Publications (263)2847.75 Total impact
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Article: Individual multi-locus heterozygosity is associated with lower morning plasma cortisol concentration.
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ABSTRACT: OBJECTIVE. STRESS IS IMPLICATED AS A RISK FACTOR FOR NUMEROUS ILLNESSES IN HUMANS, PUTATIVELY IN PART MEDIATED BY BIOLOGICAL RESPONSES TO STRESS, SUCH AS ELEVATED CORTISOL. THE THEORY OF GENETIC HOMEOSTASIS SUGGESTS THAT INDIVIDUAL HETEROZYGOSITY FACILITATES COMPENSATION FOR ENVIRONMENTAL STRESSES. WE HYPOTHESIZED THAT HETEROZYGOSITY AMELIORATES THE BIOLOGICAL RESPONSE TO A GIVEN LEVEL OF PERCEIVED STRESS, REFLECTED IN LOWER PLASMA CORTISOL CONCENTRATIONS.DESIGN. WE EXAMINE THE ROLE OF HETEROZYGOSITY ON THE ASSOCIATION BETWEEN PERCEIVED PSYCHOLOGICAL STRESS AND MORNING CORTISOL CONCENTRATIONS IN 854 INDIVIDUALS FROM THE ISOLATED ISLAND OF VIS, CROATIA.METHODS. CORTISOL WAS MEASURED IN MORNING PLASMA SAMPLES. 1184 AUTOSOMAL MICROSATELLITE MARKERS WERE GENOTYPED AND INDIVIDUAL MULTI-LOCUS HETEROZYGOSITY WAS CALCULATED AS THE PROPORTION OF HETEROZYGOUS MARKERS. GENERAL HEALTH QUESTIONNAIRE (GHQ-30) WAS USED TO ASSESS THE DEGREE OF PSYCHOLOGICAL DISTRESS.RESULTS. MEAN MULTI-LOCUS HETEROZYGOSITY WAS 34.850.45% (RANGE: 31.97-36.22%). Psychological distress (GHQ Likert score >31) was more prevalent in women (37% versus 18% in men, p<0.0001), in less educated people (β=-0.35 per year in school, p<0.001) and in lower socio-economic classes (β=-3.59, p<0.0001). Cortisol was positively associated with psychological distress (β=2.20, p=0.01). In a regression model adjusting for age, BMI, education and GHQ-30 score, multi-locus heterozygosity was independently and inversely associated with morning plasma cortisol (p=0.005).Conclusion. More heterozygous individuals, as measured by microsatellite markers, had lower morning plasma cortisol concentrations for a given level of perceived psychological stress. This may be important, as higher cortisol concentrations may increase allostatic load and be associated with higher risk of stress-related illness.European Journal of Endocrinology 05/2013; · 3.42 Impact Factor -
Article: Effectiveness of seasonal influenza vaccines in children - a systematic review and meta-analysis.
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ABSTRACT: Aim. To assess the efficacy and effectiveness of seasonal influenza vaccines in healthy children up to the age of 18 years. Methods. MedLine, EMBASE, CENTRAL, CINAHL, WHOLIS, LILACS, and Global Health were searched for randomized controlled trials and cohort and case-control studies investigating the efficacy or effectiveness of influenza vaccines in healthy children up to the age of 18 years. The studies were assessed for their quality and data on the outcomes of influenza-like illness, laboratory-confirmed influenza, and hospitalizations were extracted. Seven meta-analyses were performed for different vaccines and different study outcomes. Results. Vaccine efficacy for live vaccines, using random effects model, was as follows: (i) for similar antigen, using per-protocol analysis: 83.4% (78.3%-88.8%); (ii) for similar antigen, using intention to treat analysis: 82.5 (76.7%-88.6%); (iii) for any antigen, using per protocol analysis: 76.4% (68.7%-85.0%); (iv) for any antigen, using intention to treat analysis: 76.7% (68.8%-85.6%). Vaccine efficacy for inactivated vaccines, for similar antigen, using random effects model, was 67.3% (58.2%-77.9%). Vaccine effectiveness against influenza-like illness for live vaccines, using random effects model, was 31.4% (24.8%-39.6%) and using fixed-effect model 44.3% (42.6%-45.9%). Vaccine effectiveness against influenza-like illness for inactivated vaccines, using random effects model, was 32.5% (20.0%-52.9%) and using fixed-effect model 42.6% (38.3%-47.5%). Conclusions. Influenza vaccines showed high efficacy in children, particularly live vaccines. Effectiveness was lower and the data on hospitalizations were very limited.Croatian Medical Journal 04/2013; 54(2):135-45. · 1.80 Impact Factor -
Article: Viral etiology of hospitalized acute lower respiratory infections in children under 5 years of age - a systematic review and meta-analysis.
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ABSTRACT: Aim. To estimate the proportional contribution of influenza viruses (IV), parainfluenza viruses (PIV), adenoviruses (AV), and coronaviruses (CV) to the burden of severe acute lower respiratory infections (ALRI). Methods. The review of the literature followed PRISMA guidelines. We included studies of hospitalized children aged 0-4 years with confirmed ALRI published between 1995 and 2011. A total of 51 studies were included in the final review, comprising 56091 hospitalized ALRI episodes. Results. IV was detected in 3.0% (2.2%-4.0%) of all hospitalized ALRI cases, PIV in 2.7% (1.9%-3.7%), and AV in 5.8% (3.4%-9.1%). CV are technically difficult to culture, and they were detected in 4.8% of all hospitalized ALRI patients in one study. When respiratory syncytial virus (RSV) and less common viruses were included, at least one virus was detected in 50.4% (40.0%-60.7%) of all hospitalized severe ALRI episodes. Moreover, 21.9% (17.7%-26.4%) of these viral ALRI were mixed, including more than one viral pathogen. Among all severe ALRI with confirmed viral etiology, IV accounted for 7.0% (5.5%-8.7%), PIV for 5.8% (4.1%-7.7%), and AV for 8.8% (5.3%-13.0%). CV was found in 10.6% of virus-positive pneumonia patients in one study. Conclusions. This article provides the most comprehensive analysis of the contribution of four viral causes to severe ALRI to date. Our results can be used in further cost-effectiveness analyses of vaccine development and implementation for a number of respiratory viruses.Croatian Medical Journal 04/2013; 54(2):122-34. · 1.80 Impact Factor -
Article: Risk factors for severe acute lower respiratory infections in children: a systematic review and meta-analysis.
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ABSTRACT: Aim. To identify the risk factors in children under five years of age for severe acute lower respiratory infections (ALRI), which are the leading cause of child mortality. Methods. We performed a systematic review of published literature available in the public domain. We conducted a quality assessment of all eligible studies according to GRADE criteria and performed a meta-analysis to report the odds ratios for all risk factors identified in these studies. Results. We identified 36 studies that investigated 19 risk factors for severe ALRI. Of these, 7 risk factors were significantly associated with severe ALRI in a consistent manner across studies, with the following meta-analysis estimates of odds ratios (with 95% confidence intervals): low birth weight 3.18 (1.02-9.90), lack of exclusive breastfeeding 2.34 (1.42-3.88), crowding - more than 7 persons per household 1.96 (1.53-2.52), exposure to indoor air pollution 1.57 (1.06-2.31), incomplete immunization 1.83 (1.32-2.52), undernutrition - weight-for-age less than 2 standard deviations 4.47 (2.10-9.49), and HIV infection 4.15 (2.57-9.74). Conclusion. This study highlights the role of the above seven risk factors in the development of severe pneumonia in under-five children. In addition, it emphasizes the need for further studies investigating other potential risk factors. Since these risk factors are potentially preventable, health policies targeted at reducing their prevalence provide a basis for decreasing the burden of childhood pneumonia.Croatian Medical Journal 04/2013; 54(2):110-21. · 1.80 Impact Factor -
Article: Ending of preventable deaths from pneumonia and diarrhoea: an achievable goal.
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ABSTRACT: Global under-5 mortality has fallen rapidly from 12 million deaths in 1990, to 6·9 million in 2011; however, this number still falls short of the target of a two-thirds reduction or a maximum of 4 million deaths by 2015. Acceleration of reductions in deaths due to pneumonia and diarrhoea, which together account for about 2 million child deaths every year, is essential if the target is to be met. Scaling up of existing interventions against the two diseases to 80% and immunisation to 90% would eliminate more than two-thirds of deaths from these two diseases at a cost of US$6·715 billion by 2025. Modelling in this report shows that if all countries could attain the rates of decline of the regional leaders, then cause-specific death rates of fewer than three deaths per 1000 livebirths from pneumonia and less than one death per 1000 livebirths from diarrhoea could be achieved by 2025. These rates are those at which preventable deaths have been avoided. Increasing of awareness of the size of the problem; strengthening of leadership, intersectoral collaboration, and resource mobilisation; and increasing of efficiency through the selection of the optimum mix of a growing set of cost-effective interventions depending on local contexts are the priority actions needed to achieve the goal of ending preventable deaths from pneumonia and diarrhoea by 2025.The Lancet 04/2013; · 38.28 Impact Factor -
Article: Global burden of childhood pneumonia and diarrhoea.
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ABSTRACT: Diarrhoea and pneumonia are the leading infectious causes of childhood morbidity and mortality. We comprehensively reviewed the epidemiology of childhood diarrhoea and pneumonia in 2010-11 to inform the planning of integrated control programmes for both illnesses. We estimated that, in 2010, there were 1·731 billion episodes of diarrhoea (36 million of which progressed to severe episodes) and 120 million episodes of pneumonia (14 million of which progressed to severe episodes) in children younger than 5 years. We estimated that, in 2011, 700 000 episodes of diarrhoea and 1·3 million of pneumonia led to death. A high proportion of deaths occurs in the first 2 years of life in both diseases-72% for diarrhoea and 81% for pneumonia. The epidemiology of childhood diarrhoea and that of pneumonia overlap, which might be partly because of shared risk factors, such as undernutrition, suboptimum breastfeeding, and zinc deficiency. Rotavirus is the most common cause of vaccine-preventable severe diarrhoea (associated with 28% of cases), and Streptococcus pneumoniae (18·3%) of vaccine-preventable severe pneumonia. Morbidity and mortality from childhood pneumonia and diarrhoea are falling, but action is needed globally and at country level to accelerate the reduction.The Lancet 04/2013; · 38.28 Impact Factor -
Article: Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
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ABSTRACT: Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.Nature Genetics 04/2013; · 35.53 Impact Factor -
Article: Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
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ABSTRACT: Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.Nature Genetics 04/2013; · 35.53 Impact Factor -
Article: Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent.
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ABSTRACT: Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)(2)), waist circumference, and waist:hip ratio) single-nucleotide polymorphisms (SNPs) with age at menarche in 92,116 women of European descent from 38 studies (1970-2010), in order to estimate associations between genetic variants associated with central or overall adiposity and pubertal timing in girls. Investigators in each study performed a separate analysis of associations between the selected SNPs and age at menarche (ages 9-17 years) using linear regression models and adjusting for birth year, site (as appropriate), and population stratification. Heterogeneity of effect-measure estimates was investigated using meta-regression. Six novel associations of body mass index loci with age at menarche were identified, and 11 adiposity loci previously reported to be associated with age at menarche were confirmed, but none of the central adiposity variants individually showed significant associations. These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development.American journal of epidemiology 04/2013; · 5.59 Impact Factor -
Article: Meta-Analysis of Genome-wide Association Studies in 5 cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.
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ABSTRACT: Visual refractive errors are complex genetic traits with a largely unknown etiology. To date, genome-wide association studies (GWAS) of moderate size have identified several novel risk markers for refractive error, measured here as mean spherical equivalent. We performed a GWAS using a total of 7,280 samples from 5 cohorts: the Age-Related Eye Disease Study (AREDS); the KORA study ("Cooperative Health Research in the Region of Augsburg"); the Framingham Eye Study (FES); the Ogliastra Genetic Park-Talana (OGP-Talana) Study; and the Multiethnic Study of Atherosclerosis (MESA). Genotyping was performed on Illumina and Affymetrix platforms with additional markers imputed to the HapMap II reference panel. We identified a new genome-wide significant locus on chromosome 16 (rs10500355, p=3.9 x 10-9) in a combined discovery and replication set (26,953 samples). This SNP is located within the RBFOX1 gene which is a neuron-specific splicing factor regulating a wide range of alternative splicing events implicated in neuronal development and maturation, including transcription factors, other splicing factors and synaptic proteins.Human Molecular Genetics 03/2013; · 7.64 Impact Factor -
Dataset: Verhoeven 2013 meta-GWAS refractive error and myopia supp
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Article: Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
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ABSTRACT: Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The CREAM consortium conducted genome-wide meta-analyses, including 37,382 individuals from 27 studies of European ancestry and 8,376 from 5 Asian cohorts. We identified 16 new loci for refractive error in individuals of European ancestry, of which 8 were shared with Asians. Combined analysis identified 8 additional associated loci. The new loci include candidate genes with functions in neurotransmission (GRIA4), ion transport (KCNQ5), retinoic acid metabolism (RDH5), extracellular matrix remodeling (LAMA2 and BMP2) and eye development (SIX6 and PRSS56). We also confirmed previously reported associations with GJD2 and RASGRF1. Risk score analysis using associated SNPs showed a tenfold increased risk of myopia for individuals carrying the highest genetic load. Our results, based on a large meta-analysis across independent multiancestry studies, considerably advance understanding of the mechanisms involved in refractive error and myopia.Nature Genetics 02/2013; · 35.53 Impact Factor -
Article: Inference of identity by descent in population isolates and optimal sequencing studies.
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ABSTRACT: In an isolated population, individuals are likely to share large genetic regions inherited from common ancestors. Identity by descent (IBD) can be inferred from SNP genotypes, which is useful in a number of applications, including identifying genetic variants influencing complex disease risk, and planning efficient cohort-sequencing strategies. We present ANCHAP - a method for detecting IBD in isolated populations. We compare accuracy of the method against other long-range and local phasing methods, using parent-offspring trios. In our experiments, we show that ANCHAP performs similarly as the other long-range method, but requires an order-of-magnitude less computational resources. A local phasing model is able to achieve similar sensitivity, but only at the cost of higher false discovery rates. In some regions of the genome, the studied individuals share haplotypes particularly often, which hints at the history of the populations studied. We demonstrate the method using SNP genotypes from three isolated island populations, as well as in a cohort of unrelated individuals. In samples from three isolated populations of around 1000 individual each, an average individual shares a haplotype at a genetic locus with 9-12 other individuals, compared with only 1 individual within the non-isolated population. We describe an application of ANCHAP to optimally choose samples in resequencing studies. We find that with sample sizes of 1000 individuals from an isolated population genotyped using a dense SNP array, and with 20% of these individuals sequenced, 65% of sequences of the unsequenced subjects can be partially inferred.European Journal of Human Genetics advance online publication, 30 January 2013; doi:10.1038/ejhg.2012.307.European journal of human genetics: EJHG 01/2013; · 3.56 Impact Factor -
Article: Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis.
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ABSTRACT: BACKGROUND: The annual number of hospital admissions and in-hospital deaths due to severe acute lower respiratory infections (ALRI) in young children worldwide is unknown. We aimed to estimate the incidence of admissions and deaths for such infections in children younger than 5 years in 2010. METHODS: We estimated the incidence of admissions for severe and very severe ALRI in children younger than 5 years, stratified by age and region, with data from a systematic review of studies published between Jan 1, 1990, and March 31, 2012, and from 28 unpublished population-based studies. We applied these incidence estimates to population estimates for 2010, to calculate the global and regional burden in children admitted with severe ALRI in that year. We estimated in-hospital mortality due to severe and very severe ALRI by combining incidence estimates with case fatality ratios from hospital-based studies. FINDINGS: We identified 89 eligible studies and estimated that in 2010, 11·9 million (95% CI 10·3-13·9 million) episodes of severe and 3·0 million (2·1-4·2 million) episodes of very severe ALRI resulted in hospital admissions in young children worldwide. Incidence was higher in boys than in girls, the sex disparity being greatest in South Asian studies. On the basis of data from 37 hospital studies reporting case fatality ratios for severe ALRI, we estimated that roughly 265 000 (95% CI 160 000-450 000) in-hospital deaths took place in young children, with 99% of these deaths in developing countries. Therefore, the data suggest that although 62% of children with severe ALRI are treated in hospitals, 81% of deaths happen outside hospitals. INTERPRETATION: Severe ALRI is a substantial burden on health services worldwide and a major cause of hospital referral and admission in young children. Improved hospital access and reduced inequities, such as those related to sex and rural status, could substantially decrease mortality related to such infection. Community-based management of severe disease could be an important complementary strategy to reduce pneumonia mortality and health inequities. FUNDING: WHO.The Lancet 01/2013; · 38.28 Impact Factor -
Article: High-throughput IgG Fc N-glycosylation profiling by mass spectrometry of glycopeptides.
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ABSTRACT: Age- and sex-dependence of subclass specific immunoglobulin G (IgG) Fc N-glycosylation was evaluated for 1709 individuals from two isolated human populations. IgGs were obtained from plasma by affinity purification using 96-well protein G monolithic plates and digested with trypsin. Fc N-glycopeptides were purified and analyzed by negative-mode MALDI-TOF-MS with 4-chloro-α-cyanocinnamic acid (Cl-CCA) matrix. Age-associated glycosylation changes were more pronounced in younger individuals (<57 years) than in older individuals (>57 years) and in females than in males. Galactosylation and sialylation decreased with increasing age and showed significant sex dependence. Interestingly, the most prominent drop in the levels of galactosylated and sialylated glycoforms in females was observed around the age of 45 to 60 years when females usually enter the menopause. The incidence of bisecting N-acetylglucosamine increased in younger individuals and reached a plateau at older age. Furthermore, we compared the results to the total IgG N-glycosylation of the same populations recently analyzed by hydrophilic interaction liquid chromatography (HILIC). Significant differences were observed in the levels of galactosylation, bisecting N-acetylglucosamine and particularly sialylation which were shown to be higher in HILIC analysis. Age- and sex-association of glycosylation features was to a large extent comparable between MALDI-TOF-MS and HILIC IgG glycosylation profiling.Journal of Proteome Research 01/2013; · 5.11 Impact Factor -
Dataset: Kornfeld JCEM Brief Supplement Final
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Dataset: Kornfeld JCEM Brief Figure1
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Dataset: Kornfeld JCEM Brief pre-final-draft
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Article: Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
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ABSTRACT: Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance (P < 5 × 10(-8)). We further showed that 2 CCT-associated loci, FOXO1 and FNDC3B, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near FOXO1 had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4-1.88, P = 2.7 × 10(-10), and rs4894535 in FNDC3B had OR = 1.47, 95% CI = 1.29-1.68, P = 4.9 × 10(-9)). FNDC3B was also associated with primary open-angle glaucoma (P = 5.6 × 10(-4); tested in 3 cohorts with 2,979 cases and 7,399 controls). Further analyses implicate the collagen and extracellular matrix pathways in the regulation of CCT.Nature Genetics 01/2013; · 35.53 Impact Factor -
Article: Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
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ABSTRACT: Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.Nature genetics. 01/2013; 45(2):145-54.
Top co-authors
Top Journals
- Nature Genetics (24)
- Croatian Medical Journal (19)
- The Lancet (17)
- PLoS Genetics (12)
- Collegium antropologicum (11)
Institutions
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2009–2013
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Johns Hopkins Bloomberg School of Public Health
Baltimore, MD, USA -
National Institute for Bioprocessing Research and Training (NIBRT)
Dublin, L, Ireland (Republic of Ireland) -
World Health Organization WHO
Genève, GE, Switzerland
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2006–2013
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The University of Edinburgh
- • School of Clinical Sciences and Community Health
- • Centre for Population Health Sciences
- • Division of Health Sciences
Edinburgh, SCT, United Kingdom
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2003–2013
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University of Zagreb
- • Faculty of Pharmacy and Biochemistry (PHARMA)
- • School of Medicine (MEF)
- • Department of Biochemistry and Molecular Biology (PHARMA)
- • Department of Medical Statistics, Epidemiology and Medical Informatics
- • School of Public Health Andrija Štampar
Zagreb, Grad Zagreb, Croatia
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2012
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UNICEF
New York City, NY, USA -
Wellcome Trust Sanger Institute
Cambridge, ENG, United Kingdom -
University of Oxford
- Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM)
Oxford, ENG, United Kingdom -
National Institute of Livestock and Grassland Science
Ibaraki, Osaka-fu, Japan -
London School of Hygiene and Tropical Medicine
- Department of Infectious Disease Epidemiology
London, ENG, United Kingdom -
McGill University
- Department of Epidemiology, Biostatistics and Occupational Health
Montréal, Quebec, Canada
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2008–2012
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Uppsala University
- • The Rudbeck Laboratory
- • Department of Immunology, Genetics and Pathology
Uppsala, Uppsala, Sweden -
University of Leeds
- Leeds Institute of Health Sciences (LIHS)
Leeds, ENG, United Kingdom -
University of California, Davis
- Department of Nutrition
Davis, CA, USA
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2011
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International Centre for Diarrhoeal Disease Research, Bangladesh
Dhaka, Dhaka Division, Bangladesh -
Ludwig Boltzmann Institute for Cancer Research
Vienna, Vienna, Austria -
Erasmus Universiteit Rotterdam
Rotterdam, South Holland, Netherlands -
Institute of Genetics and Molecular Medicine
Edinburgh, SCT, United Kingdom -
Medizinische Universität Innsbruck
- Sektion für Genetische Epidemiologie
Innsbruck, Tyrol, Austria -
Stellenbosch University
- Department of Psychology
Stellenbosch, Province of the Western Cape, South Africa -
University of Leicester
- Department of Health Sciences
Leicester, ENG, United Kingdom
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2009–2011
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University of Split
Split, Splitsko-Dalmatinska Zupanija, Croatia
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2007–2011
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University of Split-School of Medicine
Split, Splitsko-Dalmatinska Zupanija, Croatia -
University of Toronto
- Joint Centre for Bioethics
Toronto, Ontario, Canada -
Medical Research Council, South Africa
Johannesburg, Gauteng, South Africa
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2010
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Trinity College Dublin
- Department of Psychiatry
Dublin, L, Ireland (Republic of Ireland) -
Europaeische Akademie Bozen - Accademia Europea Bolzano
Bolzano - Bozen, Trentino-Alto Adige, Italy -
Universitätsklinikum Regensburg
Regensburg, Bavaria, Germany -
Ruđer Bošković Institute
- Division of Molecular Medicine
Zagreb, Grad Zagreb, Croatia -
University of Michigan
- Department of Biostatistics
Ann Arbor, MI, USA -
Johns Hopkins University
- Department of Epidemiology
Baltimore, MD, USA
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2003–2009
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Institute for Anthropological Research
Zagreb, Grad Zagreb, Croatia
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2005–2008
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University Hospital Centre Zagreb
- Department of Internal Medicine
Zagreb, Grad Zagreb, Croatia -
Instituto de Investigación Nutricional
Lima, LMA, Peru -
Institute of Public Health "Andrija Štampar", Zagreb
Zagreb - Centar, Grad Zagreb, Croatia
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2003–2006
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Medical Research Council (UK)
- MRC Human Genetics Unit
London, ENG, United Kingdom
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