James S Hodges

Abbott Northwestern Hospital, Minneapolis, Minnesota, United States

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Publications (188)507.24 Total impact

  • J.O. Look, J.S. Hodges, E.L. Schiffman
    International Journal of Oral and Maxillofacial Surgery 10/2014; · 1.52 Impact Factor
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    ABSTRACT: Background Childhood cancer survivors (CCS) are at high risk of developing treatment-related late effects, including cardiovascular disease and diabetes. Late effects can be exacerbated by low physical activity (PA) levels. Relationships between PA and cardiovascular risk factors during childhood have not been well described in CCS.ProcedurePA and cardiovascular risk factors were measured cross-sectionally in 319 CCS and 208 sibling controls aged 9–18 years. Comparisons between CCS and controls and associations of outcomes with PA (dichotomized at 60 min/day or treated as continuous) were performed with linear regression.ResultsAmong CCS, the high PA group had lower percent fat mass (24.4% vs. 29.8%, P < 0.0001), abdominal subcutaneous fat (67.9 vs. 97.3 cm3, P = 0.0004), and abdominal visceral fat (20.0 vs. 24.9 cm3, P = 0.007) and greater lean body mass (41.3 vs. 39.5 kg, P = 0.009) than the low PA group. Comparing CCS to controls, differences in waist circumference (Pinteraction = 0.04), percent fat mass (Pinteraction = 0.04), and abdominal subcutaneous (Pinteraction = 0.02) and visceral (Pinteraction = 0.004) fat between low and high PA groups were greater in CCS than controls, possibly due to greater overall adiposity in CCS.Conclusions High PA in CCS resulted in an improved cardiovascular profile, consisting primarily of lower fat mass and greater lean mass, similar to that observed in controls. This suggests interventions directed to increase PA in CCS may reduce the risk of future cardiovascular disease. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
    Pediatric Blood & Cancer 10/2014; · 2.35 Impact Factor
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 09/2014;
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    ABSTRACT: Introduction: Epidermal nerve fiber (ENF) density, morphology, and epidermal innervation patterns were examined in children using 2 different techniques, punch biopsy and suction blister. Methods: Healthy children without symptoms or history of peripheral neuropathy and normal by neurologic examination were studied. Punch biopsy and suction blister specimens were collected from the lateral thigh and distal leg. ENFs were traced from confocal images of immunohistochemically stained samples. Statistical methods included repeated measures analysis of covariance. Results: Blister and biopsy nerve counts were associated. ENF density in children was dense, lower for older children (P < 0.01), with no difference between boys and girls (P = 0.92). Many ENFs appeared multi-branched and elongated. Discussion: Epidermal innervation in the pediatric population is dense and age dependent. Bister specimens are less invasive and may provide an alternative to punch biopsy for determining ENF density in children at risk for neuropathy. © 2014 Wiley Periodicals, Inc.
    Muscle & Nerve 07/2014; · 2.31 Impact Factor
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    ABSTRACT: Malaria in highland areas of Kenya affects children and adults. Local clinicians include symptoms other than fever when screening for malaria because they believe that fever alone does not capture all cases of malaria.
    Malaria Journal 04/2014; 13(1):163. · 3.49 Impact Factor
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    ABSTRACT: Background. Cerebral malaria (CM) is associated with long-term neurocognitive impairment in children 5 years of age and older. No prospective studies to date have assessed neurocognitive impairment in children with CM <5 years of age, or in children with severe malarial anemia (SMA), a form of severe malaria estimated to affect as many as 5 million children annually. Methods. Children <5 years of age presenting to Mulago Hospital, Kampala, Uganda, with CM (n=80) or SMA (n=86) were assessed for overall cognitive ability, attention, and associative memory one week after discharge and 6 and 12 months later. Z-scores for each domain were computed based on scores of 61 healthy community children (CC), who were also tested at enrollment and 6 and 12 months later. Groups were compared using mixed linear models, adjusted for age, weight for age, and child's education. Results. At 12 months, children with CM had lower adjusted scores than CC in cognitive ability (P<0.001), attention (P=0.02), and associative memory, (P=0.002). Children with SMA had lower scores than CC in cognitive ability (P=0.01) but not attention or associative memory. Cognitive ability scores in children with CM and SMA did not differ significantly. Conclusions. In children <5 years of age, SMA is associated with long-term impairment in cognitive ability, while CM is associated with additional impairment in the areas of attention and associative memory. SMA may be a major contributor to long-term neurocognitive impairment in children in sub-Saharan Africa.
    Clinical Infectious Diseases 04/2014; · 9.37 Impact Factor
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    ABSTRACT: Background. Tools that estimate recent and long-term malaria transmission in a population would be highly useful for malaria elimination programs.Methods. The prevalence of antibodies to 11 P. falciparum antigens was assessed by cytometric bead assay or ELISA in 1,000 people in a highland area of Kenya over 14 months, during a period of interrupted malaria transmission.Results. Antibodies differed by antigen in acquisition with age: rapid (>80% antibody positive by age 20 years, 5 antigens), moderate (>40% positive by age 20 years, 3 antigens), or slow (<40% positive by age 20 years, 3 antigens). Antibody seroreversion rates in the 14 months between samples decreased with age rapidly (7 antigens), slowly (3 antigens), or remained high at all ages (schizont extract). Estimated antibody half-lives in individuals >10 years of age were long (40 to >80 years) for 5 antigens, moderate (5 - 20 years) for 3 antigens, and short (<1 year) for 3 antigens.Conclusions. Antibodies to P. falciparum antigens in malaria endemic areas vary by age, antigen, and time since last exposure to P. falciparum. Multiplex P. falciparum antibody testing could provide estimates of long-term and recent malaria transmission and potentially of a population's susceptibility to future clinical malaria.
    The Journal of Infectious Diseases 04/2014; · 5.85 Impact Factor
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    ABSTRACT: Evaluate the association of abdominal visceral and subcutaneous fat, independent of total body fat, with cardiometabolic risk factors and insulin resistance among youth. Visceral and subcutaneous fat, percent total body fat, insulin resistance (adjusted for lean body mass: Mlbm), blood pressure, glucose, insulin, and lipids were obtained in 472 youth ages 6-18 years. Linear regression, adjusted for age, sex, race, Tanner stage, and percent total body fat, was used to evaluate associations of visceral and subcutaneous fat with cardiometabolic risk factors. Visceral fat was associated inversely with Mlbm (p=0.003) and positively with fasting insulin (p=0.002) and triglycerides (p=0.002). Visceral fat levels above the mean were associated inversely with HDL cholesterol (p=0.002), and positively systolic blood pressure (p<0.0001) and non-HDL cholesterol (p<0.0001). Subcutaneous fat was associated inversely with Mlbm (p=0.003) and HDL cholesterol (p<0.05), and positively with fasting glucose (p<0.05), fasting insulin (p=0.0003), systolic blood pressure (p=0.005), and triglycerides (p=0.003). Subcutaneous fat levels above the mean were associated with non-HDL cholesterol (p=0.0002). These findings suggest that there may be a threshold level of visceral and subcutaneous fat (regardless of total body fat), that when exceeded in childhood, is more likely to be associated with many cardiometabolic risk factors. Triglycerides and insulin resistance appear to be associated with these fat depots at even lower thresholds of abdominal adiposity.
    Clinical obesity. 04/2014; 4(2):101-107.
  • Lisa Henn, James S. Hodges
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    ABSTRACT: Scattered reports of multiple maxima in posterior distributions or likelihoods for mixed linear models appear throughout the literature. Less scrutinised is the restricted likelihood, which is the posterior distribution for a specific prior distribution. This paper surveys existing literature and proposes a unifying framework for understanding multiple maxima. For those problems with covariance structures that are diagonalisable in a specific sense, the restricted likelihood can be viewed as a generalised linear model with gamma errors, identity link and a prior distribution on the error variance. The generalised linear model portion of the restricted likelihood can be made to conflict with the portion of the restricted likelihood that functions like a prior distribution on the error variance, giving two local maxima in the restricted likelihood. Applying in addition an explicit conjugate prior distribution to variance parameters permits a second local maximum in the marginal posterior distribution even if the likelihood contribution has a single maximum. Moreover, reparameterisation from variance to precision can change the posterior modality; the converse also is true. Modellers should beware of these potential pitfalls when selecting prior distributions or using peak-finding algorithms to estimate parameters.
    International Statistical Review 03/2014; · 0.72 Impact Factor
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    ABSTRACT: Context. Vulvar pain level may fluctuate in women with vulvodynia even in the absence of therapy; however, there is little evidence suggesting which factors may be associated with variability. Objective. Determine the feasibility of using smartphones to collect prospective data on vulvar pain and factors that may influence vulvar pain level. Methods. 24 clinically confirmed women were enrolled from a population-based study and asked to answer five questions using their smartphones each week for one month. Questions assessed vulvar pain level (0-10), presence of pain upon wakening, pain elsewhere in their body, treatment use, and intercourse. Results. Women completed 100% of their scheduled surveys, with acceptability measures highly endorsed. Vulvar pain ratings had a standard deviation within women of 1.6, with greater variation on average among those with higher average pain levels (P < 0.001). On the weeks when a woman reported waking with pain, her vulvar pain level was higher by 1.82 on average (P < 0.001). Overall, average vulvar pain level was not significantly associated with the frequency of reporting other body pains (P = 0.64). Conclusion. Our smartphone tracking system promoted excellent compliance with weekly tracking of factors that are otherwise difficult to recall, some of which were highly associated with vulvar pain level.
    Pain research and treatment. 01/2014; 2014:659863.
  • James S. Hodges
    Environmetrics 12/2013; 24(8). · 1.10 Impact Factor
  • James W Begun, William J Riley, James S Hodges
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    ABSTRACT: This study explores characteristics that distinguish higher and lower CT use by patients and referring physicians in a population of members of a large health insurance plan. We analyzed 310,467 CT scan claims from 2009-10 in a health plan serving approximately 1.5 million members. Patients who used CT scans and their referring physicians were classified into utilization categories. Characteristics distinguishing higher from lower utilization categories were identified. Among patients receiving CT scans, patient characteristics that distinguished higher from lower utilization of scans were: male, older, seeing more total providers, using more prescription and total resources, classified as frail, having higher treatment group severity, and having government insurance. Among physicians ordering scans, physician characteristics that distinguished higher from lower referrals for CT scans were: male, board-certified, in group practice, and in particular specialties. Ownership interest was associated with higher claim volumes in a curvilinear manner but was not associated with claims per physician. Higher total referral counts were related to single-specialty practice type and larger group size. External reviewers (4 physicians) observed that the empirical relationships had plausible explanations based on reasonable medical decision-making. Aggregate-level review of claims for CT scans in a health plan revealed no striking anomalies in associations of patient and referring physician characteristics with higher utilization. Claims research that examines particular conditions and patients with high utilization rates and physicians with high referral rates would advance the evidence base for quality improvement.
    Journal of the American College of Radiology: JACR 11/2013;
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    ABSTRACT: Cancer is the leading cause of death by disease among U.S. children ages 1-14 years; however, over the last few decades there has been a dramatic increase in survival in these individuals. Although free of cancer, survivors are faced with a variety of chronic health problems including an increased risk of cardiovascular and metabolic abnormalities. The effect of cancer treatments on vascular structure and function in childhood cancer survivors (CCS) has not been examined. Measures of carotid artery stiffness (compliance and distensibility) and thickness (IMT), brachial artery endothelial-dependent dilation (EDD), and endothelial-independent dilation (EID) were obtained from ultrasound imaging in 319 CCS (age: 14.6 ± 0.1 years; male/female: 112/96) who were >5 years from diagnosis and 208 (age: 13.6 ± 0.2 years; male/female: 171/148) siblings who had never been diagnosed with cancer. Participants were 9-18 years of age at examination. Survivors of leukemia had lower carotid distensibility and compliance, indicating increased arterial stiffness, when compared to controls. There were no significant differences in measures of carotid stiffness or EDD in survivors of solid tumors and central nervous system (CNS) tumors compared to controls. EDD was lower in leukemia survivors than in controls, and EID was greater in survivors of CNS tumors than in controls. These results demonstrate that early in life, CCS have arterial changes indicating increased risk for premature atherosclerosis and cardiovascular disease. Therefore, it is reasonable to advocate that efforts should be directed at monitoring and managing cardiovascular risk factors in CCS. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
    Pediatric Blood & Cancer 10/2013; · 2.35 Impact Factor
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    ABSTRACT: Low bone mineral density (BMD) has been reported in recipients of pediatric hematopoietic cell transplantation (HCT), but it is unclear whether age at HCT has a role. The objective of this cross-sectional study was to determine if patients treated with HCT before the age of 10 years have long-term BMD deficits compared with patients transplanted at an older age and with sibling controls. The study included 151 HCT recipients (87 males), age at study 24.7±8.6 years treated with HCT for hematologic malignancies at age 10.9±6.4 years, and 92 healthy sibling controls (49 males), age at study 22.3±8.0 years. Dual-energy x-ray absorptiometry was performed to measure BMD Z-scores for total body BMD (TBMD), lumbar spine BMD (LBMD) and femoral neck BMD (FNBMD, for subjects 20 years at study visit). Patients <10 years at HCT had significantly lower TBMD and FNBMD Z-scores (by 0.5 and 0.8 s.d., respectively) compared with controls (P=0.003 and P=0.0001, respectively) and patients >18 years at HCT (P=0.04 and P=0.004, respectively) at an average of 14 years after HCT. In conclusion, this study identified young age at transplant as an important risk factor for bone deficits in young adulthood, suggesting that efforts to reduce bone loss should focus on this patient population.Bone Marrow Transplantation advance online publication, 14 October 2013; doi:10.1038/bmt.2013.156.
    Bone marrow transplantation 10/2013; · 3.00 Impact Factor
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    ABSTRACT: A previous randomized controlled trial (RCT) by Schiffman et al. (2007)(15) compared four treatments strategies for temporomandibular joint (TMJ) disc displacement without reduction with limited mouth opening (closed lock). In this parallel group RCT, 106 patients with magnetic resonance imaging (MRI)-confirmed TMJ closed lock were randomized between medical management, non-surgical rehabilitation, arthroscopic surgery, and arthroplasty. Surgical groups also received rehabilitation post-surgically. The current paper reassesses the effectiveness of these four treatment strategies using outcome measures recommended by the International Association of Oral and Maxillofacial Surgeons (IAOMS). Clinical assessments at baseline and at follow-up (3, 6, 12, 18, 24, and 60 months) included intensity and frequency of TMJ pain, mandibular range of motion, TMJ sounds, and impairment of chewing. TMJ MRIs were performed at baseline and 24 months, and TMJ tomograms at baseline, 24 and 60 months. Most IAOMS recommended outcome measures improved significantly over time (P≤0.0003). There was no difference between treatment strategies relative to any treatment outcome at any follow-up (P≥0.16). Patient self-assessment of treatment success correlated with their ability to eat, with pain-free opening ≥35mm, and with reduced pain intensity. Given no difference between treatment strategies, non-surgical treatment should be employed for TMJ closed lock before considering surgery.
    International Journal of Oral and Maxillofacial Surgery 09/2013; · 1.52 Impact Factor
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    ABSTRACT: Background: Previous case reports and animal studies suggest periodontitis is associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ). We conducted a case-control study to evaluate the association between clinical and radiographic measures of periodontal disease and BRONJ. Methods: 25 BRONJ patients were matched with 48 controls. Trained examiners measured probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) on all teeth except third molars, and gingival and plaque indices on six index teeth. Alveolar bone height was measured from orthopantomograms. Most BRONJ cases were using antibiotics (48%) or a chlorhexidine mouthrinse (84%) at enrollment. Adjusted comparisons of cases vs. controls used multiple linear regression. Results: The average number of BP infusions was significantly higher in BRONJ cases compared to controls (38.4 vs 18.8, p=0.0001). In unadjusted analyses, BRONJ cases had more missing teeth (7.8 vs 3.1, p=0.002) and high average CAL (2.18 vs 1.56 mm, p=0.047) and percent of sites with CAL ≥3 mm (39.0 vs 23.3, p=0.039) than controls. Also, BRONJ cases had lower average bone height (as a fraction of tooth length, 0.59 vs 0.62, p=0.004) and more teeth with bone height under half of tooth length (20% vs 6%, p=0.001). These differences remained significant after adjusting for age, sex, smoking, and number of bisphosphonate infusions. Conclusions: BRONJ patients have fewer teeth, greater CAL, and less alveolar bone support compared to controls after adjusting for number of bisphosphonate infusions. Group differences in antibiotics and chlorhexidine rinse usage may have masked differences in the other clinical measures.
    Journal of Periodontology 06/2013; · 2.40 Impact Factor
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    ABSTRACT: The Peters-Belson (PB) method was developed for quantifying and testing disparities between groups in an outcome by using linear regression to compute group-specific observed and expected outcomes. It has since been extended to generalized linear models for binary and other outcomes and to analyses with probability-based sample weighting. In this work, we extend the PB approach to right-censored survival analysis, including stratification if needed. The extension uses the theory and methods of expected survival on the basis of Cox regression in a reference population. Within the PB framework, among the groups to be compared, one group is chosen as the reference group, and outcomes in that group are modeled as a function of available predictors. By using this fitted model's estimated parameters, and the predictor values for a comparator group, the comparator group's expected outcomes are then calculated and compared, formally with testing and informally with graphics, with their observed outcomes. We derive the extension, show how we applied it in a study of incontinence in nursing home elderly, and discuss issues in implementing it. We used the 'survival' package in the R system to do computations. Copyright © 2013 John Wiley & Sons, Ltd.
    Statistics in Medicine 05/2013; · 2.04 Impact Factor
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    ABSTRACT: AIMS: An increasing number of patients with severe coronary artery disease (CAD) are not candidates for traditional revascularization and experience angina in spite of excellent medical therapy. Despite limited data regarding the natural history and predictors of adverse outcome, these patients have been considered at high risk for early mortality. METHODS AND RESULTS: The OPtions In Myocardial Ischemic Syndrome Therapy (OPTIMIST) program at the Minneapolis Heart Institute offers traditional and investigational therapies for patients with refractory angina. A prospective clinical database includes detailed baseline and yearly follow-up information. Death status and cause were determined using the Social Security Death Index, clinical data, and death certificates. Time to death was analysed using survival analysis methods. For 1200 patients, the mean age was 63.5 years (77.5% male) with 72.4% having prior coronary artery bypass grafting, 74.4% prior percutaneous coronary intervention, 72.6% prior myocardial infarction, 78.3% 3-vessel CAD, 23.0% moderate-to-severe left-ventricular (LV) dysfunction, and 32.6% congestive heart failure (CHF). Overall, 241 patients died (20.1%: 71.8% cardiovascular) during a median follow-up 5.1 years (range 0-16, 14.7% over 9). By Kaplan-Meier analysis, mortality was 3.9% (95% CI 2.8-5.0) at 1 year and 28.4% (95% CI 24.9-32.0) at 9 years. Multivariate predictors of all-cause mortality were baseline age, diabetes, angina class, chronic kidney disease, LV dysfunction, and CHF. CONCLUSION: Long-term mortality in patients with refractory angina is lower than previously reported. Therapeutic options for this distinct and growing group of patients should focus on angina relief and improved quality of life.
    European Heart Journal 05/2013; · 14.72 Impact Factor
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    ABSTRACT: Objective: Low frequency stimulation of peripheral nerves at adequate intensities often results in increased pain sensation and is mediated by central neural processes. Intraoral pain is mediated by trigeminal nerves; however, little is known regarding temporal summation of pain and intraoral stimulus parameters. This study assessed the effects of repeated stimulation of the gingiva on pain sensation in subjects using a device adapted for use in functional imaging environments. Measurement of psychophysical responses provide behavioral context for future investigations of intraoral pain processing using functional imaging methods. Method: A previously modified fMRI-compatible device was used to deliver punctate pressure-pain stimuli to gingiva apical of the maxillary right premolars. Data was collected from healthy female subjects (n = 24, mean age of 31 year). Mildly painful baseline pressure (1/10 intensity) was determined for each subject prior to temporal summation protocol. The summation protocol consisted of 6 runs of 10 mild pressure-pain stimuli with 3 different inter-stimulus intervals (ISI), which were 2, 5, and 10 seconds in duration, in a randomized block design. Data were analyzed by a two-way repeated measures analysis of variance. Result: For each ISI, reported pain ratings increased significantly from the first to tenth individual stimuli (p<0.0001). The increase in pain ratings at 2 second ISI was significantly higher than at 5 and 10 second ISIs (p<0.0001 for both). The reported pain increased during individual trials with greater pain intensity ratings occurring with runs that had shorter ISI duration suggests temporal summation occurred (Trial-by-ISI interaction p<0.0001). Conclusion: Pain ratings increased with stimulation of the gingiva in a frequency-dependent manner, in a similar fashion as observed by others. Experimental paradigm has acceptable properties to proceed with future experiments will rate pain sensation to intraoral stimulation while simultaneous high-resolution fMRI is used to assess brainstem activation.
    IADR/AADR/CADR General Session and Exhibition 2013; 03/2013
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    ABSTRACT: Objective: This study aimed to determine whether dental implants engaging both the alveolar crest and sinus floor bi-cortically using stopper drills and a self-threading concept (bi-cortical fixation) achieves primary and/or secondary implant stabilities comparable to short implants engaging only alveolar crest cortical bone (uni-cortical fixation) or implants engaging both crest and sinus floor but via greenstick fracture and grafting (indirect sinus lift). Method: Thirty-four patients with 7 – 11 mm bone under the sinus as confirmed by CBCT were recruited; 41 implants were placed using one of the 3 techniques (14, 13, 14 implants each, respectively), assigned by randomization. At most two implants per patient were included in the study; those two implants were placed in opposite sides of the maxilla, using different surgical techniques. Primary stability was measured 6 times immediately after implant placement from buccal and lingual with Osstell ISQ. Secondary stability was measured at 2nd stage surgery after 3-6 months' healing. Result: Primary implant stability with indirect sinus lift was highest but the surgical techniques did not differ significantly (P = 0.06; bi-cortical fixation: 70.5 [SE 2.0], uni-cortical fixation: 69.8 [2.1], indirect sinus lift: 76.2 [2.0]). The three techniques had similar secondary stability (P = 0.83; respectively 80.0 [1.1], 79.3 [1.3], 79.0 [1.3]). Baseline residual bone height was similar (P = 0.60; respectively 8.7 mm, 9.1 mm, 9.2 mm) but implant diameter and length placed in maxilla differed (P = 0.01/P < 0.01; bi-cortical fixation: 4.7/11.4 mm, uni-cortical fixation: 4.2/8.2 mm, indirect sinus lift: 4.8/12.0 mm). Conclusion: Primary and secondary implant stabilities of bi-cortical fixation did not differ significantly from those of uni-cortical fixation and indirect sinus lift. Because bi-cortical fixation technique is simpler and cheaper than indirect sinus lift and allows longer implants than uni-cortical fixation with similar secondary implant stability, its clinical usage is warranted.
    IADR/AADR/CADR General Session and Exhibition 2013; 03/2013

Publication Stats

2k Citations
507.24 Total Impact Points

Institutions

  • 2013
    • Abbott Northwestern Hospital
      Minneapolis, Minnesota, United States
    • Makerere University
      • Department of Psychiatry
      Kampala, Kampala District, Uganda
  • 2011
    • U.S. Department of Veterans Affairs
      • Center for Chronic Disease Outcomes Research (CCDOR)
      Washington, D. C., DC, United States
  • 2009
    • University of North Carolina at Chapel Hill
      North Carolina, United States
  • 1970–2009
    • University of Minnesota Duluth
      Duluth, Minnesota, United States
  • 2008
    • University of Manitoba
      • Faculty of Dentistry
      Winnipeg, Manitoba, Canada
    • University of Kentucky
      Lexington, Kentucky, United States
  • 2006–2008
    • North Carolina State University
      • Department of Statistics
      Raleigh, NC, United States
  • 2000–2007
    • University of Minnesota Twin Cities
      • • Department of Restorative Sciences
      • • Division of Biostatistics
      • • School of Dentistry
      • • Minnesota Dental Research Center for Biomaterials and Biomechanics
      Minneapolis, MN, United States
  • 2004–2005
    • Mansoura University
      • Faculty of Dentistry
      Ṭalkha, Muhafazat ad Daqahliyah, Egypt
  • 1999
    • University of Geneva
      • School of Dental Medicine
      Genève, Geneva, Switzerland