S Herpertz

University of Lausanne, Lausanne, VD, Switzerland

Are you S Herpertz?

Claim your profile

Publications (126)252.47 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Alkohol und Tabak gehören zu den ältesten Genussmitteln der Menschheit. Ihr Konsum ist bei Diabetes jedoch mit zusätzlichen gesundheitlichen Risiken verbunden. Allerdings gilt bei einer Bewertung einer möglichen schädlichen Wirkung von Alkohol und Tabak die Erkenntnis von Paracelsus: „Alle Dinge sind Gift, und nichts ist ohne Gift. Allein die Dosis macht, dass ein Ding kein Gift ist“. In der Praxis ist es eine nicht einfache Aufgabe, zwischen einem gesundheitlich unbedenklichen Konsum von Alkohol und einem schädlichen Gebrauch oder sogar einer Abhängigkeit von Alkohol und Tabak zu unterscheiden. Maßgeblich für die Unterscheidung sind sowohl die Konsummenge, das Konsumverhalten wie auch die Konsequenzen des Konsums.
    InfoDiabetologie. 01/2014; 8(1):34-40.
  • Diabetologie und Stoffwechsel 04/2013; 8(4):292-324. · 0.43 Impact Factor
  • Diabetologie und Stoffwechsel 03/2013; 8(3):198-242. · 0.43 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: [Praxisleitlinie | DDG Praxisempfehlung]
    Diabetologie und Stoffwechsel 01/2013; 8(Suppl.2):S165-S179. · 0.43 Impact Factor
  • Sänger S, Herpertz S, Petrak F
    01/2013: pages 329-352;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: [Praxisleitlinie | DDG Praxisempfehlung]
    Diabetologie und Stoffwechsel 01/2012; 7(Suppl.2):S.136-S.142. · 0.43 Impact Factor
  • Journal of Psychosomatic Research. 01/2012; 72:496-497.
  • Legenbauer T, Herpertz S, De Zwaan M
    01/2012;
  • International Journal of Obesity 01/2012; 36(4):614-24.. · 5.22 Impact Factor
  • S Munsch, S Herpertz
    [Show abstract] [Hide abstract]
    ABSTRACT: Binge eating disorder is one of the most frequent comorbid mental disorders associated with overweight and obesity. Binge eating disorder patients often suffer from other mental disorders and longitudinal studies indicate a continuous weight gain during the long-term course. As in other eating disorders gender is a risk factor, but the proportion of male binge eating disorder patients is surprisingly high.In young women with type 1 diabetes the prevalence of subclinical types of bulimia nervosa is increased. In addition, insulin purging as a characteristic compensatory behavior in young diabetic women poses a considerable problem. In patients with type 1 diabetes, disturbed eating and eating disorders are characterized by insufficient metabolic control and early development of late diabetic sequelae. Patients with type 2 diabetes are often overweight or obese. Binge eating disorder does not occur more frequently in patients with type 2 diabetes compared to healthy persons. However, the comorbidity of binge eating disorder and diabetes type 2 is associated with weight gain and insulin resistance. Especially in young diabetic patients a screening procedure for disturbed eating or eating disorders seems to be necessary. Comorbid patients should be offered psychotherapy.
    Der Nervenarzt 07/2011; 82(9):1125-32. · 0.80 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To determine the effectiveness of a structured multidisciplinary non-surgical obesity therapy program on the basis of a temporary low-calorie-diet for 12 weeks, and additional intervention modules to enhance nutritional education, to increase physical activity and to modify eating behavior. Prospective multicenter observational study in obese individuals undergoing a medically supervised outpatient-based 52-week treatment in 37 centers in Germany. A total of 8296 participants with a body mass index (BMI) of >30 kg m(-2) included within 8.5 years. Main outcome measures were body weight loss, waist circumference (WC), blood pressure, quality of life and adverse events. In females, initial body weight was reduced after the 1-year-intervention by 19.6 kg (95% confidence intervals 19.2-19.9 kg) and in males by 26.0 kg (25.2-26.8) according to per protocol analysis of 4850 individuals. Intention-to-treat (ITT) analysis revealed a weight reduction of 15.2 kg (14.9-15.6) in females and 19.4 kg (18.7-20.1) in males. Overall, the intervention resulted in mean reduction in WC of 11 cm; it reduced the prevalence of the metabolic syndrome by 50% and the frequency of hypertension from 47 to 29% of all participants (ITT, all P<0.001). The beneficial effects could be documented for up to 3 years and comprised significant improvement of health-related quality of life. The incidence of adverse effects was low; the only event repeatedly observed and possibly related to either the intervention or the underlying disease was biliary disorders. The present non-surgical intervention program is a highly effective treatment of obesity grades I-III and obesity-related diseases, and therefore, could be a valuable basis for future weight maintenance strategies required for sustained success.
    International journal of obesity (2005) 06/2011; 36(4):614-24. · 5.22 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To investigate the influence of depressive and eating disorders on short- and long-term weight loss after surgical and non-surgical weight-reduction treatment. Covariations between the disorders were considered. In a longitudinal naturalistic study, current diagnoses at baseline and lifetime diagnoses of depressive and eating disorders were assessed in participants who were undertaking a very-low-calorie diet (n = 250) and in bariatric surgery patients (n = 153). Lifetime diagnosis of a mental disorder was defined as presence of a mental disorder only in the past. Body weight was measured at baseline, 1 year after baseline, and 4 years after baseline. Mental comorbidity was assessed through use of standardized interviews at baseline. A structural equation modeling procedure was applied to test the associations between course of weight and mental disorders. Analyses were based on the intention to treat samples. Missing values were replaced by use of multiple imputation procedures. Neither depression nor eating disorders were associated with weight changes at the 1-year follow-up, but a specific effect emerged for bariatric surgery patients after 4 years: depression (current and lifetime) predicted smaller body mass index loss, whereas lifetime diagnosis of eating disorder was associated with greater weight loss. Individuals who report depressive disorders prior to bariatric surgery should be monitored more closely in order to identify patients who would benefit from additional therapy with the goal of improving weight-loss outcome.
    Comprehensive Psychiatry 01/2011; 52(3):301-11. · 2.38 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: [Praxisleitlinie | DDG Praxisempfehlung]
    Diabetologie und Stoffwechsel 01/2011; 6(Suppl.2):S.143-S.149. · 0.43 Impact Factor
  • S. Munsch, S. Herpertz
    [Show abstract] [Hide abstract]
    ABSTRACT: Die häufigste Essstörung bei Adipositas ist die Binge-Eating-Störung (BES). Die Kernsymptomatik dieser Essstörung stellen subjektiv unkontrollierbare Essanfälle dar. Ähnlich wie bei anderen Essstörungen sind häufiger Frauen betroffen; der Anteil an Männern ist jedoch erstaunlich hoch. Mit dem Krankheitsverlauf gehen eine erhöhte Komorbidität mit anderen psychischen Störungen sowie ein kontinuierlicher Gewichtsanstieg einher. Adoleszente und junge Frauen mit Diabetes mellitus Typ1 zeigen eine überzufällige Koinzidenz mit der Bulimia nervosa. Die bewusste Reduktion der Insulindosis zwecks Gewichtsreduktion mittels Glukosurie stellt eine charakteristische gegenregulatorische Maßnahme dar. Die Komorbidität von Typ-1-Diabetes-mellitus und einer Essstörung stellt einen Risikofaktor für die Entwicklung späterer diabetischer Folgeerkrankungen dar. So zeichnen sich essgestörte Patientinnen mit Typ-1-Diabetes-mellitus durch eine unzureichende Stoffwechselkontrolle und die frühzeitigere Entwicklung von diabetischen Spätschäden aus. Auch wenn die BES bei Menschen mit Typ-2-Diabetes-mellitus im Vergleich zu stoffwechselgesunden Menschen nicht häufiger aufzutreten scheint, stellt sie doch einen Risikofaktor für eine beschleunigte Gewichtszunahme dar, welche in der Regel mit einer Zunahme der Insulinresistenz einhergeht. Insbesondere bei jungen Patientinnen mit Diabetes mellitus erscheint ein diagnostisches Screeningverfahren notwendig. Patientinnen mit Diabetes mellitus und einer Essstörung sollte eine Psychotherapie angeboten werden. Binge eating disorder is one of the most frequent comorbid mental disorders associated with overweight and obesity. Binge eating disorder patients often suffer from other mental disorders and longitudinal studies indicate a continuous weight gain during the long-term course. As in other eating disorders gender is a risk factor, but the proportion of male binge eating disorder patients is surprisingly high. In young women with type 1 diabetes the prevalence of subclinical types of bulimia nervosa is increased. In addition, insulin purging as a characteristic compensatory behavior in young diabetic women poses a considerable problem. In patients with type 1 diabetes, disturbed eating and eating disorders are characterized by insufficient metabolic control and early development of late diabetic sequelae. Patients with type 2 diabetes are often overweight or obese. Binge eating disorder does not occur more frequently in patients with type 2 diabetes compared to healthy persons. However, the comorbidity of binge eating disorder and diabetes type 2 is associated with weight gain and insulin resistance. Especially in young diabetic patients a screening procedure for disturbed eating or eating disorders seems to be necessary. Comorbid patients should be offered psychotherapy. SchlüsselwörterEssstörungen–Adipositas–Diabetes mellitus–Binge-Eating-Störung–Komorbidität KeywordsEating disorders–Obesity–Diabetes mellitus–Binge eating disorder–Comorbidity
    Der Nervenarzt 01/2011; 82(9):1125-1132. · 0.80 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Previous neuroimaging studies have demonstrated abnormalities in visual body image processing in anorexia and bulimia nervosa, possibly underlying body image disturbance in these disorders. Although cognitive behavioural interventions have been shown to be successful in improving body image disturbance in eating disorders, no randomized controlled study has yet analysed treatment-induced changes in neuronal correlates of visual body image processing. Altogether, 32 females with eating disorders were randomly assigned either to a manualized cognitive behavioural body image therapy consisting of 10 group sessions, or to a waiting list control condition. Using functional magnetic resonance imaging, brain responses to viewing photographs of one's own and another female's body taken from 16 standardized perspectives while participants were wearing a uniform bikini were acquired before and after the intervention and the waiting time, respectively. Data indicate a general blood oxygen level dependent signal enhancement in response to looking at photographs of one's own body from pre- to post-treatment, whereas exclusively in the control group activation decreases from pre- to post-waiting time were observed. Focused activation increases from pre- to post-treatment were found in the left middle temporal gyrus covering the coordinates of the extrastriate body area and in bilateral frontal structures including the middle frontal gyrus. Results point to a more intense neuronal processing of one's own body after the cognitive behavioural body image therapy in cortical regions that are responsible for the visual processing of the human body and for self-awareness.
    Psychological Medicine 12/2010; 41(8):1651-63. · 5.59 Impact Factor
  • B. Herpertz-Dahlmann, S. Herpertz
    [Show abstract] [Hide abstract]
    ABSTRACT: Kinder- und Jugendpsychiatrie (KJP) und Erwachsenenpsychiatrie haben wichtige gemeinsame Arbeitsfelder, vor allem die Diagnostik und Behandlung von Erkrankungen, die im Kindes- oder Jugendalter beginnen und in das Erwachsenenalter persistieren. Vor dem Hintergrund der erst späten Hirnreifung im frühen Erwachsenenalter sind entwicklungspsychopathologische Gesichtspunkte bei Adoleszenten und jungen Erwachsenen besonders bedeutsam und können die Therapie-Compliance in diesem Lebensalter erhöhen. Weitere gemeinsame Aufgaben von KJP und Erwachsenenpsychiatrie sind die transgenerationale Versorgung, d. h. die Behandlung von Eltern und Kind, die Forschung zu Entwicklung und Verlauf psychischer Störungen, die Kooperation in Lehre und Weiterbildung sowie die Vertretung gesellschaftlicher und politischer Interessen psychisch kranker Menschen.
    Der Nervenarzt 11/2010; · 0.80 Impact Factor
  • B Herpertz-Dahlmann, S Herpertz
    [Show abstract] [Hide abstract]
    ABSTRACT: Child and adolescent psychiatry and adult psychiatry have important common research and working fields, in particular the diagnostics and treatment of disorders with onset in childhood or adolescence and persistence over the life span. Other important aspects in common are the treatment of families (e.g., special wards for children and their parents, children of mentally ill parents), in medical teaching and postgraduate education as well as representative functions in societal and political issues.
    Der Nervenarzt 11/2010; 81(11):1298, 1300, 1302, passim. · 0.80 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV. The first allele frequencies of all the SNPs were compared between a Dutch case group (182 AN, 149 EDs characterized by SV) and 607 controls. Associations rendering P-values < 0.05 from this initial study were then tested for replication in a meta-analysis with two additional independent ED case-control samples, together providing 887 AN cases, 306 cases with an ED characterized by SV and 1914 controls. A significant effect for the minor C-allele of tryptophan hydroxylase 2 rs1473473 was observed for both AN [odds ratio (OR) = 1.30, 95% CI 1.08-1.57, P < 0.003] and EDs characterized by SV (OR = 1.52, 95% CI 1.28-2.04, P < 0.006). In the combined case group, a dominant effect was observed for rs1473473 (OR = 1.38, 95% CI 1.16-1.64, P < 0.0003). The meta-analysis revealed that the tryptophan hydroxylase 2 polymorphism rs1473473 was associated with a higher risk for AN, EDs characterized by SV and for the combined group.
    Genes Brain and Behavior 10/2010; 10(2):236-43. · 3.60 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To test effects of body image therapy in anorexia nervosa, functional magnetic resonance imaging was used to assess neuronal responses to viewing photographs of one's own body before and after treatment. Activation decreases emerged in a distributed network and increases were observed in the extrastriate body area, possibly reflecting more intense body image processing.
    Psychiatry Research Neuroimaging 08/2010; 183(2):114-118. · 3.36 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Autism spectrum disorders (ASD), are pervasive developmental disorders, which are defined by qualitative impairment in reciprocal social interaction and communication as well as by stereotyped repetitive behaviour. Newer epidemiological studies report a prevalence of 1 %. However, parents and self-help organisations report a considerable lack of diagnostic services, especially in the university hospital setting. In order to receive funding for adequate treatment at an "autism therapy centre", a Consultant psychiatrist has to diagnose ASD. We assessed the diagnostic and therapeutic facilities for adults with ASD by sending out questionnaires to 33 German university hospitals. Furthermore, we evaluated the demographic data of the first 74 patients that presented at the specialist clinic for adults with ASD at the Department for Psychiatry and Psychotherapy, RWTH Aachen University. At the time of the evaluation, only 9 university hospitals in Germany offered a specialist clinic for diagnostics and/or treatment for adults with ASD. A comorbid psychiatric disorder was diagnosed in 52.9 % of the patients presenting at the specialist clinic for adult ASD. These were mostly mental retardation and affective disorders. The most common differential diagnosis for the patients presenting at the service were affective and personality disorders. There is still great need of specialist services at university hospitals in Germany for adults with ASD, although more services have been established over the past few years. Over half of the patients with ASD had other psychiatric comorbid disorders, which were mostly mental retardation and affective disorders. The most common differential diagnosis for patients presenting at the clinics were personality disorders and depression.
    Fortschritte der Neurologie · Psychiatrie 07/2010; 78(7):402-13. · 0.85 Impact Factor

Publication Stats

2k Citations
252.47 Total Impact Points

Institutions

  • 2011
    • University of Lausanne
      • Institut de psychologie (IP)
      Lausanne, VD, Switzerland
    • LWL-Universitätsklinikum Bochum
      Bochum, North Rhine-Westphalia, Germany
  • 2004–2011
    • Ruhr-Universität Bochum
      • Clinical Psychology and Psychotherapy
      Bochum, North Rhine-Westphalia, Germany
  • 2003–2010
    • University Hospital RWTH Aachen
      • Department of Neurology
      Aachen, North Rhine-Westphalia, Germany
  • 2004–2007
    • University of Rostock
      • • Klinik und Poliklinik für Psychiatrie und Psychotherapie
      • • Zentrum für Nervenheilkunde
      Rostock, Mecklenburg-Vorpommern, Germany
  • 1998–2004
    • University of Duisburg-Essen
      • • Klinik für Psychosomatische Medizin und Psychotherapie (LVR)
      • • Department of Internal and Integrative Medicine
      Essen, North Rhine-Westphalia, Germany
    • University of Cologne
      • Department of Psychiatry and Psychotherapy
      Köln, North Rhine-Westphalia, Germany
    • Lilly Deutschland GmbH
      Homburg vor der Höhe, Hesse, Germany
  • 1998–2003
    • University Hospital Essen
      • Klinik für Psychosomatische Medizin und Psychotherapie
      Essen, North Rhine-Westphalia, Germany
  • 1997–2001
    • RWTH Aachen University
      • • Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters
      • • Klinik für Psychiatrie, Psychotherapie und Psychosomatik
      Aachen, North Rhine-Westphalia, Germany
  • 2000
    • Kliniken Essen Süd
      Essen, Lower Saxony, Germany
  • 1999
    • Philipps-Universität Marburg
      • Klinik für Kinder- und Jugendpsychiatrie und -psychotherapie (Marburg)
      Marburg an der Lahn, Hesse, Germany
  • 1997–1998
    • Freie Universität Berlin
      Berlín, Berlin, Germany