Shie Akabori

Publications (3)5.38 Total impact

• Article: Polymicrogyria without epilepsy by aberrantly migrating inhibitory interneurons.

  Tomoyuki Takano, Chihiro Sawai, Shie Akabori, Yoshihiro Takeuchi
  Epilepsy & Behavior 08/2010; 18(4):505-6. · 2.34 Impact Factor
• Article: Seizure susceptibility due to antihistamines in febrile seizures.

  Tomoyuki Takano, Yuko Sakaue, Tatsuyuki Sokoda, Chihiro Sawai, Shie Akabori, Yoshihiro Maruo, Takashi Taga, Masaki Ohno, Yoshihiro Takeuchi
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  ABSTRACT: The aim of this study was to determine whether seizure susceptibility due to antihistamines is provoked in patients with febrile seizures. The study population comprised 14 patients with simple febrile seizures and 35 patients with complex febrile seizures. Detailed clinical manifestations were compared between patients with and without administration of antihistamine. The time from fever detection to the seizure onset was significantly shorter in the antihistamine group than that in the nonantihistamine group, and the duration of seizures was significantly longer in the antihistamine group than that in nonantihistamine group. Interleukin-1beta is thought to be associated with causing febrile seizures via its dual role as a pyrogen and convulsant substance. Moreover, interleukin-1beta may activate the turnover of hypothalamic neural histamine. These considerations, along with the present results, suggest that the depletion of hypothalamic neuronal histamine induced by antihistamines may increase neuronal excitability, thereby increasing seizure susceptibility in patients with febrile seizures.
  Pediatric Neurology 04/2010; 42(4):277-9. · 1.52 Impact Factor
• Article: West syndrome in a patient with balanced translocation t(X;18)(p22;p11.2).

  Shie Akabori, Tomoyuki Takano, Hiroshi Fujito, Yoshihiro Takeuchi
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  ABSTRACT: We describe a case of West syndrome with the balanced translocation t(X;18)(p22;p11.2). Treatment with high-dose vitamin B6, adrenocorticotropic hormone, thyrotropin-releasing hormone, and antiepileptic compounds was not effective, and the patient exhibited persistent refractory seizures and severe developmental delays. Although no mutation analysis and X chromosome inactivation were performed, we suggest that the chromosomal abnormality in the present patient is the main etiologic factor responsible for the infantile spasms and severe developmental delay.
  Pediatric Neurology 08/2007; 37(1):64-6. · 1.52 Impact Factor