Michel Haïssaguerre

Université Bordeaux Montaigne, Pessac, Aquitaine, France

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Publications (545)3126.15 Total impact

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    ABSTRACT: Pacemaker mediated tachycardia (PMT) is the term used to describe a repetitive sequence of sensed retrograde P waves followed by ventricular pacing at or below the maximum tracking rate. The following events can promote AV dissociation, retrograde conduction and the onset of PMT: ventricular or atrial extrasystole, an excessively long programmed AV delay, external interference or myopotentials sensed by the atrial channel, atrial sensing or pacing failure, the absence of post ventricular atrial refractory period extension after removal of a magnet, VDD pacing at a higher rate than sinus rate. In contemporary devices, each manufacturer has a proprietary algorithm to detect and terminate PMT. Because of the increase in the number and complexity of the pacing algorithms and because of manufacturer-driven differences, a basic understanding of these new algorithms is important for patient care. We review here the main elements of the physiopathology of this type of tachycardia, describe the specific characteristics of the different manufacturers and present representative clinical cases. This article is protected by copyright. All rights reserved.
    Pacing and Clinical Electrophysiology 09/2015; DOI:10.1111/pace.12750 · 1.13 Impact Factor
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    ABSTRACT: Ten years ago, electrocardiographic imaging (ECGI) started to demonstrate its efficiency in clinical settings. The initial application to localize focal ventricular arrhythmias such as ventricular premature beats was probably the easiest to challenge and validates the concept. Our clinical experience in using this non-invasive mapping technique to identify the sources of electrical disorders and guide catheter ablation of atrial arrhythmias (premature atrial beat, atrial tachycardia, atrial fibrillation), ventricular arrhythmias (premature ventricular beats) and ventricular pre-excitation (Wolff-Parkinson-White syndrome) is described here.
    Journal of electrocardiology 09/2015; DOI:10.1016/j.jelectrocard.2015.08.028 · 1.36 Impact Factor
  • Darren A Hooks · Frederic Sacher · Michel Haissaguerre · Nicolas Derval
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    ABSTRACT: A 60-year-old woman presented for radiofrequency ablation of persistent atrial tachycardia (AT) one year after pulmonary vein isolation and mitral isthmus linear ablation for atrial fibrillation. The AT (CL 288ms) was mapped using the Orion(TM) multipolar basket catheter and Rhythmia(TM) mapping system (Boston Scientific, MA, USA). Mapping points (n = 12,385) were obtained from the basket catheter (64 electrodes of 0.4mm(2) area; 2.5mm spacing) using continuous (automated) acquisition over 16 minutes, with standard beat acceptance criteria: (i) variation of CL < 13 ms, (ii) variation of activation time difference between coronary sinus (CS) electrograms < 5ms, (iii) respiration phase gated to within 13.6 μV, (iv) catheter motion < 1.7 mm per beat, and (v) catheter tracking uncertainty < 3 mm. The activation map (figure panel A) revealed localized counter-clockwise reentry within the previous mitral isthmus ablation line, appreciated in more detail in the accompanying cine frames (panel A) and Online Movie. This article is protected by copyright. All rights reserved.
    Journal of Cardiovascular Electrophysiology 09/2015; DOI:10.1111/jce.12841 · 2.96 Impact Factor
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    ABSTRACT: Background: -VT recurrence can occur after VT ablation due to incomplete and/or non-transmural ventricular lesion formation. We sought to compare the lesions made by a novel irrigated needle catheter to conventional radiofrequency (RF) lesions. Methods and results: -Thirteen female sheep (4.6±0.7yrs, 54±8kg) were studied. In 7 sheep, 60s RF applications were performed using an irrigated needle catheter. In 6 sheep, conventional lesions were made using a 4mm-irrigated catheter. 1.5 T in vivo and high-density MRI (9.4Tesla) were performed on explanted hearts from animals receiving needle RF. Conventional lesion volume was calculated as (1/6)∗π∗(A∗B(2)+C∗D(2)/2). Needle lesion volume was measured as Σ(π∗r(2))/2 with a slice thickness of 1mm. The dimensions of all lesions were also measured on gross pathology. Additional histological analysis of the needle lesions was performed. 120 endocardial left ventricular ablation lesions (conventional, n=60; needle, n=60) were created. At necropsy, more lesions were found using needle vs. conventional RF (90% vs. 75%, p<0.05). Comparing needle vs. conventional RF: Lesion volume was larger (1030±362mm3 vs. 488±384mm3, p<0.001), lesion depth was increased (9.9±2.7mm vs. 5±2.4mm, p<0.001) and more transmural lesions were created (62.5% vs. 17%, p<0.01). Pericardial contrast injection was observed in 4 apical attempts using needle RF, however with no adverse effects. Steam pops occurred in 3 attempts using conventional RF. Conclusions: -Irrigated needle ablation is associated with more frequent, larger, deeper, and more often transmural lesions compared to conventional irrigated ablation. This technology might be of value to treat intramural or epicardial VT substrates resistant to conventional ablation.
    Circulation Arrhythmia and Electrophysiology 09/2015; DOI:10.1161/CIRCEP.115.002963 · 4.51 Impact Factor
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    ABSTRACT: This study sought to determine if the acute procedural outcome of ventricular tachycardia (VT) substrate ablation is associated with a mortality benefit in patients with implantable cardioverter-defibrillators (ICD). A total of 195 ICD recipients (65±11years) with ischemic or non-ischemic dilated cardiomyopathy underwent substrate-based ablation targeting elimination of local abnormal ventricular activities (LAVA). Acute procedural success, which was defined as elimination of all identified LAVA in addition to the lack of VT inducibility, was achieved in 95 (49%) patients. During a median follow-up of 23 months, patients with acute procedure success had a significantly lower incidence of ICD shocks compared to those with ablation failure (8% vs. 30%, p<0.001). In multivariate analysis, acute procedural success was associated with a lower risk of VT recurrence (hazard ratio [HR] 0.30, 95% confidence interval [CI] 0.18-0.49, P<0.001) and all-cause mortality (HR 0.32, 95%CI 0.17-0.60, P<0.001). While the impact of ablation success on mortality was not statistically significant in patients with LVEF>35% (HR 0.45, 95%CI 0.15-1.34, P = 0.15) and those with NYHA class I/II (HR 0.63, 95%CI 0.29-1.40, P = 0.26), it was marked in patients with LVEF≤35% (HR 0.30, 95%CI 0.14-0.62, P = 0.001) and NYHA class III/IV (HR 0.17, 95%CI 0.05-0.57, P = 0.004). LAVA elimination in addition to VT non-inducibility as a procedural outcome for substrate-based ablation is associated with reduced mortality and better VT-free survival during follow-up. This prognostic benefit may be most pronounced in patients with severe heart failure as indicated by severely depressed LV function and NYHA class III/IV symptoms. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Journal of Cardiovascular Electrophysiology 09/2015; DOI:10.1111/jce.12825 · 2.96 Impact Factor
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    ABSTRACT: -The correlates of left ventricular (LV) substrate in arrhythmogenic right ventricular cardiomyopathy (ARVC) are largely unknown. -Thirty-two ARVC patients (47±14years, 6 women) were included. RV and LV dysplasia were defined from MDCT and CMR imaging. Arrhythmias were characterized as right-sided or left-sided on 12-lead ECG recordings at baseline and during isoproterenol testing. In 14 patients, the imaging substrate was compared to voltage mapping and local abnormal ventricular activity (LAVA). Imaging abnormalities were found in 32(100%) and 21(66%) patients on the RV and LV, respectively, intra-myocardial fat on MDCT being the most sensitive feature. LV involvement related to none of the Task Force criteria. Right-sided arrhythmias were more frequent than left-sided arrhythmias (P=0.003), although the latter were more frequent in case of LV involvement (P=0.02). The agreement between low voltage and fat on MDCT was high on the RV when using either endocardial unipolar or epicardial bipolar data (k=0.82 and k=0.78, respectively), but lower on the LV (k=0.54 for epicardial bipolar). LV LAVA was found in all patients with LV involvement, and none of the others. The density of LAVA within fat areas was similar between the RV and LV (P=0.57). -LV substrate is frequent in ARVC, but poorly identified by current diagnostic strategies. Left-sided arrhythmias are more frequent in case of LV involvement. LV fat hosts the same density of LAVA as RV fat, but is less efficiently detected by voltage mapping. These results support the need for alternative diagnostic strategies to identify LV dysplasia.
    Circulation Arrhythmia and Electrophysiology 08/2015; DOI:10.1161/CIRCEP.115.003213 · 4.51 Impact Factor
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    ABSTRACT: factors associated with premature ventricular contraction-induced cardiomyopathy (PVCi-CMP) remain debated OBJECTIVE: The aim of this study was to test the correlation of various factors to the presence PVCi-CMP in a large multicenter population METHODS: 168 consecutive patients referred for ablation of frequent PVCs were included. Patients were divided into group 1 with suspected PVCi-CMP (96 patients, EF 38±10 %, LV end diastolic diameter 62±8 mm, w/wo additional structural heart disease) and group 2 (control group, 72 patients with normal EF and LV dimensions). Various clinical and electrophysiological parameters were compared between groups. In univariate analysis, a left ventricular origin of the PVC, the lack of palpitations, a long PVC coupling interval, an epicardial origin of the focus, a long sinus beat QRS duration, a male gender, a high PVC burden, the presence of polymorphic PVCs, a high PVC and sinus beat QRS amplitude and an older age were significantly related to the presence of PVCi-CMP. In multivariate analysis, only the lack of palpitations, the PVC burden and an epicardial origin remained significantly and independently correlated with the presence of CMP. Even if sinus QRS duration or a PVC left ventricular origin were also found independently linked to PVCi-CMP in the whole population, they were no longer correlated when patients with additional heart disease were excluded. The lack of palpitations, the PVC burden and an epicardial origin are independent factors that identify the patients prone to develop PVCi-CMP. Copyright © 2015. Published by Elsevier Inc.
    Heart rhythm: the official journal of the Heart Rhythm Society 08/2015; DOI:10.1016/j.hrthm.2015.08.025 · 5.08 Impact Factor
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    ABSTRACT: Surgical repair of Tetralogy of Fallot (TOF) is highly successful but may be complicated in adulthood by arrhythmias, sudden death, and right ventricular or biventricular dysfunction. To better understand the molecular and cellular mechanisms of these delayed cardiac events, a chronic animal model of postoperative TOF was studied using microarrays to perform cardiac transcriptomic studies. The experimental study included 12 piglets (7 rTOF and 5 controls) that underwent surgery at age 2 months and were further studied after 23 (+/- 1) weeks of postoperative recovery. Two distinct regions (endocardium and epicardium) from both ventricles were analyzed. Expression levels from each localization were compared in order to decipher mechanisms and signaling pathways leading to ventricular dysfunction and arrhythmias in surgically repaired TOF. Several genes were confirmed to participate in ventricular remodeling and cardiac failure and some new candidate genes were described. In particular, these data pointed out FRZB as a heart failure marker. Moreover, calcium handling and contractile function genes (SLN, ACTC1, PLCD4, PLCZ), potential arrhythmia-related genes (MYO5B, KCNA5), and cytoskeleton and cellular organization-related genes (XIRP2, COL8A1, KCNA6) were among the most deregulated genes in rTOF ventricles. To our knowledge, this is the first comprehensive report on global gene expression profiling in the heart of a long-term swine model of repaired TOF.
    PLoS ONE 08/2015; 10(8):e0134146. DOI:10.1371/journal.pone.0134146 · 3.23 Impact Factor
  • Circulation Arrhythmia and Electrophysiology 08/2015; 8(4):963-71. DOI:10.1161/CIRCEP.114.001721 · 4.51 Impact Factor
  • Ashok Shah · Meleze Hocini · Michel Haissaguerre · Pierre Jaïs
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    ABSTRACT: Since more than 100 years, 12-lead electrocardiography (ECG) is the standard-of-care tool, which involves measuring electrical potentials from limited sites on the body surface to diagnose cardiac disorder, its possible mechanism, and the likely site of origin. Several decades of research has led to the development of a 252-lead ECG and computed tomography (CT) scan-based three-dimensional electro-imaging modality to non-invasively map abnormal cardiac rhythms including fibrillation. These maps provide guidance towards ablative therapy and thereby help advance the management of complex heart rhythm disorders. Here, we describe the clinical experience obtained using non-invasive technique in mapping the electrical disorder and guide the catheter ablation of atrial arrhythmias (premature atrial beat, atrial tachycardia, atrial fibrillation), ventricular arrhythmias (premature ventricular beats), and ventricular pre-excitation (Wolff-Parkinson-White syndrome).
    Current Cardiology Reports 08/2015; 17(8):616. DOI:10.1007/s11886-015-0616-6 · 1.93 Impact Factor
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    ABSTRACT: The term early repolarization has been in use for more than 50 years. This electrocardiographic pattern was considered benign until 2008, when it was linked to sudden cardiac arrest due to idiopathic ventricular fibrillation. Much confusion over the definition of early repolarization followed. Thus, the objective of this paper was to prepare an agreed definition to facilitate future research in this area. The different definitions of the early repolarization pattern were reviewed to delineate the electrocardiographic measures to be used when defining this pattern. An agreed definition has been established, which requires the peak of an end-QRS notch and/or the onset of an end-QRS slur as a measure, denoted Jp, to be determined when an interpretation of early repolarization is being considered. One condition for early repolarization to be present is Jp ≥0.1 mV, while ST-segment elevation is not a required criterion. Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
    Journal of the American College of Cardiology 07/2015; 66(4):470-7. DOI:10.1016/j.jacc.2015.05.033 · 16.50 Impact Factor
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    ABSTRACT: Substrate-based VT ablation is mostly based on maps acquired with ablation catheters. We hypothesized that multipolar mapping catheters are more effective for identification of scar and local abnormal ventricular activity (LAVA). Phase1: In a sheep infarction model (2 months post-infarction), substrate mapping and LAVA tagging (CARTO(®) 3) was performed, using a Navistar (NAV) vs. a PentaRay (PR) catheter (Biosense Webster). Phase2: Consecutive VT ablation patients from a single center underwent NAV vs. PR mapping. Point pairs were defined as a PR and a NAV point located within a 3D-distance of ≤3mm. Agreement was defined as both points in a pair being manually tagged as normal or LAVA. Four sheep (4 years, 50±4.8kg) and 9 patients were included (53±14 years, 8 male, 6 ischaemic cardiomyopathy). Mapping density was higher within the scar with PR vs. NAV (3.2 vs. 0.7points/cm(2) , p = 0.001) with larger bipolar scar area (68±55cm(2) vs. 58±48cm(2) , p = 0.001). In total, 818 point pairs were analyzed. Using PR, far-field voltages were smaller (PR vs. NAV; bipolar: 1.43±1.84mV vs. 1.64±2.04mV, p = 0.001; unipolar; 4.28±3.02mV vs. 4.59±3.67mV, p<0.001). More LAVA were also detected with PR (PR vs. NAV; 126±113 vs. 36±29, p = 0.001). When agreement on LAVA was reached (overall: 72%; both LAVA, 40%; both normal, 82%) higher LAVA voltages were recorded on PR (0.48±0.33mV vs. 0.31±0.21mV, p = 0.0001). Multipolar mapping catheters with small electrodes provide more accurate and higher density maps, with a higher sensitivity to near field signals. Agreement between PR and NAV is low. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Journal of Cardiovascular Electrophysiology 07/2015; DOI:10.1111/jce.12761 · 2.96 Impact Factor
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    ABSTRACT: Risk stratification in Brugada syndrome (BS) remains controversial. The T peak to T end (Tpe) interval, a marker of transmural dispersion of repolarisation, has been linked to malignant ventricular arrhythmias in various setting but lead to discordant results in BS. We study the correlation of Tpe with arrhythmic events in a large cohort of BS patients. 325 consecutive BS patients (47±13 years old, 259 males) with spontaneous (44%) or drug induced (56%) type 1 ECG were retrospectively included: 70% were asymptomatic, 22% presented with unexplained syncope and 8% presented with sudden death (SD) or appropriate ICD therapies (AT) at diagnosis or over a mean follow-up of 48±34 months. Tpe was calculated by the difference between QT and QT peak intervals, as measured in each of the precordial leads. Tpe from V1 to V4, Tpe maximum value and Tpe dispersion in all precordial leads were significantly higher in patients with SD/AT or in patients with syncope compared to asymptomatic patients (p<0.001). A max Tpe > 100 ms was present in 47/226 asymptomatic patients (21%), in 48/73 patients with syncope (66%) and in 22/26 patients with SD/AT (85%) (p<0.0001). In multivariate analysis, a max Tpe ≥ 100 ms was independently related to arrhythmic events with an OR of 9.61 (95% CI 3.13-29.41) (p<0.0001). Tpe in the precordial leads is highly related to malignant ventricular arrhythmias in BS in this large series of patients. This simple ECG parameter could be used for refining risk stratification. Copyright © 2015. Published by Elsevier Inc.
    Heart rhythm: the official journal of the Heart Rhythm Society 07/2015; DOI:10.1016/j.hrthm.2015.07.029 · 5.08 Impact Factor
  • Nicolas Derval · Frederic Sacher · Arnaud Denis · Michel Haïssaguerre
    Heart rhythm: the official journal of the Heart Rhythm Society 07/2015; DOI:10.1016/j.hrthm.2015.07.028 · 5.08 Impact Factor
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    ABSTRACT: A new ECG criterion has been studied in Brugada syndrome (BrS) at rest to differentiate type 2 and incomplete right bundle branch block (IRBBB). We assessed this criterion during exercise comparing BrS (46 patients) and IRBBB (17 patients). A beta angle was measured from lead V1 between the upslope of S-wave and the downslope of the r'-wave. Beta angle was significantly larger in BrS at rest (58±24° vs 25±15°, p<0.001), exercise (47±26° vs 15±11°, p<0.001), and recovery (46±24° vs 21±12°, p<0.001) with a reduction in angle at exercise compared to rest. There was a significant rebound in angle at recovery in the control group to (p<0.001); no such rebound was observed in the BrS group (p=NS). Beta angle study at rest and its evolution at exercise could help discriminate BrS patients from healthy subjects. Copyright © 2015 Elsevier Inc. All rights reserved.
    Journal of electrocardiology 06/2015; 48(5). DOI:10.1016/j.jelectrocard.2015.06.008 · 1.36 Impact Factor
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    ABSTRACT: -It is thought that compared to integrated bipolar leads, dedicated bipolar are more susceptible to T-wave oversensing. This could be of extreme importance in patients with Brugada syndrome (BrS) since T-wave oversensing in this population is more frequent compared to other ICD recipients without BrS. We aimed to compare the incidence of T-wave oversensing in patients with BrS according to the type of lead (integrated bipolar versus true/dedicated bipolar). -All BrS patients with an ICD implant in 10 tertiary hospitals between 1993 and 2013. A total of 480 patients were included (mean age 45,6 ± 14). During a mean follow-up of 74,9 ± 51,7 months (median 69, range 2-236), 28 patients had T-wave oversensing (5,8%), leading to inappropriate shock in 18 (3,8%). All these events occurred in patients with true bipolar ICD leads (p=0,01) and in two patients it was solved instantaneously by changing the configuration from a dedicated to an integrated bipolar sensing configuration. In the stepwise multivariate models only integrated bipolar ICD leads (HR 0.34; 95% CI 0,171-0,675; p=0,002) was independent predictor of non T-wave oversensing. -T-wave oversensing is a potential reason of inappropriate shocks in patients with BrS receiving ICDs. In the vast majority it can be solved by reprogramming. However, in some patients it still requires invasive intervention. Importantly, incidence is significantly lower using an integrated bipolar lead system when compared to a dedicated bipolar lead system and hence the latter should be routinely employed in BrS cases.
    Circulation Arrhythmia and Electrophysiology 06/2015; 8(4). DOI:10.1161/CIRCEP.115.002871 · 4.51 Impact Factor
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    ABSTRACT: -Left ventricular assist devices (LVADs) are increasingly used as a bridge to cardiac transplantation or as destination therapy. Patients with LVADs are at high risk for ventricular arrhythmias (VA). This study describes VA characteristics and ablation in patients implanted with a Heart Mate 2 (HM2) device. -All patients with a HM2 device who underwent VA catheter ablation at 9 tertiary centers were included. Thirty-four patients (30 male, age 58 ± 10 years) underwent 39 ablation procedures. The underlying cardiomyopathy etiology was ischemic in 21 and non-ischemic in 13 patients with a mean left ventricular ejection fraction of 17±5% before LVAD implantation. One hundred and ten ventricular tachycardias (VTs) (cycle lengths: 230-740ms, arrhythmic storm n=28) and 2 ventricular fibrillation triggers were targeted (25 transseptal, 14 retrograde aortic approaches). Nine patients required VT ablation <1 month after LVAD implantation due to intractable VT. Only 10/110 (9%) of the targeted VTs were related to the HM2 cannula. During follow-up, 7 patients were transplanted and 10 died. Of the remaining 17 patients, 13 were arrhythmia-free at 25 ± 15 months. In 1 patient with VT recurrence, change of turbine speed from 9400 to 9000 rpm extinguished VT. -Catheter ablation of VT among LVAD recipients is feasible and reasonably safe even soon after LVAD implantation. Intrinsic myocardial scar, rather than the apical cannula, appears to be the dominant substrate.
    Circulation Arrhythmia and Electrophysiology 04/2015; 8(3). DOI:10.1161/CIRCEP.114.002394 · 4.51 Impact Factor
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    ABSTRACT: Ventricular tachycardia (VT) ablation for ventricular arrhythmias is a validated approach, typically performed endocardially, or combined with an epicardial approach if endocardial ablation failed or in case of non-ischaemic cardiomyopathy. We report our experience with epicardial only procedure in a subset of patients with incessant VT or VT storm. This was a single centre retrospective study. Between 2011 and 2014, all patients referred for VT ablation were reviewed at CHU Bordeaux. All patients with an epicardial only (anterior percutaneous approach) mapping and ablation procedure were included. In total, 296 patients underwent a VT ablation and 4 (all male, 70 ± 7 years, 27 ± 11% left ventricular ejection fraction) of them underwent an epicardial only procedure: two ischaemic patients had an endocardial left ventricular thrombus and incessant VT. One patient post-myocarditis had a failed a previous endocardial procedure without local abnormal ventricular activity (LAVA). The fourth patient had a dilated cardiomyopathy and a complicated epicardial puncture followed by mild continuous bleeding (200 mL) precluding anticoagulation associated with left ventricular endocardial access. Local abnormal ventricular activity elimination was verified only epicardially in all and obtained in two patients and non-inducibility was tested and achieved in the two patients without thrombus. No further complications occurred. After a mean follow-up of 21 ± 12 months, one patient (25%) had recurrence of VT and no patient death was observed. Epicardial only ablation seems feasible and effective and useful in a limited subset of patients with incessant VT. However, endpoints are more difficult to evaluate and long-term follow-up is needed. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.
    Europace 04/2015; DOI:10.1093/europace/euv072 · 3.67 Impact Factor
  • Archives of Cardiovascular Diseases Supplements 04/2015; 7(2):162. DOI:10.1016/S1878-6480(15)30085-9
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    ABSTRACT: nMARQ is a multipolar catheter designed to simultaneously ablate at multiple sites around the pulmonary vein (PV) circumference with a single radiofrequency application. We sought to define the safety and efficacy of atrial fibrillation (AF) ablation with the nMARQ catheter. In a multicenter study, patients with drug-refractory AF were included. Procedural outcomes were documented at one-year. 374 patients underwent PV isolation using nMARQ (age 60±10 years, 264 male). 263 patients had paroxysmal AF (PAF), while 111 patients had persistent AF. 1468 out of 1474 veins (99.6%) were isolated with the nMARQ catheter alone. 35 (13%) PAF patients and 30 (27%) persistent AF patients underwent additional ablation at non-PV sites (2.4 ± 1.4 non-PV sites). Procedure time for PV isolation only was 1.9 ± 0.7 hours (fluoroscopy 24 ± 14 minutes). Procedure time for PV isolation and non-PV ablation was 2.4 ± 1.0 hours (fluoroscopy 30 ± 23 minutes). Major adverse events occurred in 2 patients (0.5%); one esophago-pericardial fistula and another mortality due to sepsis of unknown cause. One-year follow-up data was available in 65 (25%) PAF and 20 (18%) persistent AF patients. 42 (65%) PAF and 13 (65%) persistent AF patients were free of arrhythmia at one year. In patients undergoing repeat procedures (n = 17) the most frequent points of PV reconnection were: anterior RSPV, inferior RIPV, and superior LSPV. AF ablation with nMARQ is associated with short procedure times and high acute success rates. Further research is necessary to more clearly define long-term outcome. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Journal of Cardiovascular Electrophysiology 04/2015; 26(7). DOI:10.1111/jce.12698 · 2.96 Impact Factor

Publication Stats

24k Citations
3,126.15 Total Impact Points


  • 2014–2015
    • Université Bordeaux Montaigne
      Pessac, Aquitaine, France
  • 2002–2015
    • Université Victor Segalen Bordeaux 2
      Burdeos, Aquitaine, France
  • 1991–2015
    • University of Bordeaux
      Burdeos, Aquitaine, France
  • 2012
    • Maastricht University
      Maestricht, Limburg, Netherlands
  • 2010
    • University of California, San Diego
      San Diego, California, United States
    • Lund University
      • Department of Electroscience
      Lund, Skåne, Sweden
  • 1994–2010
    • Centre Hospitalier Universitaire de Bordeaux
      Burdeos, Aquitaine, France
  • 2007
    • Taipei Veterans General Hospital
      • Cardiology Division
      T’ai-pei, Taipei, Taiwan
  • 2006
    • Catholic University of the Sacred Heart
      Milano, Lombardy, Italy
  • 2000
    • The University of Fort Lauderdale
      Fort Lauderdale, Florida, United States
  • 1995
    • Università degli Studi di Torino
      • Department of Medical Science
      Torino, Piedmont, Italy