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Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 01/2011; 111(6):89-96. · 0.12 Impact Factor
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ABSTRACT: A comparative clinical and instrumental analysis of 97 patients with Sneddon's syndrome (SS), a combination of cerebrovascular ischemic disturbances with widespread livedo, and 12 patients with systemic lupus erythematosus (SLE) with the same combination, has been conducted. Despite the presence of similar features related to antiphospholipid syndrome (APS)--cerebrovascular disturbances, livedo, fetal loss, peripheral venous thrombosis, thrombocytopenia, antibodies to phospholipids, etc--there were distinct differences between SS and SLE. In SS, no skin lesions ("butterfly", discoid lupus, photosensibilization) typical for SLE as well as sores of mucous oral cavity, polyarthritis, serosity, diagnostically significant titers of antinuclear factor and antibodies to DNA were observed. SS emerged with livedo (44%), cerebrovascular disturbances (24%) and systemic APS appearances (32%). SLE in 75% cases began with its classical symptoms and in 25% with systemic APS signs and never with livedo or cerebrovascular disturbances. For 10.5 +/- 8.0 years, no cases of SS were featured by typical SLE symptoms. Pathomorphological study indicated that SS and SLE were independent diseases. Their similarity was due to development of secondary APS, including cerebrovascular disturbances and livedo, in some patients with SLE.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2005; 105(7):21-5. · 0.12 Impact Factor
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ABSTRACT: Clinical and neurovisual features were compared in 2 groups of patients who have survived the first lacunar stroke (LS). Group 1 included 35 patients (mean age 59.6 +/- 7.1 years), in stable state for 5.7 +/- 2.5 years; group 2 consisted of 39 patients (mean age 58.1 +/- 8.1 years) with LS as a debut of subcortical arteriosclerotic encephalopathy (SAE), illness duration after LS development--3.9 +/- 2.9 years. Several parameters revealed statistically significant between-group differences: "classical" lacunar syndromes, most frequently motor hemiparesis, were detected in 94% of group 1 patients and in 42% of group 2 patients. Pareses of the extremities were marked or moderate in 57% and 3% of the patients, respectively. Foci characteristic of LS were determined by MRI/CT in all the patients of group 1 and in 69% of the patients of group 2. Foci mean size (MRI, regime T1) was larger in group 1 (0.24 +/- 0.18 cm3), comparing to group 2 (0.11 +/- 0.06 cm3); foci shape was round or oval in 77% of patients in group 1 and irregular--in 51% of patients in group 2. In group 1, concomitant asymptomatic leucoareosis and lacunes were detected in 37% and 20%; in group 2--in 77% and 62%, respectively. The differences revealed may be used in prognosis of LS further course. These differences may be underlied by the lesions of intracerebral arteries of different size and differend of change occurrence that, to a certain extent, relate to different hemodynamic variants of arterial hypertension.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2004; · 0.12 Impact Factor
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ABSTRACT: Retrospective clinical analysis with a special focus on pyramidal syndrome expression in the disease course as well as morphological study of brain and spinal structures in all levels of cortical-spinal projection (from brain motor cortex to spinal lumbar segments) have been conducted for 11 section cases of lateral amyotrophic sclerosis (LAS), sporadic type. Two groups of patients were studied: with pronounced pyramidal syndrome (spasticity, hyperreflexia, etc)--7 cases and with some signs of pyramidal deficiency (anisoreflexia, stability of peritoneal reflexes)--4 cases. Pyramidal syndrome in LAS is considered as an emergence of current neurodegenerative process, embracing a significant part of upper motor neurons of both precentral convolution and its axons along the whole length of cerebrospinal axis in the form of cytoplasmic inclusions and axonal spheroids. A presence of pathomorphological changes in other upper segmental structures of motor control reveals their role in pyramidal deficiency. Comparative analysis showed that expression of pyramidal syndrome signs and its correlation to atrophic paresis appearances is specifically determined by the severity of upper and lower motor neurons lesions. With regard to morphological changes in CNS structures, the peculiarities of some pyramidal syndrome appearances in LAS are analyzed.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2003; 103(5):19-25. · 0.12 Impact Factor
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Biulleten' eksperimental'noĭ biologii i meditsiny 03/2000; 129(2):234-40.
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ABSTRACT: The autopsy cases of Creitsfeldt-Jacob disease (a sporadic form) are reported which were diagnosed clinically and supported by the data of biopsy and autopsy of the brain (classic triad: death of neurons, astrogliosis and spongiform degeneration of the gray substance of the cortex of brain hemispheres, preferentially), followed by clinical morphologic comparisons. The focal character of the disease was observed on the early stages of the disease, while diffuse alterations were found on the late stages.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/2000; 100(8):10-5. · 0.12 Impact Factor
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Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk 02/1999;
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I A Zavalishin,
V M Roĭkhel, T S Gulevskaia,
V V Gnezditskiĭ,
I E Shitikova,
D N Dzhibladze,
A I Kugoev,
G I Fokona,
L M Kondakova,
S G Sobolev,
V V Pogodina,
R P Chaĭkovskaia,
S M Lozhnikova,
A V Sakharova,
E M Kashina,
E B Sungurov
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ABSTRACT: The paper presents the data concerning usage of some original method of vital laboratory diagnostics of Creutzfeldt-Jacob disease that belongs to the group of prionic diseases. The method consisted in the inoculation of inoculative culture of rat Gasser ganglion's neurinoma by biologic materials investigated (serum and clot of blood) with the following passivation and investigation of the contaminated culture by means of both morphologic and electron microscopic methods. As an example of vital verificated case the wide pathomorphologic analysis of the biopsy sample of brain was presented. Besides, the efficiency of the investigation of cognitive evoked potentials (P300) together with EEG was also demonstrated as the method of objectification of the development of dementia in this disease.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/1998; 98(5):20-5. · 0.12 Impact Factor
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ABSTRACT: The paper presents 9 patients (5 women, 4 men, average age 58 years) with small infarctions located in either thalamus (T) or in the region of thalamofrontal ways. Such infarctions resulted in acute development of mental disorders which corresponded to dementia in 7 cases and to slight cognitive disorders in 2 cases. The complex of mental disorders resembled one in "Frontal Syndrome" and was characterised mainly by aspontaneity, adynamia, hypersomnia, disorientation, memory impairment, attention deficit, delay of all mental processes, lack of criticism and adequacy. Accompanying focal neurologic symptoms were slight in 7 patients, moderate or pronounced in 2 cases. In 5 patients the manifestation of mental disorders decreased gradually. Computer tomography revealed small infarctions in anterior or medial areas of T in 7 cases, and in thalamofrontal routes in 2 patients. Infarctions were located in dominant hemisphere of brain in 5 patients, in nondominant one--in 3 cases, in both hemispheres--in one patient. Location of all the foci corresponded to the structures through which the routes passed and connected T and reticular formation localized lower with frontal lobes of brain. It was suggested that separation of these routes resulted in cognitive disorders or dementia because of functional inactivation of the cortex of frontal lobes of brain.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/1998; 98(6):8-13. · 0.12 Impact Factor
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Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/1995; 95(1):98-103. · 0.12 Impact Factor
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Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/1994; 94(2):103-8. · 0.12 Impact Factor
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Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/1993; 93(2):90-6. · 0.12 Impact Factor
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Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 02/1993; 93(3):91-5. · 0.12 Impact Factor
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ABSTRACT: White matter of the brain in 25 autopsy cases with the stroke and chronic cerebro-vascular pathology produced by arterial hypertension (AH) was studied morphologically. Focal and diffuse changes of the white matter were found against the background of the hypertonic angiopathy. These changes were represented by lacunar infarcts, foci of incomplete necrosis, perivascular encephalolysis, more seldom by small haemorrhages in combination with edema, cribriform lesions and widespread spongiosis of the white matter. Alterations of the cortex-medullary arteries, microcirculatory bed, disturbances of the dynamics of liquor and permeability of blood-brain barrier play the most important role in the white matter damage. The authors distinguish 3 forms of this damage. The complex of these alterations is regarded as a morphological substrate of a vascular dementia associated with AH.
Arkhiv patologii 02/1992; 54(2):53-9.
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Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia: 1952) 02/1992; 92(4):97-100. · 0.06 Impact Factor
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Klinicheskaia meditsina 04/1991; 69(3):3-6.
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ABSTRACT: The authors characterize the current stage of studies into the problem of focal cerebral ischemia under experimental and clinical conditions, formulate research priorities in the prevention, pathogenesis, diagnosis and treatment of ischemic disturbances of cerebral circulation, demonstrate the significance of new approaches to and methods of solving disputable and unsolved problems of preventive and urgent angioneurology. Based on an analysis of the latest information, the authors distinguish the most important research data on the problem of ischemic disturbances of cerebral circulation and outline prospective ways of further scientific research endeavours.
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia: 1952) 02/1990; 90(1):3-8. · 0.06 Impact Factor
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Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia: 1952) 02/1990; 90(11):131-6. · 0.06 Impact Factor
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Felʹdsher i akusherka 05/1989; 54(4):22-5.
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ABSTRACT: Morphological examination of the brain in 17 autopsies of patients with arterial hypertension and cerebral stroke has revealed damage of the white matter of the large cerebral hemispheres of a focal and diffuse nature. The main role in stroke development is ascribed to changes in the intracerebral cortico-medullar arteries manifested in hypertension and persistent brain edema. The following 3 forms of white matter damage associated with arterial hypertension have been described: (1) multi-infarctional; (2) periventricular (periventricular spongiosis); (3) combined (diffuse).
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia: 1952) 02/1988; 88(7):25-32. · 0.06 Impact Factor
