Li Wang

Chinese PLA General Hospital (301 Hospital), Peping, Beijing, China

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Publications (679)1658.07 Total impact

  • BMC Microbiology 12/2015; 15(1). DOI:10.1186/s12866-015-0525-2 · 2.73 Impact Factor
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    ABSTRACT: The pharmacokinetics of parishin, gastrodin, Gastrodia elata extract and Rhizoma Gastrodiae capsule was investigated by intragastric and/or intravenous administration to rats. Parishin was metabolized into nine metabolites after intravenous administration, and the area under the curve (AUC0-∞) of parishin and its metabolites (except parishin G and parishin E) increased nonlinearly from 72.5 to 220 mg/kg. When combining regression equation with the AUC0-∞ and dose of gastrodin injection, the percent conversion of parishin to gastrodin was obtained as 50 %. Based on multi-active metabolites of parishin in vivo, integrated pharmacokinetic mode was established. It is notable that each metabolite from parishin shares the similar metabolic process at three dosages of parishin and the bioavailability of parishin was approximately 14 %. The integrated pharmacokinetic mode was successfully applied to evaluate the holistic pharmacokinetics of gastrodin injection, G. elata extract and Rhizoma Gastrodiae capsule. The results showed that the holistic pharmacokinetics of gastrodin injection and G. elata extract was closed to that of gastrodin, but for parishin and Rhizoma Gastrodiae capsule, integrated pharmacokinetic parameters were more suitable to evaluate its holistic pharmacokinetics. Graphical abstract Pharmacokinetic study of Gastrodia elata in rats.
    Analytical and Bioanalytical Chemistry 09/2015; DOI:10.1007/s00216-015-9054-y · 3.44 Impact Factor
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    ABSTRACT: This article described a novel method by coupling a universal DNA circuit with graphene sheets/polyaniline/AuNPs nanocomposites (GS/PANI/AuNPs) for highly sensitive and specific detection of BCR/ABL fusion gene (bcr/abl) in chronic myeloid leukemia (CML). DNA circuit known as catalyzed hairpin assembly (CHA) is enzyme-free and can be simply operated to achieve exponential amplification, which has been widely employed in biosensing. However, application of CHA has been hindered by the need of specially redesigned sequences for each single-stranded DNA input. Herein, a transducer hairpin (HP) was designed to obtain a universal DNA circuit with favorable signal-to-background ratio. To further improve signal amplification, GS/PANI/AuNPs with excellent conductivity and enlarged effective area were introduced into this DNA circuit. Consequently, by combining the advantages of CHA and GS/PANI/AuNPs, bcr/abl could be detected in a linear range from 10 pM to 20 nM with a detection limit of 1.05 pM. Moreover, this protocol showed excellent specificity, good stability and was successfully applied for the detection of real sample, which demonstrated its great potential in clinical application.
    Analytica chimica acta 09/2015; 889:90-97. DOI:10.1016/j.aca.2015.06.050 · 4.51 Impact Factor
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    ABSTRACT: Despite the robustness and flexibility of thermal controlled radical polymerization (CRP), it still remains a big challenge to prepare clickable polymers bearing acetenyl groups. In this paper, visible light CRP of propargyl methacrylate (PgMA) is investigated using ethyl-α-bromophenylacetate as initiator and fac-Ir(ppy)3 as a photoredox catalyst. By controlling the polymerization time, a linear increase of Mn with monomer conversion and narrow polydispersity index is achieved. Specifically, with [PgMA]/[Initiator]/[fac-Ir(ppy)3]=210:1:0.0285, the products show Mn=8300 g/mol and Mw/Mn=1.24 at 17% monomer conversion and Mn=17100 g/mol and Mw/Mn=1.52 at 50% monomer conversion. This result is much better than that of thermally activated Cu-ATRP of PgMA. When the ratio of MMA/PgMA is 5:1, the copolymerization product shows Mn=25300 g/mol and Mw/Mn=1.75 at 66% monomer conversion. The FTIR, 1H-NMR and 13C-NMR spectra of the PPgMA show no sp 2 -sp2 carbon-carbon bond, indicating that acetenyl groups are intact. In conclusion, this technology offers a versatile route for the preparation of (co)polymers with pendant alkynyl groups.
    Journal of Macromolecular Science Part A 09/2015; 52(9). DOI:10.1080/10601325.2015.1063883 · 0.81 Impact Factor
  • ACS Catalysis 09/2015; DOI:10.1021/acscatal.5b00747 · 9.31 Impact Factor
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    ABSTRACT: The electromagnetic (EM) responses of a series of single layer and bilayer terahertz (THz) metamaterials (MMs) were systematically investigated. Bilayer split ring resonators (SRRs) consisting of different SRR units and/or surrounding dielectrics show an excellent capability to tailor and tune EM responses using the combined responses in the SRRs in different layers. By avoiding complex interactions between the layers, easy and quick design for complex multi-responses MMs can be carried out. This tailoring and tuning capability of bilayer MMs shows a great potential for many novel THz applications such as signature control, chem/bio detection, and multi-response sensors.
    Microelectronic Engineering 09/2015; 145. DOI:10.1016/j.mee.2015.03.015 · 1.20 Impact Factor
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    ABSTRACT: To determine the impact of partial reimbursement for antivirals on antiviral utilization and adherence for chronic hepatitis B patients. This was a retrospective cohort study. Two separate cohorts were enrolled, including 14163 and 16288 chronic hepatitis B outpatients, respectively. These patients were referred to Beijing You'an Hospital before and after the new partial reimbursement for antivirals, which was implemented on July 1, 2011. Demographic characteristics (including medical insurance status), routine biochemical, virological and serology laboratory test results, and antiviral agents' prescription information were collected from an electronic database. Patients were also defined as new and existing patients according to treatment history. Antiviral utilization, medication possession ratio and persistence rate were calculated and compared among the patients with different characteristics. A questionnaire survey was conducted among 212 randomly sampled outpatients from the same hospital to confirm the validity of the electronic database. Propensity score matching was used to adjust the distribution of patient's characteristics which may influence the antiviral utilization. χ(2) test or ANOVA was adopted and multivariate logistic regression was used to determine the factors associated with antiviral utilization and good adherence. A total of 13364 outpatients from each cohort were enrolled after the propensity score matching. The antiviral utilization rate for the insured patients increased from 57.4% to 75.9% (P < 0.0001) after the reimbursement, and the rate among those who paid out-of-pocket increased from 54.9% to 56.7% (P = 0.028). Approximately 71% of the patients had a medication possession ratio of more than 80% in each cohort before reimbursement. This increased to 79.2% and 73.1% for insured patients and those who paid out-of-pocket, respectively (P < 0.0001). Insured patients and those who paid out-of-pocket had the similar persistence rates before reimbursement. But after reimbursement, insured patients had higher persistence rates than those who paid out-of-pocket at 6 (86.5% vs 81.5%, P < 0.0001), 9 (79.7% vs 69.9%, P < 0.0001), 12 (73.4% vs 61.9%, P < 0.0001), and 15 mo (66.6% vs 53.1%, P < 0.0001). The reimbursement could significantly improve adherence for the insured patients than those who paid out-of-pocket even after adjusting other covariates, with an interaction odds ratio of 1.422 (95%CI: 1.220-1.657, P < 0.0001). The questionnaire survey supported the validity of the electronic database. The reimbursement policy shows a positive impact on antiviral utilization as well as adherence for insured chronic hepatitis B patients.
    08/2015; 21(32):9588-97. DOI:10.3748/wjg.v21.i32.9588
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    ABSTRACT: Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) is a member of the fibrillin/LTBP super family of extracellular matrix proteins, found to be overexpressed in certain malignant tumors. However, the clinical significance and biological role of LTBP-2 in cervical adenocarcinoma has remains unclear. We found that the expression of LTBP2 was higher in cervical adenocarcinoma than in normal cervical epithelial tissue as assessed by immunohistochemistry. Expression of LTBP2 is related to clinical stage, cervical tumor size, depth of cervical stromal invasion and lymph node metastasis. Knockdown of LTBP2 expression can inhibit the proliferation and migration of HeLa cells. Moreover, LTBP2 knockdown affected multiple tumor-related pathway genes including: the MAPK signaling pathway, the PI3K-AKT signaling pathway, receptor tyrosine kinase signaling and the P53 pathway. Taken together, this work suggests that LTBP2 may promote the development of cervical adenocarcinoma and serve as a prognostic factor in the clinical evaluation of patients with cervical adenocarcinoma. Our findings provide a new strategy for the diagnosis and treatment of cervical adenocarcinoma.
    American Journal of Translational Research 08/2015; 7(6):1095-105. · 3.40 Impact Factor
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    ABSTRACT: This study aimed to characterize the miR-21 and evaluated its clinical significance. Total RNA was extracted from 30 pairs of fresh specimens of cervical cancer and normal tissues. The expression levels of the miR-21-3p and miR-21-5p were detected by quantitative reverse transcriptase polymerase chain reaction, with U6 as the internal reference gene. We compared the expression of miR-21-3p and miR-21-5p between study group and control groups, the association between miRNA expression level and clinicopathological factors was investigated. The expression of miR-21-3p and miR-21-5p in HPV positive cervical cancer samples was significantly upregulated compared to that in the paired normal samples (P < 0.05); A multivariate analysis demonstrated that the expression of miR-21 was associated with clinicopathological parameters, including depth of invasion and lymph node metastasis. MiR-21 upregulation is associated with aggressive progression and poor prognosis in cervical cancer, which suggests that miR-21 might be identified as an independent marker for predicting the clinical outcome of cervical cancer patients.
    International journal of clinical and experimental pathology 08/2015; 8(6):7131-9. · 1.89 Impact Factor
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    ABSTRACT: Citrate is commonly used as an anticoagulant in hemodialysis for chronic renal failure (CRF) and for the regulation of the immune dysfunction in CRF patients. The objective of this study was to investigate the effect of citrate on the balance of T helper 17 (Th17) and regulatory T (Treg) cells in CRF. The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) were significantly increased in the CRF model group compared to the control group, and were decreased in the citrate-treated groups. Citrate treatment inhibited the viability of Th17 cells while elevating the viability of Treg cells in CRF rats. Moreover, Th17-related cytokines significantly decreased while the Treg-related cytokines significantly increased with citrate treatment. Moreover, citrate had a negative influence on the deviation of Th17/Treg cells in CRF rats. Therefore, our study suggests that citrate had an anti-inflammatory effect on CRF through the modulation of the Th17/Treg balance.
    Inflammation 08/2015; DOI:10.1007/s10753-015-0225-y · 2.21 Impact Factor
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    ABSTRACT: Novel carbon nanotubes (CNTs) incorporated double-skinned thin film nanocomposite (TFN) membranes were fabricated by interfacial polymerization of polydopamine/CNTs and trimesoylchloride (TMC) on polysulfone (PSf) substrate. As controls, thin film composite (TFC) membrane without CNTs and FO membranes with single-skinned structures (top-skinned or bottom-skinned) was also fabricated. The prepared membranes were characterized and evaluated in terms of membrane morphology, structure, surface property, separation performance and antifouling capacity. The effect of membrane orientation, composition and concentration of draw solutions on FO performance was studied as well. It was found that CNTs had significant influence on the properties and the performances of the synthesized FO membranes. The double-skinned membranes owned excellent solute rejection without sacrificing water flux. By incorporation of CNTs, TFN membranes exhibited higher FO water flux than TFC membranes. The double-skinned TFN0.05 membrane, the optimal FO membrane, showed a 54% enhancement in water flux than double-skinned TFC membrane at TOP-FS orientation by using MgCl2 as draw solution and DI water as feed solution. Moreover, the double-skinned TFN0.05 membrane demonstrated remarkable antifouling capacity because of the prominent foulant resistance induced by CNT addition. This work paved a new way to fabricate high performance FO membrane by the utilization of double-skinned structure and incorporation of CNTs.
    Desalination 08/2015; 369. DOI:10.1016/j.desal.2015.04.020 · 3.76 Impact Factor
  • Applied Surface Science 08/2015; DOI:10.1016/j.apsusc.2015.08.077 · 2.71 Impact Factor
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    ABSTRACT: Atrial fibrillation (AF) is the most common cardiac arrhythmia at the clinic. Recent GWAS identified several variants associated with AF, but they account for <10% of heritability. Gene-gene interaction is assumed to account for a significant portion of missing heritability. Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1. Thus, we analyzed the interaction among these three AF loci. We demonstrated significant interaction between rs2106261 and rs2200733 in three independent populations and combined population with 2,020 cases/5,315 controls. Compared to non-risk genotype GGCC, two-locus risk genotype AATT showed the highest odds ratio in three independent populations and the combined population (OR=5.36 (95% CI 3.87-7.43), P=8.00×10-24). The OR of 5.36 for AATT was significantly higher than the combined OR of 3.31 for both GGTT and AACC, suggesting a synergistic interaction between rs2106261 and rs2200733. Relative excess risk due to interaction (RERI) analysis also revealed significant interaction between rs2106261 and rs2200733 when exposed two copies of risk alleles (RERI=2.87, P<1.00×10-4) or exposed to one additional copy of risk allele (RERI=1.29, P<1.00×10-4). The INTERSNP program identified significant genotypic interaction between rs2106261 and rs2200733 under an additive by additive model (OR=0.85, 95% CI: 0.74-0.97, P=0.02). Mechanistically, PITX2c negatively regulates expression of miR-1, which negatively regulates expression of ZFHX3, resulting in a positive regulation of ZFHX3 by PITX2c; ZFHX3 positively regulates expression of PITX2C, resulting in a cyclic loop of cross-regulation between ZFHX3 and PITX2c. Both ZFHX3 and PITX2c regulate expression of NPPA, TBX5 and NKX2.5. These results suggest that cyclic cross-regulation of gene expression is a molecular basis for gene-gene interactions involved in genetics of complex disease traits.
    PLoS Genetics 08/2015; 11(8):e1005393. DOI:10.1371/journal.pgen.1005393 · 7.53 Impact Factor
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    ABSTRACT: Vaccination of infants beginning at birth is recommended to prevent Hepatitis B virus (HBV) infection in China. Compared to 5μg/dose vaccine administered in other regions in China, a three-dose HB recombinant yeast vaccine at 10μg/dose has been administered for infants within 24h after birth, 1 month and 6 months of age in Beijing since 2006. In a community-based retrospective cohort study, factors influencing immunologic vaccine response were evaluated. A total of 3670 infants who completed a 3-dose 10μg recombinant HB vaccine regimen and who born to hepatitis B antigen negative mothers were included. The effect on anti-HBs titers of maternal nutrient status, infants' birth condition, growth factors, timeliness of vaccination, dosing interval and the interval until post-vaccination serologic testing (PVST) were evaluated. A total of 3666 infants with no markers of HBV infection were included in analysis. The mean anti-HB titers were 1767.17mIU/ml. Only 16.9% of the infants completed their PVST within 30-59 days after the final dose of vaccination. Multivariate linear regression analysis showed that delay in PVST (β=-0.097, p<0.0001) and maternal folic acid supplementation (β=0.067, p=0.002) were associated with log-transformed anti-HB titers. Also a trend toward significant association was observed between the calcium supplementation of infants and log-transformed anti-HBs titers (β=0.062, p=0.057). Longer interval between dose 2 and dose 3 was not observed to increase the anti-HB titers after cofactors adjustment. Our findings illustrate the importance of timing of PVST to avoid unnecessary revaccination. Multi-center large cohort studies should verify the effect and magnitude of folate and calcium supplementation on HB vaccine response. Copyright © 2015. Published by Elsevier Ltd.
    Vaccine 06/2015; DOI:10.1016/j.vaccine.2015.06.018 · 3.62 Impact Factor
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    ABSTRACT: Endogenous neural stem cells in central canal of adult mammalian spinal cord exhibit stem cell properties following injury. In the present study, the endogenous neural stem cells were labeled with Dil to track the differentiation of cells after mild spinal cord injury (SCI). Compared with 1 and 14 days post mild injury, the number of endogenous neural stem cells significantly increased at the injured site of spinal cord on 3 and 7 days post-injury. Dil-labeled βIII-tublin and GFAP expressing cells could be detected on 7 days post-injury, which indicated that the endogenous neural stem cells in central canal of spinal cord differentiated into different type of neural cells, but there were more differentiated astrocytes than the neurons after injury. Furthermore, after injury the expression of inhibitory Notch1 and Hes1 mRNA began to increase at 6 hours and was evident at 12 and 24 hours, which maintained high levels up to 7 days post-injury. These results indicated that a mild SCI in rat is sufficient to induce endogenous neural stem cells proliferation and differentiation. However, the ability to differentiate into neurons is limited, which may be, at least in part, due to high expression of inhibitory Notch1 and Hes1 genes after injury.
    International journal of clinical and experimental pathology 06/2015; 8(4):3835-3842. · 1.89 Impact Factor
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    Xi Lu · Li Wang · Caijia Yu · Daohai Yu · Gang Yu
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    ABSTRACT: It is becoming more evident that histone acetylation, as one of the epigenetic modifications or markers, plays a key role in the etiology of Alzheimer's disease (AD). Histone acetylases and histone deacetylases (HDACs) are the well-known covalent enzymes that modify the reversible acetylation of lysine residues in histone amino-terminal domains. In AD, however, the roles of these enzymes are controversial. Some recent studies indicate that HDAC inhibitors are neuroprotective by regulating memory and synaptic dysfunctions in cellular and animal models of AD; while on the other hand, increase of histone acetylation have been implicated in AD pathology. In this review, we focus on the recent advances on the roles of histone acetylation covalent enzymes in AD and discuss how targeting these enzymes can ultimately lead to therapeutic approaches for treating AD.
    Frontiers in Cellular Neuroscience 06/2015; 9:226. DOI:10.3389/fncel.2015.00226 · 4.29 Impact Factor
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    ABSTRACT: Amyloid beta (Aβ) is a key molecule in the neurodegenerative progression of Alzheimer's disease (AD). It is critical to develop a treatment that can arrest the Aβ-induced pathologic progression of AD. Erythropoietin (EPO) has various protective effects in the nervous system. However, the effect of EPO on Aβ-induced Alzheimer-like cognitive deficits and pathological changes remains unclear. In the present study, we observed that the treatment of mice with EPO (1000IU/kg) attenuated Aβ42-induced cognitive deficits and tau hyperphosphorylation at multiple AD-related sites through the regulation of glycogen synthase kinase-3β (GSK-3β). We also observed that EPO attenuated the Aβ42-induced mitochondrial dysfunction and apoptosis in brain. These results indicate a potential role for EPO in AD therapy. Copyright © 2015. Published by Elsevier B.V.
    Brain research 06/2015; 1618. DOI:10.1016/j.brainres.2015.05.031 · 2.84 Impact Factor
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    ABSTRACT: Flexible layer-layer poly(ethylene phthalate) (PET)/BaTiO3 composite films with enhanced dielectric permittivity were fabricated by spin coating method, consisting of PET substrate film layer and modified BaTiO3/acrylic resin hybrid coating layer. The thickness of coating layer was less than 3 μm (about 2% of PET film thickness), and therefore, the PET/barium titanate (BT) composite films remained flexible even at high volume fraction of BaTiO3 fillers. The volume contents of BaTiO3 were varied from 0 to 80%, and the solid contents of BaTiO3/acrylic resin were in the range of 51.8-72.9%. Scanning electron microscopy showed strong interaction of finely dispersed BaTiO3 particles with acrylic resin. Morphological profile also displayed uniform coating layer of modified BaTiO3/acrylic resin and its strong adhesion with PET film. The dielectric constant of the PET/BaTiO3 composite films increased by about 26% at 60 vol % BaTiO3 loading when compared with the pristine PET film, whereas the dielectric loss decreased slightly. In addition, PET-grafted poly(hydroxylethyl methacrylate) brushes were used as substrate to introduce covalent bonding with the coating layer. Further enhancement of dielectric constant and reduction of dielectric loss were realized when compared with the composite films with bare PET substrate. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42508.
    Journal of Applied Polymer Science 06/2015; 132(36):n/a-n/a. DOI:10.1002/app.42508 · 1.77 Impact Factor
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    ABSTRACT: The unsupported Cu and Ag catalysts with different oxidation states were prepared, and their catalytic performances for propylene epoxidation were investigated. The metallic Cu catalyst exhibits much higher catalytic activity and propylene oxide (PO) selectivity than Cu2O and CuO catalysts. The Cu0 species are the main active sites for propylene epoxidation, but Cu2O and CuO species are in favor of CO2 and acrolein production. The PO selectivity of 54.2 % and propylene conversion of 2.6 % can be achieved over the metallic Cu catalyst at 160 °C in initial stage, but metallic Cu catalyst would be oxidized to Cu2O during propylene epoxidation, resulting in a sharp decrease in the PO selectivity and propylene conversion. Nanosize AgCu x bimetallic catalysts were prepared. It is found that adding Ag to the metallic Cu catalysts can prevent the oxidation of Cu and make AgCu x bimetallic catalysts more stable under the condition of propylene epoxidation. The Ag/Cu molar ratio can remarkably affect the catalytic performance of AgCu x catalyst and the selectivity to PO and acrolein. After AgCu x was supported on MO x -modified α-Al2O3, its catalytic performance can be improved and has a close relationship with the acid-base property of support.
    Rare Metals 05/2015; 34(7). DOI:10.1007/s12598-015-0500-y · 1.01 Impact Factor

Publication Stats

5k Citations
1,658.07 Total Impact Points


  • 2015
    • Chinese PLA General Hospital (301 Hospital)
      Peping, Beijing, China
    • 307 Hospital of the Chinese People's Liberation Army
      Peping, Beijing, China
    • Institute of Chemistry and Materials
      Lutetia Parisorum, Île-de-France, France
    • Beijing University of Chemical Technology
      • College of Materials Science and Engineering (SMSE)
      Peping, Beijing, China
    • Tongji Medical University
      Shanghai, Shanghai Shi, China
  • 2014–2015
    • Chongqing Cancer Hospital and Institute
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Northwest Institute of Plateau Biology
      Hsi-ning-shih, Qinghai Sheng, China
    • Tianjin Medical University Cancer Institute and Hospital
      T’ien-ching-shih, Tianjin Shi, China
    • Beijing University of Technology
      Peping, Beijing, China
  • 2013–2015
    • Hangzhou Normal University
      Hang-hsien, Zhejiang Sheng, China
    • Huazhong (Central China) Normal University
      • • College of Chemistry
      • • Key Laboratory of Pesticide & Chemical Biology of Ministry of Education
      Wu-han-shih, Hubei, China
    • Ocean University of China
      • College of Chemistry and Chemical Engineering
      Tsingtao, Shandong Sheng, China
    • Xuzhou Medical College
      Suchow, Jiangsu Sheng, China
    • Guilin University of Electronic Technology
      Ling-ch’uan, Guangxi Zhuangzu Zizhiqu, China
  • 2012–2015
    • Xi'an Jiaotong University
      • School of Medicine
      Ch’ang-an, Shaanxi, China
    • Second Military Medical University, Shanghai
      • Department of Chemical-defence Medicine
      Shanghai, Shanghai Shi, China
    • Beijing Normal University
      Peping, Beijing, China
    • Natural History Museum, London
      • Department of Botany
      Londinium, England, United Kingdom
    • Shandong University
      Chi-nan-shih, Shandong Sheng, China
    • South China Agricultural University
      • College of Food Science
      Shengcheng, Guangdong, China
    • Liaoning ShiHua University
      Fu-shan, Liaoning, China
  • 2011–2015
    • Peking University
      • • Institute of Molecular Medicine
      • • School of Basic Medical Science
      Peping, Beijing, China
    • South China Institute Of Environmental Sciences
      Shengcheng, Guangdong, China
    • Chinese Center For Disease Control And Prevention
      Peping, Beijing, China
    • Huazhong Agricultural University
      Wu-han-shih, Hubei, China
    • China Agricultural University
      • College of Biological Sciences
      Peping, Beijing, China
    • 宁德师范学院学报
      Chiao-ch’eng-chen, Guangdong, China
    • Soochow University (PRC)
      Wu-hsien, Jiangsu Sheng, China
  • 2010–2015
    • Chongqing Medical University
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Academy of Chinese Culture of Health Sciences
      Florida, United States
    • Hebei Medical University
      Chentow, Hebei, China
    • Institute of Genetics and Developmental Biology, CAS
      Peping, Beijing, China
    • Liaocheng Teachers University
      Tungchangfu, Shandong Sheng, China
  • 2007–2015
    • East China University of Science and Technology
      • School of Materials Science and Engineering
      Shanghai, Shanghai Shi, China
    • Lanzhou Jiaotong University
      Kao-lan-hsien, Gansu Sheng, China
    • Yangtze University
      • School of Food Science and Technology
      Hu-pei-ts’un, Shanxi Sheng, China
    • Beijing Cancer Hospital
      Peping, Beijing, China
  • 2006–2015
    • Fudan University
      • • Department of Pathology
      • • Department of Physiology and Pathophysiology
      • • Department of Obstetrics and Gynecology
      • • Hospital of Obstetrics and Gynecology
      • • Department of Integrated Traditional Chinese Medicine and Western Medicine
      Shanghai, Shanghai Shi, China
    • Sichuan University
      • • State Key Laboratory of Biotherapy
      • • Department of Cardiology
      Hua-yang, Sichuan, China
    • Peking Union Medical College Hospital
      Peping, Beijing, China
  • 2004–2015
    • Third Military Medical University
      • • Department of Physiology
      • • Southwest Hospital
      Ch’ung-ch’ing-shih, Chongqing Shi, China
    • Anhui Normal University
      Wu-hu-shih, Anhui Sheng, China
    • National Space Science
      Peping, Beijing, China
  • 2003–2015
    • Jilin University
      • • College of Chemistry
      • • State Key Laboratory of Inorganic Synthesis and Preparative
      • • Department of Chemistry
      • • State Key Lab of Theoretical and Computational Chemistry
      • • Department of Molecular Biology
      Yung-chi, Jilin Sheng, China
  • 2001–2015
    • Chinese Academy of Sciences
      • • State Key Laboratory of Microbial Resources
      • • Institute of Psychology
      • • State Key Laboratory of Organic Geochemistry
      • • Laboratory of Analytical Chemistry for Life Science
      • • Institute of Biophysics
      • • Dalian Institute of Chemical Physics
      • • State Key Laboratory of Molecular Reaction Dynamics
      • • Institute of Genetics and Developmental Biology
      Peping, Beijing, China
    • Shandong University of Technology
      Chi-nan-shih, Shandong Sheng, China
  • 2013–2014
    • Zhejiang Normal University
      Jinhua, Zhejiang Sheng, China
    • Wake Forest University
      Winston-Salem, North Carolina, United States
    • Wake Forest School of Medicine
      • Center for Cancer Genomics
      Winston-Salem, North Carolina, United States
    • Hefei Institute of Physical Sciences, Chinese Academy of Sciences
      Luchow, Anhui Sheng, China
  • 2012–2014
    • Fourth Military Medical University
      • • Department of Pathology and Pathophysiology
      • • Department of Clinical Aerospace Medicine
      Xi’an, Liaoning, China
  • 2007–2014
    • Shanghai Jiao Tong University
      • • School of Agriculture and Biology
      • • Department of Cardiology (Renji)
      Shanghai, Shanghai Shi, China
  • 1998–2014
    • Dalian Institute of Chemical Physics
      Lü-ta-shih, Liaoning, China
  • 2009–2013
    • Yunnan Agricultural University
      Panlong, Shaanxi, China
    • Harbin Institute of Technology
      • School of Municipal and Environmental Engineering
      Charbin, Heilongjiang Sheng, China
    • Prince Henry's Institute
      Melbourne, Victoria, Australia
    • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
      Hua-yang, Sichuan, China
  • 2006–2013
    • Huazhong University of Science and Technology
      • • Department of Cardiology
      • • Department of Biliary-Pancreatic Surgery
      • • Department of Pathology and Pathophysiology
      • • School of Computer Science and Technology
      Wu-han-shih, Hubei, China
  • 2011–2012
    • Beijing Institute of Microbiology and Epidemiology
      Peping, Beijing, China
  • 2009–2012
    • Tsinghua University
      • • School of Medicine
      • • Department of Electronic Engineering
      Peping, Beijing, China
    • University of South Florida
      • Department of Cell Biology, Microbiology and Molecular Biology
      Tampa, Florida, United States
  • 2008–2012
    • USF Health Byrd Alzheimer's Institute
      Tampa, Florida, United States
    • South China University of Technology
      Shengcheng, Guangdong, China
  • 2010–2011
    • Nanjing Agricultural University
      • College of Animal Science and Technology
      Nan-ching, Jiangsu, China
    • Jiangsu University
      • School of Pharmacy
      Chenkiang, Jiangsu Sheng, China
  • 2008–2011
    • University of Southampton
      • • Faculty of Physical and Applied Sciences
      • • Department of Electronics and Computer Science (ECS)
      Southampton, England, United Kingdom
  • 2007–2010
    • China Pharmaceutical University
      • Department of Pharmaceutical Analysis
      Nan-ching-hsü, Jiangxi Sheng, China
  • 2005–2010
    • Dalian University of Technology
      • • State Key Laboratory of Fine Chemicals
      • • School of Chemical Engineering
      Lü-ta-shih, Liaoning, China
    • University of Connecticut
      Storrs, Connecticut, United States
    • Academy of Military Medical Sciences
      T’ien-ching-shih, Tianjin Shi, China
    • Beijing Institute Of Technology
      Peping, Beijing, China
  • 2004–2010
    • Tongji University
      • Department of Physics
      Shanghai, Shanghai Shi, China
  • 2007–2009
    • Tianjin University
      • School of Electrical Engineering and Automation
      T’ien-ching-shih, Tianjin Shi, China
  • 2006–2008
    • Shanghai Institutes for Biological Sciences
      • Institute of Health Sciences
      Shanghai, Shanghai Shi, China
  • 2005–2008
    • Chinese Academy of Medical Sciences
      • Institute of Basic Medical Sciences (IBMS)
      Peping, Beijing, China
  • 2001–2006
    • Technical Institute of Physics and Chemistry
      Peping, Beijing, China
  • 2004–2005
    • Beijing Jiaotong University
      • Institute of Optoelectronics Technology
      Beijing, Beijing Shi, China
  • 2002–2004
    • Keio University
      • Department of Applied Chemistry
      Edo, Tōkyō, Japan