A Temel

Marmara University, İstanbul, Istanbul, Turkey

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Publications (13)18.54 Total impact

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    ABSTRACT: A case of Merkel cell tumour that developed on the left upper lid of a 76-year-old white man is reported. The diagnosis was ultrastructurally made by demonstrating characteristic light microscopic features of Merkel cell carcinoma; such as large, round nuclei and frequent mitoses. Immunohistochemically, the tumour cells were shown to possess simple epithelia-type keratin intermediate filaments. Merkel cell tumour probably develops from precursor cells which give rise to keratinocytes and Merkel cells, and nearly one out of 10 Merkel cell tumours occur in the eyelid and periocular region. They tend to be bulging lesions near the lid margin of elderly patients. The condition can be misdiagnosed as lymphoma, oat cell carcinoma, malignant melanoma, sweat gland tumours, neuroblastoma and Ewing's sarcoma, and frequently invades lymphatic vessels. Nearly one out of three Merkel cell tumours recur and two thirds cause regional lymph node metastases. Wide surgical resection and reconstructive procedures, should be followed by routine postoperative irradiation. This patient was treated with wide resection and the Cutler-Beard technique, then scheduled for radiotherapy.
    European Journal of Surgical Oncology 11/1994; 20(5):587-92. · 2.61 Impact Factor
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    ABSTRACT: We evaluated two patients who developed hypotonic maculopathy following trabeculectomy and adjunctive 5-fluorouracil injections. Both patients had ocular hypotony and decreased visual acuity following these injections. The first case showed marked choroidal foldings, retinal striae, increased retinal vascular tortuosity, engorgement and optic disc oedema. The second case had radial perifoveal retinal striae, increased retinal vascular tortuosity and engorgement. The first patient regained pre-operative visual acuity while the second case had a visual acuity of 20/25 without any intervention. Fundus changes were less marked 12 months after initial evaluation in both cases. Hypotonic maculopathy is a reversible complication of trabeculectomies with adjunctive use of 5-fluorouracil.
    Ophthalmologica 02/1994; 208(6):318-20. · 1.41 Impact Factor
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    ABSTRACT: We evaluated two patients who developed hypotonic maculopathy following trabeculectomy and adjunctive 5-fluorouracil injections. Both patients had ocular hypotony and decreased visual acuity following these injections. The first case showed marked choroidal foldings, retinal striae, increased retinal vascular tortuosity, engorgement and optic disc oedema. The second case had radial perifoveal retinal striae, increased retinal vascular tortuosity and engorgement. The first patient regained pre-operative visual acuity while the second case had a visual acuity of 20/25 without any intervention. Fundus changes were less marked 12 months after initial evaluation in both cases. Hypotonic maculopathy is a reversible complication of trabeculectomies with adjunctive use of 5-fluorouracil.
    Ophthalmologica 01/1994; 208(6):318-320. · 1.41 Impact Factor
  • A Temel, T Bavbek, A Kanpolat
    International Journal of Rehabilitation Research 07/1993; 16(2):148-50. · 1.06 Impact Factor
  • A Temel, H Kazokoglu
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    ABSTRACT: Topical application of acetazolamide has no known effect on intraocular pressure (IOP). We tried to detect the hypotensive effect on IOP of acetazolamide soaked onto soft contact lenses (CL). We applied CLs soaked in either 1%, 3%, or 5% acetazolamide solution onto one eye of 29 rabbits while the contralateral eye served as a control. There was an average 32% reduction of IOP amongst all acetazolamide applied eyes, and an average 19% reduction of IOP amongst all control eyes. Amongst the 1% acetazolamide-CL applied eyes there was a mean 37% reduction of IOP, amongst the 3% acetazolamide-CL applied eyes a mean 36% reduction, amongst the 5% acetazolamide-CL applied a mean 30% reduction, and a mean 19% reduction in control eyes. The longest period of IOP reduction followed the application of 1% acetazolamide-CLs, probably owing to improved drug corneal penetration at this concentration. Our results reveal that the application of acetazolamide soaked soft CLs has a significant hypotensive effect on IOP in both the applied and contralateral control eyes of rabbits.
    Documenta Ophthalmologica 02/1992; 82(4):323-9. · 1.54 Impact Factor
  • A Temel, M Gunay
    Injury 08/1991; 22(4):327-8. · 1.93 Impact Factor
  • A Temel, H Kazokoglu, Y Taga
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    ABSTRACT: Tear lysozyme levels in various types of asymptomatic contact lens wearers were compared with those in age- and sex-matched healthy control subjects. We used a radial immunodiffusion technique, and the lysozyme levels were in the normal range in controls and contact lens wearers. A comparison of the tear lysozyme levels of 27 contact lens wearers (mean, 1.05 +/- 0.45 g/L) with 22 control subjects (mean, 0.84 +/- 0.39 g/L) was statistically significant (P less than .05). The mean tear lysozyme levels of rigid (1.12 +/- 0.54 g/L, P less than .05) and high water-content (1.20 +/- 0.43 g/L, P less than .03) contact lens wearers were increased in comparison with the control group. The tear lysozyme difference was significant (P less than .03) between high and low water-content (0.82 +/- 0.20 g/L) contact lens users. Our study revealed that, although most of the contact lens wearers were asymptomatic and there was no pathologic sign of external ocular inflammation, a change in tear lysozymes was observed. Contact lens wear is irritating to the cornea and conjunctiva, and tear lysozyme physiology is disturbed most by high water-content contact lenses.
    Annals of ophthalmology 06/1991; 23(5):191-4. · 0.16 Impact Factor
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    ABSTRACT: We assayed tear immunoglobulins (IgA, IgG, and IgM) by radial immunodiffusion in 24 contact lens wearers and 22 healthy control subjects. IgA level was found to be increased (P less than or equal to 0.02) in rigid contact lens wearers (mean: 0.14 +/- 0.07 g/L) compared to control subjects (mean: 0008 +/- 0.06 g/L). IgA levels of both of PMMA contact lens wearers (mean: 0.14 +/- 0.08 g/L; P less than or equal to 0.05) and rigid gas permeable contact lens wearers (mean: 0.13 +/- 0.07 g/L; P less than or equal to 0.05) were increased in comparison with the control group. No statistically significant differences were found in IgA levels of various types of soft contact lens wearers or in IgG or IgM levels between wearers and controls. The mean duration of lens wear was 6.4 years (range: 1-20 years), and an increase in IgG level was found, related length of lens wear (P less than or equal to 0.03). We believe that the continuous mechanical stimulation of conjunctiva alters the level of tear immunoglobulins, especially the IgA type.
    The CLAO journal: official publication of the Contact Lens Association of Ophthalmologists, Inc 02/1991; 17(1):69-71.
  • A Temel, H Kazokoğlu
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    ABSTRACT: The use of low-vision-aids (LVAs) to improve distance and near visual acuity was evaluated in 27 patients. Most of the patients had a useful distance vision with or without glasses, and 24 patients (89%) were prescribed a near visual aid successfully. The high success rate was attributed to young age, strong motivation and myopic refractive error of these patients. We recommend the trial of LVAs to patients with Stargardt's disease who have visual difficulties.
    Ophthalmologica 02/1991; 202(3):142-6. · 1.41 Impact Factor
  • A Temel, E Seber, M Gunay
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    ABSTRACT: We detected hepatitis B surface antigen (HBsAg) in tears and aqueous humor of 18 patients who upon preliminary examination were seropositive for HBsAg and were scheduled to undergo cataract extractions. HBsAg remained detectable in the serum of 10 of these patients on the day of operation, and of these, 7 were found to have detectable levels of HBsAg in their tears and aqueous humor. Based on our findings, we caution ophthalmologists to take all the necessary precautions in both surgical and nonsurgical treatment of patients at high risk for hepatitis B infection.
    Acta ophthalmologica 05/1990; 68(2):205-8. · 2.44 Impact Factor
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    ABSTRACT: Intra-ocular pressure (IOP) variations during extracorporeal circulation (ECC) and some influencing factors were studied prospectively in 38 patients undergoing cardiovascular surgery. IOPs were measured pre-operatively, during ECC (after 5 min, 10 min, 25 min and every 15 min thereafter), and on the 1st, 2nd and 3rd postoperative days. IOP, haematocrit, arterial perfusion pressure, partial O2 pressure, partial CO2 pressure, pH and blood bicarbonate levels were measured simultaneously. After the beginning of ECC, arterial perfusion pressure and haematocrit values decreased suddenly, while IOP raised immediately. Sudden increase of blood volume in the beginning of ECC can be the probable cause of IOP elevation. Afterwards, IOP levels decreased to pre-ECC levels. We think that the drop is due to the effect of mannitol in the priming solution and hyposecretion of aqueous humour due to insufficient nutrition-oxygenation of corpus ciliaris after haemodynamic stabilization.
    Ophthalmologica 02/1990; 201(3):140-4. · 1.41 Impact Factor
  • A Temel
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    ABSTRACT: One hundred and eighty-five referred patients with various eye pathologies were evaluated retrospectively after they had undergone an examination and issued with a prescription for low vision. The majority of patients (77%) benefited from the prescribing of low vision aids (LVA). Spectacle-mounted magnifiers, high reading additions and telescopes were used as LVAs. Visual acuity, age and magnification are important factors in the assessment of an LVA.
    Ophthalmic and Physiological Optics 08/1989; 9(3):327-31. · 1.74 Impact Factor
  • A. Temel, H. Kazokoğlu
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    ABSTRACT: The use of low-vision-aids (LVAs) to improve distance and near visual acuity was evaluated in 27 patients. Most of the patients had a useful distance vision with or without glasses, and 24 patients (89%) were prescribed a near visual aid successfully. The high success rate was attributed to young age, strong motivation and myopic refractive error of these patients. We recommend the trial of LVAs to patients with Stargardt’s disease who have visual difficulties.
    Ophthalmologica 202(3):142-146. · 1.41 Impact Factor