Maxime Cannesson

University of California, Irvine, Irvine, California, United States

Are you Maxime Cannesson?

Claim your profile

Publications (192)477.42 Total impact

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Perioperative fluid therapy remains a highly debated topic. Its purpose is to maintain or restore effective circulating blood volume during the immediate perioperative period. Maintaining effective circulating blood volume and pressure are key components of assuring adequate organ perfusion while avoiding the risks associated with either organ hypo- or hyperperfusion. Relative to perioperative fluid therapy, three inescapable conclusions exist: overhydration is bad, underhydration is bad, and what we assume about the fluid status of our patients may be incorrect. There is wide variability of practice, both between individuals and institutions. The aims of this paper are to clearly define the risks and benefits of fluid choices within the perioperative space, to describe current evidence-based methodologies for their administration, and ultimately to reduce the variability with which perioperative fluids are administered. Based on the abovementioned acknowledgements, a group of 72 researchers, well known within the field of fluid resuscitation, were invited, via email, to attend a meeting that was held in Chicago in 2011 to discuss perioperative fluid therapy. From the 72 invitees, 14 researchers representing 7 countries attended, and thus, the international Fluid Optimization Group (FOG) came into existence. These researches, working collaboratively, have reviewed the data from 162 different fluid resuscitation papers including both operative and intensive care unit populations. This manuscript is the result of 3 years of evidence-based, discussions, analysis, and synthesis of the currently known risks and benefits of individual fluids and the best methods for administering them. The results of this review paper provide an overview of the components of an effective perioperative fluid administration plan and address both the physiologic principles and outcomes of fluid administration. We recommend that both perioperative fluid choice and therapy be individualized. Patients should receive fluid therapy guided by predefined physiologic targets. Specifically, fluids should be administered when patients require augmentation of their perfusion and are also volume responsive. This paper provides a general approach to fluid therapy and practical recommendations.
    12/2015; 4(1). DOI:10.1186/s13741-015-0014-z
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Goal-directed fluid therapy strategies have been shown to benefit moderate- to high-risk surgery patients. Despite this, these strategies are often not implemented. The aim of this study was to assess a closed-loop fluid administration system in a surgical cohort and compare that to matched patients who received manual management. Our hypothesis was that the patients receiving closed-loop assistance would spend more time in a preload independent state, defined as percent of case time with stroke volume variation less than or equal to 12%. Patients eligible for the study were all those over 18 years of age scheduled for hepatobiliary, pancreatic, or splenic surgery and expected to receive intravascular arterial blood pressure monitoring as part of their anesthetic care. The closed-loop resuscitation target was selected by the primary anesthesia team and the system was responsible for implementation of goal-directed fluid therapy during surgery. Following completion of enrollment each study patient was matched to a non-closed-loop assisted case performed during the same time period using a propensity match to reduce bias. 40 patients were enrolled, 5 ultimately excluded, and 25 match pairs were found from the remaining 35 patients within the predefined caliper distance. There was no significant difference in fluid administration between groups. The closed-loop group spent a significantly higher portion of case time in a preload-independent state (95 ± 6% of case time versus 87 ± 14%, p = 0.008). There was no difference in case mean or final stroke volume index (45 ± 10 vs. 43 ± 9, and 45 ± 11 vs. 42 ± 11, respectively) or mean arterial pressure (79 ± 8 vs. 83 ± 9). Case-end heart rate was significantly lower in the closed-loop assisted group (77 ± 10 vs.88 ± 13, p = 0.003). In this case control study with propensity matching, clinician use of the closed-loop assistance resulted in a greater portion of case time spent in a preload independent state throughout surgery when compared to manual delivery of goal-directed fluid therapy. Identifier: NCT02020863 , Date of registration: December 19, 2013.
    Critical care (London, England) 12/2015; 19(1):827. DOI:10.1186/s13054-015-0827-7 · 4.48 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Although surgery has become much safer, it has also becoming increasingly more complex and perioperative complications continue to impact millions of patients worldwide each year. Perioperative hemodynamic optimization utilizing Goal Directed Therapy (GDT) has attracted considerable interest within the last decade due to its ability to improve postoperative short and long-term outcomes in patients undergoing higher risk surgeries. The concept of GDT in this context can be loosely defined as collecting data from minimally invasive hemodynamic monitors with the intention of using such data (flow-related parameters and/or dynamic parameters of fluid responsiveness) to titrate therapeutic interventions (intravenous fluids and/or inotropic therapy administration) with the ultimate aim of optimizing end organ tissue perfusion. Recently, the increasing amount of evidence supporting the implementation of GDT strategies has been considered so robust as to allow for the creation of national recommendations in the United Kingdom (UK), France, and Europe. These recommendations from such influential scientific societies and the potential clinical and economic benefits of GDT protocols need to also be examined within the current shift from a "pay for service" to a "pay for performance" health care system. This shift is strongly encouraged within emerging systems such as the Perioperative Surgical Home (PSH) paradigm from the United States. As a result, hospitals and clinicians around the world have become increasingly incentivized to implement perioperative hemodynamic optimization using GDT strategies within their departments. Unfortunately, its adoption continues to be quite limited and a lack of standardized criteria for perioperative fluid administrations has resulted in significant clinical variability among practitioners. This current review will provide a brief up-to-date overview of GDT, discuss current clinical practice, analyze why implementation has been limited and finally, describe the newer closed-loop GDT concept along with its potential risks and benefits.
    11/2015; DOI:10.5603/AIT.a2015.0069
  • Olivier Desebbe · Thomas Lanz · Zeev Kain · Maxime Cannesson ·

  • Davinder Ramsingh · Sumit Singh · Mike Ross · Wendell Williams · Maxime Cannesson ·

    10/2015; DOI:10.1007/s40140-015-0137-2

  • Olivier Desebbe · Alexandre Joosten · Sari Lahham · Maxime Cannesson ·

  • Maxime Cannesson · Howard Schwid · Joseph Rinehart · Zeev Kain ·

    Anesthesia and analgesia 09/2015; 121(3):591-3. DOI:10.1213/ANE.0000000000000668 · 3.47 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Several minimally-invasive technologies are available for cardiac output (CO) measurement in children, but the accuracy and precision of these devices have not yet been evaluated in a systematic review and meta-analysis. We conducted a comprehensive search of the medical literature in PubMed, Cochrane Library of Clinical Trials, Scopus, and Web of Science from its inception to June 2014 assessing the accuracy and precision of all minimally-invasive CO monitoring systems used in children when compared with CO monitoring reference methods. Pooled mean bias, standard deviation, and mean percentage error of included studies were calculated using a random-effects model. The inter-study heterogeneity was also assessed using an I(2) statistic. A total of 20 studies (624 patients) were included. The overall random-effects pooled bias, and mean percentage error were 0.13 ± 0.44 l min(-1) and 29.1 %, respectively. Significant inter-study heterogeneity was detected (P < 0.0001, I(2) = 98.3 %). In the sub-analysis regarding the device, electrical cardiometry showed the smallest bias (-0.03 l min(-1)) and lowest percentage error (23.6 %). Significant residual heterogeneity remained after conducting sensitivity and subgroup analyses based on the various study characteristics. By meta-regression analysis, we found no independent effects of study characteristics on weighted mean difference between reference and tested methods. Although the pooled bias was small, the mean pooled percentage error was in the gray zone of clinical applicability. In the sub-group analysis, electrical cardiometry was the device that provided the most accurate measurement. However, a high heterogeneity between studies was found, likely due to a wide range of study characteristics.
    International Journal of Clinical Monitoring and Computing 08/2015; DOI:10.1007/s10877-015-9757-9 · 1.99 Impact Factor
  • Maxime Cannesson ·

    Canadian Anaesthetists? Society Journal 08/2015; 62(11). DOI:10.1007/s12630-015-0465-1 · 2.53 Impact Factor
  • Darren R Raphael · Maxime Cannesson · Joseph Rinehart · Zeev N Kain ·
    [Show abstract] [Hide abstract]
    ABSTRACT: The perceptions of anesthesiologists of US health care finance reform are germane to informing the future of our specialty. For this reason, we sought to assess anesthesiologists' views of their own importance in cost-reduction strategies. In addition, respondents were asked a series of questions related to the Perioperative Surgical Home. A cross-sectional survey was sent through email to 6000 randomly chosen active members of the American Society of Anesthesiologists. Respondents were asked to indicate what level of responsibility they perceive stakeholders to have in reducing the cost of health care and perioperative care delivery. Respondents were then asked to describe their relative enthusiasm for cost-reduction strategies. To validate the primary outcome, we took advantage of the American Society of Anesthesiologists' recent focus on the Perioperative Surgical Home to ask a series of related questions as comparators. Thirty-eight percent (95% confidence interval, 35-42) of respondents indicated that physicians bear "major responsibility" for cost reduction, 58% (55-61) indicated that physicians bear "some responsibility," and 4%, only a small fraction (0.7-7.5) indicated that physicians bear "no responsibility." Respondents also indicated that other entities listed bear "major responsibility" for cost reduction including hospitals (57% [54-61]) and insurance companies (54% [51-57]). Comparator data from questions not designed to directly measure the primary outcome are reported, including questions about the Perioperative Surgical Home. US anesthesiologists surveyed perceive other stakeholders, such as hospitals and insurance companies, as having a major responsibility in cost reduction. Furthermore, they are not enthusiastic about substantial financial reform such as cuts to Medicare payments.
    Anesthesia and analgesia 07/2015; DOI:10.1213/ANE.0000000000000876 · 3.47 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The perioperative surgical home model highlights the need for trainees to include modalities that are focused on the entire perioperative experience. The focus of this study was to design, introduce, and evaluate the integration of a whole-body point-of-care (POC) ultrasound curriculum (Focused periOperative Risk Evaluation Sonography Involving Gastroabdominal Hemodynamic and Transthoracic ultrasound) into residency training. For 2 yr, anesthesiology residents (n = 42) received lectures using a model/simulation design and half were also randomly assigned to receive pathology assessment training. Posttraining performance was assessed through Kirkpatrick levels 1 to 4 outcomes based on the resident satisfaction surveys, multiple-choice tests, pathologic image evaluation, human model testing, and assessment of clinical impact via review of clinical examination data. Evaluation of the curriculum demonstrated high satisfaction scores (n = 30), improved content test scores (n = 37) for all tested categories (48 ± 16 to 69 ± 17%, P < 0.002), and improvement on human model examinations. Residents randomized to receive pathology training (n = 18) also showed higher scores compared with those who did not (n = 19) (9.1 ± 2.5 vs. 17.4 ± 3.1, P < 0.05). Clinical examinations performed in the organization after the study (n = 224) showed that POC ultrasound affected clinical management at a rate of 76% and detected new pathology at a rate of 31%. Results suggest that a whole-body POC ultrasound curriculum can be effectively taught to anesthesiology residents and that this training may provide clinical benefit. These results should be evaluated within the context of the perioperative surgical home.
    Anesthesiology 07/2015; 123(3). DOI:10.1097/ALN.0000000000000776 · 5.88 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Perioperative Goal Directed Therapy (PGDT) may improve postoperative outcome in high-risk surgery patients but its adoption has been slow. In 2012, we initiated a performance improvement (PI) project focusing on the implementation of PGDT during high-risk abdominal surgeries. The objective of the present study was to evaluate the effectiveness of this intervention. This is a historical prospective quality improvement study. The goal of this initiative was to standardize the way fluid management and hemodynamic optimization are conducted during high-risk abdominal surgery in the Departments of Anesthesiology and Surgery at the University of California Irvine. For fluid management, the protocol consisted in standardized baseline crystalloid administration of 3 ml/kg/h and any additional boluses based on PGDT. The impact of the intervention was assessed on the length of stay in the hospital (LOS) and post-operative complications (NSQIP database). In the 1 year pre- and post-implementation periods, 128 and 202 patients were included. The average volume of fluid administered during the case was 9.9 [7.1-13.0] ml/kg/h in the pre- and 6.6 [4.7-9.5] ml/kg/h in the post-implementation period (p<0.01). LOS decreased from 10 [6-16] days to 7 [5-11] days (p = 0.0001). Based on the multiple linear regression analysis, the estimated coefficient for intervention was 0.203 (SE=0.054, p=0.0002) indicating that with the other conditions being held the same, introducing intervention reduced LOS by 18 % (95 % CI: 9 %-27 %). The incidence of NSQIP complications decreased from 39 % to 25 % (p=0.04). These results suggest that the implementation of a PI program focusing on the implementation of PGDT can transform fluid administration patterns and improve postoperative outcome in patients undergoing high-risk abdominal surgeries. NCT02057653 . Registered 17 December 2013.
    Critical care (London, England) 06/2015; 19(1):261. DOI:10.1186/s13054-015-0945-2 · 4.48 Impact Factor
  • Koichi Suehiro · Alexandre Joosten · Brenton Alexander · Maxime Cannesson ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Determination of hemoglobin (Hb) concentration is essential for the detection of anemia and hemorrhage and is widely used to evaluate a patient for a possible blood transfusion. Although commonly accepted as intrinsic to the process, traditional laboratory measurements of Hb are invasive, intermittent, and time-consuming. Noninvasive Hb (NIHb)-monitoring devices have recently become available and promise the potential for detecting sudden changes in a patient's Hb level. In addition to reduced delays in clinical intervention, these devices also allow for a reduction in patient discomfort, infection risk, required personnel, and long-term costs. Unfortunately, it has been shown that many clinical factors can influence their accuracy. Many studies have been published on the accuracy and precision of NIHb-monitoring devices in various clinical settings. A recent meta-analysis has shown a small mean difference but wide limits of agreement between NIHb and laboratory measurements, indicating that caution should be used by physicians when making clinical decisions based on this device. NIHb measurements may currently be considered to be a supplemental tool for monitoring trends in Hb concentration, but are not currently developed enough to replace an invasive approach. Moreover, further studies are still required before implementing NIHb in the clinical decision-making process. Specifically, no studies have demonstrated that this technology improves clinical outcomes or patient safety.
    Current opinion in critical care 03/2015; 21(3). DOI:10.1097/MCC.0000000000000197 · 2.62 Impact Factor
  • A Joosten · J Rinehart · M Cannesson ·

    Revista espanola de anestesiologia y reanimacion 03/2015; 62(4). DOI:10.1016/j.redar.2015.01.012
  • Maxime Cannesson · Zeev Kain ·

    Journal of Clinical Anesthesia 02/2015; 27(3). DOI:10.1016/j.jclinane.2015.01.006 · 1.19 Impact Factor
  • Source
    A Joosten · T Huynh · K Suehiro · C Canales · M Cannesson · J Rinehart ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Goal directed fluid therapy (GDFT) has been shown to improve outcomes in moderate to high-risk surgery. However, most of the present GDFT protocols based on cardiac output optimization use invasive devices and the protocols may require significant practitioner attention and intervention to apply them accurately. The aim of this prospective pilot study was to evaluate the clinical feasibility of GDFT using a closed-loop fluid administration system with a non-invasive cardiac output monitoring device (Nexfin™, BMEYE, Amsterdam, Netherlands). Patients scheduled for elective moderate risk surgery under general anaesthesia were enrolled. The primary anaesthesia team managing the case selected GDFT targets using the controller interface and all patients received a baseline 3 ml kg(-1) h(-1) crystalloid infusion. Colloid solutions were delivered by the closed-loop system for intravascular volume expansion using data from the Nexfin™ monitor. Compliance with GDFT management was defined as acceptable when a patient spent more than 85% of the surgery time in a preload independent state (defined as pulse pressure variation <13%) or when average cardiac index during surgery was >2.5 litre min(-1) m(-2). A total of 13 patients were included in the study group. All patients met the established criteria for delivery of GDFT for greater than 85% of case time. The median length of stay in the hospital was 5 [3-6] days. In this pilot study, GDFT management using the closed-loop fluid administration system with a non-invasive CO monitoring device was feasible and maintained a high rate of protocol compliance. NCT02020863. © The Author 2015. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email:
    BJA British Journal of Anaesthesia 02/2015; 114(6). DOI:10.1093/bja/aev002 · 4.85 Impact Factor
  • Maxime Cannesson · Michael Pinsky ·

    Anesthesia & Analgesia 01/2015; 120(1):10-1. DOI:10.1213/ANE.0000000000000439 · 3.47 Impact Factor
  • M Lilot · J M Ehrenfeld · C Lee · B Harrington · M Cannesson · J Rinehart ·
    [Show abstract] [Hide abstract]
    ABSTRACT: Variation in clinical practice in the perioperative environment and intensive care unit is a major challenge facing modern medicine. The objective of the present study was to analyse intraoperative crystalloid administration practices at two academic medical centres in the USA. We extracted clinical data from patients undergoing intra-abdominal procedures performed at UC Irvine (UCI) and Vanderbilt University (VU) Medical Centres. Limiting data to uncomplicated elective surgery with minimal blood loss, we quantified variability in fluid administration within individual providers, between providers, and between types of procedures using a corrected coefficient of variation (cCOV). Regression was performed using a general linear model to determine factors most predictive of fluid administration. For provider analysis and model building, 1327 UCI and 4585 VU patients were used. The average corrected crystalloid infusion rate across all providers at both institutions was 7.1 (sd 4.9) ml kg(-1) h(-1), an overall cCOV of 70%. Individual providers ranged from 2.3 (sd 3.7) to 14 (sd 10) ml kg(-1) h(-1). The final regression model strongly favoured personnel as predictors over other patient predictors. Wide variability in crystalloid administration was observed both within and between individual anaesthesia providers, which might contribute to variability in surgical outcomes. © The Author 2015. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email:
    BJA British Journal of Anaesthesia 01/2015; 114(5). DOI:10.1093/bja/aeu452 · 4.85 Impact Factor

Publication Stats

3k Citations
477.42 Total Impact Points


  • 2009-2015
    • University of California, Irvine
      • Department of Anesthesiology and Perioperative Care
      Irvine, California, United States
  • 2012
    • Sichuan University
      • Department of Anesthesiology
      Hua-yang, Sichuan, China
  • 2010
    • CSU Mentor
      Long Beach, California, United States
  • 2007-2010
    • Claude Bernard University Lyon 1
      Villeurbanne, Rhône-Alpes, France
    • St George's, University of London
      Londinium, England, United Kingdom
  • 2004-2010
    • CHU de Lyon - Hôpital Cardio-vasculaire et Pneumologique Louis Pradel
      Lyons, Rhône-Alpes, France
  • 2007-2009
    • University of Pittsburgh
      Pittsburgh, Pennsylvania, United States
  • 2006-2009
    • Hospices Civils de Lyon
      Lyons, Rhône-Alpes, France
    • Hôpital Louis Pradel
      Lyons, Rhône-Alpes, France
  • 2005
    • Centre Hospitalier Lyon Sud
      Lyons, Rhône-Alpes, France