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ABSTRACT: We have used a PCR based method to analyze allelic frequencies in a (TG)n(AG)m microsatellite marker located in the first intron of the apolipoprotein C-II gene in French MS patients and controls. Samples were collected from 74 MS patients and from 102 controls. The distribution of microsatellite alleles differed between patients and controls (chi 2 = 7.82), showing a significant effect (P < 0.04) with MS due to the increased frequency of the allele 6 and a decrease frequency (P < 0.03) of allele I. Our study confirms that the apolipoprotein C-II region may influence susceptibility to MS.
Multiple Sclerosis 04/1999; 5(2):134-6. · 4.47 Impact Factor
Thrombosis and Haemostasis 10/1997; 78(3):1160. · 6.09 Impact Factor
Available from: nih.gov
The American Journal of Human Genetics 05/1997; 60(4):999-1001. · 11.20 Impact Factor
Revue De Medecine Interne - REV MED INTERNE. 01/1997; 18.