Hye Sung Kim

Seoul National University Hospital, Sŏul, Seoul, South Korea

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Publications (42)92.06 Total impact

  • Hye Sung Kim, Hyuk Sang Yoo
    Journal of controlled release : official journal of the Controlled Release Society. 09/2014; 190:64-6.
  • Hye Sung Kim, Hyuk Sang Yoo
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    ABSTRACT: Fabricating tissue architecture-mimicking scaffolds is one of the major challenges in the field of tissue engineering. Electrospun nanofibers have been considered as potent techniques for fabricating fibrous scaffolds biomimicking extracellular frameworks. Therapeutic agent-incorporated nanofibrous meshes have widely served as excellent substrates for adhesion, proliferation and differentiation. Many drugs, proteins and nucleic acids were incorporated into the scaffolds for regeneration of skin, musculoskeletal, neural and vascular tissue engineering in aims to control the release of the therapeutic agents. In the current article, we focus on introducing various fabrication techniques for electrospun nanofiber-based scaffolds and subsequent functionalization of nanofibers for therapeutic purposes. We also detail how the therapeutic nanofibrous meshes can be employed in the field of tissue engineering.
    Nanomedicine 04/2014; 9(4):517-533. · 5.26 Impact Factor
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    ABSTRACT: Background Idiopathic interstitial pneumonia (IIP) is characterized by chronic interstitial inflammation and fibrosis. Although mounting evidence has suggested that toll-like receptor (TLR) 2 and TLR4 are involved in the pathogenesis of non-infectious lung injury in vitro and in mouse models, their roles in human IIP remain unknown. Methods To address this issue, we investigated the expression patterns of TLR2 and TLR4 by immunohistochemistry in resected lung tissues from patients with usual interstitial pneumonia (UIP) or nonspecific interstitial pneumonia (NSIP). Results Type II pneumocytes, bronchial epithelial cells (BECs), and alveolar macrophages accounted for the majority of TLR2- and TLR4-expressing cells in both UIP and NSIP. The numbers of TLR2 and TLR4-positive respiratory epithelial (RE) cells, including type II pneumocytes and BECs, were significantly greater in UIP and NSIP than in the control. In particular, the numbers of TLR2-positive RE cells were much greater in UIP than in NSIP. The intensities of TLR2 and TLR4 expression in type II pneumocytes were also significantly stronger in UIP and NSIP than in the control. A comparison of the TLR expression patterns between the fibroblastic and fibrotic areas in UIP indicated that the numbers TLR2 and TLR4-positive RE cells were similar in fibroblastic areas, whereas the TLR2-positive RE cells outnumbered the TLR4-positive RE cells in the fibrotic areas. Conclusions This study demonstrates that RE cells over-express TLR2 and TLR4 in the lungs of IIP patients. These findings suggest that high expression of TLRs may contribute to the pathogenesis of human IIP.
    Respiratory medicine 01/2014; · 2.33 Impact Factor
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    The Journal of Dermatology 12/2013; · 2.35 Impact Factor
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    ABSTRACT: Breast cancer anti-estrogen resistance 3 (BCAR3) is an SH2-containing signal transducer and is implicated in tumorigenesis of breast cancer cells. In this study, we found that BCAR3 mediates the induction of ERK activation and DNA synthesis by insulin, but not by IGF-1. Specifically, the SH2 domain of BCAR3 is involved in insulin-stimulated DNA synthesis. Differential tyrosine-phosphorylated patterns of the BCAR3 immune complex were detected in insulin and IGF-1 signaling, suggesting that BCAR3 is a distinct target molecule of insulin and IGF-1 signaling. Moreover, microinjection of BCAR3 inhibitory materials inhibited membrane ruffling induced by insulin, while this did not affect insulin-mediated GLUT4 translocation. Taken together, these results demonstrated that BCAR3 plays an important role in the signaling pathways of insulin leading to cell cycle progression and cytoskeleton reorganization, but not GLUT4 translocation.
    Biochemical and Biophysical Research Communications 11/2013; · 2.28 Impact Factor
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    ABSTRACT: We investigated the electrical conductivity (sigma) and mechanical property of polyvinylchloride/carbon nanotube composites as a function of the CNT content and processing time during a solid-state process of high speed vibration mixing (HSVM) and high energy ball milling (HEBM). Both processes were suggested to avoid high temperatures, solvents, chemical modification of carbon nanotubes. In this study, the percolation threshold (phi(c)) for electrical conduction is about 1 wt% CNT with a sigma value of 0.21 S/m, and the electrical conductivity is higher value than that reported by other researchers from melt mixing process or obtained from the other solid-state processes. We found that the dispersion of CNTs and morphology change from CNT breaking are closely related to sigma. Especially, a large morphology change in the CNTs was occurred at the specific processing time, and a significant decrease in the electrical conductivity of polyvinylchloride/carbon nanotube composite occurred in this condition. A meaningful increase of electrical properties and mechanical property is observed in the sample with about 1-2 wt% CNT contents sintered at 200 degrees C after the milling for 20 min by HEBM process. Our study indicates the proper process condition required to improve sigma of PVC/CNT composites.
    Journal of Nanoscience and Nanotechnology 11/2013; 13(11):7723-7. · 1.15 Impact Factor
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    ABSTRACT: Cheonggukjang (CKJ), a fermented soybean product, has been reported to have beneficial effects on various chronic diseases, including cardiovascular disease, cancer and immune diseases. To investigate whether CKJ induces growth sensitivity in mammals, alterations of key parameters related to their growth were analyzed. Sprague‑Dawley (SD) rats were treated with a high concentration of CKJ (H‑CKJ) or a low concentration of CKJ (L‑CKJ) for 10 days, and compared with vehicle-treated rats. The CKJ contained a high concentration of total flavonoids, phenolic compounds, daidzein and genistein, compared with the non-fermented soybean product. Body weight was higher in the H‑CKJ‑treated group compared with that in the vehicle‑ and L‑CKJ‑treated groups, whereas the weights of three organs (the brain, liver and kidney) were higher in the L‑CKJ‑treated group compared with the remaining two groups. However, no significant differences in femur length and weight were detected between the CKJ‑ and vehicle‑treated groups. The thickness of the epiphyseal growth plate in proximal femoral epiphysis was broadest in the H‑CKJ‑treated group compared with the vehicle- and L‑CKJ‑treated groups. Furthermore, the level of growth hormone (GH) was highest in the serum of the L‑CKJ‑treated group, although that of the H‑CKJ‑treated group was lower compared with that in the L‑CKJ group. Moreover, the expression levels of the GH receptor increased in the liver tissue, but not in the muscle tissue, of the L‑CKJ‑ and H‑CKJ‑treated groups. In the downstream signaling pathway of the GH receptor, the phosphorylation levels of Akt and Erk were differentially regulated between the liver and muscle. These results suggest that CKJ extract may enhance the sensitivity of the femur, liver and muscle epiphyseal growth plate in SD rats, through the upregulation of GH secretion.
    Molecular Medicine Reports 10/2013; · 1.17 Impact Factor
  • International journal of dermatology 04/2013; · 1.18 Impact Factor
  • Hye Sung Kim, Hyuk Sang Yoo
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    ABSTRACT: Human epidermal growth factor (hEGF) gene therapy was achieved with an electrospun nanofibrous mesh with matrix metalloproteinases (MMPs)-responsiveness to control release of plasmid human epidermal growth factor (phEGF) in diabetic ulcers. For MMPs-responsiveness, linear poly (ethyleneimine) (LPEI) was immobilized on the surface of the nanofiber via a MMPs-cleavable linker. phEGF was electrostatically incorporated to LPEI-immobilized nanofibrous meshes with various charge ratios and phEGF incorporation efficiency was increased with increasing charge ratios. The release of phEGF and LPEI were significantly increased in the presence of MMP-2 due to the enzymatic digestion of MMP-cleavable linkage between the matrix and LPEI. Human dermal fibroblasts with the released fraction showed the highest expression level of human EGF compared to naked phEGF or phEGF/LPEI complexes. Diabetic wounds treated with phEGF-incorporated nanofibrous meshes showed high hEGF expression level and accelerated wound recovery rates without wound contractions for 14 days. Neo-collagen and cytokerain accumulation were significantly increased as well as the expression of the keratinocyte-specific markers at the re-epithelized tissue treated with phEGF NF, which clearly indicates that EGF gene was transfected to dermal cells and this consequently assisted wound recovery without phenotypic changes of the re-epithelized tissues. Thus, phEGF-incorporated nanofibrous mesh is expected to accelerate wound healing process as well as reduce wound contraction during recovery of diabetic ulcers.
    Acta biomaterialia 03/2013; · 5.68 Impact Factor
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    ABSTRACT: An eccrine poroma is a benign neoplasm that originates from the intraepidermal ductal portion of the eccrine sweat duct. Although eccrine poromas are most commonly found on the sole or side of the foot, eccrine poromas have been observed on other areas of the skin, such as the scalp, neck, and chest. We report an interesting case of an eccrine poroma, which presented as a 1×1 cm protruding dome-shaped, skin-colored-to-black nodule on the right postauricular area. The patient denied a previous history of trauma to this area. The histopathologic diagnosis was consistent with an eccrine poroma. There has been no local recurrence 5 months after complete excision.
    Annals of Dermatology 02/2013; 25(1):92-4. · 0.61 Impact Factor
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    ABSTRACT: This study was carried out to investigate the residual characteristics and calculate processing factor of the environment friendly material matrine in fresh chilli pepper by drying. Spray solution of matrine was prepared by dilution of the commercial product (2% active ingredient) with water at 1 : 1000 (v/v) ratio and sprayed onto chilli pepper plants at seven day intervals. Samples were collected at 0, 1, 3, 5 and 7 days after last application and then dried using a hot air dry oven at for 36 hours until the water content was reduced to 14%. Recoveries and storage period stabilities of matrine in the samples ranged from 106.6 to 119.1% and 106.6 to 113.1%, respectively. The residual concentrations of matrine in fresh chilli pepper and dried chilli peppers treated only once were found to be from less than 0.01 to 0.11 and from 0.03 to 0.25 mg/kg, respectively. In case of plants sprayed twice with matrine, the residual concentrations ranged from 0.02 to 0.12 and from 0.04 to 0.4 mg/kg, respectively. Processing factor of matrine in the fresh chilli pepper by drying was found to be from 1.5 to 3.3, indicating that the residual concentration of matrine in dried chilli pepper increased about two or three times by drying.
    The Korean Journal of Pesticide Science. 01/2013; 17(4).
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    Byung Ju Song, Ka Ram Kim, Hye Sung Kim
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    ABSTRACT: Microstructural and mechanical properties of Ni-YSZ fabricated using SPS processing have been investigated at various sintering temperatures. Our study shows samples to be applied as a SOFC anode have the proper porosity of 40% and high hardness when processed at . These results are comparable to the values obtained at higher sintering temperature reported by others. This result is important because when the fabrication processes are performed above , the mechanical property starts to decrease drastically. This is caused by the fast grain coarsening at the higher temperature, which initiates a mismatch between thermal expansion coefficients of Ni and YSZ and induces cracks as well.
    Journal of Korean Powder Metallurgy Institute. 01/2013; 20(6).
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    Hye Sung Kim, Doo Hyun Chung
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    ABSTRACT: INTRODUCTION: TLR4 promotes joint inflammation in mice. Despite that several studies report a functional link between TLR4 and IL-1in arthritis, TLR4-mediated regulation of the complicated cytokine network in arthritis is poorly understood. To address this, we investigated the mechanisms by which TLR4 regulates the cytokine network in antibody-induced arthritis. METHODS: To induce arthritis, we injected mice with K/BxN serum. TLR4-mediated pathogenesis in antibody-induced arthritis was explored by measuring joint inflammation, cytokine levels, and histological alteration. RESULTS: Compared to WT mice, TLR4-/- mice showed attenuated arthritis and low IFN-gamma, IL-12p35, and IL-1beta transcript levels in the joints, but high TGF- expression. Injection of LPS enhanced arthritis and exaggerated joint cytokine alterations in WT, but not TLR4-/- or IL-12p35-/- mice. Moreover, STAT4 phosphorylation in joint cells and intracellular IL-12p35 expression in macrophages, mast cells, and Gr-1+ cells were detected in WT mice with arthritis and enhanced by LPS injection. Therefore, IL-12p35 appears to act downstream of TLR4 in antibody-induced arthritis. TLR4-mediated IL-12 production enhanced IFN-gamma and IL-1beta production via T-bet and pro-IL-1 production. Recombinant IL-12, IFN-, and IL-1administration restored arthritis, but reduced joint TGF- levels in TLR4-/- mice. Moreover, a TGF-blockade restored arthritis in TLR4-/- mice. Adoptive transfer of TLR4-deficient macrophages and mast cells minimally altered joint inflammation and cytokine levels in macrophage- and mast cell-depleted WT mice, respectively, whereas transfer of WT macrophages or mast cells restored joint inflammation and cytokine expression. Gr-1+ cell-depleted splenocytes partially restored arthritis in TLR4-/- mice. CONCLUSION: TLR4-mediated IL-12 production by joint macrophages, mast cells, and Gr-1+ cells enhances IFN-gamma and IL-1beta production, which suppresses TGF-beta production, thereby promotes antibody-induced arthritis.
    Arthritis research & therapy 10/2012; 14(5):R210. · 4.27 Impact Factor
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    ABSTRACT: Doxorubicin was physically incorporated in magnetic nanoparticles by thermo-responsive manners. Magnetic nanoparticles were prepared by oxidizing ferric ions in ammonium solution. Thiolated Pluronic was synthesized by sequential modification of terminal hydroxyl groups of Pluronic to amine groups and thiol groups. Magnetic nanoparticles composed of iron oxide were surface-modified with thiolated Pluronic at different molar ratios of iron to thiol groups. Pluronic decoration on the magnetic nanoparticles was characterized by elemental analysis and transmission electron microscopy. Elemental analysis results on carbon atoms in the magnetic nanoparticles showed that the degree of Pluronic decoration was proportional to the feed ratio of thiolated Pluronic to iron oxide. Doxorubicin was incorporated to the magnetic nanoparticles thermo-responsive manners; a mixture of hydrophobized doxorubicin and the magnetic nanoparticles was incubated at 4°C and the temperature was subsequently increased to 37°C for thermally induced structural changes of the decorated Pluronic moieties. Doxorubicin-incorporated magnetic nanoparticles showed dramatic modulations of size distributions according to temperature changes, which was dependent on the degree of Pluronic decoration. Loading efficiency of doxorubicin was significantly affected by the number of decorated Pluronic on the magnetic nanoparticles; the higher Pluronic moieties the nanoparticles had, the higher loading efficiency they showed. Release profiles of doxorubicin from the nanoparticles showed that doxorubicin was liberated from the nanoparticles in response to reducing conditions of the release medium. Anti-cancer activities of the doxorubicin-incorporated nanoparticles were determined by a MTT-based cytotoxicity assay against A549 cell lines. Compared to native doxorubicin, the doxorubicin incorporated magnetites showed attenuated cytotoxicities due to slow release of doxorubicin from the carriers. Thus, thermally induced incorporation of anti-cancer drugs can be a novel method for multifunctional magnetic nanoparticles with imaging and anti-cancer treatments.
    International Journal of Pharmaceutics 03/2012; 424(1-2):107-14. · 3.99 Impact Factor
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    ABSTRACT: During interaction with APCs, invariant (i) NKT cells are thought to be indirectly activated by TLR4-dependently activated APCs. However, whether TLR4 directly activates iNKT cells is unknown. Therefore, the expression and function of TLR4 in iNKT cells were investigated. Flow cytometric and confocal microscopic analysis revealed TLR4 expression on the surface and in the endosome of iNKT cells. Upon LPS stimulation, iNKT cells enhanced IFN-γ production, but reduced IL-4 production, in the presence of TCR signals, depending on TLR4, MyD88, TRIF, and the endosome. However, enhanced TLR4-mediated IFN-γ production by iNKT cells did not affect IL-12 production or CD1d expression by DCs. Adoptive transfer of WT, but not TLR4-deficient, iNKT cells promoted antibody-induced arthritis in CD1d(-/-) mice, suggesting that endogenous TLR4 ligands modulate iNKT cell function in arthritis. Furthermore, LPS-pretreated WT, but not TLR4-deficient, iNKT cells suppressed pulmonary fibrosis, but worsened hypersensitivity pneumonitis more than untreated WT iNKT cells, indicating that exogenous TLR4 ligands regulate iNKT cell functions in pulmonary diseases. Taken together, we propose a novel direct activation pathway of iNKT cells in the presence of TCR signals via endogenous or exogenous ligand-mediated engagement of TLR4 in iNKT cells, which regulates immune diseases by altering IFN-γ and IL-4 production.
    PLoS ONE 01/2012; 7(9):e45348. · 3.53 Impact Factor
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    ABSTRACT: Multi-walled carbon nanotubes were synthesized on a Ni/Au/Ti substrate using a thermal chemical vapor deposition process. A Ni layer was used as a catalyst, and an Au layer was applied as a barrier in order to prevent diffusion between Ni and Ti within the substrate during the growth of carbon nanotubes. The results showed that vertically aligned multi-walled carbon nanotubes could be uniformly grown on the Ti substrate (i.e., metal substrate), thus indicating that the Au buffer layer effectively prevented interdiffusion of the catalyst and metal substrate. Synthesized carbon nanotubes on the Ti substrate have the diameter of about 80 to 120 nm and the length of about 5 to 10 μm. The Ti substrate, with carbon nanotubes, was prepared as an electrode for a lithium rechargeable battery, and its electrochemical properties were investigated. In a Li/CNT cell with carbon nanotubes on a 60-nm Au buffer layer, the first discharge capacity and discharge capacity after the 50th cycle were 210 and 80 μAh/cm2, respectively.
    Nanoscale Research Letters 01/2012; 7(1):61. · 2.52 Impact Factor
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    ABSTRACT: The pure titanium sheets with ultrafine grained (UFG) microstructures were produced by high-ratio differential speed rolling (HRDSR) at different roll speed ratios and different roll temperatures. Significant strengthening was achieved after HRDSR and the sample processed at a higher speed ratio or a lower processing temperature yielded a higher strength. The strengthening mechanism in the HRDSR processed Ti was examined in terms of the models based on the critical stress for activating the Frank–Read source and the grain-size strengthening. The UFG Ti exhibited high corrosion resistance in H2SO4 and HCl solutions. The corrosion rate decreased linearly with the inverse square root of the grain size. The Ti with the smallest grain size, which was HRDSR processed at room temperature, revealed the best combination of high strength and high corrosion rate.
    Materials Science and Engineering A 11/2011; 528(29):8479-8485. · 2.41 Impact Factor
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    ABSTRACT: Idiopathic pulmonary fibrosis is a fatal disease characterized by progressive destruction of the lung. Although TLR2 bridges innate and adaptive immunity by sensing tissue damage, its role in pulmonary fibrosis remains unclear. To address this issue, TLR2(-/-) and WT mice were examined for bleomycin-induced pulmonary fibrosis (BIPF). Flow cytometric and immunohistochemical analysis revealed that TLR2 expression in bronchial epithelial and immune cells of the lungs was upregulated in WT mice during BIPF. Levels of IL-27, TGF-β, chemokines, and hydroxyproline were lower in lungs of TLR2(-/-) mice than in those of WT mice, but IL-17 levels were higher in TLR2(-/-) mice. In in vivo experiments using bone marrow-chimeric mice, TLR2 expression on respiratory epithelial cells, rather than immune cells, induced IL-27 and chemokine production in the lungs, further stimulating BIPF. This effect of TLR2 depended on IRF complexes and MyD88. BIPF was more severe in IL-17A(-/-) mice and in TLR2(-/-) mice treated with anti-IL-17 mAb than in TLR2(-/-) and WT mice. Furthermore, IL-27 blockade in WT mice reduced hydroxyproline levels by enhancing IL-17 production, whereas the treatment of TLR2(-/-) mice with a chemokine mixture increased hydroxyproline levels by recruiting inflammatory cells into the lungs. TLR2 signaling promotes BIPF by inducing IL-27 and chemokine production by respiratory epithelial cells, thereby inhibiting IL-17 production and recruiting inflammatory cells into the lungs.
    The Journal of Immunology 09/2011; 187(8):4007-17. · 5.52 Impact Factor
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    ABSTRACT: Pen-2 is a key regulator of the γ-secretase complex, which is involved in the production of the amyloid β (Aβ)-42 peptides, which ultimately lead to Alzheimer's disease (AD). While Pen-2 has been studied in vitro, Pen-2 function in vivo in the brains of transgenic (Tg) mice overexpressing human Pen-2 (hPen-2) protein has not been studied. This study aimed to determine whether Pen-2 overexpression could regulate the AD-like phenotypes in Tg mice. NSE/hPen-2 Tg mice were produced by the microinjection of the NSE/hPen-2 gene into the pronucleus of fertilized eggs. The expression of the hPen-2 gene under the control of the NSE promoter was successfully detected only in the brain and kidney tissue of NSE/hPen-2 Tg mice. Also, 12-month-old NSE/hPen-2 Tg mice displayed behavioral dysfunction in the water maze test, motor activity and feeding behavior dysfunction in food intake/water intake/motor activity monitoring system. In addition, tissue samples displayed dense staining with antibody to the Aβ-42 peptide. Furthermore, NSE/hPen-2 Tg mice exhibiting feeding behavior dysfunction were significantly more apt to display symptoms related to diabetes and obesity. These results suggest that Pen-2 overexpression in NSE/hPen-2 Tg mice may induce all the AD-like phenotypes, including behavioral deficits, motor activity and feeding behavior dysfunction, Aβ-42 peptide deposition and chronic disease induction.
    International Journal of Molecular Medicine 08/2011; 28(6):961-71. · 1.96 Impact Factor
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    ABSTRACT: Synaptophysin is a synaptic vesicle glycoprotein involved in the regulation process for neurotransmitter release, which is distributed throughout neuroendocrine cells and all neurons in the brain and spinal cord. In an effort to determine whether amyloid β (Aβ)-42 peptides could influence the quantity and biochemical properties of synaptophysin, alterations in the levels of the synaptophysin protein in various soluble fractions were detected in the brains of four genotypes of transgenic mice (Tg) including Non-Tg, neuron-specific enolase (NSE)-hPS2m, NSE-hAPPsw and hAPPsw/hPS2m double Tg mice. Among the four genotypes of Tg mice, the highest levels of Aβ-42 peptides were noted in hAPPsw/hPS2m, followed by NSE-hAPPsw, NSE-hPS2m and Non-Tg mice. In the brains of these mice displaying different levels of Aβ-42 peptides, the levels of soluble synaptophysin were reduced significantly only in the hAPPsw/hPS2m double Tg mice compared to the Non-Tg mice. However, immunohistochemical analysis revealed no differences in the levels of total synaptophysin protein between the neocortex and hippocampus of the four different genotypes of mice. Western blot analysis using four-step fractions with differing solubility revealed a marked decrease in synaptophysin levels in the Tris-buffer saline fraction of hAPPsw/hPS2m double Tg mice and a significant increase in the formic acid fraction, relative to the Non-Tg mice. The results obtained from our in vivo experiments in mice are identical to the results observed in SK-N-MC cells treated with 100 nM Aβ-42 peptides. Therefore, our experiments collectively suggest that Aβ-42 peptides may alter the solubility without changing the total amount of synaptophysin.
    International Journal of Molecular Medicine 08/2011; 28(2):223-9. · 1.96 Impact Factor

Publication Stats

114 Citations
92.06 Total Impact Points

Institutions

  • 2010–2014
    • Seoul National University Hospital
      • Department of Pathology
      Sŏul, Seoul, South Korea
  • 2009–2013
    • Kangwon National University
      • • Department of Mechanical and Biomedical Engineering
      • • Department of Forest Biomaterials Engineering
      Kang-neung, Gangwon, South Korea
  • 2007–2013
    • Catholic University of Korea
      • Department of Dermatology
      Sŏul, Seoul, South Korea
  • 2010–2012
    • Pusan National University
      • • Department of Nanomaterials Engineering
      • • Department of Biomaterials Science
      Pusan, Busan, South Korea
  • 2011
    • Gyeongsang National University
      • School of Materials Science and Engineering
      Shinshū, South Gyeongsang, South Korea