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Y Rolland,
P de Souto Barreto,
G Abellan Van Kan,
C Annweiler,
O Beauchet,
H Bischoff-Ferrari,
G Berrut,
H Blain,
M Bonnefoy,
M Cesari,
G Duque, M Ferry,
O Guerin,
O Hanon,
B Lesourd,
J Morley,
A Raynaud-Simon,
G Ruault,
J-C Souberbielle,
B Vellas
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ABSTRACT: Background: The prevalence of vitamin D insufficiency is very high in the nursing home (NH) population. Paradoxically, vitamin D insufficiency is rarely treated despite of strong clinical evidence and recommendations for supplementation. This review aims at reporting the current knowledge of vitamin D supplementation in NH and proposing recommendations adapted to the specificities of this institutional setting. Design: Current literature on vitamin D supplementation for NH residents was narratively presented and discussed by the French Group of Geriatrics and Nutrition. Result: Vitamin D supplementation is a safe and well-tolerated treatment. Most residents in NH have vitamin D insufficiency, and would benefit from vitamin D supplement. However, only few residents are actually treated. Current specific and personalized protocols for vitamin D supplementation may not be practical for use in NH settings (e.g., assessment of serum vitamin D concentrations before and after supplementation). Therefore, our group proposes a model of intervention based on the systematic supplementation of vitamin D (1,000 IU/day) since the patient's admission to the NH and throughout his/her stay without the need of a preliminary evaluation of the baseline levels. Calcium should be prescribed only in case of poor dietary calcium intake. Conclusion: A population-based rather than individual-based approach may probably improve the management of vitamin D insufficiency in the older population living in NH, without increasing the risks of adverse health problems. The clinical relevance and cost effectiveness of this proposal should be assessed under NH real-world conditions to establish its feasibility.
The Journal of Nutrition Health and Aging 01/2013; 17(4):402-12. · 2.69 Impact Factor
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ABSTRACT: ObjectivesBecause of their structural, anti-inflammatory and antithrombic properties, longchain n-3 fatty acids may be key factors in
the aging process. We sought to elucidate the association between intake of long-chain n-3 fatty acids and/or fish and cognitive
function evaluated 13 years after dietary assessment.
DesignProspective population-based study.
Participants/Setting3,294 adults from the SU.VI.MAX study (Supplementat ion with Antioxidant Vitamins and Minerals study).
Measurements/Statistical analysisSubjects underwent a standardized clinical examination which included cognitive tests and self-reported cognitive difficulties
scale (2007–2009). Poor scores were defined using percentiles as cut-off. Dietary data were assessed through repeated 24-h
dietary records. Odd ratio (OR), comparing the fourth (Q4) to the first quartile (Q1), of having a poor score were calculated
using adjusted logistic regression.
ResultsSelf-reported cognitive difficulties were less frequent among subjects with higher intakes of total n-3 long chain fatty acids
(OR = 0.72, CI 95%=0.56–0.92) and eicosapentaenoic acid (OR Q4 versus Q1 = 0.74, CI 95%=0.58–0.95), even after adjustment
for depressive symptoms. A borderline significant association was also found with high fish consumption (OR Q4 versus Q1 =
0.80, CI 95%=0.63−1.01).
ConclusionCognitive complaints, which may be an early indicator of cognitive decline, are less frequent among the elderly who have a
high long-chain n-3 acids intake, as assessed 13 years earlier.
Key wordsCognition–cognitive difficulties–fish–omega-3 fatty acids
The Journal of Nutrition Health and Aging 04/2012; 15(2):115-120. · 2.69 Impact Factor
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[show abstract]
[hide abstract]
ABSTRACT: Because of their structural, anti-inflammatory and antithrombic properties, long-chain n-3 fatty acids may be key factors in the aging process. We sought to elucidate the association between intake of long-chain n-3 fatty acids and/or fish and cognitive function evaluated 13 years after dietary assessment.
Prospective population-based study.
3,294 adults from the SU.VI.MAX study (Supplementation with Antioxidant Vitamins and Minerals study). MEASUREMENTS/STATISTICAL ANALYSIS: Subjects underwent a standardized clinical examination which included cognitive tests and self-reported cognitive difficulties scale (2007-2009). Poor scores were defined using percentiles as cut-off. Dietary data were assessed through repeated 24-h dietary records. Odd ratio (OR), comparing the fourth (Q4) to the first quartile (Q1), of having a poor score were calculated using adjusted logistic regression.
Self-reported cognitive difficulties were less frequent among subjects with higher intakes of total n-3 long chain fatty acids (OR = 0.72, CI 95%=0.56-0.92) and eicosapentaenoic acid (OR Q4 versus Q1 = 0.74, CI 95%=0.58-0.95), even after adjustment for depressive symptoms. A borderline significant association was also found with high fish consumption (OR Q4 versus Q1 = 0.80, CI 95%=0.63-1.01).
Cognitive complaints, which may be an early indicator of cognitive decline, are less frequent among the elderly who have a high long-chain n-3 acids intake, as assessed 13 years earlier.
The Journal of Nutrition Health and Aging 01/2011; 15(2):115-20. · 2.69 Impact Factor
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E Orvoen-Frija,
M Benoit,
M Catto,
M Chambouleyron,
A Duguet,
J-P Emeriau, M Ferry,
M Hayot,
C Jeandel,
V Morize,
K Nassih,
H Ouksel,
F Piette,
C Prefaut,
N Roche,
B de Wazieres,
M Zureik
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ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by incompletely reversible airflow limitation, measured by a decrease of FEV(1)/FVC ratio. International consensus does not agree on a single threshold for this ratio, which can define airflow obstruction. Although the prevalence of COPD in the elderly population varies according to the definition used, it definitely increases with age and could reach 15% in those over 65 years of age. Therefore, ageing of the population should result in increased prevalence and socioeconomical costs of COPD during coming years. In France, diagnosis of COPD in the elderly is difficult, late and insufficient. Management, which has the same goals as in younger populations, has to be global and coordinated. Some points should be considered with particular attention considering the cumulative risks related on the one hand to COPD and on the other to ageing: pharmacological side-effects, decreased physical and social autonomy, nutritional impairment, comorbidities. Given the lack of specific data in elderly populations, pharmacological indications are generally considered to be the same as in younger populations, but some additional precautionary measures are necessary. Pulmonary rehabilitation seems to be beneficial at any age. Palliative care comes up against important difficulties: an indefinite beginning of the palliative stage in COPD; insufficient palliative care resources; insufficient communication; insufficient utilization of palliative care resources. Global COPD management in elderly requires coordination, best reached in health care network organizations involving medical and/or social professionals.
Revue des Maladies Respiratoires 10/2010; 27(8):855-73. · 0.59 Impact Factor
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S Gillette Guyonnet,
G Abellan Van Kan,
S Andrieu,
P Barberger Gateau,
C Berr,
M Bonnefoy,
J F Dartigues,
L de Groot, M Ferry,
P Galan, [......],
C Jeandel,
M C Morris,
F Nourhashemi,
H Payette,
J P Poulain,
F Portet,
A M Roussel,
P Ritz,
Y Rolland,
B Vellas
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ABSTRACT: Cognitive impairment can be influenced by a number of factors. The potential effect of nutrition has become a topic of increasing scientific and public interest. In particular, there are arguments that nutrients (food and/or supplements) such as vitamins, trace minerals, lipids, can affect the risk of cognitive decline and dementia, especially in frail elderly people at risk of deficiencies. Our objective in this paper is to review data relating diet to risk of cognitive decline and dementia, especially Alzheimer's disease (AD). We chose to focus our statements on homocysteine-related vitamins (B-vitamins), antioxidant nutrients (vitamins E and C, carotenoids, flavonoids, enzymatic cofactors) and dietary lipids. Results of epidemiological studies may sometimes appeared conflicting; however, certain associations are frequently found. High intake of saturated and trans-unsaturated (hydrogenated) fats were positively associated with increased risk of AD, whereas intake of polyunsaturated and monounsaturated fats were protective against cognitive decline in the elderly in prospective studies. Fish consumption has been associated with lower risk of AD in longitudinal cohort studies. Moreover, epidemiologic data suggest a protective role of the B-vitamins, especially vitamins B9 and B12, on cognitive decline and dementia. Finally, the results on antioxidant nutrients may suggest the importance of having a balanced combination of several antioxidant nutrients to exert a significant effect on the prevention of cognitive decline and dementia, while taking into account the potential adverse effects of these nutrients. There is no lack of attractive hypotheses to support research on the relationships between nutrition and cognitive decline. It is important to stress the need to develop further prospective studies of sufficiently long duration, including subjects whose diet is monitored at a sufficiently early stage or at least before disease or cognitive decline exist. Meta analyses should be developed, and on the basis of their results the most appropriate interventional studies can be planned. These studies must control for the greatest number of known confounding factors and take into account the impact of the standard social determinants of food habits, such as the regional cultures, social status, and educational level.
The Journal of Nutrition Health and Aging 03/2007; 11(2):132-52. · 2.69 Impact Factor
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E E A Simpson,
E A Maylor,
G Rae,
N Meunier,
M Andriollo-Sanchez,
G Catasta,
C McConville, M Ferry,
A Polito,
B J Stewart-Knox,
D L Secker,
C Coudray
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ABSTRACT: Baseline data are reported from a study of the effects of zinc supplementation on cognitive function in older adults as assessed by the CANTAB computerised test battery.
This is a multicentre prospective intervention study employing a randomised double-blind design.
European community-based study.
There are 387 healthy adults aged 55-87 y from centres in France, Italy and Northern Ireland.
Measures of visual memory, working memory and attention were obtained at baseline (prior to supplementation).
Younger adults (<70 y) performed significantly better than older adults (>70 y) on all tests, with minimal differences between centres. In addition, men outperformed women on tests of spatial span, pattern recognition memory and reaction times, although these gender differences varied somewhat between centres.
The results are generally consistent with previous age- and gender-related effects on cognitive functioning.
European Journal of Clinical Nutrition 12/2005; 59 Suppl 2:S26-30. · 2.46 Impact Factor
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A Polito,
N Meunier,
M Andriollo-Sanchez,
G Catasta,
E Azzini,
E E A Simpson,
J M O'Connor,
A M Roussel, M Ferry,
C Coudray,
G Maiani
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ABSTRACT: To report the rational, design, recruitment, baseline characteristics and preliminary overview of volunteers in the ZENITH study.
A multicentre prospective intervention study employing a randomised double-blind design.
Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy).
Healthy men and women middle-aged (55-70 y) and older volunteers (70-87 y).
At baseline (prior to zinc (Zn) supplementation), all volunteers underwent a full clinical examination, anthropometric measurements, health and lifestyle questionnaire, Mini Mental State Examination, Geriatric Depression Scale, and biochemistry profile.
In total, 842 volunteers (378 men and 464 women) were invited to take part in the study. A total of 49% of these volunteers were excluded on the basis of inclusion/exclusion criteria. In total, 433 participants were admitted to the Zn supplementation for 6 months. During this period, about 10% of volunteers dropped out from the study.
A total of 387 subjects (197 male and 190 female subjects) successfully completed the supplementation phase of the ZENITH study.
European Journal of Clinical Nutrition 12/2005; 59 Suppl 2:S8-12. · 2.46 Impact Factor
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E E A Simpson,
J M O'Connor,
M B E Livingstone,
G Rae,
B J Stewart-Knox,
M Andriollo-Sanchez,
E Toti,
N Meunier, M Ferry,
A Polito,
M Kelly,
J M W Wallace,
C Coudray
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ABSTRACT: To describe health and lifestyle factors of participants in the ZENITH study.
A prospective multicentre intervention study employing a randomised double-blind design.
Community dwelling older adults (n = 387), aged 55-87 y were recruited from regions in France, Italy and the UK.
A self-report questionnaire comprising socio-demographic variables, dietary habits, physical activity in the home, at work and recreation.
Participants differed with regards dietary habits and physical activity for each region. Recreational activity was higher in France and women generally tend to perform less hours of recreational activity per week than men.
The differences found for these regions of Europe in relation to lifestyle factors will affect health and well-being within these countries and may mediate the impact of zinc supplementation on various biological and psychological parameters.
European Journal of Clinical Nutrition 12/2005; 59 Suppl 2:S13-21. · 2.46 Impact Factor
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M Andriollo-Sanchez,
I Hininger-Favier,
N Meunier,
E Toti,
M Zaccaria,
M Brandolini-Bunlon,
A Polito,
J M O'Connor, M Ferry,
C Coudray,
A-M Roussel
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ABSTRACT: Inadequate intakes of micronutrients in elderly negatively affect the nutritional status. Zinc is an essential micronutrient in the elderly, especially in relation to its impact on immune function, bone mass, cognitive function and oxidative stress. However, data are lacking on zinc intake and status during normal ageing. In this study, we evaluate the intake and status of zinc in late middle-aged and older free-living subjects.
Dietary zinc intake and zinc status in 188 middle-aged subjects from Clermont-Ferrand (Fr) and Coleraine (UK), and in 199 older subjects from Grenoble (Fr) and Roma (It) were assessed at the entry in the ZENITH study.
In relation to the zinc RDA for people older than 55 y, zinc intakes in most of the middle-aged and older subjects (more than 96%) in the present study were adequate. Older people had significantly lower (P < 0.01) energy intakes as compared to middle-aged. Zinc intake expressed per MJ was also significantly (P < 0.01) higher in older people compared to middle-aged. Erythrocyte and urinary zinc concentrations were significantly (P < 0.001) higher in middle-aged subjects compared to older ones. The prevalence of biological Zn deficiency in free-living ageing European people was low (<5%).
The results of the present study showed a relatively low prevalence of zinc deficiencies in healthy free-living late middle-age and older subjects. These results should be useful for health professionals to have reference data on zinc intake and status for a healthy ageing.
European Journal of Clinical Nutrition 12/2005; 59 Suppl 2:S37-41. · 2.46 Impact Factor
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ABSTRACT: Zinc is known to be essential for a great number of biochemical activities and physiological and cognitive functions. The objective of Zenith study was to investigate the effects of Zn, as a nutritional supplement, on psychological and behavioural factors and on surrogate markers that are indicative of trends towards better health in order to evaluate the need for dietary recommendations specific to the studied population. We report in this paper the summary of baseline results obtained before Zn supplementation.
European Journal of Clinical Nutrition 12/2005; 59 Suppl 2:S5-7. · 2.46 Impact Factor
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ABSTRACT: The elderly are at nutritional risk as a result of multiple physiological, social, psychological, and economic factors. Physiological functions naturally decline with age, which may influence absorption and metabolism. Social and economic conditions can adversely affect dietary choices and eating patterns. However, at the same time, the nutrient needs of the elderly for certain nutrient (such as vitamins, minerals, proteins) is higher than for younger adults. This article reviews the importance of zinc (Zn) in elderly people, particularly for behavioural and mental function, micronutrient status, immune and antioxidant system, and bone metabolism.
European Journal of Clinical Nutrition 12/2005; 59 Suppl 2:S1-4. · 2.46 Impact Factor
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E E A Simpson,
J M O'Connor,
M B E Livingstone,
G Rae,
B J Stewart-Knox,
M Andriollo-Sanchez,
E Toti,
N Meunier, M Ferry,
A Polito,
M Kelly,
J M W Wallace,
C Coudray
European Journal of Clinical Nutrition 10/2005; · 2.46 Impact Factor
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M Andriollo-Sanchez,
I Hininger-Favier,
N Meunier,
E Toti,
M Zaccaria,
M Brandolini-Bunlon,
A Polito,
J M O'Connor, M Ferry,
C Coudray,
A-M Roussel
[show abstract]
[hide abstract]
ABSTRACT: Objective: Inadequate intakes of micronutrients in elderly negatively affect the nutritional status. Zinc is an essential micronutrient in the elderly, especially in relation to its impact on immune function, bone mass, cognitive function and oxidative stress. However, data are lacking on zinc intake and status during normal ageing. In this study, we evaluate the intake and status of zinc in late middle-aged and older free-living subjects.
European Journal of Clinical Nutrition 10/2005; · 2.46 Impact Factor
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[show abstract]
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ABSTRACT: Description of the nutritional status of healthy elderly people and investigation of its longitudinal relationship with mortality and cognitive or functional decline.
Longitudinal study.
In Dordogne, France.
A total of 169 French elderly community dwellers aged 68 y and older from in the PAQUID (Personnes Agées QUID) study were included. Dietary intake was assessed by a 3 day food record and a dietary history. Self-reported weight and height were used to calculate the body mass index (BMI, kg/m(2)). Mortality, activities of daily living (ADL), instrumental activities of daily living (IADL) and the Mini Mental State Examination (MMSE) were measured at 5 y follow-up.
Nutritional intake and BMI vary according to age and sex. Men generally have a higher nutritional intake than women. Intake decreases with age especially in men. Among the 169 subjects, 22 died. When analyzed by logistic regression, there was no relation between markers of risk of poor nutrition and mortality but a BMI greater or equal 27 at baseline was associated with a increased risk of 5 y mortality (OR=6.27, 95% CI 1.29-30.37) adjusted for sex and age. With regard to cognitive decline, subjects with a BMI greater or equal than 23 kg/m(2) had 3.6 times lower chance of presenting a decline in the subsequent 5 y adjusted by age and sex (OR=0.28, 95%, CI 0.09-0.90). BMI ranging between 23 and 27 was associated with a significantly decreased risk of IADL disability (OR=0.31, 95% CI 0.10-0.93) in multivariate analyses.
In apparently healthy elderly people a BMI ranging between 23 and 27 is associated with lower risks of functional and cognitive declines in the subsequent 5 y.
European Journal of Clinical Nutrition 05/2002; 56(4):305-12. · 2.46 Impact Factor
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Soins. Gérontologie 07/2001;
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ABSTRACT: to provide information and data on food and fluid intake of free-living elderly aged of 81-86 years old residing in the south of France.
using standardised methods data were collected from a random sample born between 1913 and 1918. The French study protocol again included data collection on dietary intake using a standardised modified dietary history consisting of a food frequency list and a 3-day estimated dietary record.
Total dietary intake was generally low as compared to the recommended daily intake for elderly subjects.
This descriptive part of the SENECA study gives the opportunity to have information on this growing segment of the population. These results should help to adapt the dietary guidelines for this category of the population.
The Journal of Nutrition Health and Aging 02/2001; 5(4):235-7. · 2.69 Impact Factor
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ABSTRACT: AGE-RELATED LOSS IN MUSCLE MASS: Aging is associated with a progressive decline in muscle mass (sarcopenia). Age-related sarcopenia results in a 50% decrease in muscle fiber area, especially type II fiber area. There are many consequences related to this reduction in muscle mass including decline in muscle strength and function and impaired functional capacity. PROTEIN INTAKE: Sarcopenia also results in a reduction in the body's major protein pool. Adequate dietary protein to replace obligatory nitrogen loss and to support protein turnover is essential for maintaining muscle mass. It is usually suggested that protein requirements in older subjects are above 1 g/kg/d. PHYSICAL EXERCISE: Sedentary lifestyle may contribute to loss of skeletal mass in elderly people. Exercise can help reverse this deficit and may improve the regeneration potential of muscle fibers.
La Presse Médicale 01/2001; 29(39):2177-82. · 0.67 Impact Factor
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Journal of the American Geriatrics Society 02/1999; 47(1):93-5. · 3.74 Impact Factor
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Soins. Gérontologie 12/1998;
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Soins. Gérontologie 10/1998;
