Publications (4)0 Total impact
-
Article: [Research on the immune response].
Viaţa medicală; revistă de informare profesională şi ştiinţifică a cadrelor medii sanitare. 02/1990; 38(1):1-5. -
Article: The role of certain immunologic parameters in silicosis.
[show abstract] [hide abstract]
ABSTRACT: The paper presents some possibilities of estimating the immunologic aggression in silicosis in a group of 68 patients divided into three subgroups according to the evolutive stage of disease. The results were compared with the data obtained in a control group of 35 clinically healthy subjects not subjected to respiratory noxae. Parameters such as the immunogram (IgG, IgA IgM, IgD), the C3 complement, the circulating immune complexes (CIC) and the C reactive protein (CRP) were investigated using classical immunochemical methods. It was observed that the immunoglobulin titer presented a polyclonal increase. The mean values of C3 complement decreased in stages I and II of disease. The CIC level presented high mean values unrelated to the stage of the disease. The incidence of CRP was found high in stage III. It was demonstrated that there is no significant correlation between the humoral immunologic abnormalities and the radiologic changes or the depression of the pulmonary functional test. These changes suggest that the humoral immunologic abnormalities are not directly responsible for the lung changes in silicosis and cannot be used as a predictive indicator of the severity of the disease or of its progress. The data obtained showed a hyperreactivity of the humoral mediated immunity over the whole course of the disease thus supporting the assumption of an immunopathogenic mechanism in this disease.Romanian journal of internal medicine = Revue roumaine de médecine interne 33(1-2):61-72. -
Article: Antineutrophil cytoplasm antibodies in patients with silicosis.
[show abstract] [hide abstract]
ABSTRACT: The presence of antineutrophil cytoplasm antibodies (ANCA) was followed up in silicosis with or without renal involvement. From the 68 patients with silicosis, 5 presented renal involvement. Of these 3 showed the presence of pANCA. The other 63 patients without renal involvement presented cANCA only in 2 cases. The control group showed no presence of ANCA. The incidence of ANCA in silicosis with renal involvement was discussed in view of an eventual elucidation of the pathogenesis of this disease, which was frequently associated with autoimmunity diseases.Romanian journal of internal medicine = Revue roumaine de médecine interne 34(3-4):233-7. -
Article: Study of lung antibodies in patients with silicosis.
[show abstract] [hide abstract]
ABSTRACT: The presence of lung antibodies was determined in a group of 68 patients with silicosis in various stages of evolution and in a control group of 35 healthy subjects, by the standard indirect immunofluorescent technique with fluorescent conjugate anti human gammaglobulin and monospecific fluorescent conjugates anti human IgG, IgA and IgM. In the group of patients investigated, lung antibodies were detected by means of fluorescent conjugate anti human gammaglobulin, in 47 cases of the 68 examined. As regards the investigations using monospecific fluorescent conjugates it was observed that all the 47 patients presented lung antibodies of the IgG class, 32 presented lung antibodies of the IgA class and 15 presented lung antibodies of the IgM class. The presence of lung antibodies in silicotic patients suggests the participation of acquired humoral immunity in the pathogeny of disease without, however, being directly responsible for the evolution of disease. The association of silicosis with various other autoimmune diseases pleads for the existence of an immune component in the evolution of this pneumoconiosis.Romanian journal of internal medicine = Revue roumaine de médecine interne 33(3-4):243-7.
