Hiroshi Takano

Osaka General Medical Center, Ōsaka, Ōsaka, Japan

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Publications (33)71.76 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: We advanced the open stent-grafting technique with a branched endoprosthesis, which reconstructs simultaneously the cervical branches and descending aorta within an acceptably short interval of deep hypothermic circulatory arrest. In this study, we evaluated the efficacy of this new technique and assessed the early and midterm results. From January 2004 to September 2007, the branched open stent-grafting technique was performed in 69 cases (55 men, average age 66.2 years, 36 degenerative aneurysms and 33 aortic dissections, 13 [18.8%] in emergency, 7 [10.1%] redo cases). Under deep hypothermic circulatory arrest, the branched endoprosthesis was delivered through the opened proximal aortic arch, and total arch repair was completed. To avoid cerebral embolism, retrograde cerebral perfusion was performed at the end of deep hypothermic circulatory arrest. Average time of operation, cardiopulmonary bypass, and deep hypothermic circulatory arrest was 417, 130, and 36 minutes, respectively. A total of 124 cervical stent grafts were inserted and successfully delivered in 121 (97.6%). Operative mortality within 30 days was 3 (4.3%). The major postoperative complications involved 4 (5.8%) strokes and 2 (2.9%) spinal cord injuries. No aorta-related death was observed after discharge from hospital, and the survival was 90.9%, 88.8%, and 88.8% at 1, 2, and 3 years, respectively. Six (5.0%) cervical stent grafts showed endoleak; however, all these cases were successfully treated by additional endovascular repair. Aortic arch repair with branched open stent grafting is an effective technique with satisfactory early results. In midterm analysis, cervical branch events were acceptably rare and controllable. This technique could be an attractive alternative to conventional total arch replacement.
    The Journal of thoracic and cardiovascular surgery 08/2009; 138(1):46-52; discussion 52-3. DOI:10.1016/j.jtcvs.2009.03.025 · 3.99 Impact Factor
  • 8th Annual International Symposium on Advances in Understanding Aortic; 01/2009
  • The American Journal of Sports Medicine 08/2008; 36(8):1611-1614. DOI:10.1177/0363546508317729 · 4.70 Impact Factor
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    ABSTRACT: This report elucidates the long-term safety and effectiveness of extended aortic arch replacement with an open stent-grafting technique from our 12 years of experience. From 1994 to 2004, 126 patients (mean age 67.8 years) with different pathologic conditions of the aortic arch with extension to the descending aorta (57 dissections [acute/chronic = 31/26] and 69 aneurysms) were operated on with an open stent-grafting technique. During deep hypothermic circulatory arrest with selective cerebral perfusion, the stent graft was delivered through the transected proximal aortic arch, and arch replacement with a 4-branched prosthesis was performed. Operative mortality within 30 days was 3.2%. Perioperative morbidity included 7 (5.6%) strokes and 8 (6.3%) spinal injuries (paraplegia in 3, transient paraparesis in 5). Sixty-three percent of the patients were extubated within 24 hours. In long-term follow-up (mean 60.4 +/- 36.5 months, maximum 153 months), survival was 81.1%, 63.3%, and 53.7% at 1, 5, and 8 years. Five (3.9%) late endoleaks were observed but treated with successful additional endovascular repair. Freedom from endoleaks was 98.0%, 91.1%, and 91.1% for 1, 5, and 8 years, respectively. Long-term observation showed safety and good durability of the open stent-grafting technique for aortic arch disease. This technique could be an attractive treatment option for aortic arch aneurysm with distal extension and aortic dissection requiring aortic arch replacement.
    The Journal of thoracic and cardiovascular surgery 07/2008; 135(6):1261-9. DOI:10.1016/j.jtcvs.2007.10.056 · 3.99 Impact Factor
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    ABSTRACT: Severe valvular heart disease is often complicated by congestive liver dysfunction, which greatly compromises the operative results. We evaluated congestive liver dysfunction by a novel approach using technetium-99 m galactosyl human serum albumin ((99m)Tc-GSA) with liver scintigraphy. Between 1998 and 2004, we performed scintigraphy accompanied by (99m)Tc-GSA in 28 patients who had valvular heart disease with moderate-to-severe tricuspid regurgitation and who showed symptoms of right heart failure. Based on the results, we calculated a receptor index (LHL15) and an index of blood clearance (HH15) and assessed the correlation between these factors and postoperative liver dysfunction, defined as the maximum serum total bilirubin level (max T-bil) as >2.0 mg/dl. Nineteen patients, including four who died in hospital, had postoperative liver dysfunction. The level of HH15 was significantly higher and the level of cholinesterase was significantly lower (P < 0.05) in patients with liver dysfunction than in those without liver dysfunction. Multivariate logistic regression analysis identified HH15 as the most sensitive indicator of postoperative hepatic dysfunction. The level of HH15 calculated using scintigraphy with (99m)Tc-GSA is a clinically useful predictor of postoperative liver dysfunction in patients with severe valvular disease.
    Surgery Today 06/2007; 37(7):564-9. DOI:10.1007/s00595-006-3460-x · 1.21 Impact Factor
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    ABSTRACT: During surgical treatment for acute type A aortic dissection, gelatin-resorcin-formalin glue is generally applied and its efficacy has been reported. However, some late complications that are potentially associated with this glue have also been reported. In the present study, we reviewed our experiences of treatment for acute type A aortic dissection and late complications that occurred in the anastomotic site, which needed a reoperation. From October 1994 to August 2005, 68 patients underwent emergency surgery for acute type A aortic dissection. Gelatin-resorcin-formalin glue was applied to 56 (82.4%) of these patients at one or both of the distal and proximal anastomosis sites. Eight (11.8%) patients died in hospital within 30 days after the operation, among which two patients already had cerebral complications prior to the surgery. There were five late deaths from causes unrelated to cardiac events. Five patients developed an aortic pseudoaneurysm at the anastomotic site and underwent a late reoperation. All of these patients had been treated with gelatin-resorcin-formalin glue during the previous operation. Histologic examination of the resected aortic wall after the reoperation revealed tissue necrosis, severe local inflammation, and organization of old thrombi at the site of the glue application. Late complications after the use of gelatin-resorcin-formalin glue may occur with a certain amount of risk, suggesting its toxicity for aortic tissue. Therefore, proper use of this glue and close follow-up of the patients are strictly required.
    The Annals of thoracic surgery 06/2007; 83(5):1621-6. DOI:10.1016/j.athoracsur.2007.01.025 · 3.65 Impact Factor
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    The Journal of thoracic and cardiovascular surgery 08/2006; 132(1):155-6. DOI:10.1016/j.jtcvs.2006.02.044 · 3.99 Impact Factor
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    ABSTRACT: A 68-year-old man was admitted with high fever and enlargement of the distal aortic arch on chest radiography. Computed tomography showed a huge proximal descending thoracic aortic aneurysm. Graft replacement of the proximal descending thoracic aorta was performed on an emergency basis, and a pectoralis major muscle flap was wrapped around the graft. Salmonella enteritidis was detected in the resected tissue. The patient recovered well, with no signs of infection.
    Asian cardiovascular & thoracic annals 07/2006; 14(3):247-9. DOI:10.1177/021849230601400317
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    ABSTRACT: The risk factors of paraplegia and paraparesis (P/P) after surgical repair of descending thoracic aortic aneurysm (TAA) are controversial. Seventy five patients underwent surgical repair of descending TAA from 2001 through 2002. The mean age was 64.2+/-5.2 years old (range; 26-81) and 58 patients (77.3%) are male. There were 47 patients (62.7%) with nondissecting aortic aneurysm and 28 patients (37.3%) with chronic dissecting aortic aneurysm. Emergent operation was performed in 13 cases (17.3%). Retrospective analysis based on data of these 75 patients was performed to determine the risk factors of P/P. 30-days hospital mortality was 2.7%. The overall incidence of P/P was 12.0% (9/75) overall (immediate paraplegia; 4 (5.3%), delayed paraplegia; 1 (1.3%), immediate paraparesis; 3 (4.0%), delayed paraparesis; 1 (1.3%)). Logistic regression analysis revealed that predictive factors of the development of P/P were; cases in which the distal part (below Th9) of the descending thoracic aorta was included in the extent of graft replacement (P=0.020; odds ratio (OR), 7.981) and nondissecting aneurysm (P=0.029; OR, 12.109). There was an increased risk of P/P after descending TAA repair in cases in which the extent of graft replacement included below the Th9 or in cases with nondissecting aortic aneurysm.
    Annals of thoracic and cardiovascular surgery: official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 07/2006; 12(3):179-83. · 0.69 Impact Factor
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    ABSTRACT: Activated protein C (APC) has beneficial effects on ischemia reperfusion injury in neuron. However, the possible mechanism of such beneficial effects is not fully understood. The aim of this study was to investigate the effects and possible mechanisms of APC on ischemic spinal cord damage. After induction of spinal cord ischemia, APC (group A) or vehicle (group I) was injected intravenously. Severity of ischemic damage was analyzed by counting the number of motor neurons. To investigate the mechanisms by which APC prevents ischemic spinal cord damage, we performed immunoreactivity and Western blotting of insulin-like growth factor 1 (IGF-1), IGF-1 receptor, and phosphorylated serine-threonine kinase (p-Akt). APC eased the functional deficits and increased the number of motor neurons after ischemia. Immunoreactivity of IGF-1 in group A was stronger than in group I at 8 hours after reperfusion but was at the same level at 1 day. Induction of IGF-1 receptor and the downstream factor p-Akt was stronger and more prolonged in group A. These results indicate that induction of IGF-1, IGF-1 receptor, and p-Akt might partially explain the neuroprotective effects of APC after transient spinal cord ischemia in rabbit.
    Stroke 05/2006; 37(4):1081-6. DOI:10.1161/01.STR.0000206280.30972.21 · 6.02 Impact Factor
  • The Journal of thoracic and cardiovascular surgery 04/2006; 131(3):755-6. DOI:10.1016/j.jtcvs.2005.11.023 · 3.99 Impact Factor
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    ABSTRACT: To study the clinical results of resternotomy in patients with dense and direct adhesion between the large vessels and the sternum, and define the morphologic features of the adhesion. Between 2000 and 2003, 67 patients with a history of cardiac surgery underwent median resternotomy. We studied each patient's profile and the measurements taken from preoperative computed tomography scans. We then conducted multivariate logistic regression analysis to determine the predictive morphologic features of adhesion between the large vessels and the sternum in these 67 patients. Twenty (29.9%) of the 67 patients had direct adhesion between the large vessels and the sternum. Sternal re-entry was performed without injury to the large vessels in 18 (90%) but the aorta was injured in 2 (10%) patients, resulting in catastrophic hemodynamic disorder and operative death in one. Multivariate logistic regression analysis revealed that an extracardiac conduit and a high occupying rate of the aorta and pulmonary artery in the mediastinal space were significant morphologic factors. The morphologic features of large vessels to sternal dense adhesion as possible risk factors for injury to the large vessels are the presence of an extracardiac conduit and a large ascending aorta or pulmonary artery in relation to the mediastinal space.
    Surgery Today 02/2006; 36(7):596-601. DOI:10.1007/s00595-006-3187-8 · 1.21 Impact Factor
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    ABSTRACT: We evaluated the effect of sivelestat sodium (SiV), a novel synthesized polymorphonuclear (PMN) elastase inhibitor, on acute lung injury (ALI) caused by cardiopulmonary bypass (CPB). Fourteen patients who underwent cardiopulmonary surgery using CPB, followed by the development of both systemic inflammatory response syndrome (SIRS) and ALI, were treated with either 0.2 mg/kg per hour SiV (SiV group, n = 7) or saline (control group, n = 7) for 4 days from the time of arrival in the intensive care unit. The SiV group had a significantly lower ratio of serum PMN elastase and interleukin (IL)-8, a significantly lower ratio of the respiratory index, and a significantly higher ratio of PaO(2)/FiO(2) after 24 h of treatment than the control group. Sivelestat sodium suppressed the production of PMN elastase and IL-8, resulting in improved respiratory function in patients with ALI caused by CPB.
    Surgery Today 02/2006; 36(4):321-6. DOI:10.1007/s00595-005-3160-y · 1.21 Impact Factor
  • Innovations Technology and Techniques in Cardiothoracic and Vascular Surgery 01/2006; 1(4). DOI:10.1097/01243895-200600140-00121
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    Journal of Cardiac Failure 12/2005; 11(9). DOI:10.1016/j.cardfail.2005.08.020 · 3.07 Impact Factor
  • Journal of Thoracic and Cardiovascular Surgery 08/2005; 130(1):219-20. DOI:10.1016/j.jtcvs.2004.11.003 · 3.99 Impact Factor
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    ABSTRACT: A 40-year-old patient with Ehlers-Danlos syndrome type VI (ocular type) had mitral regurgitation due to mitral valve prolapse. Because the patient's tissue was fragile, we replaced the mitral valve with a reinforced prosthetic valve to prevent paravalvular leakage. The excised mitral leaflet showed significant myxomatous change and decrease in collagen fibers. We believe this is the first report of cardiac surgery in a patient with Ehlers-Danlos syndrome type VI. (c) 2005 by The Society of Thoracic Surgeons.
    The Annals of thoracic surgery 08/2005; 80(1):320-2. DOI:10.1016/j.athoracsur.2003.12.099 · 3.65 Impact Factor
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    ABSTRACT: The purpose of this study was to evaluate the results of a combined resection of the thoracic aorta and primary lung cancer. Sixteen patients underwent thoracic aorta resection along with a left pneumonectomy (n = 6), left upper lobectomy (n = 9), or partial lung resection (n = 1), of whom 10 also received preoperative induction therapy. Cardiopulmonary bypass was used in 10 patients, and a passive shunt between the ascending aorta and the descending aorta was used in 4 patients. Six postoperative major complications occurred in 5 patients, including postoperative bleeding (n = 3), intraoperative bleeding (n = 1), chylothorax (n = 1), and respiratory failure (n = 1). The postoperative morbidity rate was 31%, and the mortality rate was 12.5% (2/16). Furthermore, 4 patients died of systemic tumor relapse, and 1 patient died of intrapleural recurrence. Nine patients were alive after a median follow-up of 54 months (range, 12-199 months). The median survival time of patients with postoperative pathologic N0 disease was 31 months, whereas it was 10 months for those with pathologic N2 or N3 disease. Five-year survivals were 70% for patients with N0 disease and 16.7% for patients with N2 or N3 disease ( P = .0070). Although pulmonary resection with the involved aorta might cause high surgical morbidity and mortality rates, encouraging long-term survivals were obtained in patients without mediastinal nodal involvement.
    Journal of Thoracic and Cardiovascular Surgery 05/2005; 129(4):804-8. DOI:10.1016/j.jtcvs.2004.05.010 · 3.99 Impact Factor
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    ABSTRACT: A 50-year-old man underwent replacement of the descending thoracic aorta for a DeBakey type III-b chronic dissecting aortic aneurysm. During the surgery, lumbar cerebrospinal fluid (CSF) drainage with a 10 cm H2O pop-off pressure was used to protect against spinal cord ischemia. During cardiopulmonary bypass, the patient's pupils were isocoric, but anisocoric at end of the operation. As computed tomography of the brain showed right subdural hematoma, neurosurgical drainage was instituted emergently. Although some neurological deficit remained, the patient recovered well and was discharged. This case provides a strong reminder that CSF drainage for spinal cord protection against ischemia might induce subdural hematoma, which can be catastrophic during an operation for thoracoabdominal aortic aneurysm.
    The Japanese Journal of Thoracic and Cardiovascular Surgery 11/2004; 52(10):466-8. DOI:10.1007/s11748-004-0141-9
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    ABSTRACT: We successfully treated chronic type A dissection and coronary artery disease with a functional midline crossing right internal thoracic artery (RITA) after coronary artery bypass grafting (CABG). A 68-year-old man was incidentally diagnosed as chronic type A dissection by follow-up cardiac catheterization after CABG, with 90% stenosis in the right coronary artery (RCA) No. 2. The dissecting aneurysm (max. 6 cm in diameter) was localized at the right portion of the ascending aorta with a functional RITA to the left anterior descending coronary artery. The dissecting aneurysm was treated with patch closure and the RCA was revascularized with a right gastroepiploic artery and saphenous vein composite graft through combined right antero-axillar thoracotomy and lower mini-sternotomy without RITA dissection. Treatment of chronic type A dissection following CABG becomes more challenging with a functional midline crossing RITA. It is important that a safe and less invasive surgical strategy be implemented for such complicated case.
    Annals of thoracic and cardiovascular surgery: official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 03/2004; 10(1):57-60. · 0.69 Impact Factor

Publication Stats

283 Citations
71.76 Total Impact Points


  • 2008–2009
    • Osaka General Medical Center
      Ōsaka, Ōsaka, Japan
  • 2005–2008
    • Osaka University
      • • Division of Cardiovascular Surgery
      • • Division of General Thoracic Surgery
      Suika, Ōsaka, Japan
  • 2004–2007
    • Osaka City University
      • Department of Cardiovascular Surgery
      Ōsaka, Ōsaka, Japan
  • 2002–2004
    • Osaka Police Hospital
      Ōsaka, Ōsaka, Japan
  • 2000–2003
    • Osaka Rosai Hospital
      Ōsaka, Ōsaka, Japan