Yuji Hirata

Publications (42)179.18 Total impact

• Article: Multiple cytokine- and chemokine-producing T-cell/histiocyte-rich large B-cell lymphoma.

  Shoko Nakayama, Taiji Yokote, Yuji Hirata, Kazuki Iwaki, Motomu Tsuji, Toshiaki Hanafusa
  British Journal of Haematology 12/2012; · 4.94 Impact Factor
• Article: Central nervous system infiltration of a multiple cytokine-producing double-hit B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma with CC chemokine receptor 7 expression.

  Shoko Nakayama, Taiji Yokote, Kazuki Iwaki, Nobuya Hiraoka, Yuji Hirata, Toshikazu Akioka, Takuji Miyoshi, Ayami Takayama, Uta Nishiwaki, Yuki Masuda, Motomu Tsuji, Toshiaki Hanafusa
  Acta oncologica (Stockholm, Sweden) 12/2012; · 2.27 Impact Factor
• Article: A rare case of primary clear cell sarcoma of the pubic bone resembling small round cell tumor: an unusual morphological variant.

  Shoko Nakayama, Taiji Yokote, Kazuki Iwaki, Toshikazu Akioka, Takuji Miyoshi, Yuji Hirata, Ayami Takayama, Uta Nishiwaki, Yuki Masuda, Motomu Tsuji, Toshiaki Hanafusa
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  ABSTRACT: BACKGROUND: Clear cell sarcoma (CCS) and malignant melanoma share overlapping immunohistochemistry with regard to the melanocytic markers HMB45, S100, and Melan-A. However, the translocation t(12; 22)(q13; q12) is specific to CCS. Therefore, although these neoplasms are closely related, they are now considered to be distinct entities. However, the translocation is apparently detectable only in 50%--70% of CCS cases. Therefore, the absence of a detectable EWS/AFT1 rearrangement may occasionally lead to erroneous exclusion of a translocation-negative CCS. Therefore, histological assessment is essential for the correct diagnosis of CCS. Primary CCS of the bone is exceedingly rare. Only a few cases of primary CCS arising in the ulna, metatarsals, ribs, radius, sacrum, and humerus have been reported, and primary CCS arising in the pubic bone has not been reported till date. CASE PRESENTATION: We present the case of an 81-year-old man with primary CCS of the pubic bone. Histological examination of the pubic bone revealed monomorphic small-sized cells arranged predominantly as a diffuse sheet with round, hyperchromatic nuclei and inconspicuous nucleoli. The cells had scant cytoplasm, and the biopsy findings indicated small round cell tumor (SRCT). Immunohistochemical staining revealed the tumor cells to be positive for HMB45, S100, and Melan-A but negative for cytokeratin (AE1/AE3) and epithelial membrane antigen. To the best of our knowledge, this is the first case report of primary CCS of the pubic bone resembling SRCT. This ambiguous appearance underscores the difficulties encountered during the histological diagnosis of this rare variant of CCS. CONCLUSION: Awareness of primary CCS of the bone is clinically important for accurate diagnosis and management when the tumor is located in unusual locations such as the pubic bone and when the translocation t(12; 22)(q13; q12) is absent.
  BMC Cancer 11/2012; 12(1):538. · 3.01 Impact Factor
• Article: Immunohistological analysis in diagnosis of plasma cell myeloma based on cytoplasmic kappa/lambda ratio of CD38-positive plasma cells.

  Shoko Nakayama, Taiji Yokote, Yuji Hirata, Kazuki Iwaki, Toshikazu Akioka, Takuji Miyoshi, Uta Nishiwaki, Yuki Masuda, Nobuya Hiraoka, Ayami Takayama, Yasuichiro Nishimura, Motomu Tsuji, Toshiaki Hanafusa
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  ABSTRACT: The accurate determination of cytoplasmic immunoglobulin (cIg) light chain (LC) expression is important to differentiate reactive plasmacytosis from a clonal plasma cell neoplasm such as plasma cell myeloma (PCM). Through retrospective analysis, we studied the cytoplasmic kappa/lambda ratio of CD38-positive plasma cells in the bone marrow from 19 PCM patients and 19 controls. To demonstrate cIg LC expression, the bone marrow was immunostained for IgA, IgG, IgM, kappa, and lambda. The kappa/lambda ratio was defined as the ratio of the kappa-positive cell to the lambda-positive cell in plasma cells. PCM cells were distinguished from normal plasma cells by cut-off levels between 0.59 and 4.0, a sensitivity of 94.7%, and a specificity of 94.7%. The detection of the cytoplasmic kappa/lambda ratio of CD38-positive plasma cells may be a useful tool in the diagnosis of PCM and the correct diagnosis of PCM may be achieved more simply.
  Hematology (Amsterdam, Netherlands) 11/2012; 17(6):317-20. · 1.33 Impact Factor
• Article: An approach for diagnosing plasma cell myeloma by three-color flow cytometry based on kappa/lambda ratios of CD38-gated CD138+ cells.

  Shoko Nakayama, Taiji Yokote, Yuji Hirata, Kazuki Iwaki, Toshikazu Akioka, Takuji Miyoshi, Ayami Takayama, Uta Nishiwaki, Yuki Masuda, Toshiyuki Ikemoto, Hidema Tanaka, Yasuichiro Nishimura, Motomu Tsuji, Toshiaki Hanafusa
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  ABSTRACT: BACKGROUND: World Health Organization (WHO) criteria are commonly used to diagnose plasma cell myeloma (PCM); however, these criteria are complex and require several laboratory parameters. For differentiating reactive plasmacytosis from clonal plasma cell (PC) neoplasms such as PCM, it is important to accurately determine the expression of cytoplasmic immunoglobulin light chains. METHODS: We retrospectively analyzed the records of 27 selected patients with PCM who underwent bone biopsies for confirmative diagnosis according to WHO criteria. Twenty-three controls were also investigated. In the present study, all the samples were analyzed using flow cytometry (FC) in the side scatter vs. CD38 histogram mode, and the CD38-gated PC population was identified. Bivariate histograms of CD138/kappa and CD138/lambda were assessed, and the ratios of dual-positive cells to the CD138+ PC population were calculated. The kappa/lambda ratio was defined as the ratio of CD138/kappa to CD138/lambda. RESULTS: PCM cells were distinguished from normal PCs using cutoff levels between 0.76 and 1.5, at a sensitivity of 96.3% and specificity of 95.7%. CONCLUSIONS: Three-color FC analysis is simple to perform and inexpensive, with clinically relevant data obtained soon after the completion of FC measurements. The detection of the cytoplasmic kappa/lambda ratio of CD38-gated CD138+ PCs may be a useful tool in the diagnosis of PCM. To the best of our knowledge, this report represents the first diagnostic assessment of the cytoplasmic kappa/lambda ratio in CD38-gated CD138+ PCs using FC analysis. This method may help in more simple, efficient, rapid, and accurate diagnosis of PCM.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1568085959771735.
  Diagnostic Pathology 09/2012; 7(1):131. · 1.64 Impact Factor
• Article: Multiple cytokine-producing plasmablastic solitary plasmacytoma of bone expressing multiple cytokine receptors.

  Shoko Nakayama, Taiji Yokote, Kazuki Iwaki, Yuji Hirata, Ayami Takayama, Toshikazu Akioka, Takuji Miyoshi, Uta Nishiwaki, Yuki Masuda, Motomu Tsuji, Toshiaki Hanafusa
  Leukemia & lymphoma 09/2012; · 2.40 Impact Factor
• Article: Multiple cytokine- and chemokine-producing primary testicular diffuse large B-cell lymphoma, not otherwise specified.

  Shoko Nakayama, Taiji Yokote, Kazuki Iwaki, Yuji Hirata, Uta Nishiwaki, Toshikazu Akioka, Takuji Miyoshi, Yuki Masuda, Motomu Tsuji, Toshiaki Hanafusa
  Leukemia research 05/2012; 36(8):e171-4. · 2.36 Impact Factor
• Article: Immunohistological diagnosis of plasma cell myeloma based on cytoplasmic kappa/lambda ratio of CD138-positive plasma cells.

  Shoko Nakayama-Ichiyama, Taiji Yokote, Yuji Hirata, Kazuki Iwaki, Toshikazu Akioka, Takuji Miyoshi, Ayami Takayama, Uta Nishiwaki, Yuki Masuda, Yasuichiro Nishimura, Motomu Tsuji, Toshiaki Hanafusa
  [show abstract] [hide abstract]
  ABSTRACT: Abstract For differentiating reactive plasmacytosis from clonal plasma cell neoplasms such as plasma cell myeloma (PCM), it is important to determine the expression of the cytoplasmic light chain accurately. Through retrospective analysis, we studied the cytoplasmic kappa/lambda ratio of CD138-positive plasma cells in bone marrow from 50 patients with PCM and 50 controls by immunohistological analysis. The percentage of cytoplasmic light chain immunoreactive cells out of the total plasma cell population was shown by a novel quantitative image analysis approach using an Aperio ScanScope CS and the Membrane v9 algorithm. PCM cells were distinguished from normal plasma cells by cut-off levels between 0.35 and 5.5, a sensitivity of 100% and a specificity of 98.0%. Detection of the cytoplasmic kappa/lambda ratio of CD138-positive plasma cells could be a useful tool for simple, efficient and accurate diagnosis of PCM.
  Leukemia & lymphoma 04/2012; 53(11):2205-9. · 2.40 Impact Factor
• Article: Syndrome of inappropriate antidiuretic hormone secretion associated with primary cutaneous anaplastic large cell lymphoma.

  Yuji Hirata, Taiji Yokote, Uta Nishiwaki, Motomu Tsuji, Toshiaki Hanafusa
  British Journal of Haematology 03/2012; 157(4):412. · 4.94 Impact Factor
• Article: Multiple cytokine-producing plasmablastic solitary plasmacytoma of bone with polyneuropathy, organomegaly, endocrinology, monoclonal protein, and skin changes syndrome.

  Shoko Nakayama-Ichiyama, Taiji Yokote, Yuji Hirata, Kazuki Iwaki, Toshikazu Akioka, Takuji Miyoshi, Uta Nishiwaki, Yuki Masuda, Nobuya Hiraoka, Ayami Takayama, Motomu Tsuji, Toshiaki Hanafusa
  Journal of Clinical Oncology 03/2012; 30(7):e91-4. · 18.37 Impact Factor
• Article: Aggressive primary testicular diffuse large B-cell lymphoma, not otherwise specified with expression of interferon-γ and its receptors.

  Shoko Nakayama-Ichiyama, Taiji Yokote, Yuji Hirata, Kazuki Iwaki, Uta Nishiwaki, Takuji Miyoshi, Yuki Masuda, Toshikazu Akioka, Motomu Tsuji, Toshiaki Hanafusa
  Acta oncologica (Stockholm, Sweden) 01/2012; 51(6):814-6. · 2.27 Impact Factor
• Article: Multiple cytokine-induced acute respiratory distress syndrome with a diffuse large B cell lymphoma, not otherwise specified.

  Shoko Nakayama-Ichiyama, Taiji Yokote, Kazuki Iwaki, Yuji Hirata, Uta Nishiwaki, Yuki Masuda, Satoko Oka, Toshikazu Akioka, Takuji Miyoshi, Motomu Tsuji, Toshiaki Hanafusa
  Pathology 12/2011; 43(7):740-2. · 2.38 Impact Factor
• Article: Hypercalcaemia induced by tumour-derived parathyroid hormone-related protein and multiple cytokines in diffuse large B cell lymphoma, not otherwise specified.

  Shoko Nakayama-Ichiyama, Taiji Yokote, Kazuki Iwaki, Nobuya Hiraoka, Yuji Hirata, Satoko Oka, Toshikazu Akioka, Takuji Miyoshi, Ayami Takayama, Uta Nishiwaki, Yuki Masuda, Motomu Tsuji, Toshiaki Hanafusa
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  ABSTRACT: An abstract is unavailable. This article is available as HTML full text and PDF.
  Pathology 12/2011; 43(7):742-5. · 2.38 Impact Factor
• Article: Expression of multiple cytokines and CCR4 in primary testicular diffuse large B-cell lymphoma, not otherwise specified, involving the skin.

  Shoko Nakayama-Ichiyama, Kazuki Iwaki, Taiji Yokote, Motomu Tsuji, Yuji Hirata, Toshiaki Hanafusa
  British Journal of Haematology 11/2011; 156(4):420. · 4.94 Impact Factor
• Article: Multiple cytokine-producing solitary plasmacytoma of bone with expression of cytokine receptors.

  Shoko Nakayama-Ichiyama, Taiji Yokote, Kazuki Iwaki, Yuji Hirata, Toshikazu Akioka, Takuji Miyoshi, Satoko Oka, Uta Nishiwaki, Yuki Masuda, Motomu Tsuji, Toshiaki Hanafusa
  Journal of Clinical Oncology 11/2011; 29(36):e861-3. · 18.37 Impact Factor
• Article: Matrix metalloproteinase-3 producing diffuse large B-cell lymphoma, not otherwise specified associated with rheumatoid arthritis.

  Shoko Nakayama-Ichiyama, Taiji Yokote, Nobuya Hiraoka, Kazuki Iwaki, Ayami Takayama, Yuji Hirata, Takuji Miyoshi, Satoko Oka, Toshikazu Akioka, Shigeki Makino, Motomu Tsuji, Toshiaki Hanafusa
  Journal of Clinical Oncology 08/2011; 29(28):e731-2. · 18.37 Impact Factor
• Article: Plasmablastic solitary plasmacytoma of bone expressing granulocyte colony-stimulating factor and its receptor.

  Shoko Nakayama-Ichiyama, Taiji Yokote, Kazuki Iwaki, Yuji Hirata, Motomu Tsuji, Toshiaki Hanafusa
  British Journal of Haematology 07/2011; 156(1):137. · 4.94 Impact Factor
• Article: Diffuse large B-cell lymphoma, not otherwise specified, associated with coinfection of human herpesvirus 6 and 8.

  Shoko Nakayama-Ichiyama, Taiji Yokote, Satoko Oka, Kazuki Iwaki, Kichinosuke Kobayashi, Yuji Hirata, Nobuya Hiraoka, Ayami Takayama, Toshikazu Akioka, Takuji Miyoshi, Takayuki Takubo, Motomu Tsuji, Toshiaki Hanafusa
  Journal of Clinical Oncology 05/2011; 29(21):e636-7. · 18.37 Impact Factor
• Article: Primary effusion lymphoma of T-cell origin with t(7;8)(q32;q13) in an HIV-negative patient with HCV-related liver cirrhosis and hepatocellular carcinoma positive for HHV6 and HHV8.

  Shoko Nakayama-Ichiyama, Taiji Yokote, Kichinosuke Kobayashi, Yuji Hirata, Nobuya Hiraoka, Kazuki Iwaki, Ayami Takayama, Toshikazu Akioka, Satoko Oka, Takuji Miyoshi, Hideo Fukui, Yasuhiro Tsuda, Takayuki Takubo, Motomu Tsuji, Kazuhide Higuchi, Toshiaki Hanafusa
  Annals of Hematology 02/2011; 90(10):1229-31. · 2.62 Impact Factor
• Article: Two case reports of non-secretory [correction of non-secretary]-Ig types of lymphoplasmacytic lymphoma (LPL).

  Kichinosuke Kobayashi, Taiji Yokote, Yuji Hirata, Shoko Nakayama, Nobuya Hiraoka, Ayami Takayama, Kazuki Iwaki, Toshikazu Akioka, Takayuki Takubo, Motomu Tsuji, Toshiaki Hanafusa
  Annals of Hematology 09/2010; 89(9):945-7. · 2.62 Impact Factor