Iwona Sobczyk-Krupiarz

Publications of Iwona Sobczyk-Krupiarz

• [Interleukin 8 and interferon gamma in ocular toxoplasmosis].

  Authors: Jacek Czepiel, Grazyna Biesiada, Iwona Sobczyk-Krupiarz, Grazyna Miklasszewska, Danuta Fedak, Bogdan Solnica, Tomasz Mach, Aleksander Garlicki

  Klinika oczna. 01/2011; 113(4-6):149-52.

  Toxoplasmosis is one of the most common parasitic infections in the world, it is caused by Toxoplasma gondii. The infection is typically asymptomatic or the symptoms are very mild. Approximately 10%Toxoplasmosis is one of the most common parasitic infections in the world, it is caused by Toxoplasma gondii. The infection is typically asymptomatic or the symptoms are very mild. Approximately 10% patients have limphadenopathy, involvement of the others organs, like eyes, nervous system, liver, heart, are observed more rarely. The aim of our study was to assess the level of selected cytokines in blood among patients with ocular toxoplasmosis. We have enrolled in the study 30 patients, 19-42 years old, treated for ocular toxoplasmosis, and 20 healthy volunteers, 20-48 years old, to the control group. Tests for blood morphology, C-reactive protein, the level of IL-8 and IFN-gamma were performed in all patients. The blood parameters in toxoplasmosis group were performed before antiparasitic treatment was given. The level of IFN-gamma in blood was lower among patients with ocular toxoplasmosis comparing with control group (1.52 vs. 4.18 pg/ml; p = 0.002). The level of IL-8 in blood was lower among patients with ocular toxoplasmosis comparing with control group (22.96 vs. 94.3 pg/ml; p = 0,007). There were no correlations between analyzed cytokines and blood morphology or CRP. The low level of IFN-gamma and IL-8 in blood is important factor leading to reactivation of the ocular toxoplasmosis.

• [Neurological complications among patients with zoster hospitalized in Department of Infectious Diseases in Cracow in 2001-2006].

  Authors: Grazyna Biesiada, Jacek Czepiel, Iwona Sobczyk-Krupiarz, Tomasz Mach, Aleksander Garlicki

  Przegla̧d lekarski. 01/2010; 67(3):149-50.

  Herpes zoster is an infectious disease caused by varicella zoster virus (VZV). After replication at the place of entry, VZV spreads via the blood into the skin and mucosa, causing the varicella. FromHerpes zoster is an infectious disease caused by varicella zoster virus (VZV). After replication at the place of entry, VZV spreads via the blood into the skin and mucosa, causing the varicella. From these regions VZV migrates into the sensory ganglia where it establishes a latent infection. The aim of our study was to analyze the localization of the skin changes and correlations of neurological complications among patient with zoster. We have reviewed medical documentation of the 67 patients with herpes zoster, hospitalized in our Department during the years 2001-2006. We have studied localization of the herpes zoster changes and frequency of neurological complications among these patients. Neuralgia was less intensive and last shorter time, when antiviral treatment had been started earlier. Neuralgia, meningitis, encephalitis and complications of the eye zoster were present more often among patients over 65 years old.

• Levels of sVCAM-1 and sICAM-1 in patients with lyme disease.

  Authors: Grazyna Biesiada, Jacek Czepiel, Iwona Sobczyk-Krupiarz, Dominika Salamon, Aleksander Garlicki, Tomasz Mach

  Polskie archiwum medycyny wewnȩtrznej. 05/2009; 119(4):200-4.

  INTRODUCTION: Lyme disease is a multi-organ animal-borne disease caused by the spirochete Borrelia burgdorferi (Bb). OBJECTIVES: As the pathogenesis of Lyme borreliosis is not fully understood, theINTRODUCTION: Lyme disease is a multi-organ animal-borne disease caused by the spirochete Borrelia burgdorferi (Bb). OBJECTIVES: As the pathogenesis of Lyme borreliosis is not fully understood, the study has been designed to examine levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) in serum and the cerebrospinal fluid (CSF) of patients with Lyme borreliosis and their associations with clinical signs and symptoms and anti-Borrelia burgdorferi (anti-Bb) antibody titers. PATIENTS AND METHODS: Sixty-four patients were enrolled in the study, including 39 patients treated for Lyme borreliosis and 25 without the disease (control group). In both groups sVCAM-1 and sICAM-1 levels were determined in serum and the CSF. RESULTS: Mean serum sICAM-1 and sVCAM-1 levels were higher in patients with Lyme borreliosis than in the control group. Serum sICAM-1 levels were significantly lower among patients with results positive for immunoglobulin M seroreactivity with Bb than among those with negative antibody responses. In patients with Bb-specific serum immunoglobulin G (IgG) antibodies, significantly higher serum sICAM-1 levels were found. Higher sVCAM-1 and sICAM-1 levels in the CSF were observed in patients positive for anti-Bb IgG antibody titers in the CSF. CONCLUSIONS: In patients with Lyme borreliosis, endothelial cell activation results in elevated levels of sICAM-1 and sVCAM-1 in serum and the CSF.

• Neuroborreliosis with extrapyramidal symptoms: a case report.

  Authors: Grazyna Biesiada, Jacek Czapiel, Iwona Sobczyk-Krupiarz, Aleksander Garlicki, Tomasz Mach

  Polskie archiwum medycyny wewnȩtrznej. 06/2008; 118(5):314-7.

  The disease of Lyme is a tick-borne infection. It involves skin, the nervous system, joints and the heart. Spirochaeta Borrelia burgdorferi is the etiologic agent of the disease. In the majority ofThe disease of Lyme is a tick-borne infection. It involves skin, the nervous system, joints and the heart. Spirochaeta Borrelia burgdorferi is the etiologic agent of the disease. In the majority of cases, clinical symptoms, like migrating erythema, occur from 3 to 30 days, sometimes to 3 months after a bite from a tick. The early disseminated infection involves multiple migrating erythema, neuroborreliosis, arthritis, myocarditis and other organ-related symptoms. The late stage of chronic infection involves chronic atrophic leg dermatitis, neurological and rheumatological symptoms, and other organ-related symptoms which persist for above 12 months. The diagnosis of the disease of Lyme is based upon specific clinical symptoms confirmed by serologic tests. The two-step diagnostic protocol including the ELISA method, confirmed by the Western-blot test, is optimal. The present article describes a case of a 59-year-old man, a computer specialist, who often spends his free time walking in woods for recreation, and who was bitten by a tick 3 years before hospitalization. The bite resulted in migrating erythema that subsided without antimicrobial treatment. In spite of this, the man had not changed his hobby exposing himself to bites from ticks. One year later, multiple migrating erythema and extrapyramidalis symptoms appeared without any other organ malfunctions. In the current year, the patient was admitted to the Infectious Diseases Hospital, and received antibiotics (ceftriaxon) with following neurological improvement. Several months later, extrapyramidal symptoms increased. On the day of admission to the hospital, the neurologic examination showed abnormalities of upper and lower limbs movements (propulsive walking and the right lower leg traction), the right hand tremor, pouts of the face, and sleepiness.

• [The case of Salmonella paratyphi A infection in Poland]

  Authors: Iwona Sobczyk-Krupiarz, Aleksander Garlicki, Grazyna Biesiada, Jacek Czepiel, Paweł Skwara, Dominika Salamon, Tomasz Mach

  Przegla̧d lekarski. 02/2008; 65(2):107-8.

  Paratyphoid fever is an acute infection caused by Salmonella paratyphi A, B or C. The disease is transmitted from person to person by fecal-oral way. Typical for typhoid fever are splenomegaly,Paratyphoid fever is an acute infection caused by Salmonella paratyphi A, B or C. The disease is transmitted from person to person by fecal-oral way. Typical for typhoid fever are splenomegaly, bradycardia, fever, constipation or mild diarrhoea oftten associated with abdominal tenderness. We present the case of patient who was infected by Salmonella paratyphi C while his travelling in Asia.

• [Outbreak of Lyme borreliosis with joint manifestation--case report]

  Authors: Grazyna Biesiada, Jacek Czepiel, Paweĺ Skwara, Iwona Sobczyk-Krupiarz, Tomasz Mach

  Przegla̧d lekarski. 02/2006; 63(4):231-3.

  Lyme borreliosis is caused by the spirochete Borrelia burgdorferi, which is transmitted into the human body by ticks. The clinical symptoms are associated with skin, joints, heart and nervous system.Lyme borreliosis is caused by the spirochete Borrelia burgdorferi, which is transmitted into the human body by ticks. The clinical symptoms are associated with skin, joints, heart and nervous system. Four groups of antibiotics are used in Lyme borreliosis treatment: penicillins, cephalosporins, tetracyclines and macrolides. We present the case of Lyme borreliosis with outbreak joint manifestation.

• [Studies on relationship between immunodeficiency in HIV-infected people and condition of upper gastrointestinal tract mucosa, prevalence of mycosis and Helicobacter pylori infection]

  Authors: Paweł Skwara, Tomasz Mach, Romana Tomaszewska, Iwona Sobczyk-Krupiarz, Andrzej Cieśla

  Przegla̧d lekarski. 02/2005; 62(12):1401-4.

  HIV infection leads to progressive deterioration of immunity. Upper gastrointestinal symptoms are often reported in patients with this infection. The aim of the study was to evaluate morphologicalHIV infection leads to progressive deterioration of immunity. Upper gastrointestinal symptoms are often reported in patients with this infection. The aim of the study was to evaluate morphological changes in upper gastrointestinal tract mucosa and prevalence of opportunistic infections and Helicobacter pylori in HIV-infected people in relationship to the degree of immunosupression. We studied 94 HIV-infected patients with dyspeptic symptoms, 47 suffered from severe immunodeficiency expressed by low CD4+ lymphocyte count below 200/ mm3. Control group consisted of 52 non HIV-infected patients. During endoscopy, gastrointestinal tract mucosa was evaluated and biopsy samples were taken from gastric body and antrum for histopathological analysis and rapid urease test. In patients with CD4+ lymphocyte count below 200/mm3, endoscopic examination revealed significantly more frequent esophageal candidiasis (36%); whereas reflux esophagitis (13%) was significantly less often diagnosed in comparison to the rest of the patients. Duodenitis and duodenal erosions were also less frequent in them. Prevalence of Helicobacter pylori infection in gastric antrum was significantly lower in HIV-infected patients with severe immunodeficiency (40%) in comparison to the rest of the patients (72%) and control group (69%). Chronic active gastritis of the antral mucosa was less frequent in HIV-infected patients with CD4+ lymphocyte count below 200/mm3.

• [Whooping cough in a previously vaccinated patient--case report]

  Authors: Grazyna Biesiada, Jacek Czepiel, Paweł Skwara, Iwona Sobczyk-Krupiarz, Tomasz Mach

  Przegla̧d lekarski. 02/2005; 62(2):133-4.

  Pertussis is an acute contagious human disease caused by gram-negative Coccobacilli Bordetella pertussis. Numerous factors and toxins produced by Bordetella pertussis play important role inPertussis is an acute contagious human disease caused by gram-negative Coccobacilli Bordetella pertussis. Numerous factors and toxins produced by Bordetella pertussis play important role in pathogenicity of the disease. Typical illness has three clinical stages: catarrhal, paroxysmal and convalescent. In therapy erythromycin is the antibiotic of choice. We present a case of pertussis in a seventeen year old, previously vaccinated patient.

• [Tuberculous meningoencephalitis--own observations]

  Authors: Aleksander Garlicki, Urszula Kluba-Wojewoda, Monika Bociaga-Jasik, Anna Kalinowska-Nowak, Iwona Sobczyk-Krupiarz, Tomasz Mach

  Folia medica Cracoviensia. 02/2003; 44(1-2):27-38.

  Nine cases of the tuberculous meningoencephalitis in adult men and women treated in years 1993-2000 have been presented. The diagnosis was established on the basis of clinical picture and examinationNine cases of the tuberculous meningoencephalitis in adult men and women treated in years 1993-2000 have been presented. The diagnosis was established on the basis of clinical picture and examination of the cerebrospinal fluid (CSF). Routine analysis of CSF was done, as well as the microscopic examination, biological assay, and culture on the Lowenstein-Jensena medium and using Bactec 460 TB system. Only in one case Mycobacterium tuberculosis was found in the smear of CSF stained by Ziehl-Nielsen method. In one case the biologic assay was positive and Mycobacterium tuberculosis was cultured on Lowenstein-Jensen medium. In another 4 cases the pathogen was detected by Bactec 460 TB technique. In 4 cases Mycobacterium tuberculosis was also cultured from the secretion of the respiratory tract, and in one patient urine. On chest X-ray characteristic changes for pulmonary tuberculosis were observed in 5 cases (56%). Seven patients (78%) had hydrocephalus detected on CT scan of the head. One patient died, one (11%) developed persistent complication in form of spastic paralysis of lower extremities and sphincters dysfunction. Seven patients (78%) recovered completely after the 12 months therapy with standard chemotherapeutic regimen for tuberculosis.

• [Calcifications of basal ganglia and cerebellum in patient with pseudohypoparathyroidism--case report]

  Authors: Anna Kalinowska-Nowak, Aleksander Garlicki, Monika Bociaga-Jasik, Iwona Sobczyk-Krupiarz, Tomasz Mach

  Przegla̧d lekarski. 02/2002; 59(7):548-50.

  Presented is the case report of symmetrical calcifications of basal ganglia, cerebellum and subcortical white matter of cerebral hemispheres (Fahr's syndrome) in a 34 year old man withPresented is the case report of symmetrical calcifications of basal ganglia, cerebellum and subcortical white matter of cerebral hemispheres (Fahr's syndrome) in a 34 year old man with pseudohypoparathyroidism. Attention has been put on characteristic features of Fahr's syndrome and differential diagnosis of this rare disease.