Farideh Nejat

Imam Khomeini International University, Kazvin, Qazvīn, Iran

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Publications (110)153.29 Total impact

  • Journal of Neurosurgery Pediatrics 09/2013; · 1.63 Impact Factor
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    ABSTRACT: Lipomyelomeningocele, a closed neural tube defect, usually occurs in lumbosacral area as a single lesion but can be associated with other spinal dysraphism. We report an infant with a very rare presentation of tandem lumbosacral lipomyelomeningoceles, thick filum terminale and split cord malformation.
    Journal of Pediatric Neurosciences 09/2013; 8(3):204-6.
  • Pediatric Neurosurgery 08/2013; · 0.42 Impact Factor
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    ABSTRACT: Myelomeningocele is a complex central nervous system malformation mostly associated with other neural and extraneural anomalies. A rare special feature of the forehead and skull was observed in myelomeningocele. Here, we present several patients with myelomeningocele, severe hydrocephalus, and interfrontal encephalocele accompanied by metopic suture widening and abnormally shaped frontal bones. Five children with this feature were enrolled in this series. The age, sex, location of myelomeningocele sac, neurological deficits, hydrocephalus and history of shunt surgery, and follow-up period were evaluated. Patients were aged from 1 to 12 months (mean, 6 months). All patients were male. Most sacs were located in lumbar and lumbosacral areas. Neurological deficits varying from only sphincter problem to paraplegia were found in all patients. Hydrocephalus was found in all children that needed a shunt procedure. Asymptomatic Chiari malformation, interfrontal encephalocele, and corpus callosum agenesis were evident in five, five, and three patients, respectively. Anterior fontanel anomalies known as interfrontal encephalocele associated with myelomeningocele have been reported before. The patients have an open metopic suture extending widely to the nasal radix producing hypertelorism accompanied by interfrontal herniation of frontal lobes. The associated hydrocephalus exaggerates the anomaly. Treatment of accompanying hydrocephalus is advised to decrease the severity of frontal lobe herniation. Some patients may need frontal bone reconstruction surgery to provide cosmetic correction at the place of the midline frontal bone defect.
    Child s Nervous System 08/2013; 29(8):1349-52. · 1.24 Impact Factor
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    ABSTRACT: Objective: There are controversies about seizure risk factors in shunted hydrocephalic patients which can be due to having merged two different types of seizure (preshunt and postshunt seizures) in previous studies. Also, it is not known whether a considerable change in ventricular size after shunting can be a risk factor of postshunt seizures. Methods: 150 hydrocephalic patients who underwent shunting from 2006 to 2011 in the Children's Hospital Medical Center in Tehran, Iran, were visited at least 1 year after shunting to assess risk factors of preshunt and postshunt seizures. Ventricular size was assessed by using a radiologic index of bifrontal ratio (BFR). Results: Preshunt seizures were higher in patients with postinfectious hydrocephalus and intraventricular hemorrhage. Early shunting, history of shunt complications and shunt infection, and a high number of shunt revisions were significant risk factors for developing postshunt seizures. The change in BFR after shunting was not a significant risk factor of postshunt seizures. Conclusion: The difference between risk factors of preshunt seizures and postshunt seizures shows that they are two different types of seizures with different natures. Preshunt seizures are hard to prevent as they are related to the underlying disease of the brain or the etiology of hydrocephalus. However, postshunt seizures are related to the shunt and might be decreased by preventing shunt complications.
    Pediatric Neurosurgery 06/2013; · 0.42 Impact Factor
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    Iranian Journal of Pediatrics 04/2013; 23(2):241-2. · 0.26 Impact Factor
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    ABSTRACT: Background: Craniosynostosis is a relatively common congenital abnormality. The underlying etiology and most probable risk factors of nonsyndromic craniosynostosis are unknown. We conducted a study to identify the risk factors for craniosynostosis. Materials and Methods: In this case-control project, 70 children with craniosynostosis (syndromic or nonsyndromic) hospitalized at the Children's Hospital Medical Center from September 2010 to 2011 were studied for the potential risk factors. At the same time, 70 age- and sex-matched children hospitalized with other congenital anomalies were reviewed. Information from case and control groups was obtained via personal interviews with parents of patients and a prepared checklist was filled out for each child. Results: The mean (±SE) age at admission time in the case-control group was 13 ± 1.95 (1.5-96) months, and almost half of them were boys (n = 37 or 53%). The most frequent sutures involved in craniosynostosis were coronal (n = 30 or 42.9%) and then metopic sutures (n = 16 or 22.9%), multiple (n = 12 or 17.1%), sagittal (n = 11 or 15.7%) and lambdoid (n = 1 or 1.4%). In the case group, maternal diabetes mellitus and thyroid disease were found in 8 (11.6%) and 6 (8.6%) patients, respectively. The most frequent medication used by mothers (n = 66 or 94%) in the case group during pregnancy were vitamins (including iron supplements, omega 3, folic acid and multivitamins). Conclusion: A positive family history of craniosynostosis [odds ratio (OR) 19.01 and 95% confidence interval (CI) 2.24-160.7] and using clomiphene citrate for infertility (OR 12.71 and 95% CI 1.42-113.6) were the strongest independent risk factors for craniosynostosis. More comprehensive studies with a larger sample size are required to confirm the role of environmental factors in order to decrease the occurrence of craniosynostosis.
    Pediatric Neurosurgery 02/2013; · 0.42 Impact Factor
  • Farideh Nejat, Mostafa El Khashab
    Surgical Neurology International 01/2013; 4:56. · 1.18 Impact Factor
  • Farideh Nejat, Mostafa El Khashab
    Journal of Nippon Medical School 01/2013; 80(1):83.
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    ABSTRACT: Brain abscess in young infants is extremely rare and usually associated with a previous history of bacterial meningitis or septicemia. Here we report a cerebellar abscess mimicking brain tumor with atypical clinical and paraclinical presentations. A two-month old previously well-baby boy was referred to us with persistent vomiting, strabismus and developmental regression. The brain imaging showed a right cerebellar mass with multiple small cysts inside the lesion. Elevated serum alfa-fetoprotein associated with cystic and solid posterior fossa mass proposed the preoperative diagnosis of teratoma but tumor cells were not found inside the pathology specimen. The culture of the sample was positive for staphylococcus aureus. The interest of this case lies in the atypical features of clinical and radiological evaluations in a young infant associated with an abnormal alfa-fetoprotein level of serum.
    Iranian Journal of Pediatrics 12/2012; 22(4):539-42. · 0.26 Impact Factor
  • Farideh Nejat, Mostafa El Khashab
    Journal of Neurosurgery Pediatrics 11/2012; · 1.63 Impact Factor
  • Farideh Nejat, Mostafa El Khashab
    Journal of Neurosurgery Pediatrics 11/2012; · 1.63 Impact Factor
  • Farideh Nejat
    [show abstract] [hide abstract]
    ABSTRACT: Anterior encephalocele is a rare pathologic condition in pediatric neurosurgery. Most of encephaloceles are located in the occipital region. The present study reports a series of 15 children with anterior encephaloceles. This was a descriptive retrospective survey conducted on the medical recordings of encephalocele patients underwent a neurosurgery during a 12-year period. A total of 83 cases of neurosurgery performed in a pediatric hospital (Children Hospital Medical Center, Tehran, Iran) were reviewed. The demographic, surgical approach and follow up data and recordings of these patients were collected and then analyzed. A total of 83 patients with encephalocele were operated, of which 15 have anterior encephalocele. They were classified as fronto-orbital, frontonasal, frontoethmoidal, transsphenoidal, and interfrontal. They were aged from 3 days to 7 years at the time of operation. All surgeries were performed with craniotomy or endoscopic repair of the lesion. A 1 to12-year period follow-up showed that all cases are alive and all of them except for one case have normal neurodevelopmental status. Anterior encephalocele is a rare condition in congenital central nervous system. Most of patients with anterior encephalocele encounter with face deformity because of mass or hypertelorism or orbital disfiguration. Some of them have serious complications of meningitis due to CSF leakage. In time surgical management with precious correction of cranial bone defect are necessary to prevent more complicated consequences and to reduce the need for surgery in the future. Anterior encephalocele, surgery, skull defect.
    Journal of injury & violence research 11/2012; 4(3 Suppl 1).
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    ABSTRACT: INTRODUCTION: Positioned anatomically between the spinal epidural space and the intramedullary compartment, the spinal subdural space remains the least common area of localized infection in the central nervous system. Infectious processes of the subdural spinal space include subdural spinal empyema, subdural spinal abscess, infected spinal subdural cyst, and infectious spinal subdural cyst. To date, there has been no systematic review of these entities in children, with the cumulative knowledge of the pathophysiologic, microbiologic, and demographic characteristics of these infections relegated solely to few small series and case reports. METHODS: A series of 11 recent cases culled from the collaboration of international authors are presented. In addition, an exhaustive MEDLINE search and manual review of the international literature was performed, identifying a total of 73 cases of spinal subdural infections in patients under the age of 21. Data of interest include the age, sex, signs, and symptoms at presentation, spinal location of infection, presence of spinal dysraphism, and other comorbidities, offending organism, treatment, outcome, and follow-up. RESULTS: Patients ages ranged from 4 weeks to 20 years (mean, 6.5 years). Males outnumbered females by a ratio of 2:1. Over half (53 %) of spinal subdural infections in children were associated with spinal dysraphism or other congenital abnormalities of the spine. The commonest organism to infect the spinal subdural space in children is mycobacterium tuberculosis and the thoracic spinal region was most commonly infected. CONCLUSIONS: The disease is usually treated surgically, although a more expectant approach consisting of antibiotics and observation has also been proposed.
    Child s Nervous System 09/2012; · 1.24 Impact Factor
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    ABSTRACT: Objective: Cranial dermal sinus is a very rare anomaly mostly found in the midline occipital area, presenting with diverse clinical features from asymptomatic dermal sinus to symptomatic situations including meningitis, dermoid tumor or abscess. Methods: Medical records of 18 patients with 19 cranial dermal sinuses operated at the Children's Hospital Medical Center in Tehran from 1999 to 2011 were retrospectively studied. Their presentations, accompanying anomalies, radiological and surgical findings were evaluated. Results: Patients were aged 1 month to 6 years and were followed for 2-12 years. Most sinuses were located in the midline occipital region. Infection was the most common reason for referral (50%) followed by skin dimple (33.3%). Creamy white discharge was found in 50% of patients. Posterior fossa abscess, hydrocephalus and meningitis were observed in 38.9, 38.9 and 22.2% of children, respectively. All sinus tracts with associated dermoid tumors or abscesses were removed en bloc to decrease the risk of recurrence. Conclusion: The sinus tracts are a portal of entry for pathogens which result in serious complications of meningitis or abscess. In this series, 67% of children presented with serious symptoms; therefore, we recommend prophylactic surgery in all cranial dermal sinuses. The exact time of surgery is not obvious as the natural course of the disease is unknown. If any symptom is observed surgery should be done as soon as possible. For asymptomatic sinuses identified by the pediatrician during a regular visit prophylactic surgery is recommended as soon as the child can tolerate operation.
    Pediatric Neurosurgery 09/2012; · 0.42 Impact Factor
  • Farideh Nejat, Mostafa El Khashab
    Journal of Neurosurgery Pediatrics 06/2012; 10(2):159; author reply 160. · 1.63 Impact Factor
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    ABSTRACT: Migration of the proximal and distal catheters of the ventriculoperitoneal shunt is a very rare event. Here, we report two infants with hydrocephalus and ventriculoperitoneal shunt who presented later with shunt coiling and migration. The first infant was admitted with scalp swelling around proximal incision 3 months after shunt insertion and migration and coiling of both ventricular and peritoneal catheters occurred under the scalp at that point. The second patient was referred 1 month after shunting with tense fontanel and vomiting. New brain imaging confirmed the whole shunt inside both lateral ventricles. The possible mechanisms causing this very uncommon complication and the management are explained.
    Journal of Pediatric Neurosciences 05/2012; 7(2):114-6.
  • Journal of Neurosurgery Pediatrics 05/2012; 9(5):569; author reply 569-70. · 1.63 Impact Factor
  • Child s Nervous System 03/2012; 28(3):485-7. · 1.24 Impact Factor
  • Farideh Nejat, Mostafa El Khashab
    Journal of Neurosurgery Pediatrics 02/2012; 9(2):216; author reply 216. · 1.63 Impact Factor

Publication Stats

290 Citations
153.29 Total Impact Points


  • 2010–2013
    • Imam Khomeini International University
      Kazvin, Qazvīn, Iran
  • 2009–2013
    • Hackensack University Medical Center
      Hackensack, New Jersey, United States
  • 2002–2013
    • Tehran University of Medical Sciences
      • Department of Neurosurgery
      Tehrān, Ostan-e Tehran, Iran
  • 2012
    • Shariati Hospital
      Teheran, Tehrān, Iran
    • Kerman University of Medical Sciences
      Carmana, Kermān, Iran
  • 2009–2010
    • Sina Hospital
      Mashad, Razavi Khorasan, Iran
  • 2006–2008
    • University of Tehran
      Teheran, Tehrān, Iran