Brad Petrisor

McMaster University, Hamilton, Ontario, Canada

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Publications (63)210.69 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Objectives: The objectives of this systematic review and meta-analyses are: 1) to estimate the prevalence of hypovitaminosis D in fracture patients and 2) to summarize the available evidence on the efficacy of vitamin D supplementation in fracture patients. Data sources: A comprehensive search of the MEDLINE, Embase, PubMed, and Cochrane Central Register of Controlled Trials databases was conducted. Conference abstracts from relevant meetings were also searched. Study selection: We included studies that investigate vitamin D insufficiency or examine the effect of vitamin D supplementation on 25(OH)D serum levels in fracture patients. Data extraction: Two authors independently extracted data using a pre-designed form. Data synthesis: We performed a pooled analysis to determine the prevalence of post-fracture hypovitaminosis D and mean post-fracture 25(OH)D levels. We present detailed summaries of each of the studies evaluating the impact of vitamin D supplementation. Results: The weighted pooled prevalence of hypovitaminosis D was 70.0% (95% CI: 63.7-76.0%, I = 97.7). The mean post-fracture serum 25(OH)D was 19.5 ng/ml. The studies that evaluated the efficacy of vitamin D supplementation suggest that vitamin D supplementation safely increases serum 25(OH)D levels. Only one meeting abstract showed a trend towards reduced risk of nonunion following a single large loading dose of vitamin D. Conclusions: This review found a high prevalence of hypovitaminosis D in fracture patients and that vitamin D supplementation at a range of doses safely increases 25(OHD) serum levels. To date, only one pilot study published as a meeting abstract has demonstrated a trend towards improved fracture healing with vitamin D supplementation. Level of evidence: Level IV.
    Journal of Orthopaedic Trauma 09/2015; DOI:10.1097/BOT.0000000000000455 · 1.80 Impact Factor
  • 06/2015; 3(6):e2-e2. DOI:10.2106/JBJS.RVW.N.00088
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    ABSTRACT: Intimate partner violence (IPV) is a serious global issue that results in a large number of injuries and deaths among women. Educating clinicians about IPV can help providers identify, prevent, and treat victims, and, ultimately, improve care for victims of abuse. We sought to determine the effect of a half-day educational course on IPV for orthopaedic surgical trainees on knowledge and attitudes. We asked (1) whether a half-day educational course on IPV can improve orthopaedic surgical trainees' knowledge and (2) attitudes regarding IPV; and (3) whether a course on IPV can be accepted and viewed as valuable by trainees? Using published research on IPV in patients with musculoskeletal injuries, we developed a half-day educational course. The curriculum included lectures and discussion regarding the basics of IPV, the current state of IPV research, what to do when a patient is a victim or perpetrator, and the orthopaedic surgeon's role in recognizing, preventing, and assisting with IPV. All 33 course participants (30 men and three women), all orthopaedic surgical trainees, completed a questionnaire that included general true or false or agree or disagree statements regarding their knowledge, attitudes, and practices of IPV in the musculoskeletal setting; the questionnaire also included a knowledge test of 25 true or false statements. The questionnaire was administered immediately before, immediately after, and 3 months after the course; 76% (25 of 33) took the test immediately after the course and 82% (27 of 33) completed the test at 3 months. Participant knowledge scores were compared across the three different times to determine the effect of the course. Participants increased their knowledge after the course, and the increased knowledge was retained at retesting at 3 months; the mean percentage of correct answers before the course was 57%, which increased to 73% after the course, and was 68% 3 months later (F = 9.505; p = 0.001). Before the course, most of the course participants (30 of 32; 94%) agreed that IPV is an important issue; agreement increased to 100% immediately after the course. The largest change in attitude was in response to the statement: "I am skeptical that the health care system has the resources to screen for IPV." Before the course, 53% (17 of 32) of trainees endorsed this statement, but the percent decreased to 36% (nine of 25) after the course and remained low at 33% (nine of 27), at the 3-month test. Our findings show that a short course on IPV in patients with musculoskeletal injuries led to an improvement and retention of knowledge 3 months after the course. Based on our findings, we recommend that IPV education be integrated in training programs for orthopaedic surgeons. Future projects should focus on developing and implementing a sustainable education program that can affect practice for healthcare professionals and trainees in multiple clinical settings.
    Clinical Orthopaedics and Related Research 04/2015; 473(7). DOI:10.1007/s11999-015-4325-7 · 2.77 Impact Factor
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    ABSTRACT: Conventional meta-analyses quantify the relative effectiveness of two interventions based on direct (that is, head-to-head) evidence typically derived from randomized controlled trials (RCTs). For many medical conditions, however, multiple treatment options exist and not all have been compared directly. This issue limits the utility of traditional synthetic techniques such as meta-analyses, since these approaches can only pool and compare evidence across interventions that have been compared directly by source studies. Network meta-analyses (NMA) use direct and indirect comparisons to quantify the relative effectiveness of three or more treatment options. Interpreting the methodologic quality and results of NMAs may be challenging, as they use complex methods that may be unfamiliar to surgeons; yet for these surgeons to use these studies in their practices, they need to be able to determine whether they can trust the results of NMAs. The first judgment of trust requires an assessment of the credibility of the NMA methodology; the second judgment of trust requires a determination of certainty in effect sizes and directions. In this Users' Guide for Surgeons, Part I, we show the application of evaluation criteria for determining the credibility of a NMA through an example pertinent to clinical orthopaedics. In the subsequent article (Part II), we help readers evaluate the level of certainty NMAs can provide in terms of treatment effect sizes and directions.
    Clinical Orthopaedics and Related Research 04/2015; 473(7). DOI:10.1007/s11999-015-4286-x · 2.77 Impact Factor
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    ABSTRACT: In the previous article (Network Meta-analysis: Users' Guide for Surgeons-Part I, Credibility), we presented an approach to evaluating the credibility or methodologic rigor of network meta-analyses (NMA), an innovative approach to simultaneously addressing the relative effectiveness of three or more treatment options for a given medical condition or disease state. In the second part of the Users' Guide for Surgeons, we discuss and demonstrate the application of criteria for determining the certainty in effect sizes and directions associated with a given treatment option through an example pertinent to clinical orthopaedics.
    Clinical Orthopaedics and Related Research 04/2015; 473(7). DOI:10.1007/s11999-015-4287-9 · 2.77 Impact Factor
  • R. Mundi · H. Chaudhry · G. Niroopan · B. Petrisor · M. Bhandari
    02/2015; 3(2):e1-e1. DOI:10.2106/JBJS.RVW.N.00051
  • 01/2015; 3(6):e2.
  • Harman Chaudhry · Nicole Simunovic · Brad Petrisor
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    ABSTRACT: Importance of the TopicMore than 650,000 ankle sprains present to emergency departments in the United States for treatment every year [14]. The vast majority of these sprains are injuries to the lateral ligament complex resulting from a forceful inversion of the ankle joint during physical activity [7]. The impact of a lateral ligament complex sprain is experienced through acute pain and swelling, several weeks of acute disability resulting in time lost from work or other activities, and in as many as 20% of patients, chronic instability of the ankle joint [1, 7].Anatomically, lateral ligament sprains are almost always localized to the anterior talofibular ligament. The calcaneofibular ligament is also involved in 50% to 75% of sprains [2]. The third ligament of the lateral ligament complex – the posterior talofibular ligament – is rarely involved. In cases of chronic instability, anatomic reconstructive procedures (as originally described by Brostrom [4] and subsequently modified) fre ...
    Clinical Orthopaedics and Related Research 10/2014; 473(1). DOI:10.1007/s11999-014-4018-7 · 2.77 Impact Factor
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    ABSTRACT: Background: The World Health Organization estimates that more than 15% of the global burden of road traffic trauma is in India. We performed an image-based survey of 3 major roadways in New Delhi, India, to evaluate collision-prone vehicle and pedestrian behaviors. Methods: We used a cross-sectional survey design with photograph- and video-based data collection. The study was performed at 3 purposively sampled high traffic volume roadways in New Delhi, India. The authors reviewed preliminary photographs and came to a consensus pertaining to the definition and criteria for dangerous and collision-prone behaviors. Analysis was descriptive and was based on frequency data. Results: A total of 11,214 subjects were evaluated. Eighty-six percent were vehicles (n = 9624), whereas the remaining 14% were pedestrians (n = 1572). In 99% of the frames, 1 or more predefined behavioral infraction was identified, with a total of 21% (n = 2392) of subjects committing these infractions. Specifically, 15% of all vehicles (n = 1468) and 59% of all pedestrians (n = 924) displayed a risk-taking infraction. Conclusions: Road users in New Delhi, India, engage in unacceptably high rates of collision-prone behavior. There is a need for interventions that will improve the behaviors of road users.
    Journal of orthopaedic trauma 06/2014; 28 Suppl 1:S30-S32. DOI:10.1097/BOT.0000000000000115 · 1.80 Impact Factor
  • Kevin Chan · Brad Petrisor · Mohit Bhandari
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    ABSTRACT: Emotional intelligence (EI) is the ability to understand and manage emotions in oneself and others. It was originally popularized in the business literature as a key attribute for success that was distinct from cognitive intelligence. Increasing focus is being placed on EI in medicine to improve clinical and academic performance. Despite the proposed benefits, to our knowledge, there have been no previous studies on the role of EI in orthopedic surgery. We evaluated baseline data on EI in a cohort of orthopedic surgery residents. We asked all orthopedic surgery residents at a single institution to complete an electronic version of the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT). We used completed questionnaires to calculate total EI scores and 4 branch scores. Data were analyzed according to a priori cutoff values to determine the proportion of residents who were considered competent on the test. Data were also analyzed for possible associations with age, sex, race and level of training. Thirty-nine residents (100%) completed the MSCEIT. The mean total EI score was 86 (maximum score 145). Only 4 (10%) respondents demonstrated competence in EI. Junior residents (p = 0.026), Caucasian residents (p = 0.009) and those younger than 30 years (p = 0.008) had significantly higher EI scores. Our findings suggest that orthopedic residents score low on EI based on the MSCEIT. Optimizing resident competency in noncognitive skills may be enhanced by dedicated EI education, training and testing.
    Canadian journal of surgery. Journal canadien de chirurgie 04/2014; 57(2):89-93. DOI:10.1503/cjs.022512 · 1.51 Impact Factor
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    ABSTRACT: Assessing fracture healing in clinical trials is subjective. The new Function IndeX for Trauma (FIX-IT) score provides a simple, standardized approach to assess weight-bearing and pain in patients with lower extremity fractures. We conducted an initial validation of the FIX-IT score. We conducted a cross-sectional study involving 50 patients with lower extremity fractures across different stages of healing to evaluate the reliability and preliminary validity of the FIX-IT score. Patients were independently examined by 2 orthopedic surgeons, 1 orthopedic fellow, 2 orthopedic residents and 2 research coordinators. Patients also completed the Short Form-36 version 2 (SF-36v2) questionnaire, and convergent validity was tested with the SF-36v2. For interrater reliability, the intraclass correlation coefficents ranged from 0.637 to 0.915. The overall interrater reliability for the total FIX-IT score was 0.879 (95% confidence interval 0.828-0.921). The correlations between the FIX-IT score and the SF-36 ranged from 0.682 to 0.770 for the physical component summary score, from 0.681 to 0.758 for the physical function subscale, and from 0.677 to 0.786 for the role-physical subscale. The FIX-IT score had high interrater agreement across multiple examiners. Moreover, FIX-IT scores correlate with the physical scores of the SF-36. Although additional research is needed to fully validate FIX-IT, our results suggest the potential for FIX-IT to be a reliable adjunctive clinician measure to evaluate healing in lower extremity fractures. Diagnostic Study Level I.
    Canadian journal of surgery. Journal canadien de chirurgie 10/2013; 56(5):E114-20. DOI:10.1503/cjs.004312 · 1.51 Impact Factor
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    ABSTRACT: Background: Approximately one-third of injured women presenting to fracture clinics have experienced some form of intimate partner violence in the past year. The aim of the current study was to determine patients’ perceptions on screening for intimate partner violence during visits to a surgical fracture clinic. Methods: We conducted a cross-sectional study to evaluate patients’ perceptions and opinions on screening for inti- mate partner violence in an orthopaedic fracture clinic. Eligible patients anonymously completed a self-reported written questionnaire, which included questions on patient demographics, attitudes toward intimate partner violence in general, the acceptability of screening for intimate partner violence in an orthopaedic fracture clinic, and opinions on how, when, and by whom the screening should be conducted. Results: The study included 750 patients (421 male and 329 female) at five clinical sites in Canada and the Netherlands. The majority (554, 73.9%) of the respondents either ‘‘agreed’’ or ‘‘strongly agreed’’ that the fracture clinic was a good place for health-care providers to ask about intimate partner violence. The majority (671, 89.5%) also agreed that health- care providers should screen for intimate partner violence by means of face-to-face interactions rather than other, more passive methods. Increased openness to screening was significantly associated with female sex, higher income, and higher education (F3595 = 21.950, p < 0.001). Conclusions: Our findings demonstrated that the majority of patients endorse active screening for intimate partner violence in orthopaedic fracture clinics.
    The Journal of Bone and Joint Surgery 07/2013; 95(91):1-10. DOI:10.2106/JBJS.L.01326 · 5.28 Impact Factor
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    ABSTRACT: Background Intimate partner violence (IPV) is the leading cause of non-fatal injury to women worldwide. Musculoskeletal injuries, which are often seen by orthopaedic surgeons, are the second most common manifestation of IPV. We aimed to establish the 12-month and lifetime prevalence of IPV in women presenting to orthopaedic fracture clinics. Methods The PRAISE team of 80 investigators did a cross-sectional study of a consecutive sample of 2945 female participants at 12 orthopaedic fracture clinics in Canada, the USA, the Netherlands, Denmark, and India. Participants who met the eligibility criteria anonymously answered direct questions about physical, emotional, and sexual IPV, and completed two previously developed questionnaires (Women Abuse Screening Tool [WAST] and Partner Violence Screen [PVS]). We did a multivariable logistic regression analysis to investigate the risk factors associated with IPV. Findings The overall response rate was 85% (2344 of 2759 patients provided informed consent). One in six women (455/2839, 16·0%, 95% CI 14·7–17·4%) disclosed a history of IPV within the past year, and one in three (882/2550, 34·6%, 32·8–36·5%) had experienced IPV in their lifetime. 49 women (1·7%, 1·3–2·2%) attended their clinic visit as a direct consequence of IPV, only seven of whom (14%) had ever been asked about IPV in a health-care setting. Women in short-term relationships (OR 0·584, 99% CI 0·396–0·860, p=0·0001) were at increased risk of IPV and physical abuse in the past 12 months in this study. Compared with women in Canada and the USA, those in the Netherlands and Denmark were at reduced risk of any abuse in the past 12 months, physical abuse in lifetime, and any abuse in lifetime (OR 0·595, 99% CI 0·427–0·830, p<0·0001; 0·630, 0·445–0·890, p=0·001; and 0·464, 0·352–0·612, p<0·0001, respectively). Interpretation PRAISE is the largest prevalence study done so far in orthopaedics. Orthopaedic surgeons should be confi dent in the assumption that one in six women have a history of physical abuse, and that one in 50 injured women will present to the clinic as a direct result of IPV. Our fi ndings warrant serious consideration for fracture clinics to improve identifi cation of, respond to, and provide referral services for, victims of IPV.
    The Lancet 06/2013; DOI:10.1016/S0140-6736(13)61205-2 · 45.22 Impact Factor
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    ABSTRACT: Objective: The assessment of fracture healing following intertrochanteric fracture fixation is highly variable with no validated standards. Agreement with respect to fracture healing following surgery is important for optimal patient management. The purpose of this study was to (1) assess reliability of intertrochanteric fracture healing assessment and (2) determine if a novel radiographic scoring system for hip fractures improves agreement between radiologists and orthopedic surgeons. Materials and methods: A panel of three radiologists and three orthopedic surgeons assessed fracture healing in 150 cases of intertrochanteric fractures at two separate time points to determine inter-rater and intra-rater agreement. Reviewers, blinded to the time after injury, first subjectively assessed overall healing using frontal and lateral radiographs for each patient at a single time point. Reviewers then scored each fracture using a Radiographic Union Score for Hip (RUSH) form to determine whether this improves agreement regarding hip fracture healing. Results: Inter-rater agreement for the overall subjective impression of fracture healing between reviewer groups was only fair (intraclass coefficient [ICC] = 0.34, 95 % CI: 0.11-0.52. Use of the RUSH score improved overall agreement between groups to substantial (ICC = 0.66, 95 % CI: 0.53-0.75). Across reviewers, healing of the medial cortex and overall RUSH score itself demonstrated high correlations with overall perceptions of healing (r = 0.53 and r = 0.72, respectively). Conclusions: The RUSH score improves agreement of fracture healing assessment between orthopedic surgeons and radiologists, offers a systematic approach to evaluating intertrochanteric hip fracture radiographs, and may ultimately provide prognostic information that could predict healing outcomes in patients with femoral neck fractures.
    Skeletal Radiology 04/2013; 42(8). DOI:10.1007/s00256-013-1605-8 · 1.51 Impact Factor
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    ABSTRACT: Background Intimate Partner Violence (IPV) is a major health issue that involves any physical, sexual or psychological harm inflicted by a current or former partner. Musculoskeletal injuries represent the second most prevalent clinical manifestation of IPV. Health care professionals, however, rarely screen women for IPV. Using qualitative methods, this study aimed to explore the perceived barriers to IPV screening and potential facilitators for overcoming these barriers among orthopaedic surgeons and surgical trainees. Methods We conducted three focus groups with orthopaedic surgeons, senior surgical trainees, and junior surgical trainees. A semi-structured focus group guide was used to structure the discussions. Transcripts and field notes from the focus groups were analyzed using the qualitative software program N’Vivo (version 10.0; QSR International, Melbourne, Australia). To further inform our focus group findings and discuss policy changes, we conducted interviews with two opinion leaders in the field of orthopaedics. Similar to the focus groups, the interviews were digitally recorded and transcribed, and then analyzed. Results In the analysis, four categories of barriers were identified: surgeon perception barriers; perceived patient barriers; fracture clinic barriers and orthopaedic health care professional barriers. Some of the facilitators identified included availability of a crisis team; development of a screening form; presence of IPV posters or buttons in the fracture clinic; and the need for established policy or government support for IPV screening. The interviewees identified the need for: the introduction of evidence-based policy aiming to increase awareness about IPV among health care professionals working within the fracture clinic setting, fostering local and national champions for IPV screening, and the need to generate change on a local level. Conclusions There are a number of perceived barriers to screening women in the fracture clinic for IPV, many of which can be addressed through increased education and training, and additional resources in the fracture clinic. Orthopaedic health care professionals are supportive of implementing an IPV screening program in the orthopaedic fracture clinic.
    BMC Musculoskeletal Disorders 04/2013; 14(1):122. DOI:10.1186/1471-2474-14-122 · 1.72 Impact Factor
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    ABSTRACT: Background Tibial shaft fractures are the most common long bone fracture and are prone to complications such as nonunion requiring reoperations to promote fracture healing. We aimed to determine the fracture characteristics associated with tibial fracture nonunion, and their predictive value on the need for reoperation. We further aimed to evaluate the predictive value of a previously-developed prognostic index of three fracture characteristics on nonunion and reoperation rate. Methods We conducted an observational study and developed a risk factor list from previous literature and key informants in the field of orthopaedic surgery, as well as via a sample-to-redundancy strategy. We evaluated 22 potential risk factors for the development of tibial fracture nonunion in 200 tibial fractures. We also evaluated the predictive value of a previously-identified prognostic risk index on secondary intervention and/or reoperation rate. Two individuals independently extracted the data from 200 patient electronic medical records. An independent reviewer assessed the initial x-ray, the post-operative x-ray, and all available sequential x-rays. Regression and chi-square analysis was used to evaluate potential associations. Results In our cohort of patients, 37 (18.5%) had a nonunion and 27 (13.5%) underwent a reoperation. Patients with a nonunion were 97 times (95% CI 25.8-366.5) more likely to have a reoperation. Multivariable logistic regression revealed that fractures with less than 25% cortical continuity were predictive of nonunion (odds ratio = 4.72; p = 0.02). Such fractures also accounted for all of the reoperations identified in our sample. Furthermore, our data provided preliminary validation of a previous risk index predictive of reoperation that includes the presence of a fracture gap post-fixation, open fracture, and transverse fracture type as variables, with an aggregate of fracture gap and an open fracture yielding patients with the highest risk of developing a nonunion. Conclusions We identified a significant association between degree of cortical continuity and the development of a nonunion and risk for reoperation in tibial shaft fractures. In addition, our study supports the predictive value of a previous prognostic index, which inform discussion of prognosis following operative management of tibial fractures.
    BMC Musculoskeletal Disorders 03/2013; 14(1):103. DOI:10.1186/1471-2474-14-103 · 1.72 Impact Factor
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    ABSTRACT: Background Despite the prominence of hip fractures in orthopedic trauma, the assessment of fracture healing using radiographs remains subjective. The variability in the assessment of fracture healing has important implications for both clinical research and patient care. With little existing literature regarding reliable consensus on hip fracture healing, this study was conducted to determine inter-rater reliability between orthopedic surgeons and radiologists on healing assessments using sequential radiographs in patients with hip fractures. Secondary objectives included evaluating a checklist designed to assess hip fracture healing and determining whether agreement improved when reviewers were aware of the timing of the x-rays in relation to the patients’ surgery. Methods A panel of six reviewers (three orthopedic surgeons and three radiologists) independently assessed fracture healing using sequential radiographs from 100 patients with femoral neck fractures and 100 patients with intertrochanteric fractures. During their independent review they also completed a previously developed radiographic checklist (Radiographic Union Score for Hip (RUSH)). Inter and intra-rater reliability scores were calculated. Data from the current study was compared to the findings from a previously conducted study where the same reviewers, unaware of the timing of the x-rays, completed the RUSH score. Results The agreement between surgeons and radiologists for fracture healing was moderate for “general impression of fracture healing” in both femoral neck (ICC = 0.60, 95% CI: 0.42-0.71) and intertrochanteric fractures (0.50, 95% CI: 0.33-0.62). Using a standardized checklist (RUSH), agreement was almost perfect in both femoral neck (ICC = 0.85, 95% CI: 0.82-0.87) and intertrochanteric fractures (0.88, 95% CI: 0.86-0.90). We also found a high degree of correlation between healing and the total RUSH score using a Receiver Operating Characteristic (ROC) analysis, there was an area under the curve of 0.993 for femoral neck cases and 0.989 for intertrochanteric cases. Agreement within the radiologist group and within the surgeon group did not significantly differ in our analyses. In all cases, radiographs in which the time from surgery was known resulted in higher agreement scores compared to those from the previous study in which reviewers were unaware of the time the radiograph was obtained. Conclusions Agreement in hip fracture radiographic healing may be improved with the use of a standardized checklist and appears highly influenced by the timing of the radiograph. These findings should be considered when evaluating patient outcomes and in clinical studies involving patients with hip fractures. Future research initiatives are required to further evaluate the RUSH checklist.
    BMC Musculoskeletal Disorders 02/2013; 14(1):70. DOI:10.1186/1471-2474-14-70 · 1.72 Impact Factor
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    ABSTRACT: Objectives: This study was conducted to determine interrater and intrarater reliabilities on the healing assessment of femoral neck fractures between orthopedic surgeons and radiologists and to test the performance of a checklist system for hip fracture healing. Methods: We developed and used a scoring system [radiographic union score in hip fracture (RUSH) score] to determine the validity of quantifying fracture healing. A panel of 6 reviewers (3 orthopedic surgeons and 3 radiologists) independently assessed fracture healing with the RUSH system using radiographs of 150 femoral neck fractures at various stages in healing on 2 occasions 4 weeks apart. Results: Using subjective assessment, the interrater agreement between reviewer groups for fracture healing was fair [intraclass coefficient = 0.22, 95% confidence interval (CI): 0.01-0.41] with no significant difference in agreement within the orthopedic surgeon and radiologist groups (0.17 vs. 0.21). There was higher agreement for fracture healing using the RUSH score (intraclass coefficient = 0.53, 95%CI: 0.30-0.69) compared with physician impression of healing, highlighting the difficulties with plain radiographic assessments of healing. Intrarater agreement was consistently high across all measures for both surgeons and radiologists. The RUSH score and medial cortex bridging correlated well with overall assessment of healing (r = 0.868 and 0.643, respectively). Conclusions: The level of agreement between and within orthopedic surgeon and radiologist reviewers in the assessment of fracture healing is low, though intrarater agreement is high. The RUSH score shows promise as a tool to improve agreement on fracture healing. Studies evaluating reliability and accuracy of healing with clinical information and temporal evaluation are needed and may further improve agreement.
    Journal of orthopaedic trauma 01/2013; 27(9). DOI:10.1097/BOT.0b013e318282e692 · 1.80 Impact Factor
  • Michelle Ghert · Brad Petrisor
    The Journal of Bone and Joint Surgery 07/2012; 94 Suppl 1(Suppl 1(E)):61-4. DOI:10.2106/JBJS.L.00272 · 5.28 Impact Factor
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    ABSTRACT: Deep infection following endoprosthetic limb reconstruction for sarcoma of the long bones is a devastating complication occurring in 15% of sarcoma patients. Optimizing infection protocols and conducting definitive surgical trials are critical to improving outcomes. In this study, the PARITY (Prophylactic Antibiotic Regimens in Tumor Surgery) investigators aimed to examine surgeon preferences in antibiotic prophylaxis and perceptions about current evidence, as well as to ascertain interest in resolving uncertainty in the evidence with clinical trials. We used a cross-sectional survey to examine current practice in the prescription of prophylactic antibiotics in Musculoskeletal Tumor Surgery. The survey was approved by our institution's Ethics Board and emailed to all Active Members of the Musculoskeletal Tumor Society (MSTS) and Canadian Orthopaedic Oncology Society (CANOOS). Survey answers were collected using an anonymous online survey tool. Of the 96 surgeons who received the questionnaire, 72 responded (75% response rate (% CI: 65.5, 82.5%)). While almost all respondents agreed antibiotic regimens were important in reducing the risk of infection, respondents varied considerably in their choices of antibiotic regimens and dosages. Although 73% (95% CI: 61, 82%) of respondents prescribe a first generation cephalosporin, 25% favor additional coverage with an aminoglycoside and/or Vancomycin. Of those who prescribe a cephalosporin, 33% prescribe a dosage of one gram for all patients and the reminder prescribe up to 2 grams based on body weight. One in three surgeons (95% CI: 25, 48%) believes antibiotics could be discontinued after 24 hours but 40% (95% CI: 30, 53%) continue antibiotics until the suction drain is removed. Given the ongoing uncertainty in evidence to guide best practices, 90% (95% CI: 81, 95%) of respondents agreed that they would change their practice if a large randomized controlled trial showed clear benefit of an antibiotic drug regimen different from what they are currently using. Further support for a clinical trial was observed by an overwhelming surgeon interest (87%; 95% CI: 77, 93%) in participating in a multi-center randomized controlled study. The current lack of guidelines for the prescription of prophylactic antibiotics in Musculoskeletal Tumor Surgery has left Orthopaedic Oncologists with varying opinions and practices. The lack of current evidence and strong surgeon support for participating in a definitive study provides strong rationale for clinical trials.
    BMC Musculoskeletal Disorders 06/2012; 13:91. DOI:10.1186/1471-2474-13-91 · 1.72 Impact Factor

Publication Stats

770 Citations
210.69 Total Impact Points


  • 2006–2015
    • McMaster University
      • • Department of Surgery
      • • Department of Clinical Epidemiology and Biostatistics
      Hamilton, Ontario, Canada
  • 2011
    • Hamilton College
      Клинтон, New York, United States
  • 2005–2009
    • Hamilton Health Sciences
      Hamilton, Ontario, Canada