G B Ambrosio

University of Padova, Padua, Veneto, Italy

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Publications (55)62.78 Total impact

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    ABSTRACT: summaryThe relationship between body weight and blood pressure, total serum cholesterol, triglycerides, uric acid and glucose was investigated in 203 psoriatic patients in comparison with 904 healthy controls. In the psoriatic patients, these parameters were clearly related to their body weight. Those psoriatic patients of normal weight exhibited lower mean values of all the parameters compared with overweight psoriatic patients while they did not differ from control subjects of normal weight. Our results suggest that only overweight psoriatic patients exhibit the metabolic abnormalities frequently reported in the literature, while psoriatic patients of normal weight do not differ from the general population in this respect.
    British Journal of Dermatology 07/2006; 118(2):191 - 194. DOI:10.1111/j.1365-2133.1988.tb01773.x · 4.28 Impact Factor
  • G B Ambrosio · L M Riva · S Zamboni · A Nogara · P Zanchi · R Parisi · M Scatiggio ·
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    ABSTRACT: We report on the prevalence of chronic heart failure (CHF) in a random sample of a population (aged 20-64 years) from the Veneto region in northern Italy. The relationship between CHF and hypertension and obesity was also investigated. These data were collected during an international research project coordinated by the World Health Organization. The overall prevalence of CHF was 2.0% both in the male and female population. The prevalence of CHF increased significantly with age and was positively correlated with body mass index in both sexes. Patients with borderline hypertension showed a 3.5-fold increased prevalence of CHF. The prevalence of CHF was 4.9-fold higher in hypertensive than in the normotensive subjects. Patients treated with hypotensive drugs had a significantly higher prevalence of CHF than untreated patients.
    Cardiologia (Rome, Italy) 11/1992; 37(10):685-91.
  • R Corrocher · A Pagnan · G.B. Ambrosio · S Ferrari · O Olivieri · P Guarini · A Bassi · D Piccolo · A Gandini · D Girelli ·
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    ABSTRACT: Since we have observed that monounsaturated fatty acids (MUFA) enriched diet modifies red cell membrane lipids and cation transport systems in normotensive subjects, we similarly evaluated a group of hypertensive patients undergoing an analogous dietary modification. In a group of 18 moderately hypertensive women, the diet was supplemented for two months with olive oil (about 45 g/day), which replaced an equal amount of seasoning fats. Before and after this period, red cell fatty acid composition was evaluated by gas-chromatography in order to verify diet compliance: a significant increase in oleic acid was observed, while the content of saturated and polyunsaturated fatty acids remained unchanged. After olive oil, maximal rates of Na-K pump (5580 +/- 329 vs 6995 +/- 390, p less than 0.001) and Na-K cotransport (Na-COT 544 +/- 52 vs 877 +/- 46, p less than 0.001: K-COT 790 +/- 76 vs 1176 +/- 66, p less than 0.001), cell Na content (9.58 +/- 0.4 vs 10.61 +/- 0.6, p less than 0.03) and passive permeability for Na (936 +/- 74 vs 1836 +/- 102, p less than 0.001) rose significantly. Although the reduction in maximal rate of the Li-Na CT after olive oil was not significant, it was the only cation transport parameter being correlated with the variations of membrane lipids, namely negatively with UFA (r = -0.528, p less than 0.05) and positively with SFA (r = 0.482, p less than 0.005). The change in maximal rate of Li-Na CT was also correlated with the variation of systolic and diastolic BP (r = 0.50, p less than 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)
    Journal of endocrinological investigation 06/1992; 15(5):369-76. DOI:10.1016/0378-5122(93)90143-6 · 1.45 Impact Factor
  • S Zamboni · V Urbani · L Mazzucato · G B Ambrosio · A Semplicini · C Dal Palů ·

    Giornale italiano di cardiologia 01/1991; 20(12):1155-60.
  • G B Ambrosio · L M Riva · P Zanchi ·

    Cardiologia (Rome, Italy) 10/1990; 35(9):707-12.
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    ABSTRACT: In the course of a general population survey in Mirano (Venice), Northern Italy, a random sample of 1,903 subjects (50.1% men) aged 20-59 was examined. Fifty-five were diabetic (fasting plasma glucose greater than or equal to 140 mg/dl or diagnosed by a physician) and 1,670 non-diabetic subjects (fasting plasma glucose below 110 mg/dl). In this paper an assessment was made on the more frequent occurrence of coronary risk factors (serum cholesterol and triglycerides, body mass index (BMI), systolic blood pressure, cigarette smoking) and, in particular, of their aggregation in diabetic patients as compared to non-diabetic controls. The occurrence of any one of the coronary risk factors studied was more frequent in diabetic subjects and significantly so for triglyceridemia in both sexes and for systolic blood pressure and BMI in men. The aggregation of two or more risk factors was also more frequent in diabetic subjects than controls. Finally, the combined score of coronary risk as calculated by multiple logistic function showed higher values for diabetic subjects. These results confirm the need for a systematic search for coronary risk factors in diabetic subjects in order to prevent cardiovascular complications.
    Acta diabetologica latina 03/1990; 27(1):31-9. DOI:10.1007/BF02624720
  • Giovanni B. Ambrosio · Marina Vanin · Sergio Zamboni · Simone Tasso · Domenico Fedele · Laura Riva ·

    Diabetes Research and Clinical Practice 02/1990; 8(1):75-7. DOI:10.1016/0168-8227(90)90099-F · 2.54 Impact Factor
  • C Dal Palù · S Zamboni · A Pagnan · G B Ambrosio ·

    Giornale italiano di cardiologia 10/1989; 19(9):800-10; discussion 811-9.
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    ABSTRACT: A genetically determined alteration of the cell membrane sodium metabolism may play a role in the pathogenesis of essential hypertension. The most consistent finding in patients with essential hypertension is an increased red blood cell Li/Na exchange (countertransport). It is genetically determined but it is also associated to potentially confounding variables (body weight, race, age and so on). The present study investigates the relationship between red cell Li/Na countertransport and various potentially confounding variables in a random sample of the population. It shows that this membrane cation transport system is increased in males compared to females and significantly correlated to body mass index in males and to blood pressure, alcohol consumption and, negatively, to urinary calcium excretion in females. Since body weight and alcohol consumption are correlated to blood pressure in several epidemiological studies, it can be hypothesized that they influence blood pressure control through an alteration of the cell membrane sodium transport.
    Cardiologia (Rome, Italy) 05/1989; 34(4):347-51.
  • A M Zotti · G Ambroso · G B Ambrosio · G Vidotto · C Dal Palù ·
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    ABSTRACT: The aim of this study was to evaluate the presence of "type A" behaviour and possible psychological distress in 373 hypertensive patients. One-hundred and ninety-five males, 56.2 +/- 6.2 years old and one-hundred and seventy-eight females, 57.1 +/- 6.2 years old, coming from the IPPPSH and still under double-blind treatment with or without a beta-blocker (oxprenolol 160 mg SR), were studied by means of the Jenkins Activity Survey form C and several tests from the Cognitive Behavioural Assessment Battery (CBA-2.0). Seventy-four point eight percent of the patients showed a "type A" pattern, and 25.5% were in the extreme predictive interval for coronary heart disease according to WCGS. "Type A" pattern was not influenced by variables such as age, sex, education, job or previous pharmacological treatment. The patients studied did not show any particular psychological distress at the psychometric evaluation. However, special social and cultural characteristics and different therapies influenced some symptoms, such as anxiety, depression and somatic lamentation. According to this study: "type A" behaviour seems to be a steady feature of the hypertensive patient; furthermore, it seems to be due to a "biological imprinting" which can be considered a cause of hypertension; psychological distress depends on a particular set of environmental stimuli. In the first case an accurate prevention is needed while, in the second case adequate pharmacological and/or psychological therapies are needed.
    Giornale italiano di cardiologia 03/1989; 19(2):136-44.
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    ABSTRACT: The echocardiographic features of the left ventricle of 37 obese women (body mass index above 30) and 37 lean controls, matched for sex, age, height and blood pressure levels, were studied. Twenty-six patients in each group were hypertensive. The normotensive obese patients did not show any differences, comparing to the normotensive controls; on the contrary, the hypertensive obese patients had higher left ventricular mass (LVM), stroke volume and cardiac output (CO), and lower total peripheral resistance (TPR) than the hypertensive controls. A positive correlation was found between the LVM and the CO (r = 0.57, P less than 0.01) in hypertensive obese patients, and between the relative wall thickenss (h/r, that is the ratio between the left ventricular wall thickness and the left ventricular radius) and TPR (r = 0.64, P less than 0.01) in the hypertensive controls. It is concluded that obesity per se does not determine left ventricular hypertrophy in women; however, when obesity is associated with arterial hypertension, a distinct pattern of hypertrophy, characterized by high CO and low TPR, develops.
    International Journal of Obesity 02/1989; 13(6):809-16. · 5.00 Impact Factor
  • S Zamboni · G Zanetti · G Grosso · G B Ambrosio · S Gozzetti · A Peserico ·
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    ABSTRACT: Two hundred and nineteen psoriatic in-patients and 747 non-psoriatic subjects were asked to report in a semiquantitative, self-administered questionnaire on the frequency of consumption of different foodstuffs and cooking and seasoning fats and the daily intake of alcohol (glasses/day) and coffee (cups/day). According to this a definite score was assigned to each of the 46 food items, which were divided into five groups: carbohydrates (CH), low-fat foods (LFF), high-fat foods (HFF), saturated fats (SF) and polyunsaturated fats (PUF) and the alcohol consumption in grams/day was calculated. The mean scores for each food group and the means of alcohol (grams/day) and coffee (cups/day) intake were compared in the two groups, after age-adjustment through ANOCOVA. Psoriatic patients showed higher scores for HFF and SF in males and for CH, HFF, SF and PUF in females and a higher intake of alcohol in both sexes. These dietary habits could explain the higher prevalence of metabolic abnormalities in psoriatic patients.
    Acta dermato-venereologica. Supplementum 02/1989; 146(146):182-3.
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    ABSTRACT: 1. In this study we sought to test the possibility that an olive-oil-rich diet might influence the membrane lipid composition and cation transport mechanisms in erythrocytes. 2. To this end, 11 normotensive normolipidaemic healthy volunteers were given a standard relatively low fat diet (28% of total energy) for 3 weeks, followed by a high fat (38% of total energy), olive-oil (100 g/day)-enriched diet for the 3 subsequent weeks, in a metabolic ward. The two diets contained the same amount of cholesterol (400 mg), and the polyunsaturated fatty acid/saturated fatty acid ratio was similar and comparatively low (0.35 on the standard vs 0.36 on the olive oil diet). 3. At the end of the study the lipid composition of the erythrocyte membranes showed the following changes: the oleic acid content increased by 15.7% and the amount of saturated fatty acid decreased by 3.2%. The polyunsaturated fatty acid content tended to decrease, while the polyunsaturated fatty acid/saturated fatty acid ratio did not change significantly. The cholesterol/phospholipid molar ratio increased significantly by 7.8%, still remaining within the reference range. 4. At the same time, the mean values of the maximum rates of the cation fluxes mediated by the Na+ -K+ pump, and by Na+ -K+ co-transport rose significantly, while the maximal rate of Na+ -L+ countertransport showed a non-significant trend towards lower values. 5. Urinary excretion of Na+ and K+, body weight and blood pressure did not change significantly.
    Clinical Science 02/1989; 76(1):87-93. DOI:10.1042/cs0760087 · 5.60 Impact Factor
  • S Zamboni · R Lazzaretto · G Ambroso · G B Ambrosio ·

    Cardiologia (Rome, Italy) 12/1988; 33(11):1023-7.
  • S Zamboni · R Lazzaretto · G Ambroso · G B Ambrosio ·

    Giornale italiano di cardiologia 09/1988; 18(8):683-8.
  • G B Ambrosio · S Tasso · S Zamboni · M P Vettori · F Paesotto · R Pigato · D D'Este · A Pagnan · E Piccolo · A Menotti ·
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    ABSTRACT: During the National Research Council (CNR) program called Atherosclerosis-Risk Factors 2 (ATS-RF2) a random sample of 1903 subjects (50.1% male) aged 20-59 years was examined in the general population of Mirano-Venice. Mean values of serum total cholesterol and triglycerides, body mass index, as well as systolic and diastolic blood pressure were assessed. On the whole these turned out to be higher in men and increased with age. The continuously distributed variables showed an approximately normal distribution and a close correlation. Comparing our results with those obtained by other Italian units co-operating in the same CNR program, different levels of serum total cholesterol and systolic blood pressure were observed. The overall risk factor pattern in northern Italian regions is closer to that reported in the literature for central European countries than to that of southern Italian regions. These findings might explain why mortality due to ischaemic heart disease is higher in northern Italy and becomes progressively smaller in central and southern Italy.
    Giornale italiano di cardiologia 06/1988; 18(5):369-77.
  • Giovanni B. Ambrosio · Sergio Zamboni · Gianfranco Botta ·
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    ABSTRACT: In this study, 953 patients (48 percent men) more than 60 years old with mild to moderate hypertension (class I or II) were included. After a two-week wash-out period, a starting dosage of captopril--12.5 mg twice a day--was given. Patients were examined after one and three weeks and, subsequently, at monthly intervals for a total period of four months. The dosage was adjusted to a maximum of 50 mg twice a day plus, when needed, 25 mg of hydrochlorothiazide per day. Thirty-two patients were lost to follow-up, 10 withdrew because of inadequate control of blood pressure, and only 21 (2 percent) dropped out because of side effects. Mean blood pressure decreased from 184/104 to 152/87 mm Hg. The lowest dosage (25 mg a day) was sufficient to control blood pressure in 15 percent of patients, 31 percent needed 50 mg a day, and 24 percent required 100 mg a day. Hydrochlorothiazide was added to the captopril regimen in 30 percent. No substantial changes in biochemical variables or electrocardiographic results were observed. "Quality of life" (judged as physical fitness, positive well being, mood, and sexual desire) remarkably improved.
    The American Journal of Medicine 04/1988; 84(3A):152-4. DOI:10.1016/0002-9343(88)90224-0 · 5.00 Impact Factor
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    ABSTRACT: The incidence of aortic recoarctation has been evaluated after a mean follow-up period of 8.2 years in 161 patients aged from 2 to 54 years at the time of the operation. To this aim, blood pressure levels in the upper and lower limbs were measured at rest and after bicycle ergometer exercise. Patients whose systolic pressure gradient was significant (either above 20 mmHg at rest or 35 mmHg after exercise) underwent aortic digital angiography. Aortic coarctation was diagnosed when the ratio of the aortic area at the site of the operation was less than 40% of that at diaphragmatic level (Frederiksen's index III). Thus the overall incidence of recoarctation was 10.1%. All patients with a significant gradient at rest also showed a significant gradient after exercise. This suggests that it is worthwhile performing digital angiography directly, without exercise testing, in these patients. However, 39.8% of the patients without significant rest gradients displayed a significant gradient after exercise. On the whole, only 21.4% of the patients with a significant gradient after exercise had signs of recoarctation on digital angiography.
    Giornale italiano di cardiologia 03/1988; 18(2):83-9.
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    ABSTRACT: The relationship between body weight and blood pressure, total serum cholesterol, triglycerides, uric acid and glucose was investigated in 203 psoriatic patients in comparison with 904 healthy controls. In the psoriatic patients, these parameters were clearly related to their body weight. Those psoriatic patients of normal weight exhibited lower mean values of all the parameters compared with overweight psoriatic patients while they did not differ from control subjects of normal weight. Our results suggest that only overweight psoriatic patients exhibit the metabolic abnormalities frequently reported in the literature, while psoriatic patients of normal weight do not differ from the general population in this respect.
    British Journal of Dermatology 03/1988; 118(2):191-4. · 4.28 Impact Factor
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    ABSTRACT: During the initial phase of the World Health Organization (WHO) "Community Control Program of Hypertension" in Italy, 1190 subjects with high blood pressure derived from a general population random sample (5856 people of both sexes, aged 20 to 64 years) were enrolled in a hypertension register. At the registration visit (RV), each of them gave case history details and underwent a complete clinical examination, blood and urine tests, and a standard 12-lead electrocardiogram (ECG). All the ECGs were read by a single coder, using the second version of the Minnesota Code (MC). We calculated the prevalence of electrocardiographic codes according to sex, age, and the state of antihypertensive treatment. The overall prevalence of electrocardiographic abnormalities (i.e., all codes except 1:0 and isolated 9:4) was 40.8% with a slightly higher prevalence in males than in females: 42.4% versus 39.4%. Codes related to left ventricular hypertrophy (LVH) (3:1 or 3:3) were also more frequent in males (21.2%) than in females (14.5%) but not those related to ischemia (4:1-4:3 or 5:1-5:3). In fact, group 4 codes were present in 4.0% of males and 16.1% of females; group 5 codes, in 5.7% of males and 18.1% of females. Abnormal codes generally increased with increasing age, but those related to LVH did not follow this general rule in males. In fact, in the age class 20-29 years, codes 3:1 were found in 11.1% and codes 3:3 in 17.5% of the subjects, whereas the corresponding frequencies in the oldest age group (60-64 years) were 15.2% and 12.4%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
    Journal of clinical hypertension 01/1988; 3(4):430-8. · 2.96 Impact Factor