M Mdhaffar

Publications (6)2.16 Total impact

• Article: Diagnostic concomitant d’une leucémie lymphoïde chronique B et d’un lymphome T cutané type mycosis fongoïde. À propos d’une observation

  H. Bellaaj, O. Kassar, S. Boudaya, M. Elloumi, C. Kallel, S. Mseddi, M. Mdhaffar, T. Souissi
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  ABSTRACT: La coexistence au diagnostic de deux clones lymphocytaires distincts de phénotype B et T est extrêmement rare. Nous rapportons le cas d’une femme âgée de 68 ans, présentant de façon concomitante un lymphome T cutané type mycosis fongoïde et une leucémie lymphoïde chronique de phénotype B. The coexistence of two distinct, B and T, lymphocytic clones is very rare. We report the case of a 68-year-old woman who was presenting simultaneously a cutaneous T cell lymphoma, type mycosis fungoides, and a B cell chronic lymphocytic leukaemia. Mots clésLeucémie lymphoïde chronique–Mycosis fongoïde KeywordsChronic lymphocytic leukaemia–Mycosis fungoides
  Oncologie 05/2012; 12:74-76. · 0.17 Impact Factor
• Article: Leucemie aigue myeloide de novo a chromosome philadelphie positif.

  S Hdiji Mseddi, I Ben Amor, I Frikha, N Ajmi, H Sennana, S Mnif, I Safra, I Jedidi, O Kassar, M Mdhaffar, H Bellaaj, E Moez
  La Tunisie médicale 01/2011; 89(1):119.
• Article: [Two pelvic tumors which should not be operated, lymphoma of Burkitt and actinomycosis].

  M Abid, M F Frikha, M Mdhaffar, R Mzali, M Ben Amar, M I Beyrouti
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  ABSTRACT: The treatment of the pelvic tumors depends of their histological nature. Some of them require only one medical treatment without recourse to surgery. We report two rare cases of pelvic tumors occurring in young adults. For the first case, actinomycosic nature was related to the histological study of the surgical biopsies. Concerning the second case, the lymphatic nature of a tumor of the low rectum was retained on the immunohistochimic study of the endoscopic biopsies. The evolution was uneventful in the two cases after a medical treatment containing penicillin G or a chemotherapy. We discuss at the time of these two observations the diagnostic difficulties and the therapeutic methods of these rare affections.
  Journal de Chirurgie 09/2009; 146(3):297-300. · 0.50 Impact Factor
• Article: [Fanconi anemia with precocious and inaugural oncologic events].

  O Kassar, S Mseddi, A Khanfir, L Slimi, H Bellaaj, M Mdhaffar, M Elloumi, M Frikha, T Souissi
  La Tunisie médicale 03/2009; 87(2):167-8.
• Article: [MALT lymphoma of the rectum: a case report treated by radiotherapy].

  A Amouri, L Chtourou, L Mnif, M Mdhaffar, M Abid, L Ayedi, J Daoud, M Elloumi, T Boudawara, N Tahri
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  ABSTRACT: The mucosa-associated lymphoid tissue (MALT) lymphoma is a distinct clinical pathologic entity that develops in diverse anatomic locations such as the stomach, salivary gland, thyroid, lung, skin and breast. However, colorectal involvement is extremely rare. To our knowledge, only ten cases of primary rectal MALT lymphoma have been reported in the literature. We report a 46-year-old woman with rectal MALT lymphoma, which regressed after radiotherapy. The patient had rectal bleeding. Colonoscopy showed a pseudonodular and ulcerated big fold in the rectum. Microscopic and immunohistologic studies of the biopsy specimen showed typical features of low grade MALT lymphoma. Upper endoscopy showed chronic gastritis with lymphoid follicles but without any infiltration of lymphoma cells. Helicobacter pylori infection was confirmed by histology. No extra-intestinal involvement was found on the staging evaluation, which included computed tomography (CT) of the abdomen, chest, pelvis and a bone marrow biopsy. We attempted to eradicate H. pylori with a 7-day course of omeprazole, amoxycillin, and metronidazole. Eradication was proved successful by endoscopy. Repeated colonoscopy 4 months after the end of treatment showed that the rectal tumor had not regressed. Biopsy specimens confirmed the persistent infiltration of lymphoma cells. The patient was considered to be a non-responder to eradication therapy and was indicated for radiotherapy. He underwent a total of 34 Gy. Complete regression was confirmed by colonoscopic and histologic examination at 2 months after the end of treatment. He was followed up closely with colonoscopy, but no relapse of these lesions was detected after 12 months.
  Cancer/Radiothérapie 01/2009; 13(1):61-4. · 1.49 Impact Factor
• Article: [Diagnostic and therapeutic aspects of lymphatic tuberculosis: apropos of 42 cases].

  M Elloumi, S Fakhfakh, M Frikha, S Mseddi, H Bellaaj, M Mdhaffar, T Souissi
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  ABSTRACT: We report a retrospective study of 42 cases of lymph node tuberculosis. We noted symptoms of tuberculosis impregnation in 92%, cervical localization in 71%, positive tuberculin intra-dermo-reaction in 77%, and accelerated erythrocyte sedimentation rate in 73% of the cases. Koch bacillus was detected in expectoration, urine or gastric liquid at the rate of 11% of the cases. Lymph node function was suggestive in 4 out of 12 patients, showing giant cells with or without caseum. Lymph node biopsy, performed in 32 patients, was contributive in 94% of them. Another tuberculous localization was found in 14 cases mainly pulmonary (8 cases).
  La Tunisie médicale 11/1999; 77(10):491-6.