Timucin Aydogan

Publications (9)24.01 Total impact

• Article: Some inflammatory cytokine levels, iron metabolism and oxidan stress markers in subjects with nonalcoholic steatohepatitis.

  Sema Uysal, Ferah Armutcu, Timucin Aydogan, Kayihan Akin, Mustafa Ikizek, M Ramazan Yigitoglu
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  ABSTRACT: The relation between nonalcoholic steatohepatitis and iron metabolism is still controversial. Free fatty acids, iron, and other sources of oxidative stress probably result in cell damage, and necroinflammation mediated by various cytokines. Sixty patients were diagnosed with NASH were included in the study, and the patient group was divided into three subgroups. Iron metabolism markers, inflammatory cytokines, including TNF-α, IL-6 and IL-8, MDA and nitric oxide levels were measured. Serum ferritin, inflammatory cytokines, and oxidative stress markers were significantly higher in the patient group. Among three patient groups, divided according to the results of ultrasonic examination, there were significant changes with regard to these parameters. The study results suggest that liver iron and fat accumulation, oxidant stres, and inflammatory cytokines are closely related. Therefore, levels of serum ferritin, MDA, IL-6, TNF-α and IL-8 could represent the indices of activity and progression of NASH.
  Clinical biochemistry 12/2011; 44(17-18):1375-9. · 2.02 Impact Factor
• Source

  Available from: nih.gov

  Article: A case of bilateral psoas abscesses and lumbar osteomyelitis due to recurrent salmonella infection.

  Mustafa Altay, Mehmet Kanbay, Ilhan Kurultak, Fatma Aybala Altay, Timucin Aydogan, Ali Akcay, Murat Duranay
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  ABSTRACT: Psoas abscess and lumbar osteomyelitis due to salmonella infection is very rare, although it is frequently seen all over the world. These two complications have severe clinical progress, poor prognosis and high mortality. Here, we report a case of salmonellosis presenting with bilateral multiple psoas abscesses and lumbar osteomyelitis, which resolved completely following medical treatment and percutoneous drainage of abscess.
  Journal of the National Medical Association 12/2006; 98(11):1855-6. · 1.16 Impact Factor
• Article: Kikuchi Fujimoto disease secondary to Entamoeba histolytica: case report.

  Timucin Aydogan, Mehmet Kanbay, Cem Uraldi, Arif Kaya, Burak Uz, Ayse Isik, Ali Akcay, Selim Erekul
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  ABSTRACT: Kikuchi Fujimoto disease (KFD) is a rare histiocytic necrotizing lymphadenitis which has a benign self-limiting clinical course. Its origin is unknown, but an abnormal autoimmune reaction has been suggested and infection is often considered to be an inciting agent. A 50-year-old man presented with fever, malaise, fatigue and sweat of 7 days duration, and diarrhea for 2 days. Physical examination revealed five mobile and painless cervical adenopathies. Entamoeba histolytica trophozoites and cysts were detected by microscopy of feces. Parenteral ornidazole treatment was commenced. Thorax computerized tomography showed lymph node sizes congruent with infection in the mediastinum, right hilus and right axillary region. Axillary lymph node biopsy and immunohistochemical analyses were then performed, and the results were consistent with histiocytic necrotizing lymphadenitis. From day 4 of antibiotic treatment the patient's body temperature decreased and reached a normal level on day 10. After discharge the patient returned for follow-up twice and was asymptomatic; his lymph nodes were either unpalpable or were decreased in size. We could not find any previous study or case report about a probable role for E. histolytica. Amebiasis can be a triggering factor in KFD or alternatively it is possible that its occurrence is coincidental.
  The Journal of infection 11/2006; 53(4):e171-3. · 4.13 Impact Factor
• Article: Incidence and etiology of thrombocytosis in an adult Turkish population.

  Timucin Aydogan, Mehmet Kanbay, Ozlem Alici, Ali Kosar
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  ABSTRACT: The aim of the study was to determine the incidence and etiology of thrombocytosis in an adult Turkish population. The medical records of 2000 patients were reviewed retrospectively to determine (i) the etiology of elevated platelet counts, (ii) additional laboratory parameters (i.e., complete blood counts), and (iii) the presence of thromboembolic complications. Within 5 years, 174 678 platelet counts had been performed for 124,340 patients. Of the 124,340 patients, 2000 (1.6%; mean age, 55.2 +/- 17.4 years; range 16-94 years; male-to-female ratio, 3.6:1 [1570:430]) had one or more platelet counts of 500 x 10(3)/mm3 or higher during the study period. Secondary thrombocytosis was the most frequent cause of an elevated platelet count and occurred in 1934 cases (96.7%). Infection was the most common cause of secondary thrombocytosis, occurring in 1001 patients (50.1%). Compared with secondary thrombocytosis, primary thrombocytosis was significantly associated with a higher rate of thromboembolic complications. It is concluded that a high platelet count may have both diagnostic and therapeutic implications. Secondary thrombocytosis is a common finding and mostly secondary to infection. Primary thrombocytosis has a higher risk for thromboembolic events than does secondary thrombocytosis.
  Platelets 09/2006; 17(5):328-31. · 1.85 Impact Factor
• Source

  Available from: Burak Uz

  Article: A Rare but serious side effect of Levofloxacin: hypoglycemia in a geriatric patient.

  Mehmet Kanbay, Timucin Aydogan, Rifat Bozalan, Ayse Isik, Burak Uz, Arif Kaya, Ali Akcay
  Diabetes Care 08/2006; 29(7):1716-7. · 8.09 Impact Factor
• Article: Fatal hyperphosphatemia secondary to a phosphosoda bowel preparation in a geriatric patient with normal renal function.

  Timucin Aydogan, Mehmet Kanbay, Burak Uz, Arif Kaya, Ayse Isik, Rifat Bozalan, Mehtap Erkman, Ali Akcay
  Journal of Clinical Gastroenterology 03/2006; 40(2):177. · 3.16 Impact Factor
• Article: Effect of dialysis type on serum lipids, apolipoproteins, and lipoproteins.

  Mehmet Kanbay, Tuncay Delibasi, Arif Kaya, Timucin Aydogan, Cemile Koca, Ali Akcay, Murat Duranay, Ramazan Yigitoglu
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  ABSTRACT: Dyslipidemia is common among patients with end-stage renal disease, whether treated by hemodialysis (HD) or peritoneal dialysis (PD). However, there are not enough data about the effect of dialysis type on serum lipoprotein (a) [Lp(a)], apolipoprotein (a) [Apo(a)], apolipoprotein (b) [Apo(b)], and lipid levels. The aim of this study was to determine the effect of dialysis type on serum lipid levels. This study enrolled 40 HD patients (20 men and 20 women, aged 48.1 +/- 17.6 years) and 69 PD patients (35 men and 34 women, aged 45.2 +/- 16.3 years). Serum lipid profile including total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), triglyceride (TG), Apo(a), Apo(b), and Lp(a) were determined in HD and PD patients. Patients who have used statins within the last six months were not included in the study. No significant differences in TC, LDL-C, HDL-C, TG, Apo(a), Apo(b), or Lp(a) serum levels were found between HD and PD patients. Serum TC, LDL-C, HDL-C, TG, Apo(a), Apo(b), and Lp(a) in HD and PD patients were 172.2 +/- 42.7 (mg/dL) vs. 181.0 +/- 53.0 (mg/dL), 97.2 +/- 36.2 (mg/dL) vs. 101.4 +/- 33.6 (mg/dL), 45.3 +/- 11.9 (mg/dL) vs. 41.4 +/- 11.1 (mg/dL), 144.7 +/- 71.8 (mg/dL) vs. 173.0 +/- 76.8 (mg/dL), 1.2 +/- 0.5 (g/L) vs. 1.0 +/- 0.2 (g/L), 0.9 +/- 0.3 (g/L) vs. 1.2 +/- 0.3 (g/L), and 43.1 +/- 40.6 (mg/dL) vs. 46.0 +/- 42.7 (mg/dL), respectively. The results of this study show that the maintenance CAPD treatment is associated with more pronounced alterations of the lipoproteins and lipid metabolism than those observed during HD treatment.
  Renal Failure 02/2006; 28(7):567-71. · 0.82 Impact Factor
• Article: Isotonic saline or hypertonic saline: which is best for sinusitis?

  Ahmet Karadag, Hanifi Kurtaran, Oguz Tekin, Cem Uraldi, Timucin Aydogan, Hanifi Kurturan
  The Journal of family practice 09/2004; 53(8):637. · 0.61 Impact Factor
• Article: Gabapentin induced edema in a geriatric patient.

  Mehmet Kanbay, Arif Kaya, Rifat Bozalan, Timucin Aydogan, Burak Uz, Ayse Isik, Ali Akcay
  Clinical Neuropharmacology 29(3):186. · 2.17 Impact Factor