Zhong-Jian Jia

Lanzhou University, Kao-lan-hsien, Gansu Sheng, China

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Publications (78)137.56 Total impact

  • Kun Gao, Zhong-Jian Jia
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 01/2010; 31(31).
  • [Show abstract] [Hide abstract]
    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 01/2010; 30(8).
  • Xiao-Xiong Wang, Xue Gao, Zhong-Jian Jia
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    ABSTRACT: A new guaianolide and a new eudesmanolide were isolated from Lactuca tatarica, as well as eight known sesquiterpenoids. The new compounds were elucidated on the basis of spectroscopic methods including IR, HRESIMS, 1D and 2D NMR, and the known compounds were established by comparing their physical data with those of the corresponding compounds in the literature.
    Fitoterapia 08/2009; 81(1):42-4. · 2.23 Impact Factor
  • Source
    Ping Mu, Xue Gao, Zhong-Jian Jia, Rong-Liang Zheng
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    ABSTRACT: Pedicularioside G is a new compound of phenylpropanoid glycosides, isolated from Pedicularis striata in our laboratory. Pedicularioside G inhibited two major angiogenic responses, human umbilical vein endothelial cell proliferation and migration, as well as neovascularization in a chicken embryo chorioallantoic membrane model. In addition, pedicularioside G inhibited human hepatoma cells proliferation and migration in vitro along with transplanting tumour formation and growth in a chicken embryo chorioallantoic membrane model. So pedicularioside G has anti-angiogenic, antitumour growth, antimetastatic and antitumoural effects. Pedicularioside G also remarkably reduced reactive oxygen species level in both vein endothelial cells and hepatoma cells in a concentration-dependent manner. These results suggest that the anti-angiogenic and antitumoural effects of pedicularioside G might partially attribute to its antioxidative activity.
    Basic & Clinical Pharmacology & Toxicology 02/2008; 102(1):30-4. · 2.18 Impact Factor
  • Xue Gao, Wei-Dong Xie, Zhong-Jian Jia
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    ABSTRACT: Four new oplopane and guaiane type sesquiterpenoids (1-3), and a monoterpenoid (4) together with three known monoterpenoids (5-7), have been isolated from the roots of Ligularia narynensis. The structures of 1-4 were elucidated as 3beta,4-diacetoxy-8alpha-(2-methylbutyryloxy)-9alpha-(4-methylsenecioyloxy)-11alpha,12-epoxyoplop-10 (14)-ene (1), 3beta,4-diacetoxy-9alpha-(4-acetoxy-4-methylsenecioyloxy)-2beta,8alpha-di (2-methylbutyryloxy)-11alpha,12-epoxyoplop-10 (14)-ene (2), 2alpha-hydroxy-1betaH,7alphaH,10alphaH-guai-4,11 (12)-dien-3-one (3) and 1alpha,2beta,3alpha,6alpha-tetrahydroxy-p-menthane (4) by spectroscopic methods. 1 and 2 were evaluated for their in vitro cytotoxic activity against cultured SMMC-7721 (human hepatoma), L02 (human hepatocyte), and HL-60 (human promyelocytic leukaemia) cell lines.
    Journal of Asian Natural Products Research 01/2008; 10(1-2):185-92. · 0.95 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 01/2008; 39(33).
  • Zhan-Xin Zhang, Dong-Qing Fei, Zhong-Jian Jia
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 01/2008; 39(48).
  • Zhan-Xin Zhang, Wei-Dong Xie, Zhong-Jian Jia
    Biochemical Systematics and Ecology - BIOCHEM SYST ECOL. 01/2008; 36(5):467-472.
  • Ping-Lin Li, Zhan-Xin Zhang, Zhong-Jian Jia
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 01/2008; 37(3):308-309.
  • Chemistry Letters - CHEM LETT. 01/2008; 37(3):346-347.
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    ABSTRACT: Six new eremophilane sesquiterpenes, including a novel nortrieremophilane carbon skeleton, were isolated from the roots of Ligularia virgaurea. Their structures were elucidated as 3 alpha,4 alpha-epoxy-6 alpha-(2'-methylacryloyl)oxy-8 alpha-methoxyeremophil-7(11)-en-8 beta,12-olide (1), 3 alpha,4 alpha-epoxy-6 alpha-(2'-methylacryloyl)oxy-8 alpha-ethoxyeremophil-7(11)-en-8 beta,12-olide (2), 1 beta,10 beta-epoxy-6 beta-(2'-methylacryloyl)oxy-8 beta-methoxyeremophil-7(11)-en-8 alpha,12-olide (3), 1 beta,10 beta-epoxy-6 beta-angeloyloxy-8 beta-methoxyeremophil-7(11)-en-8 alpha,12-olide (4), 6 beta-methoxyeremophil-7(11)-en-8 beta,12-olide (5), and 5 beta-angeloyloxy-3a,4,5,6,7,7a-hexahydro-3a beta-methyl-1 H-indene-2,4 beta-dioic acid methyl ester (6) by spectral methods, including IR, HR-ESI-MS, 1D and 2D NMR techniques. All of compounds were evaluated for their in vitro cytotoxic activities against human hepatoma (SMMC-7721), human promyelocytic leukemia (HL-60), and human hepatocyte (L-02) cells.
    Planta Medica 07/2007; 73(6):585-90. · 2.35 Impact Factor
  • Xue Gao, Chang-Jun Lin, Zhong-Jian Jia
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    ABSTRACT: Four new highly oxygenated germacranolides (1, 4, 6, and 7) and four new acyclic diterpenes (8-11), along with three known germacranolides (2, 3, and 5), were isolated from the seeds of Carpesium triste. The structures of the new compounds were elucidated by spectroscopic methods including IR, HRESIMS, and 1D and 2D NMR experiments, and the absolute configurations of compounds 1 and 8-10 were established by CD and Mosher's methods, respectively. Compounds 1, 2, and 4-10 were evaluated for their in vitro cytotoxic activity against cultured SMMC-7721 (human hepatoma), HL-60 (human promyelocytic leukemia), and L02 (human hepatocyte) cell lines. Compounds 1, 2, and 4-7 exhibited significant cytotoxicity against HL-60 cells, and compound 10 exhibited cytotoxicity against SMMC-7721 cells.
    Journal of Natural Products 06/2007; 70(5):830-4. · 3.29 Impact Factor
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    ABSTRACT: To study the effects of different reactive oxygen species (ROS) on the resting tension of porcine coronary artery rings and to identify the effects of genistein (GEN), resveratrol (RES) and 17beta-estradiol (EST) on ROS-elicited vasoconstriction, porcine coronary rings were prepared and mounted in an organ bath and, after an equilibration period, the changes induced by the drugs were observed. Rings with intact endothelium showed an obvious but slow contraction after treatment with xanthine (100 microM)/xanthine oxidase (20 mU x mL(-1)) (X/XO) whereas endothelium-denuded rings showed no effects. H2O2 (200 microM) induced a fast and transient contraction in endothelium-denuded rings and failed to do so in intact-endothelium rings. Like superoxide dismutase (SOD, 200 U x mL(-1)), GEN (1 microM) and RES (1 microM) significantly inhibited contractile response evoked by X/XO, however in contrast to GEN and RES, EST (1 microM) had no obvious effect. GEN (30 microM) and RES (30 microM), like catalase (CAT, 800 U x mL(-1)), markedly attenuated the contraction elicited by H2O2. The results demonstrate that GEN and RES have distinct inhibitory effects on vasoconstriction induced by O2*- generated by X/XO and H2O2, and their actions are clearly greater than to that of EST.
    Pharmazie 06/2007; 62(5):378-81. · 0.96 Impact Factor
  • Source
    Jun-Gang Yin, Cheng-Shan Yuan, Zhong-Jian Jia
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    ABSTRACT: A new iridoid (1) and thirteen known compounds 2-14 were isolated from Pedicularis kansuensis forma albiflora Li., and their structures were elucidated by spectroscopic methods including 2D-NMR techniques.
    Archives of Pharmacal Research 05/2007; 30(4):431-5. · 1.54 Impact Factor
  • Er-Wei Li, Xue Gao, Kun Gao, Zhong-Jian Jia
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    ABSTRACT: Four new labdane-type rhamnopyranosides derived from 13-epimanool, compounds 1-4, with differently acetylated sugar moieties, were isolated from A. veitchianus. Their structures and absolute configurations were elucidated by chemical transformation, spectroscopic and mass-spectrometric analyses (IR, 1D- and 2D-NMR, HR-ESI-MS), as well as by single-crystal X-ray diffraction (compound 1). The isolates 2-4 were investigated for their cytotoxic properties against cultured human hepatoma (SMMC-7721), ovarian neoplasm (HO-8910), and leukemia (HL-60) cells, and for their antibacterial activities against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus.
    Chemistry & Biodiversity 04/2007; 4(3):531-8. · 1.81 Impact Factor
  • Chun-Ming Wang, Zhong-Jian Jia, Rong-Liang Zheng
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    ABSTRACT: Using the MTT assay and the telomeric repeat amplification protocol (TRAP)-based PCR-ELISA assay, the cytotoxicity and telomerase inhibiting ability of 17 sesquiterpenes (extracted from Chinese herbs) were tested in the human ovarian cancer cell line HO-8910. The results indicated that seven sesquiterpenes inhibited cell proliferation without having an effect on telomerase activity; two sesquiterpenes inhibited neither cell proliferation nor telomerase activity; and the other eight sesquiterpenes inhibited both cell proliferation and telomerase activity to a certain extent. Without exception, none of these 17 sesquiterpenes could only inhibit telomerase activity without inhibiting cell proliferation. This indicated that the telomerase inhibiting activity is not a universal mechanism for all anticancer drugs but is only one of several possible mechanisms. The structure-activity relationships of 5 groups of sesquiterpenes are also discussed. This study may help to develop anticancer drugs.
    Planta Medica 03/2007; 73(2):180-4. · 2.35 Impact Factor
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    ABSTRACT: Three new triterpenoids, 19-hydroxy-2,3-secours-12-ene-2,3,28-trioic acid 3- methyl ester (1), 19-hydroxy-1-oxo-2-nor-2,3-secours-12-ene-3,28-dioic acid (2), and (3beta,18alpha,19alpha)-3,28-dihydroxy-20,28-epoxyursan-24-oic acid (3), were isolated from the roots of Potentilla multicaulis. Their structures were elucidated on the basis of spectroscopic methods (IR, HR-ESI-MS, and 1D- and 2D-NMR). Compound 2b exhibited moderate cytotoxic activity against human promyelocytic leukemia (HL-60) cells.
    Chemistry & Biodiversity 02/2007; 4(1):17-24. · 1.81 Impact Factor
  • Jun-Gang Yin, Cheng-Shan Yuan, Zhong-Jian Jia
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    ABSTRACT: A new iridoid (1) and thirteen known compounds2- 14 were isolated fromPedicularis kansuensis formaalbiflora Li., and their structures were elucidated by spectroscopic methods including 2D-NMR techniques.
    Archives of Pharmacal Research 01/2007; 30(4):431-435. · 1.54 Impact Factor
  • Source
    Xiu-Ping Yang, Cheng-Shan Yuan, Zhong-Jian Jia
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    ABSTRACT: Phytochemical investigation of the roots of Patrinia rupestris afforded a new triterpenoid patrirupin A (1) and a new iridoid patrirupin B (2), as well as three known triterpenoids: 3-oxo-olean-12-en-28-oic acid (3), ursolic acid (4), a-amyrin (5), three known iridoids: isovaltratum (6), 11-ethoxyviburtinal (7), homobaldrinal (8), five known steroids: ergosterol (9), ergost-6,22-diene-3b,5a,8a-triol (10), 6-hy-droxenone (11), b-sitosterol (12), daucosterol (13), and two known flavones: 1-hydroxy-5-methoxy xanthen-9-one (14), 3¢,4¢,5,7-tetrahydroxyflavanone (15). The new compounds were characterized by means of spectroscopic methods including UV, IR, 1D, 2D NMR and HRESIMS, and the known ones were established on the basis of comparing their NMR data with those of the corresponding compounds in the literature.
    Journal of the Chinese Chemical Society. 01/2007; 54(2).
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    ABSTRACT: Ligulasagitins A–E (1–5), five new eremophilane-derived metabolites possibly formed via a Diels–Alder reaction in the biosynthetic process, were isolated from Ligularia sagitta Maxim. Among them 1 and 2 possess a novel C19 skeleton, 4 and 5 are two novel dimeric eremophilane type derivatives. Their structures were determined by extensive spectroscopic analysis and the structure of 2 was also confirmed by a single-crystal X-ray diffraction analysis. Furthermore, 4 and 5 showed weak cytotoxic activity against HL-60 (human promyelocytic leukemia) cells.
    ChemInform 01/2007; 63(51):12665-12670.

Publication Stats

418 Citations
137.56 Total Impact Points

Institutions

  • 1993–2010
    • Lanzhou University
      • • State Key Laboratory of Applied and Organic Chemistry
      • • School of Life Science
      Kao-lan-hsien, Gansu Sheng, China
  • 1997
    • Government of the People's Republic of China
      Peping, Beijing, China