Fatima Tabache

La Faculté de Médecine et de Pharmacie de Rabat, Rabat, Rabat-Salé-Zemmour-Zaër, Morocco

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Publications (28)17.72 Total impact

  • Joint, bone, spine: revue du rhumatisme 05/2011; 78(4):420-1. · 2.25 Impact Factor
  • Joint, bone, spine: revue du rhumatisme 03/2011; 78(3):321-2. · 2.25 Impact Factor
  • Revue Du Rhumatisme - REV RHUM. 01/2011; 78(3):298-299.
  • Revue Du Rhumatisme - REV RHUM. 01/2011; 78(3):294-295.
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    ABSTRACT: In this study, the authors analyze the role of antiangiogenesis as a therapeutic target in the treatment of metastatic renal cancer through a clinical case of pulmonary metastases secondary to renal cancer. A marked regression of pleuropulmonary metastases was observed on chest radiograph and CT scan after one year of treatment with sorafenib. Survival in the present case is 15 months, and no side effects have been reported. This class of drugs plays a significant role in the therapeutic strategies of adjuvant treatment for chemoresistant renal cancer and appears to be a breakthrough especially since currently there are few effective treatment options. Les auteurs mettent au point à travers un cas clinique des métastases pulmonaires secondaires à un cancer rénal, la place des antiangiogéniques en tant que thérapeutiques ciblées dans le traitement du cancer rénal métastatique. L’évolution de ce cas sous traitement avec le sorafénib était marquée par une nette régression des métastases pleuropulmonaires sur la radiographie thoracique et le scanner thoracique de contrôle après un an de traitement, et la survie actuellement dans ce cas est de 15 mois, et aucun effet secondaire n’a été notifié. Cette classe thérapeutique commence à prendre une place dans les stratégies thérapeutiques de la prise en charge adjuvante du cancer du rein chimiorésistant, ce qui apparaît comme une avancée surtout que ce domaine connaissait peu de thérapeutique efficace.
    Journal africain du cancer / African Journal of Cancer. 01/2011; Volume 3:263-267.
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    ABSTRACT: Infectious complications of sickle cell disease are common and can be serious and difficult to diagnose. Epidemiological aspects of these infections are well documented. The most common germ in children is pneumococcus followed by Haemophilus influenzae and minor salmonella. In adults gram-negative germs including minor salmonella are the most frequent. The purpose of this report is to describe a case of a Citrobacter freundii spondylitis with prevertebral abscess extending to dorsal and lumbar spinal areas. Diagnosis was made during work-up for persistent vaso-occlusive manifestations. Treatment consisted of percutaneous lumbar drainage associated with antibiotherapy.
    Médecine tropicale: revue du Corps de santé colonial 08/2010; 70(4):387-9.
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    ABSTRACT: Pyomyositis is a primary pyogenic muscular infection. It has been originally described in the tropics. Presenting signs and symptoms are not specific. It is frequently misdiagnosed in the early stages. We report the case of a 47-year-old woman with systemic lupus erythematosus treated with corticosteroids who presented a thigh pyomyositis evidenced by echography and MRI. Outcome was uneventful after antibiotics and surgical drainage. Pyomyositis is increasingly described among immunocompromised people, including lupus patients treated with corticosteroids.
    Revue De Medecine Interne - REV MED INTERNE. 01/2010; 31(3).
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    ABSTRACT: We report a case of 36-year-old woman, admitted for hypotonic tetraparesis. Laboratory tests revealed severe hypokalaemia, acidosis, hyperchloremia and alkaline urinary pH allowing the diagnosis of distal tubular acidosis. Additional investigations led to the diagnosis of primary Sjögren's syndrome associated with Hashimoto's thyroïditis. The evolution was favorable under potassium citrate alkalinisation, the corticosteroid therapy and hormonal substitution. Based on this observation, the pathogenesis of distal tubular acidosis during auto-immune diseases (Sjögren's syndrome, monoclonal hypergammaglobulinemia, hypothyroidism) was discussed as well as its consequences and management.
    Néphrologie & Thérapeutique 10/2009; 6(1):52-6. · 0.50 Impact Factor
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    ABSTRACT: The aetiological inquiry in the presence of systemic granulomatosis should consider some uncommon forms of tuberculosis infections. For instance, Poncet's tuberculous rheumatism is a rare entity subject to controversy. A 32-year-old man presenting febrile polyarthritis associated with spontaneously vanishing erythematous papular skin rash. The tests revealed a biological inflammatory syndrome and mediastinal lymph nodes. The biopsies showed cutaneous and mediastinal adenoid granulomatosis. The cutaneous lesions resolved spontaneously. The culture of the ganglionic sample was positive. The evolution was favourable under treatment and the articular pain disappeared within a few days. Poncet's tuberculous rheumatism may underly evolving visceral tuberculosis. It's presence requires a search for tuberculosis when systemic granulomatosis with cutaneous and articular involvement may simulate sarcoidosis.
    Revue de Pneumologie Clinique 07/2009; 65(3):173-6. · 0.20 Impact Factor
  • La Revue du praticien 05/2009; 59(4):458.
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    ABSTRACT: Pyomyositis is a primary pyogenic muscular infection. It has been originally described in the tropics. Presenting signs and symptoms are not specific. It is frequently misdiagnosed in the early stages. We report the case of a 47-year-old woman with systemic lupus erythematosus treated with corticosteroids who presented a thigh pyomyositis evidenced by echography and MRI. Outcome was uneventful after antibiotics and surgical drainage. Pyomyositis is increasingly described among immunocompromised people, including lupus patients treated with corticosteroids.
    La Revue de Médecine Interne 05/2009; 31(3):e4-6. · 0.90 Impact Factor
  • Revue De Medecine Interne - REV MED INTERNE. 01/2009; 30(6):523-524.
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    ABSTRACT: Introduction The aetiological inquiry in the presence of systemic granulomatosis should consider some uncommon forms of tuberculosis infections. For instance, Poncet's tuberculous rheumatism is a rare entity subject to controversy. Case report A 32-year-old man presenting febrile polyarthritis associated with spontaneously vanishing erythematous papular skin rash. The tests revealed a biological inflammatory syndrome and mediastinal lymph nodes. The biopsies showed cutaneous and mediastinal adenoid granulomatosis. The cutaneous lesions resolved spontaneously. The culture of the ganglionic sample was positive. The evolution was favourable under treatment and the articular pain disappeared within a few days. Conclusion Poncet's tuberculous rheumatism may underly evolving visceral tuberculosis. It's presence requires a search for tuberculosis when systemic granulomatosis with cutaneous and articular involvement may simulate sarcoidosis.
    Revue De Pneumologie Clinique - REV PNEUMOL CLIN. 01/2009; 65(3):173-176.
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    ABSTRACT: Le léflunomide est un agent immunomodulateur qui a prouvé son efficacité dans le traitement de la polyarthrite rhumatoïde. Sa tolérance est globalement bonne. Quelques rares cas de syndrome de Lyell ont été rapportés. Observation Mme L.A., âgée de 36 ans, est suivie pour une polyarthrite rhumatoïde. Elle a été traitée successivement par la Salazopyrine®, le méthotrexate associé au traitement symptomatique. Devant la non-amélioration clinique et biologique le léflunomide a été prescrit. Deux semaines plus tard, la patiente a développé une éruption maculopapuleuse fébrile qui s’est rapidement étendue à l’ensemble des téguments avec des ulcérations de la muqueuse buccale et oculaire. Le léflunomide a été arrêté. La procédure du wash out associée à 60 mg de prednisolone fut instaurée. Au bout d’un mois, les lésions cutanées ont cicatrisé mais la patiente a perdu la vue suite à une kératite ponctuée et la formation d’un pannus cornéen. Discussion Les principaux effets indésirables du léflunomide comportent les diarrhées, les nausées, l’élévation des enzymes hépatiques, l’hypertension artérielle, l’alopécie et les réactions cutanées allergiques. Quelques rares cas d’effets secondaires cutanés sévères tels que le syndrome de Lyell ont été rapportés. Ces réactions cutanées imposent l’arrêt du médicament et son élimination immédiate par la procédure du wash out. Conclusion En raison de la sévérité de ces réactions cutanées, il faut être vigilent lors de l’utilisation de ce médicament.
    Revue du Rhumatisme. 10/2008; 75(9):871–874.
  • La Revue de Médecine Interne 09/2008; 30(6):523-4. · 0.90 Impact Factor
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    ABSTRACT: Buschke-Ollendorff syndrome (BOS) is an autosomal dominant disorder characterized by elastin-rich hamartomas and osteopoikilosis. CASE REPORT: In a 21-year-old woman, osteopoikilosis led to the diagnosis of BOS. She had multiple, grouped, buff-colored papules over the thighs and trunk. There was no pain or pruritus associated with the skin lesions. Examination of a biopsy specimen from a papule showed thick uniform collagen fibers and normal numbers of broad interlacing elastic fibers. DISCUSSION: BOS is a rare disease that affects 1/20,000 population. The diagnosis rests on a thorough physical examination and careful examination of radiographs. BOS must be distinguished from other bone abnormalities such as sclerotic bone metastases, particularly when osteopoikilosis is the inaugural manifestation.
    Joint, bone, spine: revue du rhumatisme 04/2008; 75(2):212-4. · 2.25 Impact Factor
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    ABSTRACT: Le syndrome de Buschke–Ollendorff (SBO) est une affection autosomique dominante associant un hamartome de type élastique et une ostéopœcilie. Observation Une jeune femme âgée de 21 ans est atteinte de syndrome de Buschke–Ollendorff révélé par une ostéopœcilie. Elle présentait des lésions cutanées à type de papules groupées de couleur chair, non douloureuses, non prurigineuses et inesthétiques au niveau de la cuisse et du tronc. La biopsie cutanée d’une papule a montré des fibres de collagène épaissies et homogènes. Les fibres élastiques étaient larges et entrecroisées sans augmentation de leur nombre. Discussion Le syndrome de Buschke–Ollendorff est une maladie rare (un cas sur 20 000). Son diagnostic est basé sur un bon examen clinique et sur l’analyse radiologique. Il est important d’établir le diagnostic avec précision afin d’éviter les erreurs diagnostiques (métastases condensantes) notamment quand l’ostéopœcilie est révélatrice.
    Revue du Rhumatisme. 03/2008; 75(3):292–294.
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    ABSTRACT: IntroductionLeflunomide is an immunomodulating agent with proven efficacy in rheumatoid arthritis. Although its overall safety profile is good, a few cases of toxic epidermal necrolysis have been reported.Case reportThis 36-year-old woman had rheumatoid arthritis that proved refractory to sulfasalazine and methotrexate, which were used successively in combination with symptomatic drugs. Leflunomide was started. A maculopapular rash and a fever developed 2 weeks later. The skin lesions spread rapidly to most of the body, and ulcers of the ocular and oral mucosa appeared. Leflunomide was stopped. Cholestyramine washout and prednisolone (60 mg/day) were given. The skin lesions healed over the next month. Punctate keratitis with keratinization of the cornea led to complete loss of vision.DiscussionThe main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions. A few cases of severe skin reactions such as toxic epidermal necrolysis have been reported. They require immediate discontinuation of the drug and a washout procedure to hasten drug elimination from the body.ConclusionClose monitoring for severe skin reactions is in order when using leflunomide.
    Joint, bone, spine: revue du rhumatisme 01/2008; · 2.25 Impact Factor
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    ABSTRACT: Few cases of Sweet's syndrome have been reported in patients with Behçet's disease. CASE REPORT: A 47-year-old woman with five year history of oral and genital ulcers that had not been investigated previously was admitted for an eruption of tender, erythematous, vesicle-like papules over the face, neck, palms, and legs. She reported polyarthralgia and weight loss of 6 kg over the previous month. At admission, she had a fever of 38.5 degrees C and conjunctivitis. Joint tenderness to mobilization without evidence of synovitis was noted. Laboratory tests showed inflammation and leukocytosis (12.5x10(9)/L) with 74% neutrophils. The skin biopsy was typical for Sweet's syndrome, and the pathergy test was positive. Glucocorticoid therapy 40 mg/day and colchicine were effective in alleviating the manifestations. DISCUSSION: Overlap exists between the clinical manifestations of Sweet's syndrome and Behçet's disease. Data from the literature suggest that Behçet's disease may be among the conditions that underlie Sweet's syndrome.
    Joint, bone, spine: revue du rhumatisme 11/2007; 74(5):495-6. · 2.25 Impact Factor
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    ABSTRACT: We report a case of a serious myopathy related to hypothyroidism with pituitary enlargement and hyperprolactinemia. Mr D.L 33 years old man suffering from myalgia, muscular weakness and cramps for six months. The laboratory check-up revealed a high serum creatin phosphokinase level, an autoimmune hypothyroidism, hyperprolactinemia and pituitary enlargement. The electromyogram was normal and the muscle biopsy showed no obvious inflammation. The outcome was favourable under L. thyroxin. The frequency of myopathy during hypothyroidism ranges from 30 to 80%. The main symptoms related are weakness, muscular cramps and myalgia. However, hyperprolactinemia and pituitary enlargement described in this case are due to reactional mechanism. These several hypothyroid manifestations improve remarkably under L.thyroxin. Proximal myopathy may rarely be displayed as the sole manifestation of hypothyroidism. Therefore, it is recommended that hypothyroid myopathy should be taken into account during differential diagnosis of proximal muscle weakness.
    La Revue de Médecine Interne 07/2007; 28(6):429-31. · 0.90 Impact Factor

Publication Stats

15 Citations
17.72 Total Impact Points

Institutions

  • 2011
    • La Faculté de Médecine et de Pharmacie de Rabat
      Rabat, Rabat-Salé-Zemmour-Zaër, Morocco
  • 2007–2011
    • Military Hospital Moulay Ismail
      Mekinez, Meknès-Tafilalet, Morocco