D Lipsker

Hopitaux Civils De Colmar, Kolmar, Alsace, France

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Publications (245)625.52 Total impact

  • R. Goussot · C. Wettle · C. Le Coz · B. Cribier · D. Lipsker ·

    Annales de Dermatologie et de Vénéréologie 12/2015; 142(12):S569-S570. DOI:10.1016/j.annder.2015.10.311 · 0.92 Impact Factor

  • Annales de Dermatologie et de Vénéréologie 12/2015; 142(12):S479-S480. DOI:10.1016/j.annder.2015.10.111 · 0.92 Impact Factor
  • A. Kieny · B. Cribier · D. Lipsker ·

    Annales de Dermatologie et de Vénéréologie 12/2015; 142(12):S687. DOI:10.1016/j.annder.2015.10.554 · 0.92 Impact Factor
  • L. Gusdorf · D. Bessis · D. Lipsker ·

    Annales de Dermatologie et de Vénéréologie 12/2015; 142(12):S459. DOI:10.1016/j.annder.2015.10.075 · 0.92 Impact Factor
  • C. Moulinas · H. Dollfus · D. Lipsker ·

    Annales de Dermatologie et de Vénéréologie 12/2015; 142(12):S537. DOI:10.1016/j.annder.2015.10.245 · 0.92 Impact Factor
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    ABSTRACT: We report a didactic and typical case of distal bone sarcoidosis studied by (18) F-FDG PET/CT in a 34-year-old North-African man with mediastinal and cutaneous histologically proven sarcoidosis. Physical examination only revealed a painful swelling of the 4(th) and 5(th) fingers of the right hand and the 2(nd) , 3(rd) and 4(th) fingers of the left hand (A). X-rays showed characteristic pseudocystic lytic lesions limited to a few phalanges, and a grid appearance of the cancellous bone due to thickened trabeculae (B). Surprisingly, (18) F-FDG PET/CT revealed a striking bilateral (18) F-FDG uptake in almost all phalanges, all metacarpals and both ulnar heads
    Arthritis and Rheumatology 10/2015; DOI:10.1002/art.39457
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    ABSTRACT: Oculocutaneous albinism (OCA) is an autosomal recessive disease affecting 1/17,000 person in the general population. It is characterized by hypopigmentation of the skin, hair and eyes. The main handicap in patients is at the ophthalmologic level (nystagmus, reduced visual acuity, photophobia, foveal hypoplasia). There are nowadays 6 known OCA genes (TYR, OCA2, TYRP1, SLC45A2, SLC24A5, C10ORF11) (OCA1, 2, 3, 4, 6, 7 respectively). An OCA5 locus has been localized, but the gene is not known yet. Apart from the OCA types, an X-linked ocular albinism gene (OA1, GPR143) and 10 genes involved in syndromic forms (Hermansky-Pudlak Syndrome, HPS1-9, and Chediak-Higashi Syndrome, CHS) of albinism have been identified (for a review see Montoliu et al. 2014). This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Pigment Cell & Melanoma Research 08/2015; DOI:10.1111/pcmr.12408 · 4.62 Impact Factor
  • M. Huther · C. Gronier · D. Lipsker ·
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    ABSTRACT: Nous rapportons le cas d’un volumineux hémangiome infantile segmentaire du tronc associé à des anomalies cardiovasculaires, tableau similaire à celui du syndrome PHACE, mais de localisation extra-faciale.
    Annales de Dermatologie et de Vénéréologie 06/2015; DOI:10.1016/j.annder.2015.04.164 · 0.92 Impact Factor
  • A Kieny · C Wettlé · D Lipsker · B Cribier ·

    Annales de Dermatologie et de Vénéréologie 06/2015; 142(10). DOI:10.1016/j.annder.2015.04.015 · 0.92 Impact Factor
  • M. Freysz · G.B.E. Jemec · D. Lipsker ·
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    ABSTRACT: The diagnosis of Hidradenitis Suppuratva (HS) is clinical and relatively straightforward for an experienced clinician. However, the terminology needed for a detailed and precise description of the lesions is more problematic. The aim of this study was to identify, enumerate and clearly define the primary lesions described in HS so as to compile a glossary that can be used to define clinical patient profiles. A review of the literature in English was performed on Medline (Pubmed), extending from 1949 to October 2013. This review targeted semantic aspects. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    British Journal of Dermatology 06/2015; DOI:10.1111/bjd.13940 · 4.28 Impact Factor
  • C. Moulinas · H. Dollfus · D. Lipsker ·

    Annales de Dermatologie et de Vénéréologie 05/2015; 142(6-7). DOI:10.1016/j.annder.2015.01.028 · 0.92 Impact Factor
  • F Bourlond · B Cribier · D Lipsker · C Velter ·

    Annales de Dermatologie et de Vénéréologie 04/2015; 142(6-7). DOI:10.1016/j.annder.2015.03.012 · 0.92 Impact Factor
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    ABSTRACT: Some authors consider that morphoea and systemic sclerosis (SSc) could be part of the same disease spectrum. The aim of this study was to analyse the prevalence of signs indicative of SSc in a cohort of patients with morphoea. This is a prospective multi-centre study performed in four French academic dermatology departments: 76 patients with morphoea and 101 age- and sex-matched controls, who underwent complete clinical examination, were enrolled. A systemic search for signs indicative of SSc (e.g. Raynaud's phenomenon, reflux) was performed with the help of a standardised questionnaire. There were 58 women and 18 men (ration =3/1) with a median age of 59 years. Mean age at diagnosis was 54 years (extremes, 13-87). 49 subjects had plaque morphoea, 9 had generalised morphoea and 18 had linear morphoea. Mean duration of morphoea was 7.9 years. Signs possibly indicative of SSc were noted in four patients of the control group and in 8 patients with morphoea. This difference was not statistically significant (p=0.129). Further investigations ruled out SSc in all patients. Signs indicative of SSc are statistically not more frequently present in patients with morphoea than in controls and this study does not support the view that those 2 entities are part of a common disease spectrum.
    Clinical and experimental rheumatology 03/2015; 33 Suppl 91(4). · 2.72 Impact Factor
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    ABSTRACT: Neutrophilic dermatoses (NDs) are inflammatory skin conditions that are not associated with infection. The classification and clinical approach to these conditions in children is poorly described. This review classifies these conditions into five nosological subtypes: Sweet's syndrome, pyoderma gangrenosum, aseptic pustules, neutrophilic urticarial dermatoses, and Marshall's syndrome. In addition, we review the various secondary diseases that need to be excluded in the clinical management of the NDs of childhood, with a focus on the autoinflammatory conditions that the reader may not be familiar with. We propose a practical clinical approach to these disorders. © 2015 Wiley Periodicals, Inc.
    Pediatric Dermatology 02/2015; 32(4). DOI:10.1111/pde.12502 · 1.02 Impact Factor
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    ABSTRACT: Lyme disease is the most important vector-borne disease in the Northern hemisphere and represents a major public health challenge with insufficient means of and reliable diagnosis. Skin is rarely investigated in proteomics but constitutes in the case of Lyme disease the key interface where the pathogens can enter, persist and multiply. Therefore, we investigated proteomics on skin samples to detect Borrelia proteins directly in cutaneous biopsies in a robust and specific way. We first set up a discovery Ge-LC-MS/MS approach on a murine model infected by B. burgdorferi sensu stricto that allowed the identification of 25 Borrelia proteins among more than 1300 mouse proteins. Then we developed a targeted Ge-LC-SRM assay to detect 9/33 Borrelia proteins/peptides in mice skin tissue samples using heavy labeled synthetic peptides. We successfully transferred this assay from the mouse model to human skin biopsies - naturally infected by Borrelia - and we were able to detect two Borrelia proteins: OspC and flagellin. Considering the extreme variability of OspC, we developed an extended SRM assay to target a large set of variants. This assay afforded the detection of nine peptides belonging to either OspC or flagellin in human skin biopsies. We further shortened the sample preparation and showed that Borrelia is detectable in mouse and human skin biopsies by directly using a liquid digestion followed by LC-SRM analysis without any prefractionation. This study thus shows that a targeted SRM approach is a promising tool for the early direct diagnosis of Lyme disease with high sensitivity (<10 fmol OspC per mg of human skin biopsy). Copyright © 2015, The American Society for Biochemistry and Molecular Biology.
    Molecular &amp Cellular Proteomics 02/2015; 14(5). DOI:10.1074/mcp.M114.046540 · 6.56 Impact Factor
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    N. Boulanger · Dan Lipsker ·
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    ABSTRACT: Les tiques sont en mesure de transmettre différentes maladies infectieuses virales (encéphalite à tique), parasitaires (babésiose) et bactériennes dont notamment, en France, la borréliose européenne. En climat tempéré comme en France, les tiques sont actives surtout de mars à octobre. La prévention des piqûres de tique repose sur des mesures vestimentaires et éventuellement le recours aux répulsifs, dont les principaux sont passés en revue ici. Il existe des répulsifs naturels issus de l’eucalyptus, la tomate et la noix de coco et des répulsifs de synthèse dont le plus utilisé est le DEET (N,N,-Diethyl–m- toluamide). Il existe des molécules plus récentes comme l’IR3535 qui serait à la fois moins toxique et plus efficace sur les tiques. Certaines substances s’appliquent sur la peau, d’autres comme la perméthrine, davantage un insecticide qu’un vrai répulsif, peuvent s’appliquer sur les vêtements.
    Annales de Dermatologie et de Vénéréologie 01/2015; 142(4). DOI:10.1016/j.annder.2014.11.018 · 0.92 Impact Factor
  • E. Levy · B. Cribier · D. Lipsker ·

    Annales de Dermatologie et de Vénéréologie 12/2014; 141(12):S391. DOI:10.1016/j.annder.2014.09.370 · 0.92 Impact Factor

  • Annales de Dermatologie et de Vénéréologie 12/2014; 141(12):S429. DOI:10.1016/j.annder.2014.09.451 · 0.92 Impact Factor
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    Laurence Gusdorf · Didier Bessis · Dan Lipsker ·
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    ABSTRACT: Toll-like receptor (TLR) 9 plays a role in intestinal inflammation that, in turn, is related to the tumorigenesis of colorectal cancer. Nuclear factor κB (NFκB), and interferon regulatory factor (IRF) 5 and IRF7 can be activated by TLR9 and induce the production of proinflammatory cytokines and type I interferon, respectively. This study investigated the mRNA expressions of TLR9 and its downstream signaling molecules in both the tumor and the normal tissues of colorectal cancer. Eighty-four subjects with colorectal cancer were consecutively recruited at a community-based hospital, and the mRNA expression of TLR9, NFκB, IRF5, IRF7, interleukin 6 (IL6), and interferon α/β/ω receptor 1 (IFNAR1) in the tumor and normal tissue were determined by real-time reverse transcription polymerase chain reaction using TaqMan FAM-labeled MGB probes (Life Technologies, Carlsbad, CA). The tumor had higher percentages of detection of TLR9, IFNAR1, and IL6 mRNA expressions than normal tissue. The absence of detectable TLR9 mRNA expression was associated with an absence of significance in the correlation between IL6 and NFκB or IRF5, but not that between IRF7 and IFNAR1 in both the tumor and the normal tissues. An absence of detectable IFNAR1 mRNA expression in the tumor (hazard ratio: 3.77; 95% confidence interval: 1.22–11.60) and advanced stage (stages III and IV, 7.86; 1.76–35.40) were significant predictors for overall survival. IFNAR1 is a predictor for overall survival and mRNA expression is correlated to IRF7, but not TLR9 in colorectal cancer. The results cast doubt on the usefulness of TLR9 agonist in treating colorectal cancer.
    Medicine 12/2014; 93(29):e351. DOI:10.1097/MD.0000000000000351 · 5.72 Impact Factor
  • Dan Lipsker · Cédric Lenormand ·
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    ABSTRACT: Introduction: Schnitzler’s syndrome is a paradigm of an acquired autoinflammatory disorder, involving IL-1, which can now be pharmacologically targeted.Areas covered: Management of Schnitzler’s syndrome is covered in detail, by reviewing all published papers on this topic until May 2014. Schnitzler’s syndrome usually affects adult patients in their fifties. The main symptoms are an urticarial rash, fever, joint and/or bone pain, elevated CRP and leukocytosis in a patient with a monoclonal IgM (or rarely IgG) gammopathy. It is a chronic/recurrent disorder and spontaneous remissions are exceedingly rare. Patients are at specific risk of inflammatory anemia and AA-amyloidosis. The risk of associated lymphoid malignancy seems to be comparable to the one associated to monoclonal gammopathy of undetermined significance in general. Diagnosis relies on the Lipsker or the Strasbourg criteria.Expert opinion: Treatment relies on IL-1 inhibitors which allow a rapid and complete control of all signs. The IL-1 receptor antagonist anakinra, which has a short half-life and necessitates daily injections, is the treatment of choice in patients with Schnitzler’s syndrome who have alteration in their quality of life or persistent elevation of markers of inflammation. The other IL-1 inhibitors with longer half-lives need further investigation.
    Expert Opinion on Orphan Drugs 08/2014; 2(9). DOI:10.1517/21678707.2014.939170 · 0.53 Impact Factor

Publication Stats

3k Citations
625.52 Total Impact Points


  • 2015
    • Hopitaux Civils De Colmar
      Kolmar, Alsace, France
  • 2000-2015
    • University of Strasbourg
      • Faculty of Medicine
      Strasburg, Alsace, France
  • 2008-2014
    • CHRU de Strasbourg
      Strasburg, Alsace, France
    • Hôpital Tenon (Hôpitaux Universitaires Est Parisien)
      • Service de Dermatologie - Allergologie
      Paris, Ile-de-France, France
  • 2012
    • Centre Hospitalier Universitaire de Dijon
      Dijon, Bourgogne, France
  • 2009
    • Assistance Publique – Hôpitaux de Paris
      Lutetia Parisorum, Île-de-France, France
  • 2002-2003
    • Etablissement Français du Sang (EFS)
      Lutetia Parisorum, Île-de-France, France
    • Etablissement Français du Sang Alsace
      Strasburg, Alsace, France