; Group 2 (n = 10): segmental nerve resection + no repair; Group 3 (n = 10): segmental nerve resection + nerve grafting; Group 4 (n = 15): segmental nerve resection + TEST. Functional recovery was evaluated by walking-track analysis. The sciatic nerves and gastrocnemius muscles were harvested for histologic and quantitative histomorphometric evaluation at 12 weeks. Sciatic functional indices and histomorphometric analyses revealed statistically significant differences between the sham control and the three experimental groups (p < 0.001). The difference between the TEST group and the nerve graft group was not significant; however functional recovery was significantly improved in these two groups, compared to the non-repaired group (p < 0.05). The authors suggest that the TEST provides a suitable conduit between two stumps, eliminates donor-site morbidity, reduces the number of suture sites, fibrosis, and operating time, and might be an alternative to nerve grafting for nerve gap repair.
Journal of Reconstructive Microsurgery 07/2000; 16(5):371-8. · 1.43 Impact Factor
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ABSTRACT: The diagnosis of condyloma acuminatum generally relies on the presence of characteristic clinical features. However, atypical
cases can cause diagnostic problems. With the development of the molecular biological techniques, the disease can be readily
diagnosed. A case of atypical condyloma acuminatum in a 25-year-old male is reported, he presented with midpenile hypospadias
and a mass extending from the scrotum to the corona through the chordee deformity. The clinical diagnosis was condyloma acuminatum.
A tissue specimen was obtained for histopathological analysis and in-situ hybridization assay for human papilloma virus. Histopathological
analysis showed papilloma. The immunohistochemical assay was negative for human papilloma virus. However, in-situ hybridization
for human papilloma virus was strongly positive. Condyloma acuminatum should be suspected in hypospadias patients with atypical
papillomatous lesions on the chordee deformity. In-situ hybridization is extremely useful in establishing the diagnosis. Since
condyloma acuminatum is the cause of viral contamination and malignant transformation, it is worth considering histopathological
examination and molecular biological techniques to protect both the patient and the sexual partner.
European Journal of Plastic Surgery 07/1999; 22(5):279-281.
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Plastic & Reconstructive Surgery 04/1999; 103(3):1076-8. · 3.38 Impact Factor
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ABSTRACT: Lymphangioma circumscriptum of the penis and scrotum is an unusual entity that may be indistinguishable from genital warts. After confirmation of the diagnosis, a treatment plan consisting of wide excision should be outlined. To lower the chance of recurrence, not only the affected skin but all the subjacent subcutaneous tissue, including the deeper components of the lymphatic malformation just above the deep fascia, should be removed.
Plastic & Reconstructive Surgery 02/1999; 103(1):175-8. · 3.38 Impact Factor
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ABSTRACT: Four patients with temporomandibular joint ankylosis, three bilateral, one unilateral, were treated successfully by using
the technique of silicone cap arthroplasty. Among these patients two were recurrent cases. Mean maximum incisal opening distance
was 6.0 mm preoperatively and 24.7 mm postoperatively. In the follow-up period ranging between 19 months and 5 years, all
of the patients had satisfactory mouth opening for chewing and speaking without any reankylosis. We believe that the silicone
cap provides a satisfactory range of motion and prevents cortical callus formation across the cap by wrapping around the mandibular
stump, this reduces the risk of reankylosis. The simplicity and the short duration of the operation as well as the nonexistence
of an additional scar are other reasons for preferring this method. Furthermore, the silicone cap arthroplasty technique has
the advantage of controlling the amount of bone removal thus decreasing the risk of the development of a short ramus.
European Journal of Plastic Surgery 01/1999; 22(1):46-48.
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ABSTRACT: The combination of chemical peeling and dermabrasion for the improvement of facial wrinkles, acne, posttraumatic scars, and abnormal pigmentation was first described by Dupont in 1972 and Horton in 1984. We have been using the combined technique since 1972, and we have obtained more satisfying results than by using these techniques independently. The purpose of this paper is to summarize the results obtained using the combined technique of chemical peeling and dermabrasion and to emphasize a simple method of postoperative care that can be applied after any physical or chemical rejuvenation technique. Whereas the combined technique takes advantage of depth-controlled surgery, less bleeding, less postoperative pain, less risk of local and systemic complications, and longer lasting results, the covering of the wound with one layer of fine mesh gauze is another advantage that provides easy postoperative care.
Plastic & Reconstructive Surgery 10/1998; 102(4):1238-46. · 3.38 Impact Factor
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ABSTRACT: It has been proposed that selenium (Se) and Vitamin E (Vit E) are involved synergistically in protection of cell membrane lipids from peroxidation. However, little is known about the effect of both deficiencies of Se and Vit E and toxic status of those antioxidants on the peroxidation potentiality of the brain. We aimed to study the effects of both Se and Vit E inadequate diet and Se rich diet on the learning and memory processes of third-generation young rats. Their ancestors were also fed by the same diets starting from their births. To test the learning and memory, the rats aged 60 days were trained by using automated two ways active avoidance shuttle box. The acquisition tests were terminated with training the rat from each group to be 25 trials per day during three days. Ten days after the last acquisition test, the retention test was performed and the acquisition of the conditioned avoidance responses (CAR) of the rats were evaluated. It is demonstrated that the CAR of all rats from three groups showed a significant increase in three consecutive days while the differences observed in CAR of same sessions was not significantly different among three groups. The memory process of these young rats also was not affected significantly by two types of diets. Under the light of our results one can suggest that, in the case of alterations in antioxidant defense status, the learning and the memory mechanisms seems to be not affected. Further researches are needed to be able to explain the possible role of oxidative stress on the mechanisms of learning and memory.
Biological Trace Element Research 02/1998; 64(1-3):151-60. · 1.92 Impact Factor
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ABSTRACT: Neuronal supply in soft tissues may be an important part of cutaneous wound healing. In order to observe the effect of denervation on wound contraction, rectangular full-thickness skin defects were created on the dorsum of two groups of Wistar rats. In the experimental group (n = 20), spinal nerves corresponding to the area of the open wound (T11 to L2) were isolated and divided bilaterally. In the control group (n = 20), the same pairs of spinal nerves were dissected but left intact. Limits of denervation were verified by the pinprick test. Wound healing, which is primarily in the form of wound contraction in this model, was evaluated by tracing wound margins onto millimetric paper weekly. Wound contraction was delayed significantly in the experimental group (p < 0.05) at all follow-up periods when compared with the controls. Loss of neuropeptide secretion from the nerve endings in denervated tissues may be responsible for the retarded wound contraction, since neuropeptides are thought to exert trophic effects on skin wound healing.
Plastic & Reconstructive Surgery 12/1996; 98(6):1063-7. · 3.38 Impact Factor
