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ABSTRACT: PURPOSE: The imaging factor predicting the response to bevacizumab (BV) as concomitant chemotherapy has yet to be determined. This study examined correlation between response to chemotherapy with concomitant BV for hepatic metastasis of colorectal cancer and degree of contrast enhancement (CE) using contrast-enhanced computed tomography (CT). METHODS: Data were analyzed retrospectively for 35 patients treated with oxaliplatin-based chemotherapy as the first-line chemotherapy. Patient data were divided according to treatment with concomitant BV (BV group: n = 20, non-BV group: n = 15). Using an image control system, the degree of CE was evaluated by the ratio of the contrast-enhanced CT value of hepatic metastatic lesions to plain CT value, whereby patients were classified into the high-CE and low-CE group. RESULTS: After completion of chemotherapy treatment, the degree of enhancement of hepatic metastasis in the BV group was significantly lower than that in the non-BV group (p = 0.03). In the BV group, a significant correlation between higher contrast enhancement and higher tumor shrinkage rate was observed (R (2) = 0.25, p = 0.03), whereas no such correlation was noted in the non-BV group. In the high-CE group (n = 18), the tumor shrinkage rate increased to 29.6 % in the BV group compared with -1.46 % in the non-BV group (p = 0.03), whereas in the low-CE group, no significant difference was noted between patients in the two groups. CONCLUSION: Pretreatment evaluation of the degree of CE correlated with the response to concomitant chemotherapy with BV.
Cancer Chemotherapy and Pharmacology 05/2013; · 2.83 Impact Factor
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ABSTRACT: We herein report the case of a 50-year-old man with malignant fibrous histiocytoma (MFH) of the esophagus. The patient was
admitted to our hospital because of cough, dysphagia, and weight loss. Esophagography and upper gastrointestinal endoscopy
revealed a giant protruding lesion in the cervical esophagus. Total esophagectomy was performed with total laryngectomy and
pharyngogastrostomy. The tumor was composed of proliferating spindle cells mixed with pleomorphic giant cells. The histopathological
diagnosis was malignant fibrous histiocytoma of the esophagus. Although there have been several case reports of MFH of the
alimentary tract, MFH of the esophagus is extremely rare. We recently experienced a case of this disease.
Esophagus 04/2012; 4(2):73-77. · 0.66 Impact Factor
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ABSTRACT: We herein report three cases of the malignant esophageal stenosis successfully treated with the Niti-S™ esophageal stent. CASE 1: The hilar lung cancer and its mediastinal lymph node metastasis pressed the esophagus extramurally and caused the marked stenosis. CASE 2: A metastatic lymph node along the left laryngeal nerve caused the stenosis of the trachea. A primary esophageal lesion located at the middle thoracic esophagus also caused the marked stenosis. At first, tracheal stent was placed because of dyspnea, and two weeks later, we placed an esophageal stent. Case 3: Esophageal cancer at lower thoracic esophagus after definitive radiation therapy caused the marked stenosis. Because of the stenosis of esophago-gastric junction( EGJ), we used an esophageal stent with a long cover in order to prevent a reflux into the esophagus. This new Niti-STM esophageal stent was easy to place at the stenosis without difficulty using a conventional device. The symptom was improved immediately for each case. We hope this new device will be used widely.
Gan to kagaku ryoho. Cancer & chemotherapy 11/2011; 38(12):2417-9.
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ABSTRACT: We evaluated the effectiveness of pre-operative chemotherapy with S-1 plus CDDP against advanced gastric cancer with paraaortic lymph node metastasis. 8 patients received pre-operative chemotherapy with S-1 plus CDDP, according to the following regimen: S-1, 80 mg/m(2), was administered for 21 consecutive days followed by a 14-day rest period, and CDDP, 60 mg/m(2), was administered on day 8. The adverse event rate was 50%. However, a grade greater than 3 was not revealed. There were 5 partial responses (PR) and 3 stable diseases (SD). We performed 7 total gastrectomies and one distal gastrectomy, and the surgical curability (cur) resulted in 6 cases of cur B and two cases of cur C. The histological antitumor effect was grade 2 in three cases. The median overall survival rate was 623 days and the one-year survival rate was 75%. Analyzing for overall survival with antitumor effect and operative curability, both groups of PR and cur B prolonged survival. Pre-operative chemotherapy with S-1 plus CDDP, when used against advanced gastric cancer with paraaortic lymph node metastasis, might be an effective treatment.
Gan to kagaku ryoho. Cancer & chemotherapy 10/2011; 38(10):1623-6.
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Miki Miyazawa, Yoshihiko Naritaka,
Akira Miyaki,
Shinichi Asaka,
Noriyuki Isohata,
Kentaro Yamaguchi,
Minoru Murayama,
Takeshi Shimakawa,
Takao Katsube,
Kenji Ogawa,
Mariko Fujibayashi
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ABSTRACT: Low-grade myofibroblastic sarcoma (LGMFS) is a fusiform cell tumor which develops in bone or soft tissues. This type of tumor frequently occurs in the oral cavity and extremities, while it is extremely rarely found in the abdominal cavity. This article reports a case of LGMFS exceeding 20 cm in diameter in the abdominal cavity observed in a 65-year-old male patient. The patient visited our hospital complaining of a heavy feeling of the stomach and abdominal distension. Imaging examinations revealed a giant solid tumor in the abdomen, and surgical treatment was scheduled. During the operation, a tumor about 20 cm in diameter with its anterior aspect covered with the greater omentum was found. The tumor had firm adhesions to the surrounding tissues, and it was excised with concomitant resections of the tail of the pancreas and the spleen. Histopathologically, fusiform cells were arranged in a complicated or storiform pattern, and immunohistochemical staining revealed that the tumor was positive for α-smooth muscle actin, negative for S100β, H-caldesmon and c-KIT, and a diagnosis of LGMFS was made.
Anticancer research 09/2011; 31(9):2989-94. · 1.73 Impact Factor
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Shunichi Shiozawa,
Dal Ho Kim,
Takebumi Usui,
Akira Tsuchiya,
Toshio Masuda,
Satoshi Inose,
Masaki Aizawa,
Kazuhiko Yoshimatsu,
Takao Katsube, Yoshihiko Naritaka,
Kenji Ogawa
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ABSTRACT: To evaluate the reliability of a screening method in patients with common bile duct (CBD) stones before laparoscopic cholecystectomy (LC) based on predictive factors, and to determine the cases for which preoperative therapeutic endoscopic retrograde cholangiography (ERC) is indicated.
Alkaline phosphatase, total bilirubin, amylase, and dilation of CBD results were defined as predictive factors for CBD stones. In cases in which all these 4 factors were negative, preoperative ERC was omitted, and in cases in which 1 of the 4 factors was positive, ERC was performed before LC.
A total of 323 patients (83.7%) in whom all 4 factors were negative, ERC was omitted. In all the 63 patients (16.3%) in whom 1 of the 4 factors was positive, ERC was performed. In 52 (82.5%) of them, CBD stones were present and in 43 of them, LC was performed after endoscopic choledocholithotomy.
For cases in which any 1 of the 4 factors was positive before LC, it was strongly recommended to perform preoperative ERC.
Surgical laparoscopy, endoscopy & percutaneous techniques 02/2011; 21(1):28-32. · 1.23 Impact Factor
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Takebumi Usui,
Shunichi Shiozawa,
Dal Ho Kim,
Akira Tsuchiya,
Toshio Masuda,
Satoshi Inose,
Masaki Aizawa,
Kazuhiko Yoshimatsu,
Takao Katsube, Yoshihiko Naritaka,
Kenji Ogawa
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ABSTRACT: Transcatheter arterial chemoembolization (TACE) was performed as the initial therapy for advanced hepatocellular carcinoma (HCC). However, no effective chemotherapy has been established for patients who did not respond to TACE, and for those the therapy was not suitable. Since 2004, transcatheter arterial infusion (TAI) chemotherapy using fine-powder cisplatin has been applied at our department to such cases mentioned before. This report described the therapeutic results of TAI therapy and presented a case of HCC accompanied by portal vein tumor thrombus (PVTT) for which the therapy was effective.
TAI was performed using cisplatin in 16 patients with inoperable advanced HCC between 2004 and 2010. Cisplatin was infused into the proper hepatic artery at a dose of 65 mg/m2 for 30 minutes.
TAI was performed in each patient 1.8 times on average, ranging from 1 to 8 times. Therapeutic Effect 4 (TE4) was obtained in 1 case, TE3 in 2, TE2 in 1, and TE1 in 11 cases. The only severe adverse event rated as grade 3 or above during the study were nausea and anorexia reported in 6.3% of the patients, and adverse events rated as less than grade 2 were increased serum hepato-biliary enzyme levels in 68.8%, nausea in 68.8% of the patients. The overall 1-year survival rate was 31.2%, and the 50% survival period was 314 days.
As a treatment option following the initial TACE therapy for advanced HCC, TAI using cisplatin can improve the prognosis of HCC.
Gan to kagaku ryoho. Cancer & chemotherapy 11/2010; 37(12):2702-4.
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Yoshihiko Naritaka,
Shinichi Asaka,
Akira Miyaki,
Noriyuki Isohata,
Takeshi Shimakawa,
Kentaro Yamaguchi,
Takao Katsube,
Toko Muraoka,
Shunichi Shiozawa,
Kazuhiko Yoshimatsu,
Kenji Ogawa
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ABSTRACT: Nephrotic syndrome associated with a malignant tumor may remit following resection of the tumor. This report documents a case of esophageal cancer with concurrent nephrotic syndrome in which a surgical resection of the tumor resulted in a complete remission of nephrotic syndrome. A 78-year-old male patient noticed edema of his lower legs in February 2009 and was diagnosed with nephrotic syndrome. An endoscopic examination revealed an indented lesion with a nearly semiannular low elevation on the posterior wall of the esophagus at 31 to 34 cm from the upper incisors, and a diagnosis of esophageal cancer was made. A two-stage operation was planned. In March 2009, a subtotal resection of the thoracic esophagus through a right thoracic approach and cervical external esophagostomy were performed, and in April 2009, antethoracic route esophagogastrostomy was performed. The urinary protein levels were negative by the 86th day of hospitalization, and the patient progressively improved and was discharged on the 91st hospital day. There has been no recurrence of esophageal cancer or relapse of nephrotic syndrome at 12 months following the operation. In esophageal cancer patients with nephrotic syndrome, surgical treatment should be undertaken because the remission of nephrotic syndrome may be expected following tumor resection. For this purpose, selecting the appropriate operative procedures and careful perioperative management, including nutritional management, are of profound importance.
Anticancer research 09/2010; 30(9):3763-7. · 1.73 Impact Factor
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ABSTRACT: It is difficult to perform radical surgery for esophageal cancer with multiple lymph node metastases. Therefore, effective neoadjuvant adjuvant treatment is necessary to achieve successful radical resection. The use of neoadjuvant chemotherapy of docetaxel, cisplatin (CDOP) and 5-fluorouracil (5-FU) (DCF) in an advanced case is reported. The patient (a 67-year-old female) was diagnosed with esophageal cancer, T3, N4, M0, stage IVa with a large number of lymph node metastases in the mediastinum and in the abdominal cavity. Neoadjuvant DCF chemotherapy was initiated in August 2006. Adverse events were mild. A complete response of the lymph node metastases in the abdominal cavity and a partial response of the esophageal lesion were achieved. The surgical procedure included a right thoracolaparotomy followed by a subtotal excision of the esophagus and two-field lymph node dissection. The cancer was diagnosed to be moderately differentiated squamous cell cancer, pT2, pN4(3c) and pstage IVa. The histological efficacy of the chemotherapy was determined to be grade 1a. Two additional courses of DCF therapy were administered followed by postoperative adjuvant chemotherapy.
Anticancer research 01/2010; 30(1):221-6. · 1.73 Impact Factor
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ABSTRACT: The present study was performed to investigate the effects of the nutrition screening index and pulmonary function test data for patients who underwent surgery for esophageal cancer, based on the incidence of postoperative complications and the duration of postoperative hospitalization.
A total of 69 patients who received esophageal cancer resection were included in the study. It was determined how the parameters studied (ie, between ages, concomitant diabetes mellitus, body mass index( BMI), serum albumin level, Onodera's prognostic nutritional index, percentage of vital capacity(%VC), and forced expiratory volume[ FEV]1.0%) were related to the incidence of complications and the duration of postoperative hospital days, as expressed by the median days for all patients and the frequency of long-term hospitalization.
The incidence of postoperative complications was significantly higher in patients aged 65 and above and those with a %VC value of less than 80%. The median duration of postoperative hospitalization was longer in those aged 65 and above and those with a FEV1.0% value of less than 70%, which was related to BMI. In addition, the frequency of long-term hospitalization was higher in those aged 65 and above, which was also related to BMI.
The results of the present study confirm that postoperative complications and length of postoperative hospital stay in patients with surgically treated esophageal cancer were largely dependent on their pulmonary function as well as age and BMI used for the nutrition screening index. Nutrition screening combined with pulmonary function tests, using age, BMI, %VC, and FEV1.0%, is considered desirable to avoid postoperative complications associated with esophageal cancer.
Gan to kagaku ryoho. Cancer & chemotherapy 11/2009; 36(12):1961-3.
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Takebumi Usui,
Shunichi Shiozawa,
Dal Ho Kim,
Akira Tsuchiya,
Toshio Masuda,
Satoshi Inose,
Masaki Aizawa,
Kazuhiko Yoshimatsu,
Takao Katsube, Yoshihiko Naritaka,
Kenji Ogawa
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ABSTRACT: We report two cases of advanced hepatocellular carcinoma( HCC) with a portal vein tumor thrombus (PVTT) responding to transcatheter arterial infusion chemotherapy (TAI) using cisplatin (CDDP). Case 1: A 65-year-old male patient was diagnosed with unresectable multiple HCCs. After 5 courses of transcatheter arterial chemoembolization (TACE), the tumor became markedly enlarged, and a PVTT (Vp2) and lymph node metastasis were noted. TAI was conducted as the second- line chemotherapy, and the liver tumor, PVTT, and lymph node metastasis shrank. The clinical response was rated as a partial response (PR). Case 2: A 72-year-old female patient was diagnosed with single HCC. After a course of TACE, the tumor became markedly enlarged and was accompanied by a PVTT (Vp4). TAI was performed as the second-line chemotherapy, and the liver tumor and PVTT significantly shrank. The clinical response was also rated as a PR. TAI using CDDP as the second-line chemotherapy for advanced HCC is a promising treatment likely to contribute to the improvement of the patient's prognosis.
Gan to kagaku ryoho. Cancer & chemotherapy 11/2009; 36(12):2359-61.
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ABSTRACT: We developed a modified method of endoscopic aspiration mucosectomy (m-EAM) which includes the pre-cutting of the peripheral mucosa before aspiration, and which has been employed in this department since 1998. An endoscopic submucosal dissection (ESD), which enables the resection of a larger area of the lesion using newly-developed surgical devices, has also been employed here since March 2003. This study was performed to investigate the efficacy of ESD at the present time by assessing the short-term therapeutic results for the procedure in patients with a preoperative diagnosis of early-stage differentiated gastric mucosal cancer, by tumor diameter, as well as by comparing these results with those obtained previously with m-EAM.
The study included 110 patients with a preoperative diagnosis of early-stage differentiated gastric mucosal cancer (57 underwent m-EAM and 53 received ESD). A comparison was made between these two groups regarding the short-term therapeutic response (en bloc resection rate, curability, complications, and days of postoperative hospitalization) by the tumor diameter.
The en bloc resection rate was significantly higher for patients with a tumor measuring 21 mm or larger who underwent ESD in comparison to that for those with a similar tumor size who underwent m-EAM (p<0.05). Complications were reported significantly more frequently in patients treated with ESD for a tumor measuring 11 mm or larger (p<0.05) in comparison those treated with m-EAM. There was no significant difference between the two groups with regard to the curability and the days of postoperative hospitalization.
This study confirmed the efficacy of the ESD procedure which enables surgeons to perform a more reliable en bloc tumor resection.
Anticancer research 10/2009; 29(10):4271-4. · 1.73 Impact Factor
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Masano Sagawa,
Takao Katsube,
Soichi Konno,
Minoru Murayama,
Kentarou Yamaguchi,
Noriyuki Isohata,
Kazuhiko Yoshimatsu,
Shunichi Shiozawa,
Takeshi Shimakawa, Yoshihiko Naritaka,
Kenji Ogawa
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ABSTRACT: We evaluated the role of the prognostic nutritional index reported by Onodera (Onodera's PNI) in patients with gastrointestinal cancer regarding the occurrence of postoperative complications.
Subjects were 324 patients (42 with esophageal cancer, 107 with gastric cancer, and 175 with colon cancer). We classified them into the high risk group (< or = 40) and the non-high risk group (> 40) according to Onodera's PNI. We evaluated the rate of the occurrence of postoperative complications between the high risk group and the non-high risk group.
The rate of postoperative complications occurring in the high risk group was higher than that of the non-high risk group (p=0.04).
Onodera's PNI is useful for patients with gastrointestinal cancer regarding the occurrence of postoperative complications.
Gan to kagaku ryoho. Cancer & chemotherapy 11/2008; 35(12):2253-5.
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ABSTRACT: Non-curative resection for cholangiocarcinoma usually leads to a poor prognosis. We present a case successfully treated with gemcitabine for residual tumor after extra hepatic bile duct resection with positive surgical margin. The patient was a 77-year-old male who was diagnosed as having a common bile duct cancer. Extra hepatic bile duct resection was performed, but intraoperative pathology diagnosed the surgical margin of duodenal-side bile duct was positive for cancer. Although additional resection of bile duct was done, pathological diagnosis resulted in positive margin again. We had to avoid pancreatoduodenectomy in light of the patient's wishes, so a curative resection could not be carried out. Adjuvant chemotherapy with gemcitabine(800 mg/m2 on days 1, 8 and 15 every 4 weeks)was started at the seventh postoperative day. A residual lesion was shown in the pancreas head by abdominal CT after 2 courses of chemotherapy. Follow-up CT was performed every 6 months, and the lesion gradually seemed to become unclear. Finally, CT showed disappearance of the residual lesion 28 months after surgery. The chemotherapy has been continued up to the present(3 years and 5 months after surgery). No evidence of recurrence nor adverse events of WHO grade 2 or more has been observed.
Gan to kagaku ryoho. Cancer & chemotherapy 07/2008; 35(7):1229-31.
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ABSTRACT: We present a case of interstitial pneumonitis induced by gemcitabine. The patient was a 48-year-old male who underwent pancreaticoduodenectomy with portal vein resection for ductal adenocarcinoma of the pancreas head. Twenty-two days after operation, adjuvant chemotherapy with gemcitabine(1,000 mg/m(2) on days 1, 8 and 15 every 4 weeks)was started. During three courses of chemotherapy, no adverse event of WHO grade 2 or more was observed. Seven days after the last infusion, fever and consciousness disorder emerged without respiratory symptoms. Arterial blood gas analysis revealed severe hypoxemia. Chest X-ray and CT showed diffuse bilateral interstitial infiltrates. Oxygenation and respiratory support were immediately given, and steroid pulse therapy with 1,000 mg/day of methylprednisolone was started. His symptoms and radiolographical findings were dramatically improved. The patient could be discharged on the 14th day after admission. Acute pulmonary toxicity induced by gemcitabine is rare, but could lead to severe complications. The review of reported cases showed the effectiveness of corticosteroid therapy for pulmonary toxicity due to the agent.
Gan to kagaku ryoho. Cancer & chemotherapy 02/2008; 35(1):133-6.
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Shunichi Shiozawa,
Akira Tsuchiya,
Dal Ho Kim,
Takebumi Usui,
Satoshi Inose,
Masaki Aizawa,
Toshio Masuda,
Kazuhiko Yoshimatsu,
Takao Katsube, Yoshihiko Naritaka,
Kenji Ogawa
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ABSTRACT: We evaluated a clinical usefulness and safety of transradial approach for transcatheter arterial chemoembolization (TAE) in patients with unresectable and recurrent hepatocellular carcinoma (HCC) compared with that of conventional transfemoral approach. The two groups (radial group; n=385, 1999.7-2007.3, femoral group; n=150, 1997.4-1999.6) of cases were retrospectively compared with regard to the successful rate of angiography, TAE, interventional time, Lipiodol retention pattern and complications. Hepatic angiography and TAE were completed in 379 (98.4%) of 385 cases in the radial group. There was no inter-group difference of interventional time. Minor complications (dull pain or numbness of puncture site) occurred in 29 (7.6%) patients in the radial group. Transradial approach has some advantages as follows: (1) No time will be required to stop breeding after removal of sheath. (2) The patient may freely walk after the examination. TAE by our new transradial approach for HCC was found to have a therapeutic efficacy with lower complications comparable to that of conventional transfemoral approach.
Gan to kagaku ryoho. Cancer & chemotherapy 12/2007; 34(12):2096-8.
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ABSTRACT: In this study, we investigated a short-term outcome of 56 cases of ESD for early gastric cancer performed in our department concerning the tumor diameter within or over 20 mm. Seventeen lesions were larger than 21 mm (large group), and 39 lesions were within 20 mm (indication group). There was no significant difference in the background factors between the two groups. The mean operating time and median of post operative hospital stay of the large group were longer than those of the indication group, and those differences were statistically significant. On the other hand, no significant difference was seen in the rate of one-piece resection, the incidence of complications and curability. With a further improvement of our skills, an ESD application in a case where the tumor diameter is larger than 21 mm may be extended.
Gan to kagaku ryoho. Cancer & chemotherapy 12/2007; 34(12):2153-5.
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Yoshihiko Naritaka,
Shunichi Shiozawa,
Takeshi Shimakawa,
Yoshihisa Wagatsuma,
Akira Tsuchiya,
Dal Ho Kim,
Noriyuki Isohata,
Shinichi Asaka,
Kazuhiko Yoshimatsu,
Takao Katsube,
Kenji Ogawa
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ABSTRACT: Transradial vascular intervention for heart disease has been expanding recently because it is less invasive, but this approach has only been used to treat abdominal disease at a few institutions. Since 2000, we have performed partial splenic embolization (PSE) via the transradial approach with the aim of achieving the least invasive procedure possible.
During the past five years, transradial abdominal angiography was performed in 426 patients and eight of them (two men and six women undergoing PSE for LC) were included in this study. They ranged from 48 years to 72 years in age, consisting of three patients in Child class A and five in Child class B. To perform transradial partial splenic embolization, a 4-Fr sheath was inserted in the left radial artery. Under fluoroscopy, intrasplenic branches of the splenic artery supplying about 60-70% of the parenchyma of the spleen were selected and embolized with a newly developed transradial catheter inserted along a guide wire running through the descending aorta. After treatment, the puncture site was compressed by applying a tourniquet. No restriction on movement of the lower or upper extremities is required and the patient is allowed to walk freely.
Transradial embolization was successful in all 8 patients. The procedure required 70 minutes on average. The mean platelet count was 3.3x10(4)/microL before treatment, and it increased to 16.3x10(4) and 11.3x10(4)/microL after two weeks and three months, respectively. All patients suffered from fever and pain after treatment, which were treated conservatively. Occlusion of the radial artery, digital paralysis, or splenic abscess did not occur in any patient.
This transcatheter technique facilitates hemostasis and requires neither shaving of hair nor insertion of a urinary catheter. In addition, no restriction on movement is needed after the procedure. Consequently, this minimally invasive transradial approach is highly satisfactory for patients and should become a first-line approach for PSE.
Hepato-gastroenterology 10/2007; 54(78):1850-3. · 0.66 Impact Factor
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ABSTRACT: Gastric emptying after PPG is directly associated with postoperative QOL. Few studies have investigated gastric emptying after a gastrectomy for stomach cancer using carbon-labeled acetic acid breath test.
We analyzed gastric emptying in 28 patients who underwent a gastrectomy for gastric carcinoma. Among the patients, 14 underwent pylorus-preserving gastrectomy and 14 underwent distal gastrectomy. We recruited 15 healthy subjects as controls. Gastric emptying was evaluated with the 13C-Acetic acid breath test was performed. Postprandial breath samples were collected at a 15-min interval for 2 hours and at a 30-min interval thereafter. We calculated the ratio of (13)CO2 expired per hour and determined the time required to reach peak (13)CO2 expiration level.
The time required to reach peak (13)C02 expiration level were 1.78 hours for the patients who underwent pylorus-preserving gastrectomy, 1.19 hours for the control group and 0.70 hours for the patients who underwent distal gastrectomy.
Our 13C-Acetic acid breath test following an intake of solid foods showed that gastric retention can be preserved after a pylorus-preserving gastrectomy.
Hepato-gastroenterology 04/2007; 54(74):639-42. · 0.66 Impact Factor
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ABSTRACT: TS-1/CPT-11 treatment for the patients with advanced colorectal cancer is expected to be equal to FOLFOX and FOLFIRI regimen. The aim of this study was to investigate the relationship between host immunity and this regimen. Four patients were enrolled in this study. Host immunity was investigated before and after chemotherapy. PHA response, serum IAP level and the productions of any cytokines did not change significantly before and after the chemotherapy. Although these changes were not significant: both Th1/Th2 ratio and NK cells ratio were decreased, and the ratio of suppressor T cells was increased. These results suggest that TS-1/CPT-11 regimen may influence host immunity a little bit worse.
Gan to kagaku ryoho. Cancer & chemotherapy 11/2005; 32(11):1589-91.
