Mehmet Aksoy

University of Gaziantep, Ayıntap, Gaziantep, Turkey

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Publications (55)108.89 Total impact

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    ABSTRACT: Objectives: We aimed to investigate the efficacy and safety of a belt mechanism (anjiobelt), which we developed recently and patented, which allows mobility after coronary operations and the application of adjustable pressure to the femoral artery. Study design: Between October 2012 and April 2013, 189 consecutive patients undergoing percutaneous coronary intervention electively or due to acute coronary syndrome were enrolled. There were 96 patients in the sandbag group and 93 patients in anjiobelt group. Manual compression was applied to the femoral artery until reaching primary homeostasis. Then, a 4-5 kilogram sandbag or anjiobelt was placed. Mobilization was allowed in case of need in the anjiobelt group. Twenty-four hours after the procedure, superficial bruising in the femoral region, hematoma, pseudo-aneurysm, and arteriovenous fistula, as femoral artery complications, were noted using Doppler ultrasound. Results: Hematoma occurred more frequently in the sandbag group. Hematoma of <1 cm developed in 52 patients with sandbag and in 25 patients with anjiobelt (p<0.0001), while hematoma of 1-5 cm developed in 5 patients with sandbag and in 3 patients with anjiobelt (p<0.0001). Femoral artery pseudoaneurysm was seen in 4 patients (2 with anjiobelt, 2 with sandbag; p=0.975). Conclusion: Anjiobelt significantly reduces the incidence of hematoma in comparison to conventional sandbag in patients undergoing percutaneous coronary intervention. Other complications of the femoral region in terms of efficiency and safety appear to be similar to those observed with sandbag. The main problems occurring in these patients due to absolute immobilization have been eliminated with the anjiobelt.
    Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir 12/2013; 41(8):699-704.
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    ABSTRACT: Objectives: The Stent for Life (SFL) project's main mission is to increase the use of primary percutaneous coronary intervention (PCI) in more than 70% of all acute ST segment elevation myocardial infarction (STEMI) patients. Previous to the SFL project, thrombolysis was the dominant reperfusion strategy since a low percentage of acute STEMI patients had access to primary PCI in our country. In this study, we present the main barriers of access to primary PCI in the centers that were involved with the SFL project. Study design: Patients with acute STEMI admitted to the centers that were involved in the SFL project between 2009 and 2011 were included in the analysis. Results: Since the inception of the SFL project, the primary PCI rate has reached over 90% in SFL pilot cities. In the last 5 years, the number of ambulances and emergency stations has increased. Since the collaboration with 112 Emergency Service, a great majority of cases were reached via the emergency medical system. The mean door-to-balloon time for the pilot cities was 54.72±43.66 minutes. Conclusion: After three years of the SFL project, primary PCI has emerged as the preferred reperfusion strategy for patients with STEMI in pilot cities.
    Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir 09/2012; 40(5):414-8.
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    ABSTRACT: Introduction: Dynamic mitral regurgitation (MR) is frequently investigated in patients with left ventricular systolic dysfunction (LVSD). Data about the dynamic MR in patients with organic valve disease are limited. The aim of this study was to evaluate the alteration of MR by exercise in patients with rheumatic valve disease (RVD). Methods: Asymptomatic patients with rheumatic MR and normal left ventricular function had been included in our study. Transthoracic echocardiography and Doppler measurements were performed at rest and just after submaximal exercise test performed with treadmill. Severity of MR was evaluated quantitatively by measuring effective regurgitant orifice area (EROA) with flow convergence method. Results: A total of 34 patients with rheumatic MR had been included. Severity of MR increased in 10 patients with exercise (Group 1) and decreased in 24 of them (Group 2). When the variables of two groups were compared; diastolic blood pressure after exercise, EROA, left atrial volume, left ventricular diastolic volume and mitral annular area values were significantly higher in Group 1 patients. A linear regression model was constructed by considering change of EROA by exercise the dependent, and the variables showing significant differences as the independents. Mitral annular area was found to be independently associated with EROA increase with exercise (R(2) = 0.499; P < 0.001). Conclusion: Mitral annular dilation is independently associated with increase of MR with submaximal exercise in asymptomatic patients with MR due to RVD with normal left ventricular function.
    Echocardiography 07/2012; 29(9):1031-7. · 1.26 Impact Factor
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    ABSTRACT: Objectives: The aim of this study was to determine the prevalence of heart failure (HF) in adult residents of Turkey based on echocardiography and N-terminal B type natriuretic factor. Study design: 4650 randomly selected residents aged ≥35 years were enrolled. Height, weight, waist and hip circumference, and blood pressure measurements were taken, and a 12-lead ECG was performed. Advanced age, hypertension (HT), diabetes mellitus (DM), obesity, and chronic renal failure (CRF) were assessed. History of any heart disease, any abnormal ECG, or an NT-proBNP ≥120 pg/mL was accepted as echocardiography indication. Patients with systolic and/or diastolic dysfunction, or NT-proBNP ≥2000 pg/mL were classified as having HF if their functional capacity was NYHA ≥Class II, and were classified as having asymptomatic left ventricular dysfunction (ASVD) if their functional capacity was NYHA <Class I. Results: The absolute and estimated prevalences were 2.9% and 6.9% for HF, and 4.8% and 7.9% for ASVD, respectively. Advanced age, male gender, history of heart disease, HT and CRF were independent predictors of HF. In patients with ejection fraction (EF) <50%, HF prevalence was higher in men, while HF prevalences were higher in women when EF≥50%. In global sum, HF and ALVD prevalence were similar in male and females. Conclusion: The prevalences of HF and ASVD are higher in Turkey when compared with western countries, despite a younger Turkish population. The established predictors of HF are valid for Turkey as well. There is a significant ASVD population in Turkey with similar characteristics and risk factors to HF. Focusing on the early detection and treatment of ASVD may prevent the progression to HF, and therefore would decrease the prevalence of HF in Turkey.
    Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir 06/2012; 40(4):298-308.
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    ABSTRACT: Percutaneous closure of secundum atrial septal defects (ASD) has become an important alternative treatment to surgery. We evaluated our clinical experience with, and short-term results of transcatheter closure of ASDs with the Amplatzer septal occluder in adult patients. The study included 52 patients (36 women, 16 men; mean age 33±14 years; range 14 to 69 years) who underwent transcatheter ASD closure with the Amplatzer occluder device. The mean ASD diameter measured by transesophageal echocardiography was 19.5±5.7 mm and the mean device diameter was 24.5±5.7 mm. All the patients were assessed clinically and echocardiographically one month after the procedure. Transcatheter ASD closure was successfully performed in 48 patients (92.3%) and failed in four patients (7.7%). Echocardiographic controls showed significant decreases in tricuspid regurgitation, right ventricular dilatation, and pulmonary artery pressure (p=0.003, p=0.026, and p=0.0001, respectively). Functional capacity of the patients also showed significant improvements (p=0.0001). After implantation, residual shunts were detected in four patients, all of which disappeared one month after the procedure. Major complications were seen in two patients. One patient developed ventricular fibrillation immediately after the procedure due to device embolization. One patient with left ventricular dysfunction developed device thrombosis due to cessation of dual antiplatelet therapy, which was successfully treated by anticoagulation therapy. Arrhythmia was not observed in any patient. Percutaneous closure of secundum ASDs with the Amplatzer occluder device is a safe and effective procedure with a high success rate.
    Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir 01/2011; 39(1):35-40.
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    ABSTRACT: We aimed to evaluate epidemiological, clinical, and microbiological features of infective endocarditis (IE) in a tertiary university hospital. The study included 72 patients (31 women, 41 men; mean age 45+/-16 years; range 18 to 80 years) who were diagnosed as having definite IE, according to the modified Duke criteria, between 2004 and 2007. Data were reviewed on age, sex, underlying heart disease, predisposing conditions for bacteremia, echocardiographic and microbiological findings, treatment, complications, and mortality. Infective endocarditis developed on a native valve in 47 (65.3%), a mechanical prosthetic valve in 21 (29.2%), and a pacemaker in two cases. The location of IE could not be determined in two cases (2.8%). Rheumatic heart disease (36.1%) was the most common preexisting valvular abnormality. The mitral valve was the most commonly affected valve in both native valves (43.1%) and prosthetic valves (13.9%). The most frequent symptom was fever (n=60, 83.3%). Electrocardiography showed abnormal findings in 24 cases (33.3%). Transthoracic and/or transesophageal echocardiography showed a vegetation in 63 cases (87.5%), moderate or severe mitral regurgitation in 41 cases (56.9%), aortic regurgitation in 21 cases (29.2%), and tricuspid regurgitation in 29 cases (40.3%). Staphylococci (26.4%) and streptococci (22.2%) were the most common causative agents. Cultures were negative in 26 cases (36.1%). Twenty patients (27.8%) underwent surgical treatment. Congestive heart failure (n=23, 31.9%) and cerebrovascular accidents (n=10, 13.9%) were the major complications. In-hospital mortality occurred in 11 cases (15.3%). Our data reflect epidemiological, clinical, and microbiological profile of IE in a tertiary hospital located in the Southeastern Anatolia.
    Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir 03/2010; 38(2):107-11.
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    ABSTRACT: We report a case of persistent left superior caval vein whom presented with angina pectoris and exertional dyspnea. Echocardiography showed wall motion disturbances with an ejection fraction of 40% and a very large coronary sinus. Our case is a very rare case with a very large coronary sinus presented with angina pectoris. KeywordsPersistent-Left-Superior-Caval-Vein-Ischemia
    Journal of Echocardiography 01/2010; 8(4):133-134.
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    ABSTRACT: Aortic valve sclerosis (AVS) is a progressive disease that is characterized by aortic valve thickening without causing significant narrowing and in which pathology resembles atherosclerotic coronary heart disease. We aimed to evaluate the relationship between AVS and platelet indices including mean platelet volume (MPV), platelet distribution weight (PDW), and platelet count. Two hundred ten patients who were evaluated in the echocardiography unit due to various reasons between January and October 2008 were consecutively included in the study. The patients were divided into 2 groups according to presence or absence of AVS. The patient group consisted of 150 patients (76 females and 74 males; mean age, 64.5 + or - 11.5 years). Patients without AVS (24 females and 36 males; mean age, 49.8 + or - 15.7 years) were assigned as control group. The MPV, PDW, and platelet count were measured. The MPV (9.56 + or - 1.3 fL vs 9.15 + or - 1.0 fL, P = .022) and PDW (16.9 + or - 2.3% vs 14.9 +/- 2.3, P = .001) were significantly higher in patients with AVS (+) compared to the AVS (-) group. No significant difference was demonstrated between the groups in terms of white blood cell and platelet counts (P > .05). When the AVS (+) group was compared to the AVS (-) group, a significant difference was found in respect of hypertension, diabetes mellitus, and smoking status. Platelet production indices including MPV and PDW were increased in patients with AVS. The complex interrelationship between increased platelet production indices and AVS and value of antithrombotic therapies in patients with AVS need to be evaluated in further studies.
    Clinical and Applied Thrombosis/Hemostasis 10/2009; 16(5):563-7. · 1.58 Impact Factor
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    ABSTRACT: Recent studies have suggested that nuts have favorable effects beyond lipid lowering. We aimed to investigate effect of the Antep pistachio (Pistacia vera L.) on blood glucose, lipid parameters, endothelial function, inflammation, and oxidation in healthy young men living in a controlled environment. A Mediterranean diet was administered to normolipidemic 32 healthy young men (mean age 22 y, range 21-24) for 4 wk. After 4 wk, participants continued to receive the Mediterranean diet but pistachio was added for 4 wk by replacing the monounsaturated fat content constituting approximately 20% of daily caloric intake. Fasting blood samples and brachial endothelial function measurements were performed at baseline and after each diet. Compared with the Mediterranean diet, the pistachio diet decreased glucose (P<0.001, -8.8+/-8.5%), low-density lipoprotein (P<0.001, -23.2+/-11.9%), total cholesterol (P<0.001, -21.2+/-9.9%), and triacylglycerol (P=0.008, -13.8+/-33.8%) significantly and high-density lipoprotein (P=0.069, -3.1+/-11.7%) non-significantly. Total cholesterol/high-density lipoprotein and low-density lipoprotein/high-density lipoprotein ratios decreased significantly (P<0.001 for both). The pistachio diet significantly improved endothelium-dependent vasodilation (P=0.002, 30% relative increase), decreased serum interleukin-6, total oxidant status, lipid hydroperoxide, and malondialdehyde and increased superoxide dismutase (P<0.001 for all), whereas there was no significant change in C-reactive protein and tumor necrosis factor-alpha levels. In this trial, we demonstrated that a pistachio diet improved blood glucose level, endothelial function, and some indices of inflammation and oxidative status in healthy young men. These findings are in accordance with the idea that nuts, in particular pistachio nuts, have favorable effects beyond lipid lowering that deserve to be evaluated with prospective follow-up studies.
    Nutrition 07/2009; 26(4):399-404. · 2.86 Impact Factor
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    ABSTRACT: We aimed to evaluate our experience with echocardiography-guided pericardiocentesis with the apical approach for pericardial effusions. We evaluated 32 pericardiocenteses performed under echocardiography guidance and with the apical approach in 29 patients (15 men, 14 women; mean age 49 years; range 18 to 72 years). Indications were diagnostic purpose, pericardial tamponade, or symptomatic pericardial effusion. Procedural success, the amount of drainage, and complications were assessed. Common causes of pericardial effusion were malignancy (n=6), postpericardiotomy syndrome (n=5), idiopathic (n=5), chronic renal disease (n=4), and myocardial infarction (n=3). The amount of drainage was 120 ml to 2,200 ml and the duration of pericardial catheter placement in the pericardial space was 24 to 144 hours. Mortality did not occur. Echocardiographic control showed residual effusion in the lateral wall in one case, which required repositioning of the pericardial catheter for complete removal. The procedure failed in one patient due to insufficient drainage caused by multiple septations and fibrinous fluid in the pericardial space. The success rate of the procedures was 96.9%. Four cases developed hemopneumothorax requiring tube drainage, vasovagal reaction, nonsustained ventricular tachycardia, and frequent ventricular extrasystoles, respectively. Apical puncture was repeated in two cases due to erroneous left ventricular puncture and pleural catheter placement, respectively. Echocardiography-guided pericardiocentesis with the apical approach is readily performed bedside without the need for catheterization laboratory, with a high success rate and low complication rate. It should be considered especially in cases in which anterior pericardial collection is more prominent where it will reduce unnecessary surgical interventions.
    Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir 02/2009; 37(3):177-81.
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    ABSTRACT: Patients with severe congestive heart failure (CHF) often have unexplained elevations in serum concentrations of troponin T (TnT), and it is proposed that this is due to cardiac TnT release because of underlying cardiac disease. We investigated whether impaired renal function is an additional underlying phenomenon contributing to increased TnT levels in patients with CHF. Sixty-two patients with nonischemic CHF, New York Heart Association (NYHA) class III-IV, with normal coronary angiogram and normal serum creatinine were included in the study. Baseline glomerular filtration rate (GFR) was calculated using the Cockcroft Gault equation. Although mean creatinine level was normal (0.92 +/- 0.17 mg/dL), mean GFR was low (56 +/- 16 mL/min) in the cohort. Elevated (>or=0.02 microg/L) TnT was measured in 33 patients (53%). Compared with patients with normal (<0.02 microg/L) TnT levels, patients with elevated TnT had significantly higher NYHA class (p = 0.02), longer duration of disease (p = 0.02), lower GFR (p = 0.0001), and lower LVEF (p = 0.0001). There were significant associations between TnT levels and duration of disease (r = 0.29, p = 0.01), creatinine (r = 0.30, p = 0.01), GFR (r = -0.55, p < 0.0001), and LVEF (r = -0.39, p = 0.001). Independence of these associations was evaluated in multiple linear regression analysis, and serum TnT was independently and negatively associated only with GFR (p = 0.005). Renal function (GFR) correlated significantly and more strongly than cardiac function (LVEF) with the serum TnT levels in patients with CHF. This supports our hypothesis that impaired renal function causes the accumulation of troponin and is very likely the cause of unexplained elevations of serum TnT in patients severe CHF.
    Renal Failure 01/2009; 31(4):272-7. · 0.94 Impact Factor
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    ABSTRACT: Sleep deprivation (SD) is known to be associated with worse cardiovascular outcome including mortality. We investigated the association between acute SD and electrocardiographic maximum QT interval (QTmax), QT, and corrected QT dispersion (QTd/cQTd), which are known to be among predictors of ventricular arrhythmias and sudden death. We obtained electrocardiograms of 37 healthy young volunteers (age: 28.45 +/- 7.97 years; 11 women) after a night with regular sleep and repeated after a night with sleep debt. We measured minimum QT interval (QTmin), QTmax, QTd, and cQTd in milliseconds. Average sleep time of the subjects were 7.7 +/- 0.8 hours during regular sleep and 1.7 +/- 1.6 hours during a night with sleep debt (P < 0.001). Subjects had similar values of QTmin in milliseconds after a night of sleep debt when compared to after regular sleep (347.56 +/- 29.75 vs 344.59 +/- 20.89; P = 0.51), whereas they had significantly higher values of QTmax, QTd, and cQTd (396.48 +/- 30.11 vs 378.10 +/- 23.90; P = 0.001, 49.45 +/- 9.11 vs 33.51 +/- 10.05; P < 0.001 and 54.92 +/- 10.42 vs 37.23 +/- 10.81; P < 0.001, respectively). In Pearson's correlation analysis, QTmax, QTd, and cQTd were inversely correlated with sleep time (P = 0.012, r =-0.291; P < 0.001, r =-0.625 and P < 0.001, r =-0.616, respectively) In conclusion, we clearly demonstrated that even one night of SD is associated with significant increase in QTmax, QTd, and cQTd in healthy young adults despite remaining within normal limits. These electrocardiographic changes in acute SD might contribute to development and/or recurrence of arrhythmias. This implication deserves further studies for clarifying the possible linkage between SD and arrhythmias.
    Pacing and Clinical Electrophysiology 09/2008; 31(8):979-84. · 1.75 Impact Factor
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    ABSTRACT: Diabetes mellitus (DM) is accepted as coronary heart disease equivalent even in the presence of normal coronary artery on coronary angiography. We aimed to evaluate microvascular circulation with novel angiographic perfusion indexes "myocardial blush grade" (MBG) and "myocardial filling time" (MFT) in patients with uncomplicated DM. Among 4563 angiographic studies performed between November 2001 and May 2004, 70 subjects with DM who were normotensive, non-smokers and with normal lipid profiles were recruited into the study. Patients were divided into 2 groups according to angiographic results. DM-1: diabetic normotensive and normolipidemic subjects with normal coronary angiography (n: 30) and DM-2: diabetic subjects with lesions in the left anterior descending artery (LAD) less than 50% (n: 40). Non-diabetic, normotensive and normolipidemic 60 subjects were assigned as the control group. Control group was also divided into 2 groups according to angiographic results Control-1: subjects with normal coronary angiography (n: 30) and ; Control-2: subjects with lesions in the left anterior descending artery (LAD) less than 50% (n: 30). MBG was defined between 0 and 3 according to myocardial dyeing density and wash-out speed with 0 as the least and 3 as the most. MFT was calculated by conversion of the frame count, from the beginning of myocardial blushing till the time with the highest amount of contrast, to milliseconds. MFT was longer in the group DM-2 when compared with other groups (p<0.0001). MFT was similar in Control-2 and DM-1. MFT was shorter in Control-1 when compared with DM-1 and DM-2 (p<0.0001). MBG was lower in DM-2 when compared with Control-1 and Control-2 (p=0.001). However MBG was similar in DM-1 when compared with Control-1 and Control-2. Microvascular function is worse in subjects with both diabetes and coronary artery disease than in non-diabetic subjects with coronary artery disease. The most impressive result of our study is diabetic patients with normal coronary angiography have similar MBG and MFT results with non-diabetic coronary artery disease patients. DM causes microvascular dysfunction even one has normal coronary angiography and this put them in the same risk group with non-diabetic coronary artery patients.
    International journal of cardiology 08/2008; 127(2):262-5. · 6.18 Impact Factor
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    ABSTRACT: We investigated the association between chronic carbon monoxide (CO) exposure and electrocardiographic maximum/minimum P-wave duration (Pmax/Pmin), P-wave dispersion (Pd), maximum/minimum QT interval (QTmax/QTmin), and QT and corrected QT dispersion (QTd/cQTd), which are known as predictors of atrial fibrillation, ventricular arrhythmias, and sudden death. We obtained electrocardiograms of 48 apparently healthy male indoor barbecue workers (age mean +/- SD; 33.6 +/- 9.4) who were working in various restaurants for at least 3 yr and 51 age-matched healthy men (age mean +/- SD; 35.1 +/- 6.7). Average working time of the indoor barbecue workers in their jobs was 15.6 +/- 7.1 yr. P-wave parameters were analyzable in 39 barbecue workers and 40 control subjects and QT intervals were analyzable in 44 barbecue workers and 47 control subjects. Clinical characteristics of indoor barbecue workers and the control group were comparable in terms of age, sex, body mass index, blood pressure, heart rate, Pmin, and QTmin. However, COHb levels, Pmax, Pd, QTmax, QTd, and cQTd measurements were higher in indoor barbecue workers than in the control group (6.48 +/- 1.43 vs. 2.19 +/- 1.30, p < .001; 106.15 +/- 7.47 vs. 101.50 +/- 6.62, p < .005; 30.51 +/- 7.59 vs. 24.50 +/- 6.77, p < .001; 406.59 +/- 17.64 vs. 390.85 +/- 13.15, P < .001; 48.40 +/- 8.87 vs. 34.89 +/- 5.85, P < .001; 53.64 +/- 9.14 vs. 37.77 +/- 6.71, P < .001, respectively). In Pearson correlation analysis there were significant correlations between COHb level and Pd, QTmax, QTd, and cQTd (r = .315 P < .005; r = .402, P < .001, r = .573, P < .001, r = .615, P < .001, respectively). In conclusion, the present study is the first to assess and find an association between chronic CO exposure and electrocardiographic Pd and QTd/cQTd.
    Inhalation Toxicology 07/2008; 20(9):879-84. · 1.89 Impact Factor
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    ABSTRACT: Sleep deprivation (SD) is associated with worse cardiovascular outcome including mortality. Prolonged P-wave duration and P-wave dispersion (Pd) are known to represent inhomogeneous conduction of sinus impulses and are known to be electrophysiologic predictors of atrial fibrillation. Pd in normal subjects has been reported to be influenced by the autonomic tone. Because autonomic tone is affected by sleep and sleep duration, we evaluated the effect of acute SD on P-wave duration and Pd in healthy young adults and whether the effect was gender selective. We obtained electrocardiograms of 37 healthy young volunteers (age: 28.45 +/- 7.97; 11 women) after a night of regular sleep and repeated after a night with sleep debt. We measured minimum and maximum P-wave durations (Pmin, Pmax) and Pd in milliseconds. Average sleep time of the subjects were 7.7 +/- 0.8 hours during regular sleep and 1.7 +/- 1.6 hours during a night of sleep debt (P < 0.001). Subjects had significantly lower values of Pmin in milliseconds after a night of sleep debt when compared to regular sleep (65.13 +/- 8.03 vs 74.86 +/- 10.95; P < 0.001), whereas they had significantly higher values of Pmax and Pd (102.16 +/- 9.46 vs 95.13 +/- 11.21; P < 0.001 and 37.02 +/- 8.11 vs 20.27 +/- 11.42; P < 0.001, respectively). In Pearson's correlation analysis Pmin was positively and Pmax and Pd were negatively correlated with sleep time (P < 0.001, r = 0.465; P = 0.003, r =-0.336 and P < 0.001, r =-0.698 respectively). Effect of SD on P-wave duration and Pd was similar for both men and women. In conclusion, prolongation of Pmax and Pd in acute SD suggests that acute SD might contribute to development and/or recurrence of atrial fibrillation.
    Pacing and Clinical Electrophysiology 05/2008; 31(4):438-42. · 1.75 Impact Factor
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    ABSTRACT: We aimed to investigate whether there is an association between ABO blood groups, cardiovascular risk factors and myocardial infarction (MI) in a Turkish cohort. Four hundred and seventy-six patients with acute ST elevation MI (mean age 56.7+/-11.7; 80% men) and 203 age and sex matched healthy subjects were enrolled in the study. ABO blood group distribution of patients was compared with control group. Furthermore, in each ABO blood group, frequency of major cardiac risk factors was determined to find any correlation between blood groups and cardiovascular risk factors. The distribution of ABO blood groups in patients versus control group was A in 43.1 versus 44.3%, B in 15.1 versus 15.3%, AB in 10.7 versus 12.3% and O in 31.1 versus 28.1% (P>0.05 for all). ABO blood group distribution of both patients and control group was concordant with the official data from general Turkish population. The frequency of cardiovascular risk factors was similar in patients with different blood groups; however, the patients with blood group A were younger (P=0.004) and coronary artery disease detection age was lower (P=0.001) than those with the other blood groups. The distribution of ABO blood groups in patients with MI was quite similar to that in control group and that of general Turkish population, which supports the idea that ABO blood group might not be significantly associated with the development of MI. Association of ABO blood group distribution with cardiovascular risk factors, coronary artery disease and MI needs to be clarified with multicenter, prospective and large-scale studies.
    Blood Coagulation and Fibrinolysis 04/2008; 19(3):231-4. · 1.25 Impact Factor
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    ABSTRACT: Cough is a common symptom in cardiovascular disorders and may be defined as an explosive expiration which helps in clearing the tracheobronchial system from secretions and foreign bodies. It is caused by a variety of cardiac and non-cardiac disorders. Although cough is generally accepted as an ominous symptom which indicates progressing or worsening disease state or drug side effect, it might sometimes be a life saving manoeuvre in the catheterization labs. The possible mechanisms by which cough helps us in the catheterization lab are discussed in this letter.
    International journal of cardiology 04/2008; 133(3):e120-1. · 6.18 Impact Factor
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    ABSTRACT: Although data about circadian variation of myocardial infarction (MI) in western populations reveal morning peak between 06:00 and 12:00 hours, differences have been reported in different regions of the world and ethnic groups. We aimed to evaluate circadian variation of MI in a Turkish cohort. A total of 476 patients (mean age 56.7 +/- 11.7; 80% men) with acute st elevation MI were included into the study. Patients were categorised into four 6-h increments (00:01-06:00; 06:01-12:00; 12:01-18:00 and 18:01-24:00 hours). Onset of MI exhibited significant circadian variation among four time periods (p < 0.001), demonstrating afternoon peak (between 12:01 and 18:00 hours) and trough between 00:01 and 06:00 hours. Incidence of MI between 12:01 and 18:00 hours was significantly higher when compared with other three 6-h periods (p = 0.001). Incidence of MI between 00:01 and 06:00 hours was significantly lower when compared with other three 6-h periods (p = 0.001). Incidence of MI between 12:01 and 18:00 hours was 1.64 times that of average frequency of the remaining 18:00 hours of the day and 2.3 times that of frequency between 00:01 and 06:00 hours. When analysed for the subgroups of the study sample, only smoking blunted the afternoon peak. Instead of early morning peak in western countries, there is afternoon predominance in circadian variation of MI in a Turkish cohort. It may be related with genetic and/or demographic characteristics of Turkish population. Further studies are required to determine underlying pathophysiological mechanisms causing these differences in chronobiology of MI among populations.
    International Journal of Clinical Practice 03/2008; 63(1):82-6. · 2.43 Impact Factor
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    ABSTRACT: Double right coronary artery (RCA) is a very rare coronary anomaly. So far, the number of reported cases of double RCA is not so much. Nevertheless, there have been several reports of double RCA in the literature, particularly in the last decade. We aimed to report two cases with double RCA and review the literature in this issue. In brackets, we searched the words - double right coronary artery - in medline (www.ncbi.nlm.nih.gov) and limit the search into the title. According to the results, so far double RCA have been reported 18 times and in 20 cases. Here in this case report and minireview we discussed the characteristics of the previous 20 and the present 2 cases with double RCA. The age of diagnosis of double RCA was in the fifth decade on average. Of the 22 cases reported, 19 were male. 14 of them originated from single ostia whereas 8 from separate ostia. 7 of 22 cases were complicated with atherosclerosis and 4 had associated anomalies. In conclusion, although controversy exists about definition of double RCA and generally considered as a benign entity, it might be atherosclerotic and can cause acute coronary syndromes including myocardial infarction and be associated with other anomalies. It is predominantly seen in males and might origin from either single or separate ostia. Although coronary angiography is the most widely used diagnostic modality, multidetector computed tomography might also be helpful.
    International journal of cardiology 02/2008; 130(2):e74-7. · 6.18 Impact Factor
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    ABSTRACT: A 62-year-old female underwent percutaneous coronary stent implantation of the left anterior descending artery without any complications except for a small haematoma in the right inguinal region where femoral artery puncture was performed. Forty days after discharge, she presented to the emergency department with a deep ulcerative wound in the femoral artery puncture site. The wound-site culture revealed methicillin-sensitive Staphylococcus aureus. After appropriate antibiotic treatment and wound care, the deep inguinal infection healed with proper epithelisation and without any complications. This case underscores the importance of prevention and management of access site haematoma during percutaneous procedures.
    The New Zealand medical journal 02/2008; 121(1269):68-70.