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ABSTRACT: Background/objective:Dietary patterns in Western populations have been linked to type 2 diabetes, but the association of distinctive dietary patterns of Japanese population remains unclear. We prospectively investigated the association between dietary patterns and risk of developing type 2 diabetes among Japanese adults.Subjects/methods:Participants were 27 816 men and 36 889 women aged 45-74 years who participated in the second survey of the Japan Public Health Center-based prospective study and had no history of diabetes. Dietary patterns were derived by using principal component analysis of the consumption of 134 food and beverage items ascertained by a food frequency questionnaire. Odds ratios of self-reported physician-diagnosed type 2 diabetes over 5 year were estimated using logistic regression analysis.Results:A total of 1194 new cases (692 men and 502 women) of type 2 diabetes were self-reported. We identified three dietary patterns: prudent, westernized and traditional Japanese patterns. Any dietary pattern was not significantly associated with type 2 diabetes risk after adjustment for covariates in both men and women. The multivariate-adjusted odds ratios (95% confidence interval) for type 2 diabetes for the highest versus lowest quartile of each dietary pattern score in men and women, respectively, were 0.93 (0.74-1.16) and 0.90 (0.69-1.16) for the prudent pattern, 1.15 (0.90-1.46) and 0.81 (0.61-1.08) for the westernized pattern, and 0.97 (0.74-1.27) and 0.87 (0.66-1.15) for the traditional pattern.Conclusions:Although a small protective effect of the prudent dietary pattern cannot be excluded, dietary patterns may not be appreciably associated with type 2 diabetes risk in Japanese.European Journal of Clinical Nutrition advance online publication, 24 October 2012; doi:10.1038/ejcn.2012.171.
European journal of clinical nutrition 10/2012; · 3.07 Impact Factor
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ABSTRACT: Background/Objectives:The association between vitamin D status and insulin resistance (IR) has been less studied among Asians, and it remains elusive whether calcium could modify such an association. We examined the association of serum 25-hydroxyvitamin D (25(OH)D) concentrations with IR markers and the potential effect modification by calcium intake among a Japanese population.Subjects/Methods:The authors analyzed data (n=494) from a cross-sectional survey conducted in 2009 among a Japanese working population aged 20-68 years. Fasting serum 25(OH)D and insulin, as well as fasting plasma glucose were determined, and homeostatic model assessment of IR (HOMA-IR) was calculated. Calcium intake was assessed using a validated diet history questionnaire. Multiple linear regression was done with adjustment of potential confounding variables.Results:Fasting insulin and HOMA-IR were significantly inversely associated with 25(OH)D concentration across quartiles of 25(OH)D after fully adjusting for covariates (P(trend)=0.04 and 0.02, respectively). Across clinically relevant categories of 25(OH)D, compared with participants in the vitamin D sufficiency group, those in the vitamin D insufficiency group had a 5% higher HOMA-IR score, and those in the hypovitaminosis D group had an 18% higher HOMA-IR score (P(trend)=0.01). In an analysis by calcium intake, the HOMA-IR score was highest among participants with both a low calcium intake and lowest 25(OH)D concentrations, with significant inverse trend being observed in the group with lower calcium intake (P(trend)=0.02).Conclusions:Our findings suggest that low vitamin D status is associated with IR among Japanese adults.European Journal of Clinical Nutrition advance online publication, 24 October 2012; doi:10.1038/ejcn.2012.169.
European journal of clinical nutrition 10/2012; · 3.07 Impact Factor
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ABSTRACT: Aims/hypothesisCalcium and vitamin D have been implicated in the development of type 2 diabetes, but epidemiological evidence is limited.
We examined prospectively the relation of calcium and vitamin D intake to type 2 diabetes risk in a Japanese cohort.
MethodsParticipants were 59,796 middle-aged and older men and women, who participated in the Japan Public Health Center-based Prospective
Study and had no history of type 2 diabetes or other serious diseases. Dietary intake of calcium and vitamin D were estimated
using a validated food frequency questionnaire. Logistic regression was used to assess the association between intake of these
nutrients and self-reported newly diagnosed type 2 diabetes.
ResultsDuring a 5year follow-up, 1,114 cases of type 2 diabetes were documented. Overall, calcium intake was not associated with
a significantly lower risk of type 2 diabetes; the multivariable odds ratio for the highest vs lowest quartiles was 0.93 (95%
CI 0.71–1.22) in men and 0.76 (95% CI 0.56–1.03) in women. However, among participants with a higher vitamin D intake, calcium
intake was inversely associated with diabetes risk; the odds ratio for the highest vs lowest intake categories was 0.62 (95%
CI 0.41–0.94) in men and 0.59 (95% CI 0.38–0.91) in women. Dairy food intake was significantly associated with a lower risk
of type 2 diabetes in women only.
Conclusions/interpretationCalcium and vitamin D may not be independently associated with type 2 diabetes risk. Our finding suggesting a joint action
of these nutrients against type 2 diabetes warrants further investigation.
KeywordsCalcium-Cohort studies-Type 2 diabetes-Vitamin D
Diabetologia 04/2012; 52(12):2542-2550. · 6.81 Impact Factor
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ABSTRACT: OBJECTIVE:To examine the relationship between short sleep duration and body mass index (BMI), waist circumference (WC), visceral fat area (VFA) and subcutaneous fat area (SFA) among a working population in Japan.DESIGN:Health-center-based, cross-sectional study.SUBJECTS:The study subjects included 5400 men and 642 women aged 30 to 75 years who underwent an abdominal computed tomography (CT) scanning examination in a comprehensive health checkup.MEASUREMENTS:Height and weight were measured, and BMI was calculated. WC, VFA and SFA were measured using a CT scanner. Sleep duration was self-reported. Analysis of covariance was used to estimate adjusted means of BMI, WC, VFA and SFA across categories of sleep duration with adjustments for potential confounders. Trend of the association was assessed using multiple linear regression analysis.RESULTS:In men, the mean values of BMI, WC and SFA decreased with increasing sleep duration after adjustment for age, physical activity, smoking and drinking (P-value for trend <0.001). Additional adjustment for physical illnesses did not attenuate the explanatory power of the models (P-value for trend <0.001). In addition, the association between sleep duration and SFA did not change after controlling for VFA (P-value for trend <0.001). The mean values of SFA for subjects sleeping '<5 h', '5 to <6 h', '6 to <7 h' and '7 h' per day were 145.8±67.4 cm(2), 138.7±61.5 cm(2), 134.7±60.4 cm(2) and 132.5±49.2 cm(2), respectively. Sleep duration was not appreciably associated with VFA. In women, no significant association was detected in any models.CONCLUSION:Shorter sleep duration is associated with higher BMI, WC and SFA in men. Further research is needed to explicate the biological mechanisms behind these relationships and to see whether interventions addressing inadequate sleep could treat or prevent obesity by taking gender differences into consideration.International Journal of Obesity advance online publication, 21 February 2012; doi:10.1038/ijo.2012.17.
International journal of obesity (2005) 02/2012; · 4.34 Impact Factor
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K Matsuo, T Mizoue,
K Tanaka,
I Tsuji,
Y Sugawara,
S Sasazuki,
C Nagata,
A Tamakoshi,
K Wakai,
M Inoue,
S Tsugane
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ABSTRACT: Obesity has been recognized as important risk factors for colorectal cancer. However, limited evidence is available on colorectal cancer and body mass index (BMI) in Asian population.
We conducted a pooled analysis of eight population-based prospective cohorts studies in Japan with more than 300,000 subjects to evaluate an impact of obesity in terms of BMI on colorectal cancer risk with unified categories. We estimated summary hazard ratio (HR) by pooling of study-specific HR for BMI categories with random effect model.
We found a significant positive association between BMI and colorectal cancer risk in male and female. Adjusted HRs for 1 kg/m(2) increase were 1.03 [95% confidence interval (CI) 1.02-1.04] for males and 1.02 (95% CI 1.00-1.03) for females. The association was stronger in colon, especially in proximal colon, relative to rectum. Males showed a stronger association than females. Population attributable fraction for colorectal cancer by BMI ≥ 25 kg/m(2) was 3.62% (95% CI 1.91-5.30) for males and 2.62% (95% CI 0.74-4.47) for females.
We found significant association between BMI and colorectal cancer risk by pooling of data from cohort studies with considerable number of subjects among Japanese population. This information is important in cancer control planning, especially in Asian population.
Annals of Oncology 05/2011; 23(2):479-90. · 6.43 Impact Factor
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ABSTRACT: This study examined the association between magnesium intake and type II diabetes risk among Japanese adults. Participants were 25 872 men and 33 919 women aged 45-75 years who had no history of diabetes. Magnesium intake was ascertained using a 147-item food frequency questionnaire. Odds ratio of self-reported physician-diagnosed type II diabetes over 5 years was estimated using logistic regression analysis. A total of 1114 new cases of type II diabetes were self-reported. Magnesium intake was not significantly associated with type II diabetes in either men or women. The multivariable-adjusted odds ratios (95% confidence intervals) of type II diabetes for the highest versus lowest quintile of magnesium intake were 0.86 (0.63-1.16) and 0.92 (0.66-1.28) for men and women, respectively. Although a small effect cannot be excluded in men, magnesium intake may not be appreciably associated with risk of type II diabetes for Japanese adults.
European journal of clinical nutrition 10/2010; 64(10):1244-7. · 3.07 Impact Factor
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ABSTRACT: Although several studies have reported associations of depressive state with specific nutrients and foods, few studies examined the association with dietary patterns in adults. We investigated the association between major dietary patterns and depressive symptoms in Japanese.
Subjects were 521 municipal employees (309 men and 212 women), aged 21-67 years, who participated in a health survey at the time of periodic checkup. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) Scale. Dietary patterns were derived by using principal component analysis of the consumption of 52 food and beverage items, which was assessed by a validated brief diet history questionnaire. Logistic regression analysis was used to estimate odds ratios of depressive symptoms (CES-D >or=16) with adjustment for potential confounding variables.
We identified three dietary patterns. A healthy Japanese dietary pattern characterized by high intakes of vegetables, fruit, mushrooms and soy products was associated with fewer depressive symptoms. The multivariate-adjusted odds ratios (95% confidence intervals) of having depressive symptoms for the lowest through highest tertiles of the healthy Japanese dietary pattern score were 1.00 (reference), 0.99 (0.62-1.59) and 0.44 (0.25-0.78), respectively (P for trend=0.006). Other dietary patterns were not appreciably associated with depressive symptoms.
Our findings suggest that a healthy Japanese dietary pattern may be related to decreased prevalence of depressive status.
European journal of clinical nutrition 08/2010; 64(8):832-9. · 3.07 Impact Factor
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ABSTRACT: Folate and homocysteine have been implicated to have a role in depression. However, results of epidemiologic studies on this issue have been inconsistent. The objective of this study was to clarify the association between serum folate and homocysteine concentrations and depressive symptoms in Japanese adults.
We analyzed cross-sectional data for 530 municipal employees (313 men and 217 women), aged 21-67 years, who participated in a health survey at the time of periodic checkup. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression analysis was used to estimate odds ratios of depressive symptoms (CES-D scale scores of >or=16) with adjustment for potential confounding variables.
In total, 113 men (36.1%) and 79 women (36.4%) had depressive symptoms. A higher serum folate was associated with a decreased prevalence of depressive symptoms in men. The multivariate-adjusted odds ratios (95% confidence interval) of depressive symptoms for the lowest to highest quartiles of serum folate were 1.00 (reference), 0.53 (0.27-1.03), 0.33 (0.16-0.68) and 0.51 (0.25-1.03), respectively (trend P=0.03). Furthermore, the data suggested a positive association between serum homocysteine and depressive symptoms in men (trend P=0.06). In women, neither folate nor homocysteine was associated with depressive symptoms.
Low serum folate may be related to an increased prevalence of depressive symptoms in Japanese men.
European journal of clinical nutrition 03/2010; 64(3):289-96. · 3.07 Impact Factor
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ABSTRACT: It is unclear whether weight change during adulthood influences subsequent mortality in Asian populations, who have a relatively lean body mass.
To assess the relation of weight change over 5 years to all-cause, cancer and cardiovascular disease mortality among Japanese men and women.
Subjects were 36 220 men and 44 091 women aged between 45 and 75 years without a history of serious disease at baseline. Weight change was calculated as the difference of body weight between two surveys with a 5-year interval.
During 699 963 person-years of follow-up, we identified 4232 deaths of all-cause, 1872 cancer deaths and 1021 cardiovascular deaths. The relation between weight change and all-cause mortality was reverse J-shaped. Multivariate hazard ratios (95% confidence interval) for weight loss of 5 kg or more versus weight change of less than 2.5 kg were 1.62 (1.45-1.81) in men and 1.76 (1.51-2.05) in women, whereas those for weight gain of 5 kg or more were 1.40 (1.22-1.59) in men and 1.25 (1.02-1.54) in women. These associations remained statistically significant even after the exclusion of deaths in the first 3 years of follow-up. The weight change-mortality association was pronounced in underweight persons or in nonsmoking men. The risk of cancer mortality increased in both men and women who lost weight by 5 kg or more. With regard to cardiovascular disease, mortality risk tended to increase with weight loss both in men and women, whereas its increase with weight gain was observed only in women.
A large weight change, both loss and gain, was associated with an increased risk of mortality. Weight loss and gain may be predictors of early death in apparently healthy adult Japanese.
International journal of obesity (2005) 11/2009; 34(2):348-56. · 4.34 Impact Factor
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ABSTRACT: Calcium and vitamin D have been implicated in the development of type 2 diabetes, but epidemiological evidence is limited. We examined prospectively the relation of calcium and vitamin D intake to type 2 diabetes risk in a Japanese cohort.
Participants were 59,796 middle-aged and older men and women, who participated in the Japan Public Health Center-based Prospective Study and had no history of type 2 diabetes or other serious diseases. Dietary intake of calcium and vitamin D were estimated using a validated food frequency questionnaire. Logistic regression was used to assess the association between intake of these nutrients and self-reported newly diagnosed type 2 diabetes.
During a 5 year follow-up, 1,114 cases of type 2 diabetes were documented. Overall, calcium intake was not associated with a significantly lower risk of type 2 diabetes; the multivariable odds ratio for the highest vs lowest quartiles was 0.93 (95% CI 0.71-1.22) in men and 0.76 (95% CI 0.56-1.03) in women. However, among participants with a higher vitamin D intake, calcium intake was inversely associated with diabetes risk; the odds ratio for the highest vs lowest intake categories was 0.62 (95% CI 0.41-0.94) in men and 0.59 (95% CI 0.38-0.91) in women. Dairy food intake was significantly associated with a lower risk of type 2 diabetes in women only.
Calcium and vitamin D may not be independently associated with type 2 diabetes risk. Our finding suggesting a joint action of these nutrients against type 2 diabetes warrants further investigation.
Diabetologia 10/2009; 52(12):2542-50. · 6.81 Impact Factor
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ABSTRACT: Both depressive symptoms and vitamin D insufficiency are common during winter. This study examined the association between serum 25-hydroxyvitamin D and depressive symptoms by survey season. Subjects were 527 municipal employees aged 21-67 years of two municipal offices in Japan. Overall, there was no measurable association. However, in the workplace surveyed in November, multivariate-adjusted odds ratios (95% confidence interval) of having depressive symptoms (Center for Epidemiologic Studies Depression score of >or=16) for the lowest through highest quartiles of serum 25-hydroxyvitamin D were 1.00 (reference), 0.84 (0.45-1.58), 0.83 (0.44-1.58) and 0.59 (0.30-1.15), respectively (trend P=0.14). The association with the severe depressive state was more pronounced. By contrast, there was no such association in the workplace surveyed in July. Overall, this study did not provide evidence linking higher blood vitamin D levels with decreased depressive symptoms. The suggestive inverse association in sun-deprived season warrants further investigation.
European journal of clinical nutrition 08/2009; 63(12):1444-7. · 3.07 Impact Factor
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ABSTRACT: Limited data are available with regard to longitudinal changes in body weight by food taste preference. Here, we examined the associations between taste preferences and weight change in adults for a large-scale cohort study in Japan.
Longitudinal analysis of data from a population-based cohort study, the Japan Public Health Center-based Prospective Study (JPHC Study).
A total of 29,103 middle-aged men and women, who participated in a JPHC Study and returned questionnaires on lifestyle and diet, including taste preferences, at both baseline and the 10th year of follow-up.
We assessed the relations of preferences for rich and heavy taste and a sweet taste to weight changes between the age of 20 years and baseline and those during the 10-year follow-up period.
Preferences for rich and heavy taste and for sweet taste were significantly positively associated with weight increases between the age of 20 years and baseline (P for trend <0.001); the fully adjusted odds ratios (95% confidence interval) comparing the 'like' versus 'dislike' groups with a preference for rich and heavy taste were 1.45 (1.31-1.24) for men and 1.28 (1.16-1.41) for women, whereas that for a sweet taste preference was 1.22 (1.09-1.36) for women. As regards weight change during the 10 years of follow-up, subjects who liked the sweet taste and those who neither liked nor disliked this taste experienced a significantly greater increase than those who disliked it in both men and women. There was no such difference for rich and heavy taste.
These results suggest that food taste preferences may be an important predictor of weight changes in adults. Taste preferences need to be considered when counseling patients to achieve weight control.
International journal of obesity (2005) 07/2009; 33(10):1191-7. · 4.34 Impact Factor
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ABSTRACT: Limited data are available regarding longitudinal changes in body weight. Here, we describe changes in the prevalences of overweight and obesity and calculated the incidence of these indices during a 10-year follow-up period for a large-scale cohort study in Japan.
Longitudinal analysis of data from a population-based cohort study, the Japan Public Health Center (JPHC) Study.
A total of 65 095 Japanese men and women, who were between the ages of 40 and 69 years at baseline and participated in the 5th- and 10th-year follow-up surveys of the JPHC, were enroled in the study.
Mean body mass index (BMI), calculated using self-reported height and weight, and the prevalences of overweight (BMI >or=25 kg/m(2)) and obesity (BMI >or=30 kg/m(2)) at each survey period. Incidences of overweight and obesity during the 10-year period.
On an average, individuals living in Okinawa had much higher BMIs than those living on the Main islands for all sex and age groups. During the follow-up period, the prevalences of overweight and obesity steadily increased in the cohorts aged less than 50 years at baseline in both sexes. Men in younger cohorts had a higher mean BMI than those in the same age group of older cohorts, whereas the opposite trend was observed in women. The incidence of overweight individuals was greater in Okinawa than on the Main islands and among younger generations than among older ones.
A longitudinal analysis at the individual level showed that the prevalences of overweight and obesity increased among middle-aged Japanese participants during the follow-up period. Among men, an increasing prevalence of obesity was observed among the younger generations. These findings should be taken into consideration when planning preventive strategies for obesity and its related diseases.
International journal of obesity (2005) 10/2008; 32(12):1861-7. · 4.34 Impact Factor
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ABSTRACT: Several studies have reported positive associations between oral infections and systemic diseases. The purpose of the present study was to evaluate the effects of oral symptoms on mortality from cardiovascular disease (CVD) and pneumonia. Using data from a cohort study in Japan, we analyzed 4,139 individuals aged 40-79 years. The baseline questionnaire included the following items related to oral symptoms: 'sensitive teeth', 'difficulty in chewing tough food substances', 'bleeding gums', and 'mouth feels sticky'. We used the Cox proportional hazard model to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs) for mortality, after adjustments for lifestyle, socio-economic factors, and history of diseases. Persons complaining that their 'mouth feels sticky' had a two-fold higher risk of pneumonia (HR = 2.1; 95%CI, 1.2-3.6), while those complaining of 'sensitive teeth' had a lower risk of CVD (HR = 0.4; 95%CI, 0.2-0.9). Some oral symptoms may be predictors of mortality from pneumonia and CVD.
Journal of Dental Research 06/2008; 87(5):485-9. · 3.49 Impact Factor
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ABSTRACT: To prospectively examine the association of cigarette smoking and alcohol drinking with oral and pharyngeal carcinogenesis, we analyzed data from a nation-wide large-scale cohort study in Japan.
A total of 34 136 men and 43 711 women aged 40-79 years were included in the study. The Cox proportional hazard model was used to estimate the relative risk (RR) and 95% confidence interval (95% CI) of oral and pharyngeal cancer for smoking and drinking by sex, while adjusting for age, consumption of green tea, preference for salty foods, and consumption of green yellow vegetables.
Current smokers were found to have a higher risk of death caused by oral and pharyngeal cancer compared with non-smokers in both sexes: the RR was 2.6 (95% CI: 1.0-6.7) in men and 8.2 (95% CI: 2.1-32.1) in women. Men who drank more than 46 g ethanol per day had an approximately threefold increased risk of oral and pharyngeal cancer. Simultaneous exposure to both factors was significantly associated with an elevated risk of oral and pharyngeal cancer (RR: 3.3, 95% CI: 1.1-9.6).
The result supports the carcinogenic effect of cigarette smoking and alcohol drinking on the oral cavity and pharynx.
Oral Diseases 06/2008; 14(4):314-9. · 2.49 Impact Factor
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ABSTRACT: The aim of this paper is to develop a short version of the Japanese OHIP (OHIP-J) appropriate for use in young and middle-aged adults, and to evaluate its properties using cross-sectional data.
A study population of 8,658 workers aged 20-59 years rated their oral health by means of a self-administered questionnaire. Using a factor analysis approach, a shortened version of OHIP-J was derived. Internal consistency, floor effect, and construct validity were determined.
We derived a subset of 18 items from OHIP-J (OHIP-JA18), grouped into four subscales: "functional limitation", "physical pain", "psychological discomfort", and "disability & handicap". All four subscales had acceptable internal consistency (Cronbach alpha > 0.79). OHIP-JA18 demonstrated an acceptable floor effect, which was determined by the proportion of subjects who obtained a 0 score (< 30%); however, the floor effect of the ordinary shortened version based on OHIP-14 (OHIP-J14) was not acceptable. We confirmed the conceptual framework of OHIP-JA18 that "disability & handicap" is affected by "functional limitation", "physical pain" and "psychological discomfort", because the model fitted the data moderately well by structural equation modeling (SEM) analysis (GFI = 0.90, RMSEA = 0.08).
OHIP-JA18 demonstrated acceptable measurement parameters to justify its use in outcome assessment for oral health related quality of life (OHQOL) in young and middle-aged adults in Japanese workers. Further studies will be needed to evaluate an intervention such as worksite health promotion.
Community dental health 03/2008; 25(1):38-43. · 0.75 Impact Factor
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ABSTRACT: To examine whether the risk of mortality varies according to parents' age at death.
A large prospective study in Japanese men and women from 45 communities across Japan. A total of 51 485 men and women aged 40-79 years completed self-administered questionnaires at baseline and followed up for 9.6 years.
The risk of mortality from stroke, cardiovascular disease, and all causes was 20-30% lower in men and women with fathers who died at age > or = 80 years, compared with those with fathers whose age at death was <60 years. A similar reduction was found when the age at death of mothers was > or = 85 years compared with <65 years. Furthermore, the risk reduction was more evident amongst persons with both parents being long-lived parents compared with those with being short-lived parents, especially for death from cardiovascular disease.
Our findings indicate that parental longevity could be a predictor for reduced risk of mortality from stroke, cardiovascular disease, and all causes for both Japanese men and women.
Journal of Internal Medicine 03/2006; 259(3):285-95. · 5.48 Impact Factor
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H Yatsuya,
H Toyoshima,
A Tamakoshi,
S Kikuchi,
K Tamakoshi,
T Kondo, T Mizoue,
N Tokui,
Y Hoshiyama,
K Sakata,
N Hayakawa,
T Yoshimura
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ABSTRACT: We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58-16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.
British Journal of Cancer 09/2004; 91(5):929-34. · 5.04 Impact Factor
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Y Hoshiyama,
T Kawaguchi,
Y Miura, T Mizoue,
N Tokui,
H Yatsuya,
K Sakata,
T Kondo,
S Kikuchi,
H Toyoshima,
N Hayakawa,
A Tamakoshi,
Y Ohno,
T Yoshimura
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ABSTRACT: To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40-79 years. Cox proportional hazards regression analysis was used to estimate the RRs for stomach cancer. It was found that green tea consumption had no protective effect against stomach cancer. After adjustment for age, smoking status, H. pylori infection, history of peptic ulcer, and family history of stomach cancer along with certain dietary elements, the risks associated with drinking one or two, three or four, five to nine, and 10 or more cups of green tea per day, relative to those of drinking less than one cup per day, were 1.3 (95% confidence interval (CI): 0.6-2.8), 1.0 (95% CI: 0.5-1.9), 0.8 (95% CI: 0.4-1.6), and 1.2 (95% CI: 0.6-2.5), respectively (P for trend=0.899). We found no inverse association between green tea consumption and the risk of stomach cancer.
British Journal of Cancer 02/2004; 90(1):135-8. · 5.04 Impact Factor
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ABSTRACT: Evidence has accumulated concerning the adverse effects of smoking on hearing acuity, but it is not clear whether smoking modifies the association between exposure to noise and hearing loss.
To examine the synergistic effect of these variables on hearing.
Data used were derived from periodic health examinations for 4624 steel company workers in Japan and included audiometry testing and information on smoking habits. Occupational exposure to noise was determined based on company records. Logistic regression was used to examine the dose-response association between smoking and hearing loss. The Cochran-Mantel-Haenszel method was used to calculate the prevalence rate ratio (PRR) of hearing loss for each combination of smoking and noise exposure factors, taking non-smokers not exposed to occupational noise as a reference. The interaction between smoking and noise exposure was assessed using a synergistic index, which equals 1 when the joint effect is additive.
Smoking was associated with increased odds of having high frequency hearing loss in a dose-response manner. The PRR for high frequency hearing loss among smokers exposed to occupational noise was 2.56 (95% CI 2.12 to 3.07), while the PRR for smokers not exposed to noise was 1.57 (95% CI 1.31 to 1.89) and the PRR for non-smokers exposed to noise was 1.77 (95% CI 1.36 to 2.30). The synergistic index was 1.16. Smoking was not associated with low frequency hearing loss.
Smoking may be a risk factor for high frequency hearing loss, and its combined effect on hearing with exposure to occupational noise is additive.
Occupational and Environmental Medicine 02/2003; 60(1):56-9. · 3.02 Impact Factor
