Zhong-Jian Jia

Publications (56)90.11 Total impact

• Article: Sesquiterpenoids from Lactuca tatarica.

  Xiao-Xiong Wang, Xue Gao, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: A new guaianolide and a new eudesmanolide were isolated from Lactuca tatarica, as well as eight known sesquiterpenoids. The new compounds were elucidated on the basis of spectroscopic methods including IR, HRESIMS, 1D and 2D NMR, and the known compounds were established by comparing their physical data with those of the corresponding compounds in the literature.
  Fitoterapia 08/2009; 81(1):42-4. · 1.85 Impact Factor
• Article: New Acyclic 12‐Hydroxygeranylgeraniol‐Derived Diterpenoids from the Seeds of Carpesium triste

  Xue Gao, Zhan‐Xin Zhang, Zhong‐Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: Five new acyclic 12-hydroxygeranylgeraniol-derived diterpenoids, i.e., 1–5, were isolated from the seeds of Carpesium triste. The structures including the absolute configurations of the new compounds were elucidated by spectroscopic methods. All the compounds, except for 2, were evaluated for their in vitro cytotoxic activity against cultured SMMC-7721 (human hepatoma), HL-60 (human promyelocytic leukemia), and L02 (human hepatocyte) cells.
  Helvetica Chimica Acta 10/2008; 91(10):1934 - 1939. · 1.48 Impact Factor
• Article: A New Triterpene and New Sesquiterpenes from the Roots of Ligularia sagitta

  Ping‐Lin Li, Zhong‐Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: One new triterpene and seven new eremophilane-type sesquiterpenes were isolated from the roots of Ligularia sagitta, among them 1a, an O-acetylated oleanane type triterpene, 2a and 3a, two 11-nor eremophilane-type sesquiterpenes, 4a, 5, and 6, three standard eremophilane-type sesquiterpenes, and 7 and 8, two tri-nor eremophilane-type sesquiterpenes. Their structures were established by extensive spectral analyses (1D, 2D-NMR, IR, and MS). Compound 1a showed moderate cytotoxicity against two tumor cell lines.
  Helvetica Chimica Acta 09/2008; 91(9):1717 - 1727. · 1.48 Impact Factor
• Article: Eremophilane‐Type Sesquiterpenes from the Roots of Ligularia virgaurea

  Zhan‐Xin Zhang, Dong‐Qing Fei, Zhong‐Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: From the roots of Ligularia virgaurea, five new eremophilane-type sesquiterpenes were isolated, including three new eremophilenolides, 6β-(angeloyloxy)-1α,8β,10β-trihydroxyeremophil-7(11)-en-12,8α-olide (1), 6β-(angeloyloxy)-1β,10β-epoxy-8β-ethoxyeremophil-7(11)-en-12,8α-olide (2), and 1β,10β-epoxy-8β-ethoxy-6β-[(2-methylacryloyl)oxy]eremophil-7(11)-en-12,8α-olide (3), two new noreremophilanes, 3β-[(2-methylacryloyl)oxy]-8-oxo-12-noreremophil-6-en-11-one (9), and 9β-hydroxy-8-oxo-12-noreremophil-6-en-11-one (10), and six known eremophilanes, namely 4–8, and 11. Their structures were elucidated by means of spectral methods, such as IR, HR-ESI-MS, and 1D- and 2D-NMR, and by comparison of the spectral data with those reported for structurally related compounds.
  Helvetica Chimica Acta 07/2008; 91(6):1045 - 1052. · 1.48 Impact Factor
• Article: Natural antioxidant pedicularioside G inhibits angiogenesis and tumourigenesis in vitro and in vivo.

  Ping Mu, Xue Gao, Zhong-Jian Jia, Rong-Liang Zheng
  [show abstract] [hide abstract]
  ABSTRACT: Pedicularioside G is a new compound of phenylpropanoid glycosides, isolated from Pedicularis striata in our laboratory. Pedicularioside G inhibited two major angiogenic responses, human umbilical vein endothelial cell proliferation and migration, as well as neovascularization in a chicken embryo chorioallantoic membrane model. In addition, pedicularioside G inhibited human hepatoma cells proliferation and migration in vitro along with transplanting tumour formation and growth in a chicken embryo chorioallantoic membrane model. So pedicularioside G has anti-angiogenic, antitumour growth, antimetastatic and antitumoural effects. Pedicularioside G also remarkably reduced reactive oxygen species level in both vein endothelial cells and hepatoma cells in a concentration-dependent manner. These results suggest that the anti-angiogenic and antitumoural effects of pedicularioside G might partially attribute to its antioxidative activity.
  Basic & Clinical Pharmacology & Toxicology 02/2008; 102(1):30-4. · 2.18 Impact Factor
• Article: New weakly cytotoxic eremophilane sesquiterpenes from the roots of Ligularia virgaurea.

  Zhan-Xin Zhang, Chang-Jun Lin, Ping-Lin Li, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: Six new eremophilane sesquiterpenes, including a novel nortrieremophilane carbon skeleton, were isolated from the roots of Ligularia virgaurea. Their structures were elucidated as 3 alpha,4 alpha-epoxy-6 alpha-(2'-methylacryloyl)oxy-8 alpha-methoxyeremophil-7(11)-en-8 beta,12-olide (1), 3 alpha,4 alpha-epoxy-6 alpha-(2'-methylacryloyl)oxy-8 alpha-ethoxyeremophil-7(11)-en-8 beta,12-olide (2), 1 beta,10 beta-epoxy-6 beta-(2'-methylacryloyl)oxy-8 beta-methoxyeremophil-7(11)-en-8 alpha,12-olide (3), 1 beta,10 beta-epoxy-6 beta-angeloyloxy-8 beta-methoxyeremophil-7(11)-en-8 alpha,12-olide (4), 6 beta-methoxyeremophil-7(11)-en-8 beta,12-olide (5), and 5 beta-angeloyloxy-3a,4,5,6,7,7a-hexahydro-3a beta-methyl-1 H-indene-2,4 beta-dioic acid methyl ester (6) by spectral methods, including IR, HR-ESI-MS, 1D and 2D NMR techniques. All of compounds were evaluated for their in vitro cytotoxic activities against human hepatoma (SMMC-7721), human promyelocytic leukemia (HL-60), and human hepatocyte (L-02) cells.
  Planta Medica 07/2007; 73(6):585-90. · 2.15 Impact Factor
• Article: Cytotoxic germacranolides and acyclic diterpenoides from the seeds of Carpesium triste.

  Xue Gao, Chang-Jun Lin, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: Four new highly oxygenated germacranolides (1, 4, 6, and 7) and four new acyclic diterpenes (8-11), along with three known germacranolides (2, 3, and 5), were isolated from the seeds of Carpesium triste. The structures of the new compounds were elucidated by spectroscopic methods including IR, HRESIMS, and 1D and 2D NMR experiments, and the absolute configurations of compounds 1 and 8-10 were established by CD and Mosher's methods, respectively. Compounds 1, 2, and 4-10 were evaluated for their in vitro cytotoxic activity against cultured SMMC-7721 (human hepatoma), HL-60 (human promyelocytic leukemia), and L02 (human hepatocyte) cell lines. Compounds 1, 2, and 4-7 exhibited significant cytotoxicity against HL-60 cells, and compound 10 exhibited cytotoxicity against SMMC-7721 cells.
  Journal of Natural Products 06/2007; 70(5):830-4. · 3.13 Impact Factor
• Source

  Available from: sookmyung.ac.kr

  Article: A new C-10 acetylene and A new triterpenoid from Conyza canadensis.

  Wei Dong Xie, Xue Gao, Zhong Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: From the whole plants of Conyza canadensis (Compositae), a new C-10 acetylene, namely 8R, 9R-dihydroxymatricarine methyl ester (1), and a new triterpenoid, namely 3beta, 16beta, 20beta-trihydroxytaraxast-3-O-palmitoxyl ester (4), were isolated along with eleven known compounds (2, 3, 5-13). The structures of all 13 compounds were elucidated on the basis of their spectral data. The antibacterial activities of compounds 1-3 were evaluated.
  Archives of Pharmacal Research 06/2007; 30(5):547-51. · 1.59 Impact Factor
• Article: Effects of phytoestrogens and 17beta-estradiol on vasoconstriction elicited by reactive oxygen species.

  Peng Zhang, Hong-Fang Li, Zhi-Feng Tian, Xiao-Qing Qiu, Jin-Xia Wu, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: To study the effects of different reactive oxygen species (ROS) on the resting tension of porcine coronary artery rings and to identify the effects of genistein (GEN), resveratrol (RES) and 17beta-estradiol (EST) on ROS-elicited vasoconstriction, porcine coronary rings were prepared and mounted in an organ bath and, after an equilibration period, the changes induced by the drugs were observed. Rings with intact endothelium showed an obvious but slow contraction after treatment with xanthine (100 microM)/xanthine oxidase (20 mU x mL(-1)) (X/XO) whereas endothelium-denuded rings showed no effects. H2O2 (200 microM) induced a fast and transient contraction in endothelium-denuded rings and failed to do so in intact-endothelium rings. Like superoxide dismutase (SOD, 200 U x mL(-1)), GEN (1 microM) and RES (1 microM) significantly inhibited contractile response evoked by X/XO, however in contrast to GEN and RES, EST (1 microM) had no obvious effect. GEN (30 microM) and RES (30 microM), like catalase (CAT, 800 U x mL(-1)), markedly attenuated the contraction elicited by H2O2. The results demonstrate that GEN and RES have distinct inhibitory effects on vasoconstriction induced by O2*- generated by X/XO and H2O2, and their actions are clearly greater than to that of EST.
  Pharmazie 06/2007; 62(5):378-81. · 1.01 Impact Factor
• Source

  Available from: sookmyung.ac.kr

  Article: A new iridoid and other chemical constituents from Pedicularis kansuensis forma albiflora Li.

  Jun-Gang Yin, Cheng-Shan Yuan, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: A new iridoid (1) and thirteen known compounds 2-14 were isolated from Pedicularis kansuensis forma albiflora Li., and their structures were elucidated by spectroscopic methods including 2D-NMR techniques.
  Archives of Pharmacal Research 05/2007; 30(4):431-5. · 1.59 Impact Factor
• Article: Labdane diterpenoid glycosides from Aster veitchianus.

  Er-Wei Li, Xue Gao, Kun Gao, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: Four new labdane-type rhamnopyranosides derived from 13-epimanool, compounds 1-4, with differently acetylated sugar moieties, were isolated from A. veitchianus. Their structures and absolute configurations were elucidated by chemical transformation, spectroscopic and mass-spectrometric analyses (IR, 1D- and 2D-NMR, HR-ESI-MS), as well as by single-crystal X-ray diffraction (compound 1). The isolates 2-4 were investigated for their cytotoxic properties against cultured human hepatoma (SMMC-7721), ovarian neoplasm (HO-8910), and leukemia (HL-60) cells, and for their antibacterial activities against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus.
  Chemistry & Biodiversity 04/2007; 4(3):531-8. · 1.80 Impact Factor
• Article: The effect of 17 sesquiterpenes on cell viability and telomerase activity in the human ovarian cancer cell line HO-8910.

  Chun-Ming Wang, Zhong-Jian Jia, Rong-Liang Zheng
  [show abstract] [hide abstract]
  ABSTRACT: Using the MTT assay and the telomeric repeat amplification protocol (TRAP)-based PCR-ELISA assay, the cytotoxicity and telomerase inhibiting ability of 17 sesquiterpenes (extracted from Chinese herbs) were tested in the human ovarian cancer cell line HO-8910. The results indicated that seven sesquiterpenes inhibited cell proliferation without having an effect on telomerase activity; two sesquiterpenes inhibited neither cell proliferation nor telomerase activity; and the other eight sesquiterpenes inhibited both cell proliferation and telomerase activity to a certain extent. Without exception, none of these 17 sesquiterpenes could only inhibit telomerase activity without inhibiting cell proliferation. This indicated that the telomerase inhibiting activity is not a universal mechanism for all anticancer drugs but is only one of several possible mechanisms. The structure-activity relationships of 5 groups of sesquiterpenes are also discussed. This study may help to develop anticancer drugs.
  Planta Medica 03/2007; 73(2):180-4. · 2.15 Impact Factor
• Article: Three new triterpenoids from Potentilla multicaulis.

  Ping-Lin Li, Chang-Jun Lin, Zhan-Xin Zhang, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: Three new triterpenoids, 19-hydroxy-2,3-secours-12-ene-2,3,28-trioic acid 3- methyl ester (1), 19-hydroxy-1-oxo-2-nor-2,3-secours-12-ene-3,28-dioic acid (2), and (3beta,18alpha,19alpha)-3,28-dihydroxy-20,28-epoxyursan-24-oic acid (3), were isolated from the roots of Potentilla multicaulis. Their structures were elucidated on the basis of spectroscopic methods (IR, HR-ESI-MS, and 1D- and 2D-NMR). Compound 2b exhibited moderate cytotoxic activity against human promyelocytic leukemia (HL-60) cells.
  Chemistry & Biodiversity 02/2007; 4(1):17-24. · 1.80 Impact Factor
• Article: Eudesmane sesquiterpenoids from the Asteraceae family.

  Quan-Xiang Wu, Yan-Ping Shi, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: This review covers the structures and biological activities of eudesmane-type sesquiterpenoids from the plants of the Asteraceae family. Biosynthetic studies or chemical syntheses leading to the revision of structures or stereochemistries have also been included, and 593 references are cited.
  Natural Product Reports 11/2006; 23(5):699-734. · 9.79 Impact Factor
• Article: New bisabolane sesquiterpenes and coumarin from Leontopodium longifolium.

  Ji-Xin Li, Chang-Jun Lin, Xiu-Ping Yang, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: From the roots of Leontopotium longifolium, three new bisabolane sesquiterpenes, rel-(1S,4R,5S,6R)-4,5-diacetoxy-6-[(R)-1,5-dimethylhexa-3,5-dienyl]-3-methylcyclohex-2-enyl (Z)-2-methylbut-2-enoate (1), rel-(1S,4R,5S,6R)-4,5-diacetoxy-6-[(R)-5-hydroxy-1,5-dimethylhex-3-enyl]-3-methylcyclohex-2-enyl (Z)-2-methylbut-2-enoate (2), rel-(1R,2S,4R,5S)-4-acetoxy-2-[(R)-5-hydroxy-1,5-dimethylhex-3-enyl]-5-methylcyclohexyl (Z)-2-methylbut-2-enoate (3), and a new coumarin, 2,3-dihydro-5-hydroxy-2-(1-methylethenyl)-7H-pyrano[2,3-g][1,4]benzodioxin-7-one (4) together with nine known compounds have been isolated. The structures of these compounds were established by spectroscopic methods. Compounds 1 and 2 exhibited moderate cytotoxic activities against human promyelocytic leukemia (HL-60) cells.
  Chemistry & Biodiversity 08/2006; 3(7):783-90. · 1.80 Impact Factor
• Article: Five new iridoids from Patrinia rupestris.

  Xiu-Ping Yang, Er-Wei Li, Qi Zhang, Cheng-Shan Yuan, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: Five new iridoids, namely rupesin A-E (1-5, resp.), together with six known iridoids, 6-11, were isolated from the roots of Patrinia rupestris. Their structures were elucidated by spectroscopic methods including IR, UV, MS, and 1D- and 2D-NMR experiments, and comparison with data of known analogues. Compounds 4 and 11, compounds 1, 2, 5, 6, 8, 9, and 10, and compounds 3, 4, and 8 showed significant antibacterial activities against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus, respectively.
  Chemistry & Biodiversity 08/2006; 3(7):762-70. · 1.80 Impact Factor
• Article: New Oplopane‐Type Sesquiterpenes from Ligularia narynensis

  Xue Gao, Chang-Jun Lin, Wei-Dong Xie, Tong Shen, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: Four new, highly oxygenated oplopane-type sesquiterpenes (3–6) were isolated from the roots of Ligularia narynensis, together with four known compounds, and their structures were elucidated by spectroscopic methods and comparison with literature data. Selected congeners were evaluated for their in vitro cytotoxic activities against cultured SMMC-7721 (human hepatoma), L02 (human hepatocyte), and HL-60 (human promyelocytic leukemia) cells, but were found to be inactive.
  Helvetica Chimica Acta 07/2006; 89(7):1387 - 1394. · 1.48 Impact Factor
• Article: Two new benzofurans and other constituents from Ligularia przewalskii.

  Wei-Dong Xie, Xue Gao, Tong Shen, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: Two new benzofurans, 2-(1,2-dihydroxyisopropyl)-5,6-dimethoxybenzofuran (1) and 2-(1-O-feruloyl-2-hydroxyisopropyl)-5,6-dimethoxybenzofuran (2), along with eleven known compounds (3-13) were isolated from the roots of Ligularia przewalskii. Their structures were established on the basis of spectroscopic methods. The antibacterial activity of compounds 1 and 3-5 was tested.
  Pharmazie 07/2006; 61(6):556-8. · 1.01 Impact Factor
• Article: Triterpenoids and Sesquiterpenes from Mulgedium tataricum.

  Xiao-Xiong Wang, Chang-Jun Lin, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: The chemical investigation of Mulgedium tataricum afforded six new compounds which were identified as lanost-9(11),23 Z(24)-diene-3beta,25-diol (1), lanost-9(11),25-diene-3beta,24beta-diol (2), ursane-20-ene-3beta,22alpha-diol (3), 4 E,10 E-3beta,11beta-dihydroxygermacra-4(5),10(1)-dien-12,6alpha-olide (4), 4 E-1beta-hydroperoxy-3beta,11beta-dihydroxygermacra-4(5),10(14)-dien-12,6alpha-olide (5) and lactucin-8-O-P-methoxyphenyl acetate (6) by using a combination of MS and NMR techniques. Compound 6 exhibited significant cytotoxicity against cultured human hepatoma cells (SMMC-7721) and human acute promyelocytic leukemia cells (HL60). The antibacterial activity study indicated that 1 and 2 strongly inhibited the growth of Escherichia coli.
  Planta Medica 07/2006; 72(8):764-7. · 2.15 Impact Factor
• Article: Differential mechanisms involved in effects of genistein and 17-beta-estradiol on porcine coronary arteries.

  Hong-Fang Li, Peng Zhang, Zhi-Feng Tian, Xiao-Qing Qiu, Ying-Fu Zhang, Jin-Xia Wu, Zhong-Jian Jia
  [show abstract] [hide abstract]
  ABSTRACT: The purpose of this work was to examine the differential mechanisms involved in relaxation induced by genistein and 17-beta-estradiol in isolated porcine coronary arteries. Similar to 17-beta-estradiol, genistein could dose-dependently relax 30 mM KCI-precontracted coronary artery rings. The pD2 values of genistein and 17-beta-estradiol were 4.91 +/- 0.13 and 4.98 +/- 0.12 respectively. Incubation with N-L-nitroarginine (L-NNA), endothelium removal or in the presence of a potent inhibitor of protein tyrosine phosphatase sodium orthovanadate did not affect the relaxation induced by genistein, but could partially reduce the vasorelaxation induced by 17-beta-estradiol. The relaxations induced by genistein and 17-beta-estradiol were unaffected by the estrogen receptor antagonist tamoxifen, the inhibitor of prostanoid synthesis indomethacin and the protein synthesis inhibitor, cycloheximide. In addition, both of genistein and 17-beta-estradiol could decrease the contractile responses of KCI, 5-HT and CaCl2, and shift their cumulative concentration-response curves rightward in a parallel manner. These findings suggest that the relaxant effects induced by genistein and 17-beta-estradiol are probably mainly due to inhibition of Ca2+ influx through voltage-dependent calcium channels (VDCCs), and are not related to sex hormone receptor and classical genomic activities. Also there is an interesting finding that the relaxing response of 17-beta-estradiol is partially endothelium-dependent, but that of genistein is not.
  Pharmazie 06/2006; 61(5):461-5. · 1.01 Impact Factor